Gene aSWK454 (Nematode worm)

aSWK454

Species: Nematode worm
Alias: aSWK454
External Links:
Annotation:

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
aSWK454.AA Protein None 564 None Fasta, JSON

Protein domain

Protein domains of aSWK454.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 aSWK454.AA SH2 59-150 22 8.3e-15 56.44 SMART 1-87 (87) Show / Hide 
Range on Protein: 59-150
Range on HMM: 1-87/87
Sequence Identity: 22% (22 aa)

TPWYHGMMFGQTVEKLLKW----DHAYLVRRAMQRNSKKVLCLSVKIDGKICHLTLNSNK-DGWSCAKLLAKFPKITPKRFQHIHHLLDAWSLVVNS
 |||||.. .. .|.|||.    | ..|||   .  ... ..|||. .||..|  ...|. ...... .       ....|. . .|.. ..    .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDET-------WRRKFPSL-ELVNHYQHNPLG
Kinase aSWK454.AA Fer 166-423 37 4.2e-130 438.51 In-house 1-283 (283) Show / Hide 
Range on Protein: 166-423
Range on HMM: 1-283/283
Sequence Identity: 37% (105 aa)

IHLENILGNGAFGEVLKAR-----YIPRGHT-NGVEVAVKRALGT-AQRDQMQEFCHEAQIMGT-LKHDNVVKLYGIASLEQPIMLVMELITGGDLKKYL
..|...||.|||||| |.|     . ...|. | |.|.||.  .. |...|..||.|||.|| . ..|.||||.||....|||||.|||...||.|..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

QSTPS--IPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVK--ISDFGLAVQATEVIVKKL-----GKAPTRWLAPETFQKGIFNEKTD
. ...  .. ...| .....|.||..|  |..||||.||||||..   ...|  |||||...| ........      |.|.|||||||.|.||...|||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSFGVVLTEILTRCAADPLA------PRTL-EECKKYIIESPHPHRIENKEPKELADLVE-MCCDKNTICRANFQNAKRRLK
||||||...|| |..| ....      . .. ....| ||.. ......|  |.|.. ... .|..|.. .|.... ....||
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase aSWK454.AA TyrKc 166-422 32 7.1e-102 345.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 166-422
Range on HMM: 1-280/280
Sequence Identity: 32% (97 aa)

IHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRDQMQEFCHEAQIMGTL--KHDNVVKLYGIASLE-------QPIMLVMELITGGDLKKY
|.|. .||.|||||| |....       ..||||     |    ...|..||.||  |  .|.|.|.|||... .       .|.|.|||.  .||||.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LQSTPS-IPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKISDFGLAVQATEV--------IVKK----LGK--APTRWLAPETFQKG
|...   .....|. |...||.||..|  |..|||||||||||....  .||||||||.   ..           .|     ||   | ||.|||....|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

IFNEKTDVWSFGVVLTEILTRCAADP-------LAPRTLEECKKYIIESPHPHRIENKE------PKELADLVEMCCDKNTICRANFQNAKRRL
.|..|.|||||||.. ||.|...  .       . .. . |. |     | |. ..  .      |.|. .. ..|.. .  .| .|.. ....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase aSWK454.AA Pkinase_Tyr 166-382 38 2.2e-85 289.77 Pfam 1-231 (270) Show / Hide 
Range on Protein: 166-382
Range on HMM: 1-231/270
Sequence Identity: 38% (89 aa)

IHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRDQ--MQEFCHEAQIMGTL-KHDNVVKLYGIAS-LEQP--IMLVMELITGGDLKKYLQS
|..   || |||||| |... . .  ....||||    .|  .|  ...| .||.|| .| .|.|.|.|||. .  ..|  |..|||.  .|||..||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TPSIPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKISDFGLAVQA-----TEVIVKKLGKAPTRWLAPETFQKGIFNEKTDVW
     ....  .|. ....||.|| .|  |. |||||||||||... ...|||.|||||          . ... || | .|.||| .. |.|..|.|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVVLTEILTRCAADP-LAPRTLEECKKYI-IE
||||.. ||.|...  |  .  . || ..||  .
SFGVLMWEIFTYGE-QPTYPGMSNEEVYEYIYED
Kinase aSWK454.AA TK 166-422 19 2.4e-83 279.15 In-house 1-486 (486) Show / Hide 
Range on Protein: 166-422
Range on HMM: 1-486/486
Sequence Identity: 19% (94 aa)

IHLENILGNGAFG---EVLKARYIPRG--------------------HTNGV-EVAVKRAL---GTAQRDQMQEFCH----------EAQIMGTLK----
|.|.. || |.||   || |.....|.                    ...|. .||||      ...|.....|..|          ||..|  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNVVKLYGIASLE------------QPIMLVMELITGGD----LKKYLQSTPS---------------------------------------------
 |.|.|.|||. . .            .|.|.|||.  .||    |..||.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IPNRQLIAFALDIANGMRHLVIK------KVIHRDLAARNCLISRPTL----------QVKISDFGLAV
                               .. .||. ....||.||..|  |      ...||||||||||...             ..||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

QAT-----------EVIVKK------------------------LGKAPTRWLAPETFQ---------KGIFNEKTDVWSFGVVLTEILTRCAADPLAPR
| .           .  .|.                         || | ||.|||...         .|.| .|.|||||||.. ||.|.... .    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TL---------------------------------EECKKYIIESP-----HPHRIENKEPKELADLVEMCCDKNTICRANFQNAKRRL
.                                   ....    ..     . | .....|.|..||  .|....   | .|.  ...|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase aSWK454.AA UTK 166-367 33 1.4e-60 205.97 In-house 1-240 (296) Show / Hide 
Range on Protein: 166-367
Range on HMM: 1-240/296
Sequence Identity: 33% (80 aa)

IHLENILGNGAFGEVLKARYIP-RGHTNGVEVAVKRAL-GTAQRDQMQ---EFCHEAQ---IMGTLK-HDNVVKLYGIASLEQPIMLVMELITGGDLKKY
..| . || |||||| |||. . ..|   . |||| .  . . ....    .|  ||.   .|. .. | ||..|.|. . |.|.|.|.|.  .||| .|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQSTPSIPN--------RQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPT------LQVKISDFG---LAVQAT------------EVIVKKLGK
|.. .  |.        .|.. .|.|||.|| .|  ....||||||||||. .        ...||.|||   .. ..             ..     ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

APTRWLAPETFQKG-IFNEKTDVWSFGVVLTEILTRCAADP
.| || ||| . ..  | .|.||||||||. ||.|. .. |
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLP
Kinase aSWK454.AA TK-Unique 166-361 32 6.2e-60 205.32 In-house 1-234 (294) Show / Hide 
Range on Protein: 166-361
Range on HMM: 1-234/294
Sequence Identity: 32% (76 aa)

IHLENILGNGAFGEVLKARYIPRG--HTNGVEVAVKRALGTAQRDQMQEFCHEAQIMGTLK-HDNVVKLYGIASLEQ-PIMLVMELITGGDLKKYLQ---
. .....| ||||.| .. . ..   .   . ||||     |.  . |.|  |.|.|  |. | |.|...|.    . | |..|| . .|.| .||.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

--------------------STPS---IPNRQLIAFALDIANGMRHLVI--KKVIHRDLAARNCLISRPTLQVKISDFGLA--VQATEVIVKKL--GKAP
                    ..|.   |  ..|. || .||.|| .|    ||..||||.|||.|...  ...||.|||.|  |....|....   |. |
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-DKVCKICDFGMARDVYTNGVYSMMCSQGRIP

TRWLAPETFQ--KGIF-NEKTDVWSFGVVLTEILT
 ||.||| ..  .|.. ..|.|||||||.. ||.|
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase aSWK454.AA Src 166-362 39 5.7e-55 185.18 In-house 1-196 (255) Show / Hide 
Range on Protein: 166-362
Range on HMM: 1-196/255
Sequence Identity: 39% (81 aa)

IHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRDQM--QEFCHEAQIMGTLKHDNVVKLYGIASLEQPIMLVMELITGGDLKKYLQ---ST
|.|.  ||.| |||| .. .      . ..||||    |  ...|  . |  ||||| .|.|...|.|| . | | ||  | |. . | | .||.    .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVK----TLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEG

PSIPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKISDFGLAVQAT----EVIVKKLGKAPTRWLAPETFQKGIFNEKTDVWSFGVVL
 ... .||| .|  .|.||  |  ...||||||||| |..  .. .|. |||||        |   ..  | | .| ||| .. | |. |.||||||. |
RHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGE-NNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILL

TEILTR
||| |.
TEIVTY
Kinase aSWK454.AA TKL 172-422 21 4.7e-51 175.93 In-house 1-364 (364) Show / Hide 
Range on Protein: 172-422
Range on HMM: 1-364/364
Sequence Identity: 21% (79 aa)

LGNGAFGEVLKARYI------PRGHTNGVEVAVKRALGTA--------------------------QRDQMQEFCHEAQIMGTLKHDNVVKLYGIASLEQ
.| |.|||| |...       | .   | .||||.   .                           ..  ....  |. .|  |.|.|.|...|..  ..
IGSGGFGEVYKGKWRGWGGKCP-S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

P-------------IMLVMELITGGD-LKKYLQSTPSIPNRQLIAFALDIANGMRHLVI--------KKVIHRDLAARNCLISR-------------PTL
.             ...|||.. ||. |  ..         |.. .||||| || .|          ...|||||  .|.|. .              . 
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

QVKISDFGLAVQATEVIV-------------------KKLGKA-PTRWLAPETFQ----------------KGIFNEKTDVWSFGVVLTEILTRCAADP-
 .||.||||.   ..                      ..  .   .||.||| ..                .. ..||.||.|||.|| ||||||     
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LAPRTLE------ECKKYII-ESPHPHRI-----------ENKEPKELADLVEMCCDKNTICRANFQNAKRRL
. ... .      |  .... .. .| .            ..  |.....| ..|.| .   | .||  . ||
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase aSWK454.AA Met 167-364 31 4.8e-49 158.77 In-house 1-217 (271) Show / Hide 
Range on Protein: 167-364
Range on HMM: 1-217/271
Sequence Identity: 31% (70 aa)

HLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRD--QMQEFCHEAQIMGTLKHDNVVKLYGIASLEQPI---MLVMELITGGDLKKYLQS-T
|.. ..| | || | ...|.. .  |   .|.|   |  ..|  .  .|  |. .|  ..| || .| ||. |.      . | .   .||||..  . .
HFDDVIGQGHFGCVYHGMYHD-NDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGIC-LDPEGHMPWVVLPYMKHGDLKTFIRNPQ

PSIPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKISDFGLAVQA---TEVIVKKLGKA----PTRWLAPETFQ--------KGI-FN
  .  |.|| |....| ||  .  .| .|||||.|||...   . ||. ||||..     .|  . .   .    | .|.|||  |        . . |.
NNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDE-HFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFT

EKTDVWSFGVVLTEILTRCA
 |.||||||||. | .|| |
TKSDVWSFGVVMWELMTRGA
Kinase aSWK454.AA EGFR 166-361 34 1.8e-46 152.21 In-house 1-198 (258) Show / Hide 
Range on Protein: 166-361
Range on HMM: 1-198/258
Sequence Identity: 34% (68 aa)

IHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRDQMQEFCHEAQIMGTLKHDNVVKLYGIASLEQPIMLVMELITGGDLKKYL-QSTPSIP
. .  .|| |||| | |  .|| | .  . ||.|    .  . . .|.  || .|. ..|...|.| |.   .| ..||  ..  | |  |. |    | 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIG

NRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKISDFGLA---VQATEVIVKKLGKAPTRWLAPETFQKGIFNEKTDVWSFGVVLTEILT
 ..|. ... || ||  |  ....|||||||| |.  |  .||| |||||    .  . .  . || | .|.| | ......  . ||||.|| . |..|
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPN-HVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMT
Kinase aSWK454.AA Src-Unclassified 166-361 33 2.1e-46 157.07 In-house 1-222 (284) Show / Hide 
Range on Protein: 166-361
Range on HMM: 1-222/284
Sequence Identity: 33% (77 aa)

IHLENILGNGAFGEVLKARYIPRGHTNG-VEVAVKR-------ALGTAQRD--QMQEFCHEAQIMGTLKHDNVVKLYGIASLEQPIMLVMELITGGDLKK
.||   || | |||| .. .       | |.||||         . ...    ..  || |||||  ..| |.|.||.. | | |.  . |. . | |  
VHLLRKLGRGQFGEVWYGKW------RGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQ

YLQSTP--SIPNRQL------------IAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTL----QVKISDFGLA----VQATEVIVKKLGKAPTRWL
.|.       . . .            .  |  .|.||  |  || .|||||||| ||          ||. |||||    .|  . . ..  . |  | 
WLREGGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWM

APETFQKGIFNEKTDVWSFGVVLTEILT
||| |  |.|. |.||||.|. | || |
APECFIYGNFSIKSDVWSYGILLWEIMT
Kinase aSWK454.AA ALK 166-360 38 7.9e-46 156.17 In-house 1-211 (273) Show / Hide 
Range on Protein: 166-360
Range on HMM: 1-211/273
Sequence Identity: 38% (82 aa)

IHLENILGNGAFGEVLKARYIP-RGHTNGVEVAVKRALGTAQRDQMQEFCHEAQIMGTLKHDNVVKLYGIASLEQPIMLVMELITGGDLKKYLQSTPSIP
| | . || ||||||  . |.   |      ||.|     . ...   || || |||. .|.|||.. ||   .|| | | |.. |||.|..|  .   |
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

N---------RQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQ--VKISDFGLAVQA--TEVIVKKLGKA--PTRWLAPETFQKGIFNEKTDV
.         . |.  ..|.| | . |  .. |||| |||||| . .  .  .|| ||| |           | |.|  |  |  || |. |||  ||||
ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV

WSFGVVLTEIL
||||| . ||.
WSFGVLCWEIF
Kinase aSWK454.AA S_TKc 166-426 24 1.3e-42 148.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 166-426
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

IHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRDQMQEFCHEAQIMGTLKHDNVVKLYGIASLEQPIMLVMELITG--GDLKKYLQSTPS-
 .. ...| ||||.| |.| .      | .||.|.          . .. | ||.   .|.|.||||..    . . .|||.. |  |||..|... .. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----IPNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQVKISDFGLAVQATEVIVKKLGKAPTRWLAPETFQKGIFNE-KTDVWSFGVVL
     .|  .   ..  |.... ..  ...|||||   | |...   ..||.||||| |       .       ..||| .    ..  | |.||.|..|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

TEILTRCAADPLAPRTLEECKKYIIESPHPHRIENKEPKELADLVEMCCDKNTICRANFQNAKR-----RLKIVI
 | |...   |    ....  | |             ..|. |... |..|.   |     | .     ..   .
YEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase aSWK454.AA Pkinase 166-422 23 7.6e-34 120.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 166-422
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

IHLENILGNGAFGEVLKARYIPRGHTNGVEVAVKRALGTAQRDQM-QEFCH--EAQIMGTLKHDNVVKLYGIASLEQPIMLVMELITGG----DLKKYLQ
.|.. ..| |.||.| |.. .  |.    .||||.     ..... |.  .  |.|||  |.|.|.|.||..   .. | .|||.  ||    ||. |..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--STPSI--PNRQLIAFALDIANGMRHLVIKKVIHRDLAARNCLISRPTLQV----KISDFGLAVQA-TEVIVKKLGKAPTRW-LAPETFQ-KGIFNEKT
  .  ..  . .... ... |. |. ..  ...|||||   |.||.  . ..    ||.||||| |. .   .   . . |.| .|||  .       | 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSFGVVLTEILTR----CAA------DPLAPRTLEECKKYIIESPHPHRIE-------------NKEPKELADLVEMCCDKNTICRANFQNAKRR--L
|.||.|..| | |..    . .      |...   .  ....  ..| ...|               . ..|. |... |..|.  .| ... ..    .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF