Gene SgK493a (Sea Urchin)

SgK493a

Species: Sea Urchin
Alias: Spk402, SgK493a
External Links:
Annotation:

Classification

Group: Other
Family: SgK493

Sequence

Name Sequence Type Origin Length Description Download
SgK493a.AA Protein None 438 None Fasta, JSON
SgK493a.kin_dom Protein Kinase Domain None 222 None Fasta, JSON

Protein domain

Protein domains of SgK493a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK493a.AA SgK493 185-418 58 6.8e-199 576.2 In-house 1-234 (234) Show / Hide 
Range on Protein: 185-418
Range on HMM: 1-234/234
Sequence Identity: 58% (139 aa)

GRTIGQGHTKVVQEGTLLG-RKVAVKSAGMQVKSVKDCLEKGIYHKKEDCLILAMYKVLKEAMILRQVRHPHIVNLIGLCARSENGSPNIKERGITLVVE
|..|||||||.|..|...| ||||.|...|||..||.||....||.||||...||||..||.|.|||.||||||.|.|.|.|..||||.|...|||.|||
GQYIGQGHTKEVYRGRYMGGRKVAIKMVDMQVHDVKMCLNRRDYHIKEDCYRYAMYKLMKEMMYLRQLRHPHIVQLYGYCYRDDNGSPDIRDQGITTVVE

LGTPVHLHELVEDTWAKRVKYCMEIGRLLQFLEDSPMGSTAISDFRDEQFVIVDGALKLSDVDDLSSTEPDCDENMQCLVNGKS---AVKCSSNMKCGGL
||.|||.|.||...|..|..|||..||||..||.|||||..||||||.|||.|||.||..|.||.|..|.|||..|.|..|||.   ||||..||.|.|.
LGKPVHMHQLVQTMWEQRFRYCMDLGRLLHHLEHSPMGSVNISDFRDNQFVLVDGRLKVTDLDDMSTQEQDCDRSMDCIINGKDRNFAVKCCANMWCEGM

NASLNLFHAYEVFIGPLLSRDVPPSLDTAAKRLLKSLQ
||..||.|||..|..|||..||||||    . || |. 
NAKRNLYHAYRFFFTPLLQHDVPPSL----RPLLDSIV
Kinase SgK493a.AA FAK 182-263 30 5.3e-09 26.13 In-house 1-93 (285) Show / Hide 
Range on Protein: 182-263
Range on HMM: 1-93/285
Sequence Identity: 30% (28 aa)

IKVGRTIGQGHTKVVQEGTLLGRKV-----------AVKSAGMQVKSVKDCLEKGIYHKKEDCLILAMYKVLKEAMILRQVRHPHIVNLIGLC
|. .| || |    | .|. .  |              .|   .  |  | ..  |   |..|      | ..||.|..|  ||||| |||.|
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGIC
Kinase SgK493a.AA Csk 182-209 42 3e-06 17.59 In-house 1-28 (251) Show / Hide 
Range on Protein: 182-209
Range on HMM: 1-28/251
Sequence Identity: 42% (12 aa)

IKVGRTIGQGHTKVVQEGTLLGRKVAVK
...| .||.|    |  |....||||||
LHLGECIGHGEFGDVMQGEYQNRKVAVK
Kinase SgK493a.AA TyrKc 182-438 10 3e-06 -121.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 182-438
Range on HMM: 1-280/280
Sequence Identity: 10% (37 aa)

IKVGRTIGQGHTKVVQEGTLLGRKVAVKSAGMQVKSVKDCLEKGIYHKKEDCLILAMYKVLKEAMILRQV--RHPHIVNLIGLCARS-ENGSPNIKERGI
|. |...| |.  .| .||.  ..||||.                           .   ..|| |....  .||.||.|.| |  . .|    .    .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPL

TLVVELGTPVHLHELVEDTW-----AKRVKYCMEIGRLLQFLEDSPMGSTAISDFRDEQFVIVDGALKLSDVDDLSSTEPDCDENMQ----------CLV
 .|.|.     |..   ..      .. ...|  | .  ..|..                                          .          |||
MIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-----------------------------------------NCIHRDLAARNCLV

NGKS-----------AVKCS-------SNMKCG---GLNA----------SLNLFHA---------------YEVFIGPLLSRDVP----PSLDTAAKRL
. .            ...         .  .     | ..          ..  ..                .|.|         .     | . . ...
GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV

LKS--LQKGELD-------AEGMVYRL---------------KNLQSIP
 .   . . . |       .   .|..               ... .. 
KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SgK493a.AA UTK 182-267 20 5e-06 16.69 In-house 1-83 (296) Show / Hide 
Range on Protein: 182-267
Range on HMM: 1-83/296
Sequence Identity: 20% (19 aa)

IKVGRTIGQGHTKVVQEGTLLGRKVAVKSAGMQVKSVKDCLEKGIYHKKEDCLILAMY-KVLKEAM---ILRQVR-HPHIVNLIGLCARSE
.. ||..|||.  .|.....   . .   .. ....||.| ...   ....      | ....||    .. |.. ||....|.|.| ..|
VQLGRQLGQGAFGEVHKARF---TQCSEHMYEMDVAVKVCQHHADAQQEPEP-----YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEE
Kinase SgK493a.AA Pkinase_Tyr 242-267 42 6e-06 20.83 Pfam 51-78 (270) Show / Hide 
Range on Protein: 242-267
Range on HMM: 51-78/270
Sequence Identity: 42% (12 aa)

LKEAMILRQV-RHPHIVNLIGLCA-RSE
..|| |..|  .||.||.|.| |  ..|
MREAKIMKQLGHHPNIVRLYGVCTDQGE
Kinase SgK493a.AA RTKL 241-264 50 1.8e-05 9.89 In-house 46-69 (259) Show / Hide 
Range on Protein: 241-264
Range on HMM: 46-69/259
Sequence Identity: 50% (12 aa)

VLKEAMILRQVRHPHIVNLIGLCA
||.||. | |  ||||. . |  |
VLYEAVLLHQLHHPHIIQMHGCTA
Kinase SgK493a.AA CAMKL 183-259 21 3.9e-05 12.18 In-house 2-80 (297) Show / Hide 
Range on Protein: 183-259
Range on HMM: 2-80/297
Sequence Identity: 21% (19 aa)

KVGRTIGQGHTKVVQEGTLL---GRKVAVKSAGMQVKSVKDCLE------KGIYHKKEDCLILAMYKVLKEAMILRQVR---HPHIVNL
..|.|.|.|.  .|. .|     |.|||.|    . .. ... .      |             | .. .|. |.....   ||.|. |
RIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH---------ESDM-RIRREIQIMKMLNIGKHPNIIKL
Kinase SgK493a.AA SFK-Abl 242-265 50 5.7e-05 11.89 In-house 41-64 (251) Show / Hide 
Range on Protein: 242-265
Range on HMM: 41-64/251
Sequence Identity: 50% (12 aa)

LKEAMILRQVRHPHIVNLIGLCAR
.||| |... .||  | ||| | |
MKEAHIMKRMQHPNLVRLIGVCTR
Kinase SgK493a.AA TK 242-268 34 8.1e-05 11.24 In-house 86-117 (486) Show / Hide 
Range on Protein: 242-268
Range on HMM: 86-117/486
Sequence Identity: 34% (11 aa)

LKEAMILRQVR-----HPHIVNLIGLCARSEN
|.||... . .     ||.||.|.| | ..|.
LEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEP
Kinase SgK493a.AA Abl 242-265 50 0.000142 10.63 In-house 43-66 (252) Show / Hide 
Range on Protein: 242-265
Range on HMM: 43-66/252
Sequence Identity: 50% (12 aa)

LKEAMILRQVRHPHIVNLIGLCAR
|||| |.....|| .| |.| | |
LKEAAIMKEMKHPNLVQLLGVCTR
Kinase SgK493a.AA Met 242-273 31 0.000646 8.4 In-house 49-80 (271) Show / Hide 
Range on Protein: 242-273
Range on HMM: 49-80/271
Sequence Identity: 31% (10 aa)

LKEAMILRQVRHPHIVNLIGLCARSENGSPNI
|.|... .   ||..  ||| | ..|  .| .
LREGIMMKHFDHPNVLSLIGICLDPEGHMPWV
Kinase SgK493a.AA S_TKc 182-437 8 0.000959 -122.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 182-437
Range on HMM: 1-231/231
Sequence Identity: 8% (26 aa)

IKVGRTIGQGHTKVVQEGTLLG--RKVAVKSAGMQVKSVKDCLEKGIYHKKEDCLILAMYKVLKEAMILRQVRHPHIVNLIGLCARSENGSPNIKERGIT
 ...|.||.|   .|  ..  .  |.||.|                              ....|  ||.. .||.||.|.. .              . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLY

LVVELGTP--VHLHELVEDTWAKRVKYCMEIGRLLQFLEDSPMGSTAISDFRDEQFV----------IVDGALKLSD---------------------VD
.| |.       |... ..   .. .. .   .   ..        |.    . ...          . .  .|..|                     . 
MVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY---QICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQLTTFCGTPWYMAPEVL-

DLSSTEPDCDE----------NMQCLVNGKSAVKCSSNMKCGGLNASLNLFHAYEVFIGPLLSRDVPPSLDTAAKRLLKSLQKGELDAEGMVYRLKN---
         .            .  .. |.                  ...  ...              .  || ... . . . .    .  . .   
-------GYGKCKCDWWSCGCILYEMLCGYPPFP--------------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

----LQSI
     . .
DIKCHPWF
Kinase SgK493a.AA Met 183-210 30 0.021903 3.3 In-house 1-33 (271) Show / Hide 
Range on Protein: 183-210
Range on HMM: 1-33/271
Sequence Identity: 30% (10 aa)

KVGRTIGQGHTKVVQEGTLLG-----RKVAVKS
 ... |||||  .|  |...       ..|.||
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKS
Kinase SgK493a.AA Pkinase_Tyr 182-210 31 0.622921 3.78 Pfam 1-35 (270) Show / Hide 
Range on Protein: 182-210
Range on HMM: 1-35/270
Sequence Identity: 31% (11 aa)

IKVGRTIGQGHTKVVQEGTLL------GRKVAVKS
|. |...|.|.  .| .||.       . .||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKM