Gene NRK (Human)

NRK

Species: Human
Alias: NRK, ZC4
External Links:
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MSN

Sequence

Name Sequence Type Origin Length Description Download
NRK.AA Protein None 1582 None Fasta, JSON
NRK.NA RNA None 8080 None Fasta, JSON
NRK.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of NRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NRK.AA MSN 25-313 64 4.6e-195 649.88 In-house 1-265 (265) Show / Hide 
Range on Protein: 25-313
Range on HMM: 1-265/265
Sequence Identity: 64% (186 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQ
|.|....|.||||..|.|.|.|||...|.|||..|.                        ||||....|.|.|.|||.|.||...||||.|.||||..||
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVRE------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQ

LWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVI
||||||.|.||||||.|.||..||||||||||||||||.||||||.|.|||||||||||||||||||||||||||||..||.||||.|||||||||||||
LWMVMEFCGAGSVTDLVKMTKGQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI

DCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV
.|||.|...||||||.|||||||||||||.||||...|..|||.|.|...|..||..||.|||||||||.|||...||....||.|||.
ACDENPDATYDYRSDLWSVGITAIEMAEGQPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase NRK.AA STE20 25-313 41 4.1e-142 478.42 In-house 1-288 (288) Show / Hide 
Range on Protein: 25-313
Range on HMM: 1-288/288
Sequence Identity: 41% (130 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAF----TAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG
. | . || |.|| .|.. | .||       |.|.|| .|   .                 .  ||.||. .| . ....  |.|||..||...| ... 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNE-----------------Q--DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTC-

QRHQLWMVMELCAAGSVTDVVR--MTSNQ-----SLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSR----TNG-R
 ...||.|||.|..||.||...  |. ..     ...|..|||||||.||||..||....||||||..|.|||...||||.||||.||...    |.. .
-DDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFK

RNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVIL--RESAPTVK---SSGWSRKFHNFMEKCTIKNFLFRPT
||.|.||||||||||| |.|.|.  |||..|.||.|||||||||| ||.....|. |.| |.  ..  || |   .. || .||.|..||  |.  .|||
RNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPT

SANMLQHPFV
.  .|.|||.
ASQLLKHPFI
Kinase NRK.AA STE 25-313 28 1e-114 387.41 In-house 1-359 (359) Show / Hide 
Range on Protein: 25-313
Range on HMM: 1-359/359
Sequence Identity: 28% (110 aa)

FSLDKTIGLGTYGRIYLGLHEK---------------TGAFTAVKVMNARK---------TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKY
. . . || |..|  |.... |               || . |.|.|| ..             |             . .. ..|....  |.....|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-E-------------LENKNHEEMQQILKEIKIMKKC

SF-HKNIVSFYGAFFKLSPP-GQRHQLWMVMELCAAGSVTDVVRM--TSNQSLK----------EDWIAYICREILQG-LAHLHAHRVIHRDIKGQNVLL
.  |.||| .||..|| ... .....||..||....||..|...     ...|.          |..||||||.||.| |..|| |..||||||..|.||
NHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL

THNAEVKLVDFGVSAQVSR---------------TNG-RRNSFIGTPYWMAPEVIDCDEDP-RRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFV
     |||.||||..|..                |.. .||.|.||| |||||||.... . .  ||...|.||.|.|.||||.| ||.....|..|.| 
-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFM

ILRE---------------SAPTVKS------------------SGWSRKFHNFMEKCTIKNFLFRPTSANMLQ--HPFV
|...                 |. ..                  . || .|..|..|| .|.   |||.  .|.  |||.
IPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NRK.AA NinaC 84-313 46 1.1e-94 320.86 In-house 36-267 (267) Show / Hide 
Range on Protein: 84-313
Range on HMM: 36-267/267
Sequence Identity: 46% (109 aa)

SDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVR--MTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQ
.| .|.   | | ||.|. | |.| ||| ..|  . .   |||.|||.|. ||||| |.  .   . ..|. |||| .| . || ||| ..|||||.|| 
HDHDEEIEAEYNILRDYCDHPNVVRFYGMYYKKDKCNG-DQLWFVMEYCNGGSVTDMVKGLLKCGRRMREEHIAYILHEACMGLQHLHCNHVIHRDVKGN

NVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPT-VKSS
|.||| .  |||.|||||||.. | .|||  .|||.||||||| | .    .|| | |||| ||||||.. | ||. .. |  |.| | |   ||  .  
NILLTTEGGVKLCDFGVSAQLDSTRHRRNTCVGTPCWMAPEVIACMQQYDPDYDARCDVWSLGITAIELGDGDPPFADMHPMRAMFKIPRNPPPTLMHPE

GWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV
 |. .|  |  .| .|..  ||.  .||.|||.
NWCQEFNDFISQCLEKDYEKRPMMVHMLEHPFI
Kinase NRK.AA YSK 84-313 40 2.3e-84 253.89 In-house 38-257 (257) Show / Hide 
Range on Protein: 84-313
Range on HMM: 38-257/257
Sequence Identity: 40% (95 aa)

SDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNV
.|| ||.  | . |       .|  .||.. | .       || .|| |. ||. |  .     .. |  || | ||||.||  ||  |.||||||  ||
EDEIEDIQQEIQFLSQCDSP-YITKYYGSYLKDT------KLWIIMEYCGGGSCLDLMKPKYVGQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANV

LLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDC--DEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSG
||. . .||| ||||..|.  |  .|| |.||||||||||| .  ..     ||.  |.||.||||.||| | ||.| . |. ..| |  .  |. . . 
LLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSY-----YDFKADIWSLGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEGRS

WSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV
.|  | .| | |  |.  .||.  . | | |.
YSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase NRK.AA MST 104-313 47 2.1e-82 261.74 In-house 54-254 (254) Show / Hide 
Range on Protein: 104-313
Range on HMM: 54-254/254
Sequence Identity: 47% (101 aa)

KNIVSFYGAFF--KLSPPGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQ
|.|| .|| .|  |        ..| ||| |..||| |... | .. | |. || |..  ||||. ||  . ||||||  | || |  | || |||||.|
KYIVKYYGSYFDAK------NNHCWIVMEYCGMGSVCDIMKIT-QRTLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQ

VSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKS-SGWSRKFHNFMEKCTIKNFLF
 . |.. ||..||||||||||||         ||.  | || |||||||||| ||. ...|  |.| |     || |  . ||  | .|  || .||   
LTDTMAKRNTVIGTPYWMAPEVIQ-----EIKYDCKADIWSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQ

RPTSANMLQHPFV
|.|.   |||||.
RWTAEQLLQHPFI
Kinase NRK.AA S_TKc 25-313 26 2.6e-82 280.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-313
Range on HMM: 1-231/231
Sequence Identity: 26% (81 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQ
. . ..|| |..|. |.. | |||   |.|...                              |..| |...|.|   |.||| .|..|         . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------EHIRREIQILKK--HHPNIVKLYDVFQD-------DH

LWMVMELCAA--GSVTDVVRMTSN----QSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYW
|.||||.|    |.. |. .        . . | ........|...|...| |..||||.| .|.||..  ..|. |||...|.       ..|.|||..
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWY

MAPEVIDCDEDPRRSYDY-RSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQ-------H
|||||.        .|.. ..|.||.|.. .||. | || .  |. . . .|.            |. . .|..||  |.   |||    ||       |
MAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFV
|..
PWF
Kinase NRK.AA KHS 103-313 47 1.5e-76 257.01 In-house 55-258 (258) Show / Hide 
Range on Protein: 103-313
Range on HMM: 55-258/258
Sequence Identity: 47% (101 aa)

HKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQV
| |||...|....      | .||..|| | .||. |. ..|   .|.|  |||.|||.||||..||..  .|||||| |.|||.. .||| |||||||.
HPNIVAYFGSYLR------RDKLWICMEYCGGGSLQDIYHVTG--PLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQI

SRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRES--APTVKS-SGWSRKFHNFMEKCTIKNFL
. | ..| |||||||||||||   .   .  |.   |.|.|||||||.||  ||. .| |. |||.. . .   |..|  . || .||.|.  . .||  
TATIAKRKSFIGTPYWMAPEVAAVER--KGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPK

FRPTSANMLQHPFV
 |||.  .||||||
KRPTAEKLLQHPFV
Kinase NRK.AA PAKA 99-313 41 1.3e-73 250.89 In-house 53-260 (260) Show / Hide 
Range on Protein: 99-313
Range on HMM: 53-260/260
Sequence Identity: 41% (90 aa)

KYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTS--NQS-LKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVD
| . ||||| .. ..         ..||.|||  ..|. |||.  .   . . ..|. |||.|||.||||  .|.. .||||||  |.||  ...||. |
KECKHKNIVNYIDSYLV------DDELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITD

FGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSG-WSRKFHNFMEKCT
||  || .. . .||.  |||||||||||      |. ||.  |.|| || ||||.|| ||  |  || |.. |  . .|  |.   || .|..|..|| 
FGFCAQLTQEQQKRNTMVGTPYWMAPEVIR-----RKQYDEKVDIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCL

IKNFLFRPTSANMLQHPFV
 ..   |...   |.||| 
CVDVDRRASAQELLHHPFL
Kinase NRK.AA SLK 77-313 39 3.5e-73 246.21 In-house 30-259 (259) Show / Hide 
Range on Protein: 77-313
Range on HMM: 30-259/259
Sequence Identity: 39% (95 aa)

KSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHR
|..  .  .| ||   |...| .   | |||  |.|..        ..|||..| |. | | | . .  ...|.|| |.|.|......| .|| ..||||
KMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYY------YDNKLWMMIEFCDGGAV-DNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHR

DIKGQNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPT
|.|  |.|.| . .|.| ||||||.  .|  .| .||||||||||||. |.    . |||..|.||.||| ||||.. ||  ...|.  |. | .   ||
DLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPT

VKS-SGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV
..  | ||..|..|..||  |.   |.|.|...||..|
LEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase NRK.AA Pkinase 25-313 24 2.6e-65 228.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-313
Range on HMM: 1-293/293
Sequence Identity: 24% (81 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQ
. . ..|| |..|. |.. | .||   |||... |..   .  ...|                    .|. .... . |.||| .|..|        .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------------------SEIQIMKRLN-HPNIVRLYDWFED------KDH

LWMVMELCAAG----SVTDVVRMTSNQSL--KEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEV----KLVDFGVSAQV-SRTNGRRNSFI
..||||.|  |    .  |...  .. ..   |. .  ....||.||...|....||||.| .|.|. .| ..    |. |||...|.    |.  ..| 
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC

GTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNL----QPLEALFVILRESAPTVKSSGW----------------------SRKFH
|||..||||||      .. |....|.||.|.. .||. | || ..       .. ...| |   | .... .                      |. . 
GTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

NFMEKCTIKNFLFRPTSANMLQHPFV
 |...|  |.   ||| .  ||||..
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NRK.AA TAO 103-313 43 3e-65 212.01 In-house 58-254 (254) Show / Hide 
Range on Protein: 103-313
Range on HMM: 58-254/254
Sequence Identity: 43% (91 aa)

HKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQV
| |.. . | . .       |  |.||| |  || .|.. .   . ..|. || ||.. ||||. ||.|..||||||  |.||| .. ||| |||  . |
HPNCIEYKGCYLR------EHTCWLVMEYC-LGSASDILDVH-KKPMQEVEIAAICHGALQGLRYLHSHKMIHRDIKAGNILLTEHGQVKLADFGSASMV

SRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRP
.      |||.|||||||||||   .. .  || . ||||.||| ||.||  ||| |.  . ||. |    .||.....|| .||.|..||  |    ||
CPA----NSFVGTPYWMAPEVILAMDEGQ--YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQQNEWSDCFHQFVDKCLQKMPQERP

TSANMLQHPFV
.....|.|.||
SAEECLRHEFV
Kinase NRK.AA Pkinase_Tyr 25-266 24 3e-27 92.93 Pfam 1-225 (270) Show / Hide 
Range on Protein: 25-266
Range on HMM: 1-225/270
Sequence Identity: 24% (65 aa)

FSLDKTIGLGTYGRIYLGLHE----KTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEE----EDLRTELNLLRKYSFHKNIVSFYGAFFKL
 ...|..| | .|..|.|       .|.   |||...                         ....|    ||.  |.......  |.|||..||.  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK------------------------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQ

SPPGQRHQLWMVMELCAAGSVTDVVRMT--SNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQV--------SRTN
. |.   |...|||... |.  |  |    ..|.|.  ..  .|..| .|...|.... ||||.   |.|.|.|  ||  ||| .  .        .|..
GEPN---QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGG

GRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAE-GAPP-LCNLQPLEAL
|.   .     |||||.|   .     .   ||||| |..  |.   |. |   .. . | .
GKLPIK-----WMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY
Kinase NRK.AA TyrKc 25-316 21 6.3e-17 51.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-316
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKY-SFHKNIVSFYGAFFKLSPPGQR-
 .|.|..| | .|..|.|         |||.... .                          .||.. |.....|.   |.||| .||.    . .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------------------REDFMREARIMCKLGGHHPNIVRLYGV---CTQQGRNF

---HQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSRT--------NGRRNS
   ..|..|||... |.  |  | . .. |. .   ..|  | .| ..|| ...||||.   |.|...|  ||  ||| |  .             |  .
MYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE

FIGTP-----YWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAE-GAPPLCN-----LQPLEALFVILRESAPTVKSSG-------WSRKFHNFMEKC
  |.       |||||.|       . .   ||||| |..  |.   |..|  .     . . |..  . .   .    ..        . . .. |..|
HKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC

TIKNFLFRPTSANMLQHPFVRDI
   .   ||| ..      ....
WHEDPEDRPTFSEI-----HECF
Kinase NRK.AA YSK 25-57 30 0.000106 9.69 In-house 1-33 (257) Show / Hide 
Range on Protein: 25-57
Range on HMM: 1-33/257
Sequence Identity: 30% (10 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMN
|.    || | .| .| |   .|.   |.|. .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIID
Kinase NRK.AA KHS 25-56 34 0.000197 10.67 In-house 1-32 (258) Show / Hide 
Range on Protein: 25-56
Range on HMM: 1-32/258
Sequence Identity: 34% (11 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
. | . .| |||| .|   . ...  .||||.
YELLQRVGSGTYGDVYKARDIQSDELAAVKVI
Kinase NRK.AA MST 25-57 33 0.000236 9.66 In-house 1-33 (254) Show / Hide 
Range on Protein: 25-57
Range on HMM: 1-33/254
Sequence Identity: 33% (11 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMN
|..   .| | ||  |  .| .||   |.|...
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVP
Kinase NRK.AA NinaC 25-56 34 0.004294 8.03 In-house 1-32 (267) Show / Hide 
Range on Protein: 25-56
Range on HMM: 1-32/267
Sequence Identity: 34% (11 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVM
.    ||| ||||...  .  . |   |||..
WEIYETIGKGTYGKVFKVKNKDNGQIAAVKIQ
Kinase NRK.AA TAO 25-57 30 0.015892 3.74 In-house 1-33 (254) Show / Hide 
Range on Protein: 25-57
Range on HMM: 1-33/254
Sequence Identity: 30% (10 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMN
|.  . || | .| .|   ...|    |.| |.
FQDLREIGHGSFGAVYFARDKHTEEVVAIKKMS
Kinase NRK.AA PAKA 25-57 31 0.017911 4.68 In-house 1-35 (260) Show / Hide 
Range on Protein: 25-57
Range on HMM: 1-35/260
Sequence Identity: 31% (11 aa)

FSLDKTIGLGTYGRIYLGLHEKTGAF--TAVKVMN
.   . || |  |  |..   ||.     |.|.||
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMN
CNH NRK.AA CNH 1213-1385 18 3.1e-30 110.51 Pfam 1-188 (336) Show / Hide 
Range on Protein: 1213-1385
Range on HMM: 1-188/336
Sequence Identity: 18% (38 aa)

CCGSLWGVNLLLG-TRSNLYLMDR------SGKADITKLIRRRPFRQIQVLEPLNLLITI--SGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEE
.|   ||..||.| | . ||....      .. . | ....| .. || |.| .|.||.|  ..  ..|.|..| || .|...... .. ... . .  |
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSR-RVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-E

--------ACKAIDKLTGCEHFS--VLQHEETTYIAIALKS-----SIHLYAWAP--KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAK-IQAA---
        ..  . .. .| .|.  . ... ......|.|.     .|..| |..  |.| .... |              . | . |..   ...    
RIMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFK--------------GNQEWFRKFRECFYIPLPP

-DPV
 ...
MTEC
CNH NRK.AA CNH 1399-1549 12 1.2e-14 54.19 Pfam 170-336 (336) Show / Hide 
Range on Protein: 1399-1549
Range on HMM: 170-336/336
Sequence Identity: 12% (21 aa)

KLKVFPT-LDHK----PVTVDLAIGSEKRLKIFFSSADGYHLIDAE-SEVMSDVTLPKNPLEIII-----------PQNIIILPDCLGIGMMLTFNAEAL
... |.  ...     .. ..... .....|.......|.|... . . .....  | .. .  .           |  .. ..|. . ...|... .. 
WFRKFRECFYIPLPPMTECFSMHWLPQEKPKLCVGCQKGFHIVNLDGTGQPWWLHDPADHSV--QQDFMARRENCKPICMHRINDD-E-EFLLCYDECCV

SVEANEQ-LFK--KILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSR-VLESELKRRSIKKLRFLCTRG
 |  . .   .  .   || . | |.|. |.   ...  ..||.|.....  .. ..   . ...|||. ..
YVNKQGWPRSRKHDWEIMWEGMPQSFAC-CYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH NRK.AA CNH 1204-1558 17 2.6e-09 37.91 SMART 1-375 (375) Show / Hide 
Range on Protein: 1204-1558
Range on HMM: 1-375/375
Sequence Identity: 17% (70 aa)

YEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGK------ADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWL--RNKILNNDPE--SKR
. . ....| |  |||..||.|| . .|. ....       .  .... || . .. |.| .|.|..||| | .|... | ||  ... . . |     .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

RQEEMLKTEEAC-KAIDKLTG-CEHFSV-LQHEE--TTYIAIALKSSIHLYAWAPKSFDESTAIKV--CIDQSADSEGDYMSYQAYIRILAKIQAADPVN
 ..  .   ..    |  . | | |. |  . .    .... |...|...|....... .   .|.   |                |   ....      
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNI------------LNNEIEMFKHFR------

RFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSAD------GYHLIDAE-------------SEVMSDVTLPKNPLEII------IPQNI
                || . . ||.|.. . |  |..| . .        |.| .. .             .  |.|  |. .  . .       |. .
----------------FPEIFPVPVFVCFHHDSFERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQV

IILPDCLG---IGMMLTFNAEALSVEAN----EQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVRSLQSRVL-ESELKRR---SIKKLRFLCT---
....   |      .| .. ... |       ..  . || .|   | . |.     . ... ..|..|..... .   .. .|    ..|.|.|||   
HQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRRWRNPIL-HWEFMPEYFAYHY-PYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCEC

RGDKLFFTSTL
| .| |. |  
RDRKIFYCSQP