Gene TGFbR1 (Sea Urchin)

TGFbR1

Species: Sea Urchin
Alias: Spk327, TGFbR1, SpAlk4/5/7, SPU_028066
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
TGFbR1.AA Protein None 365 None Fasta, JSON
TGFbR1.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of TGFbR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TGF_beta_GS TGFbR1.AA TGF_beta_GS 8-19 100 1.2e-05 21.71 Pfam 18-29 (29) Show / Hide 
Range on Protein: 8-19
Range on HMM: 18-29/29
Sequence Identity: 100% (12 aa)

GLPLLVQRTIAR
||||||||||||
GLPLLVQRTIAR
Kinase TGFbR1.AA Type1 21-308 72 2.2e-273 750.24 In-house 1-290 (290) Show / Hide 
Range on Protein: 21-308
Range on HMM: 1-290/290
Sequence Identity: 72% (209 aa)

IVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLILVSDYHENGSLFDYLNSHVIDVPGMLR
|....||||||||||.|||||||.||||||.||.|||||||.|||||||.||||||||||||.||||.||||.|..||||.|||.||||.|..|. .|||
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

MALSIATGLAHLHMEIMGMQ--GKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVTDTVDIFPNNRIGTKRYMAPEVLDDTINMNHFDSFKRADVY
.|.|.|.|||||||||.|.|  |||||||||||||||.||.||||.||||||||||...||..|| .|.|.||||||||||||.|.|||.|.|.|.||.|
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

SFGLVLWEIGRRCQVFGIYEEFCLPYHPWVPMDPPIDDMRRIVCIEKRRPPVPNRWNSHKIMESYAKVMKECWYQNGAARLTALRIKKTL
|||||.||| |||.|.||.|...|||. |||.|| ..|||..||..| ||..||||.||..|...||.||||||||..||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase TGFbR1.AA STKR 21-308 57 2.2e-216 705.45 In-house 1-312 (312) Show / Hide 
Range on Protein: 21-308
Range on HMM: 1-312/312
Sequence Identity: 57% (180 aa)

IVIQDCIGKGRYGEVYRGKWRG----ESVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN-GTWTQLILVSDYHENGSLFDYLNSHVIDV
|... ||||||||||..|||||    |.||||||.||.|.|||||.|||||.|.||||||.|||||.|.. |.|||. |...|||||||.|||..|.||.
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

PGMLRMALSIATGLAHLHMEIM--GMQ--GKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVTDTVDIF-------PNNRIGTKRYMAPEVLDDTI
..|.|||.|.|.|||||||||.  |.|  .|||||||||||||||||..|.|.|||.|||.|||. |...||        .|...||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NMNHFDS-FKRADVYSFGLVLWEIGRRCQVFG------IYEEFCLPYHPWVPMDPPIDDMRRIVCIEKRRPPVPNRWN-SHKIMESYAKVMKECWYQNGA
|...|.| |||.|.|..|||.||| |||...|      |..|...|.. |||..| ..||. .||....||..||||. .|. |.| .|.|.|||.....
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase TGFbR1.AA TKL 27-308 30 2.7e-110 372.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 27-308
Range on HMM: 1-364/364
Sequence Identity: 30% (116 aa)

IGKGRYGEVYRGKWRG----------ESVAVKIFSSRE-------------------------ERSWFREAEIYQTVM---LRHENILGFIAADNKDN--
||.|..||||.|||||          . ||||.|.|..                         | ||||. |.....|   |||.||. |.....  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GTWTQLILVSDYHENGSLFDYLNSHVIDVPGMLRMALSIATGLAHLHMEIM--GMQGKPAIAHRDIKSKNILVKRNGQ--------------C
       |.|.|| .| .|...|||..||.      . ..|.||.|| |...||...   ..  ||.|.|||.|||||||..|..              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

AIADLGLAVRHDSVTDTVDIF---------------PNNRIGTKRYMAPEVLDDTINMNH----------FDSFKRADVYSFGLVLWEIGRRCQVFGIYE
 |.|.||. ...  ..  |.                 ....||.|.||||||....| ..          |. ....||||||.|||||  ||.      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

EFCLPYHPWVPMDPPIDDMRRIVCIEKRRPPVPNRWNS-------HKIMESYAKVMKECWYQNGAARLTALRIKKTL
....|| |....|| ...|  .|| ...|||.|..|..       . ...|..| |..|| ..  .|.....|.|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TGFbR1.AA Type2 21-308 39 1.9e-107 355.86 In-house 1-315 (315) Show / Hide 
Range on Protein: 21-308
Range on HMM: 1-315/315
Sequence Identity: 39% (123 aa)

IVIQDCIGKGRYGEVYRGKWRGE-----SVAVKIFSSREERSWFREAEIYQT-VMLRHENILGFIAADN-KDNGT--WTQLILVSDYHENGSLFDYLNSH
|     |||||.|.|....| ..      ||||||. ..  ||  | .||.. ....||||| ||.|.  .  ..  | .. ||...|..||| ||| .|
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

VIDVPGMLRMALSIATGLAHLHMEIM-GMQ---GKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVTDT--------VDIFPNNRIGTKRYMAPEV
.|| . ..|||.|.| |||||| ||  . |    ||.||||||||||.||| .. |.|||.|||.| .  . .         |    .  ||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDDTINMNH-FDSFKRADVYSFGLVLWEIGRRCQVFG---IYEEFCLPYHPWVPMD-PPIDDMRRIVCIEKRRPPVPNRWNSHKIME-SYAKVMKECWYQ
|. ..| .   |.||..|.|..||||||.  || ...      |. .|.   |    | ..||.  |  ...||. |. |  |  |. .    . .|| .
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NGAARLTALRIKKTL
   |||||. ..  .
DAEARLTAQCVQERM
Kinase TGFbR1.AA Pkinase 21-308 23 1.2e-53 189.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 21-308
Range on HMM: 1-293/293
Sequence Identity: 23% (76 aa)

IVIQDCIGKGRYGEVYRGKWRGES--VAVKIFSSREERSWFREA-----EIYQTVMLRHENILGFIAADNKDNGTWTQLILVSDYHENG----SLFDYLN
..|  .||.| .|.||.....|..  |||||.. |.|.||....     ||.   .|.|.||. .. .        . . .| .|.|.|    .||||. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---SHVI--DVPGMLRMALSIATGLAHLHMEIMGMQGKPAIAHRDIKSKNILVKRNGQC----AIADLGLAVRHDSVTDTVDIFPNNRIGTKRYMAPEVL
   . ..  .     .... |. ||...| .         | |||.|. |||...||..     |.| |||  .|      .  .. . || .|||||| 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEV-

DDTINMN-HFDSFKRADVYSFGLVLWEIGRRCQVFGIYEEFCLPYHPWVPMDPPIDDMRRIVCIEKRRPPVPNRWNSHKIM-----------------ES
      . . .  ...|..|.|..|.|   .           .|.   .  ... .|.. ..|  ...|.  ...... |.                 |.
-----IRGGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEE

YAKVMKECWYQNGAARLTALRIKKT--L
  ...| |. .. . |.||  |..   .
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TGFbR1.AA MLK 21-227 26 5.9e-40 136.31 In-house 1-229 (291) Show / Hide 
Range on Protein: 21-227
Range on HMM: 1-229/291
Sequence Identity: 26% (66 aa)

IVIQDCIGKGRYGEVYRGKWRGES-----VAVKIFS-------SREERSWFREAEIYQTVMLRHEN----ILGFIAADNKDNGTWTQLILVSDYHENGSL
| ..  ||.| .|.|..|.||..      ||||..        . .. .|  | |...  .|.|.|    |  | .. ....    .. .|. | |.|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

FDYLNSH---------------VIDVPGMLRMALSIATGLAHLHMEIMGMQGKP-AIAHRDIKSKNILVKR------NGQCAIADLGLAV-RHDS-VTDT
...|..                |.|.  ... || .| |.. ||..      .| .| |||.||.|||. .      .|.. |.| |..   |..  . .
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

VDIFPNNRIGTKRYMAPEVL----DDTINMNHFDSFKRADVYSFGLVLWEI
      ...|| ..|||||.     .. ..        .||.|.|.||||.
------SNAGTYAWMAPEVIQQFRCEKYSE-------KCDVWSWGVVLWEM
Kinase TGFbR1.AA TKL-Unique 23-232 30 2.5e-36 125.69 In-house 1-226 (290) Show / Hide 
Range on Protein: 23-232
Range on HMM: 1-226/290
Sequence Identity: 30% (73 aa)

IQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWFREAE-IYQTV----MLR-HENILGFIAADNKDNGTWTQLILVSDYHENGSLFDYLN-------
.   || | ||.||.|||||..||.|.|.  .| | ... .  .  |    .|. |.||. ....  ..  .  ....|..| . ||| |.|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----SHVIDVPGMLRMALSIATGLAHLHMEIMGMQGKPAIAHRDIKSKNILVKRN-----GQCAIADLGLAVRHDSVTDTVDIFPN-----NRIGTKRYM
    .. ..   ...||. || |. .|| ..     .| |.|||.||.|.|| .|      .  |.| ||.   .. ...  . ..      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDDTINMNHFDSFKRADVYSFGLVLWEIGRRCQ
||||| .    ....  . .|||||| |||||  |..
APEVLRMNF--CQYS--EKSDVYSFGIVLWEIATRKI
Kinase TGFbR1.AA S_TKc 21-309 20 5.4e-26 93.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-309
Range on HMM: 1-231/231
Sequence Identity: 20% (64 aa)

IVIQDCIGKGRYGEVYRGKWRG--ESVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLILVSDYHEN--GSLFDYLNSHV----
  | . |||| .|.||......  . ||.|| .    ..  || .| .    .|.||  .. .        . | .| .| ..  |.||||. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IDVPGMLRMALSIATGLAHLHMEIMGMQGKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVTDTVDIFPNNRIGTKRYMAPEVLDDTINMNHF
   ..     ...  |. .|...|        .  | |||.|  |||. .  .  |.| ||| .            .  .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL--------G

DSFKRADVYSFGLVLWEIGRRCQVFGIYEEFCLPYHPWVPMDPPIDDMRRIVCIEKRRPPVPNRWNSHKIMESYAK-VMKECWYQNGAARLTALRIKK--
 .....|..|.| .|.|   ..  |                   .. | ....                   . ||  .. |.  . . |.||  . .  
YGKCKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

------TLA
         
WDIKCHPWF
Kinase TGFbR1.AA TK 21-227 16 1.6e-25 81.87 In-house 1-387 (486) Show / Hide 
Range on Protein: 21-227
Range on HMM: 1-387/486
Sequence Identity: 16% (67 aa)

IVIQDCIGKGRYG---EVYRGKWRG---------------------------ESVAVKIFS---SREERSWFR-----------------EAEIYQTVML
|.. . .|.| .|   |||.|.|||                           . ||||.     . ...  |                  |... .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIAADNKDNGTW--------TQLILVSDYHENGS----LFDYLNSHV----------------------------------------------
.|.||. ....  .. .            ...|  | ..|.    | ||| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IDVPGMLRMALSIATGLAHLHME---IMGMQGKPAI---AHRDIKSKNILVKRNGQ-----------CA
                               .... .| |.. || |...||              |    |||.   |.|| .|..           | 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

IADLGLA----------VRHDSVTDTVDIFPNNR-----------------IGTKR---YMAPEVLDDTIN-----MNHFDSFKRADVYSFGLVLWEI
||| ||.          . .|.   ...    .|                  |.|    .||||.|.| .       ..| .    ||.||| ..|||
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTT--KSDVWSFGVLMWEI
Kinase TGFbR1.AA STE 21-226 19 2.7e-22 75.63 In-house 1-260 (359) Show / Hide 
Range on Protein: 21-226
Range on HMM: 1-260/359
Sequence Identity: 19% (54 aa)

IVIQDCIGKGRYGEVYRGKWR-----------------GESVAVKIFSSREERS---------------WFRE---AEIYQTVMLR--HENILGFIAADN
  ....|||| .|.||... .                 || .|.|. . .....                 ..    ||     ..  |.||  .. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD---NGTWTQLILVSDYHENGSLFDYLNS---------------HVIDVPGMLRMALSIATG-LAHLHMEIMGMQGKPAIAHRDIKSKNILVKRNGQCA
|.   ..  ..| ..  | ..||| | ...               |... .   ... .|  | |..||           | |||||. |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADLGLAVRHDSVTD------------TVDIFPNNRIGTKRYMAPEVLDDTINM--NHFDSFKRADVYSFGLVLWE
..| |.. . ..  .            | .   |  .||  .|||||..   .   .. |   ..|..|.|....|
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD--TKCDIWSLGCTIIE
Kinase TGFbR1.AA Dicty4 102-227 32 2.1e-18 58.16 In-house 87-210 (277) Show / Hide 
Range on Protein: 102-227
Range on HMM: 87-210/277
Sequence Identity: 32% (47 aa)

GSLFDYLNS------HVIDVP--GMLR---MALSIATGLAHLHMEIMGMQGKPAIAHRDIKSKNILVKRNGQCAIADLGLAV---RHDSVTD---TVDIF
|.|.  |..        |  .   ..|   ||...| |...||  .      | | |||.|| |.||  | .  ..|.||.    .| . .|   |.   
GNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA---

PNNRIGTKRYMAPEVLDDTINMNHFDSFKRADVYSFGLVLWEI
    .||  .|||||.      . ...   |||||||.|||||
----CGTPCWMAPEVM----MHQPYNE--KADVYSFGIVLWEI
Kinase TGFbR1.AA TyrKc 21-308 26 6.3e-16 34.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-308
Range on HMM: 1-280/280
Sequence Identity: 26% (82 aa)

IVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSREERSWFREAEIYQTVML--RHENILGFIAADNKD--NGTW---TQLILVSDYHENGSLFDYLNSHV-
|.  . .| | .||||.|.|. . ||||   .  ..   |||.|    .|  .|.||. ....  ..  |  .    .| .|  | ..|.| ||| .|  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKHRP

-IDVPGMLRMALSIATGLAHLHMEIMGMQGKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSV----TDTVDIFPNNRIGTK-----RYMAPEVLDD
 . .. .| ... || | ..||           . |||.   |.||..|... |.| ||.  ...       .  . .  . |.|     | ||||..  
KLCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

TINMNHFDSFKRADVYSFGLVLWEIGRRCQVFGIYEEFCLPYHPWVPM---DPPIDDMRRIVCIEKRRPPVPN-----RWNSHKIMESYAKVMKECWYQN
  | . | .    ||.||| ..|||            | .   |.  |   . . ..... |   .|.|. ||         .   | |  .||.||  .
--NYGKFTTK--SDVWSFGVCMWEI------------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQ-IMKQCWHED

GAARLTALRIKKTL
 . | |   |.. .
PEDRPTFSEIHECF
Kinase TGFbR1.AA Dicty4 21-53 54 3.6e-15 47.2 In-house 1-33 (277) Show / Hide 
Range on Protein: 21-53
Range on HMM: 1-33/277
Sequence Identity: 54% (18 aa)

IVIQDCIGKGRYGEVYRGKWRGESVAVKIFSSR
|.|.. |||| .||||.|.|||  ||||.. ..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNH
Kinase TGFbR1.AA Pkinase_Tyr 21-133 27 4.3e-14 48.36 Pfam 1-128 (270) Show / Hide 
Range on Protein: 21-133
Range on HMM: 1-128/270
Sequence Identity: 27% (37 aa)

IVIQDCIGKGRYGEVYRGKWR------GESVAVKIF--SSREE----RSWFREAEIYQTVML-RHENILGFIAADN-KDN-GTWTQLILVSDYHENGSLF
|..   .|.| .||||.|.|.      .  ||||.   .. .|    .. .|||.|     | .|.||. ....   ..  .   |...|  | ..|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMK--QLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

DYLNSH-----VIDVPGMLRMALSIATGLAHLH
||| .|      .... .| |.. || |...|.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase TGFbR1.AA DRK 21-48 64 1e-12 39.46 In-house 1-28 (258) Show / Hide 
Range on Protein: 21-48
Range on HMM: 1-28/258
Sequence Identity: 64% (18 aa)

IVIQDCIGKGRYGEVYRGKWRGESVAVK
|.|.  ||.| ||||.|| |||  ||||
IKIGNRIGRGNYGEVFRGTWRGTQVAVK
Kinase TGFbR1.AA DRK 118-227 36 1e-11 36.03 In-house 100-195 (258) Show / Hide 
Range on Protein: 118-227
Range on HMM: 100-195/258
Sequence Identity: 36% (40 aa)

MLRMALSIATGLAHLHMEIMGMQGKPAIAHRDIKSKNILVKRNGQCAIADLGLAVRHDSVTDTVDIFPNNRIGTKRYMAPEVLDDTINMNHFDSFKRADV
|..|.. .| |.  ||         | | ||| || | ||  . |  .|| ||. |   . .    |    .||    ||||| .            |||
MKQMMFDCAKGMIYLHCC------NPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHK--FAMTMCGTPCWTAPEVLRNQRYTE------KADV

YSFGLVLWEI
|||. ||||.
YSFAIVLWEC
Kinase TGFbR1.AA TK 280-308 22 0.000993 7.53 In-house 447-486 (486) Show / Hide 
Range on Protein: 280-308
Range on HMM: 447-486/486
Sequence Identity: 22% (9 aa)

M-----------ESYAKVMKECWYQNGAARLTALRIKKTL
|           | |. .|..||  . . | |   ... |
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TGFbR1.AA Pkinase_Tyr 193-227 37 0.007554 10.27 Pfam 179-207 (270) Show / Hide 
Range on Protein: 193-227
Range on HMM: 179-207/270
Sequence Identity: 37% (13 aa)

RYMAPEVLDDTINMNHFDSFKRADVYSFGLVLWEI
. ||||.. . .    | .    ||.||| ..|||
KWMAPECINYGK----FTT--KSDVWSFGVLMWEI
Kinase TGFbR1.AA Pkinase_Tyr 147-171 48 0.013463 9.42 Pfam 134-158 (270) Show / Hide 
Range on Protein: 147-171
Range on HMM: 134-158/270
Sequence Identity: 48% (12 aa)

HRDIKSKNILVKRNGQCAIADLGLA
|||.  .|.||..|... |.| |||
HRDLAARNCLVTENNVVKICDFGLA