Gene ANKK1 (Sea Urchin)

ANKK1

Species: Sea Urchin
Alias: SPU_005215, ANKK1, Spk321
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
ANKK1.AA Protein None 1242 None Fasta, JSON
ANKK1.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of ANKK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ANKK1.AA RIPK 52-313 49 1.4e-166 559.75 In-house 1-290 (290) Show / Hide 
Range on Protein: 52-313
Range on HMM: 1-290/290
Sequence Identity: 49% (143 aa)

LGGGSFGEVYKAVHKVHGDVAVKLAKPGKE-----DQVVLMYQKEAGKHVLSLTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHGSLWDFRISKW--
.|||.||||.||.|...||...|..||.|.     |. . |||||..||. .|. .|||.|.||.|||...|||. |.|||||||..||||.|...||  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCK-LYGIVMEYMENGSLWHFLHTKWPY

QDRPDLWPLTNRMVHQISSGMHFLHSKD--IIHRDLKLENVLVDGNLNVKVADLGLATNLQTS--FGDER-------------CGTNSHKPPEAFRTDLP
|..||.|||..||.|.||.||..|||..  |||||||.||.|||.|..||.||.||||....|  ..|..             .||.|..|||.||||..
QHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

NSTKVVTPEYDVYSFAMTLYELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQPIPASTPED-----LIRVMEESWSYEPNDRPNFREITEWV
...|||||.|||||||....|.||..|||.||...||......... |||||.| ..||.     .|..|...|...|||||.|.|..||.
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase ANKK1.AA TKL 52-313 24 1.3e-87 297.43 In-house 1-364 (364) Show / Hide 
Range on Protein: 52-313
Range on HMM: 1-364/364
Sequence Identity: 24% (91 aa)

LGGGSFGEVYKAVHKVHG---------DVAVKLAKPGK-------------------------EDQVVLMYQKEAGKHVLSLTSNHIVSIKGFVQCEKAA
.| |.||||||.... .|         |||||  |                            | .      .|  .. ..|   .||...|...|..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

CDCGC------LIGIVMEYMKHGSLWDFRISKWQDRPDLWPLTNRMVHQISSGMHFLHSKD--------IIHRDLKLENVLVDGNLN-------------
| |.        ..|||||...|||... .         |... |....|..||..|||..        ||||||| .|.||| |..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKVADLGLATNLQTSFGDE---------------------RCGTNSHKPPEAFRTDLPNSTKV----------VTPEYDVYSFAMTLYELLTGIHPYSD
 .|..|.||......|....                     .|||  . .||..| ..... ||           ..  |||||.. |.|.||. .||.|
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

RGFY---------MMMLLKVDSKQSPCLQPIPAS---------TPEDLIRVMEESWSYEPNDRPNFREITEWV
 ...         .|. . .| .. | . ||. .         .|..... |.. |...|..||.| ||... 
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase ANKK1.AA Pkinase 46-309 25 1.3e-39 141.14 Pfam 1-287 (293) Show / Hide 
Range on Protein: 46-309
Range on HMM: 1-287/293
Sequence Identity: 25% (76 aa)

EHEGCHLGGGSFGEVYKAVHKVHGD-VAVKLAKPGKEDQVVLMYQK---EAGKHVLSLTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHG----SLW
 | |  .| ||||.|||..||  |. ||||  |  .|.  ....     |.  .     . .|| ...... ..  .       .||||. .|    .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY-------MVMEYCEGGLYVMDLF

DFRISKWQDRPD--LWPLTNRMVHQISSGMHFLHSKDIIHRDLKLENVLVDGNLNV----KVADLGLAT---NLQTSFGDERCGTNSHKPPEAFRTDLPN
  .|| |....    .    ... || .|. ..||. |||||||.||.|.| | ..    |..| |||    .   |  . .|||    .||  |     
-DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----

STKVVTPEYDVYSFAMTLYELLTGIHPYSDR-------GFYMMMLLKVDSKQSPCLQPIPAS---------------TPEDLIRVMEESWSYEPNDRPNF
. .  .|. |..|.  .|||.|.|  |....         .|. . .     ... .... |               ..|... ...  . . |..||..
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA

REI
..|
EQI
Kinase ANKK1.AA MLK 46-313 26 9.9e-39 132.01 In-house 1-291 (291) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-291/291
Sequence Identity: 26% (82 aa)

EHEGCHLGGGSFGEVYKAVHKVHGD-----VAVKLAKPGKEDQVVLMY--QKEAGKHVLSLTSNHIVSIKG----FVQCEKAACDC-GCLIGIVMEYMKH
  .  ..| ||||.|.|.. .   |     |||| ..  ..  .. .|  |..  . .  |    |.| .     ..|  ...| . .|  .|||||. .
IQFHEWIGSGSFGKVWKGRWRNK-DIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLR---ILSHPNNHPCIIQ-FYGVCLQPPCHFCIVMEYCEG

GSLWDFR---ISKWQ--------DRPDLWPLTNRMVHQISSGMHFLHSKD---IIHRDLKLENVLVD------GNLNVKVADLGLATNLQTSFGD---ER
||| ..     |||         ||     . ..  .|...|||.|||..   |||||||  |.|.|      .....|..| |... ....  .    .
GSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSN

CGTNSHKPPEAF--RTDLPNSTKVVTPEYDVYSFAMTLYELLTGIHPYS-DRGFYMMMLLKVDSKQSPCLQPIPASTPEDLIRVMEESWSYEPNDRPNFR
.||     ||..      ..| |.     ||.|... |.|.||. .||. .    .     .  .. |   ||| . || . . |.. |. .|..||.||
AGTYAWMAPEVIQQFRCEKYSEKC-----DVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFR

EITEWV
.| .  
QIVQHL
Kinase ANKK1.AA TK 46-313 16 8.7e-35 113.49 In-house 1-486 (486) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

EHEGCHLGGGSFG---EVYKAVHKVHG--------------------------DVAVKLAKPGKEDQVVLMYQ----------------KEAGKHVL-SL
 . |  || | ||   ||||.  . ..                          .||||  |.| ...   . .                 |. .  .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

TSNHIVSIKGFVQCEKA------ACDCGCLIGIVMEYMKHGS----LWDFRISKWQDRPDLWPLTNR---------------------------------
   .||.. | .  ..         . .  . ||||||.||.    | |.  ..  .. .  .   .                                 
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

---------------------------------------MVHQISSGMHFLHSKDI------IHRDLKLENVLVDGNLN-----------VKVADLGLAT
                                       | .||..|| .|||| .      .||||   |.||. |..           .|.|| ||. 
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

N----LQTSFGD--ERCGTNSHK------------------------------PPEAFRTDLPNST---KVVTPEYDVYSFAMTLYELLT-G-IHPYSDR
.    |    ..  . . ..|..                              .||....  . .    .. |.. ||.||  ...|..| |   .| . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

G----------FYMMMLLKVD-----------SKQSPCLQPIPAS-----------TPEDLI-RVMEESWSYEPNDRPNFREITEWV
             .| .|.                 .. ||  ..           .|.... ..| . |.|.|.|||.|... |  
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ANKK1.AA S_TKc 46-313 22 1.6e-33 118.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

EHEGCHLGGGSFGEVYKAVHKV-HGDVAVKLAKPGKEDQVVLMYQKEAGKHVLSLTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKH--GSLWDFRIS
 . . ..| |.||.|||..||  .  ||.|  |         . ..|   .       .|| .... |           . .||||. .  |.| |.  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKK

KWQ---DRPDLWPLTNRMVHQISSGMHFLHSKDIIHRDLKLENVLVDGNLNVKVADLGLATNLQTSFGDERCGTNSHKPPEAFRTDLPNSTKVVTP-EYD
.     ..|     . ....|| ... ..||. ||||||| ||.|.|   ..|..| |||. |     .  |||    .|| .           .. . |
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---------GYGKCKCD

VYSFAMTLYELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQPIPASTPEDLIRVMEESWSYEPNDRPNFREITE---------WV
..|.  .|||.|.|  |..   . |. ...                .....  ..  . ..|..||   |. .         |.
WWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ANKK1.AA TKL-Unique 126-313 27 8e-29 98.85 In-house 77-290 (290) Show / Hide 
Range on Protein: 126-313
Range on HMM: 77-290/290
Sequence Identity: 27% (61 aa)

IVMEYMKHGSLWDFRISK--------WQDRPDLWPLTNRMVHQISSGMHFLHSKD--IIHRDLKLENVLVDGN-----LNVKVADLGLATNLQTS----F
|||||. .||| |  ..          .  .  . . ..|...|..||..||...  |||||||  |.||| |     .|.|..| ||.... ..    .
IVMEYCPGGSLYDV-LHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN

G-------DERCGTNSHKPPEAFRTD-LPNSTKVVTPEYDVYSFAMTLYELLTGIH------PYSDRGFY-MMMLLKV--DSKQSPCLQPIPASTPEDLI
.       ..|||.    .|| .|      |.|.     |||||.. |.|..|.        ||..  ..    ....  ....     ||| . |... 
NEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKS-----DVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYR----PPIPNHCPKEYR

RVMEESWSYEPNDRPNFREITEWV
  ... |  .| .||.| || .  
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase ANKK1.AA Dicty4-Unclassified 126-313 30 2.8e-28 93.93 In-house 79-263 (263) Show / Hide 
Range on Protein: 126-313
Range on HMM: 79-263/263
Sequence Identity: 30% (60 aa)

IVMEYMKHGSLWDFRISKWQDRPDLWPLTN----RMVHQISSGMHFLHSKDIIHRDLKLENVLVDGNLNVKVADLGLATNLQTSFGDERCG-TNSHKPPE
|||| |  | |     ||  ..     |      ..   |  || .||....||||.|  |.|.| . |.|.||.|..      |     . |     ||
IVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPE

AFRTDLPNSTKVVTPEYDVYSFAMTLYELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQP-IPASTPEDLIRVMEESWSYEPNDRPNFREITEWV
  .    |.        ||||.|| ||||.||  || .    | .   | .|    |.| || . .  . .     |. .|| || . .|..  
CLMHESYNQ------KSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKK---LRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase ANKK1.AA STE 47-313 19 1.6e-25 87.14 In-house 1-359 (359) Show / Hide 
Range on Protein: 47-313
Range on HMM: 1-359/359
Sequence Identity: 19% (71 aa)

HEG-CHLGGGSFGEVYKAVHKVHGD----------------VAVKLAKPGKED----------------QVVLMYQKEAGKHVLSLT-SNHIVSIKGFVQ
 ||   .| |.||.||||...  ..                .|.|  .  ...                . .  ..||   .  .   . .||   |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

CE---KAACDCGCLIGIVMEYMKHGSLWDFRISKWQDRPDLW-----------PLTNRMVHQISSG-MHFLHSKDIIHRDLKLENVLVDGNLNVKVADLG
 |   . ..|    . |.||||  ||| |.  .|.    .|            ..  ....||  | ...|||. |||||.|  |.|.     || .| |
KEGHNHKNDDE---LWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFG

LATNLQT---------------SFGDER---CGTNSHKPPEAFRTDLPNST-KVVTPEYDVYSFAMTLYELLTGIHPYSDRGFYMMMLLKVDS-------
....|.                . . .|   .||  .  ||  . .  . . |  .   |..|.  |. |..|| .|..|     .|... ..       
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------KQSPCLQPI----------------PASTPEDLIRVMEESWSYEPNDRPNFREITE----WV
       ...| |..                 | .  ....  ..    ..||.||.  .  .    ..
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ANKK1.AA TyrKc 46-313 26 1.7e-24 88.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-280/280
Sequence Identity: 26% (83 aa)

EHEGCHLGGGSFGEVYKAVHKVHGDVAVKLAKPGKEDQVVLMYQKEAGKHVLSL--TSNHIVSIKGFVQCE-------KAACDCGCLIGIVMEYMKHGSL
 . |  || | ||||||.. |   .||||  |...    . .  .|| .   .|     .|| . | .  .       .  .       ||||||.||.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREA-RIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM-------IVMEYMPHGDL

WDFRISKWQDRPDLWPLTNRMVHQISSGMHFLHSKDIIHRDLKLENVLVDGNLNVKVADLGLATNLQTS--FGDERCGTNS------HK--------PPE
 |.  ..  .    ..    . .||..|| .|||| .|||||   |.||. |. ||..| ||. ..      | |.  . .       |        .||
KDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPE

AFRTDLPNSTKVVTPEYDVYSFAMTLYELLT-GIHPYSD------RGFYMMMLLKVDSKQSPCLQPIPAS--------TPEDLIRVMEESWSYEPNDRPN
..       ... |.. ||.||  ...|..| |  ||..        . .. ..|          |.|..         |... ..|.. | ..|.|||.
CI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-----RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

FREITEWV
|.|| |  
FSEIHECF
Kinase ANKK1.AA Pkinase_Tyr 47-199 35 2.1e-22 76.53 Pfam 2-158 (270) Show / Hide 
Range on Protein: 47-199
Range on HMM: 2-158/270
Sequence Identity: 35% (59 aa)

HEGCHLGGGSFGEVYKAVHK-----VHGDVAVKLAKPGKEDQ---VVLMYQKEAGKHVLSL-TSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHGSLW
. |  || |.||||||.. |      . .||||  |.|  ..      . . || |   .|    .||.  | . ...        | ||||||.||.| 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EA-KIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLL

DFRISK--WQDRPDLWPLTNRMVHQISSGMHFLHSKDIIHRDLKLENVLVDGNLNVKVADLGLA
|.  ..  .......  | . | .||..|| .|.|| .|||||   |.||. |. ||..| |||
DYLRKHREDKQPLTMKDLLQ-MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase ANKK1.AA Dicty4 126-204 38 1.6e-17 55.16 In-house 79-166 (277) Show / Hide 
Range on Protein: 126-204
Range on HMM: 79-166/277
Sequence Identity: 38% (35 aa)

IVMEYMKHGSLWDFRISK------WQDRPDLWPLTNR---MVHQISSGMHFLHSKD--IIHRDLKLENVLVDGNLNVKVADLGLATNLQT
||.|||  |.|    . .        . .| |||  |   |   .  ||  ||. .  |||||||  | ||| |..|||.|.||..  ..
IVTEYMPKGNLYSL-LHDKPSEQQQSIKLD-WPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK
Kinase ANKK1.AA LRRK 126-200 34 5.2e-17 56.71 In-house 132-226 (351) Show / Hide 
Range on Protein: 126-200
Range on HMM: 132-226/351
Sequence Identity: 34% (33 aa)

IVMEYMKHGSLWDFRISKWQDR-----PD-LWPLTNRMVHQISSGMHFLHSKD--IIHRDLKLENVLV---D---------GNLNVKVADLGLAT
.||||. ||.| .|  .| ||.     ..  | |. . . ||..|| .|||..  ||||||| .|.|.   .          . ..|.|| |. .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR
Kinase ANKK1.AA RAF 160-200 48 4.3e-16 48.37 In-house 111-151 (282) Show / Hide 
Range on Protein: 160-200
Range on HMM: 111-151/282
Sequence Identity: 48% (20 aa)

QISSGMHFLHSKDIIHRDLKLENVLVDGNLNVKVADLGLAT
|.. || .||.| |||||||  |.. .  . ||. | ||.|
QVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMT
Kinase ANKK1.AA LRRK 238-315 25 9.5e-12 37.83 In-house 264-351 (351) Show / Hide 
Range on Protein: 238-315
Range on HMM: 264-351/351
Sequence Identity: 25% (22 aa)

DVYSFAMTLYELLTGI-HPYSD---RGFYMMMLLKVD---SKQSPCLQ---PIPASTPEDLIRVMEESWSYEPNDRPNFREITEWVAN
|.|||.| |.||||.  ||. .   .... .| .  |   ... | .      | ... ..   ... |. .|..|| | .|..    
DCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase ANKK1.AA RAF 234-315 27 1e-11 33.98 In-house 199-282 (282) Show / Hide 
Range on Protein: 234-315
Range on HMM: 199-282/282
Sequence Identity: 27% (24 aa)

TPEYDVYSFAMTLYELLTGIHPY----SDRGFYMMMLLKVDSKQSPCLQPIPASTPEDLIRVMEESWSYEPNDRPNFREITEWVAN
... ||||| . .|||.|.  ||    ..|  .. |  .     .| |  .   .|. . | ||. |......|| |..| . .  
SFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGR--GYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase ANKK1.AA Pkinase_Tyr 238-316 29 3.7e-07 24.88 Pfam 196-270 (270) Show / Hide 
Range on Protein: 238-316
Range on HMM: 196-270/270
Sequence Identity: 29% (24 aa)

DVYSFAMTLYELLT-GIHP-YSDRGFYMMMLLK-VDSKQSPCLQPIPASTPEDLIRVMEESWSYEPNDRPNFREITEWVANL
||.||  ...|..| |  | | .   . .. .   |  .     |.|  .|... ..| . | |.|.||| |.||   .  |
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR----MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI---HEQL
Kinase ANKK1.AA Dicty4 238-257 55 2e-06 17.95 In-house 199-218 (277) Show / Hide 
Range on Protein: 238-257
Range on HMM: 199-218/277
Sequence Identity: 55% (11 aa)

DVYSFAMTLYELLTGIHPYS
|||||.. |.|.||.  ||.
DVYSFGIVLWEILTRQEPYQ
Kinase ANKK1.AA Dicty4 279-318 30 2.2e-05 14.09 In-house 239-277 (277) Show / Hide 
Range on Protein: 279-318
Range on HMM: 239-277/277
Sequence Identity: 30% (12 aa)

PIPASTPEDLIRVMEESWSYEPNDRPNFREITEWVANLDT
|||...|  ... ... |. .|. || | ||..    |..
PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRI-LEH
Kinase ANKK1.AA RAF 49-74 53 0.000332 9.2 In-house 4-27 (282) Show / Hide 
Range on Protein: 49-74
Range on HMM: 4-27/282
Sequence Identity: 53% (14 aa)

GCHLGGGSFGEVYKAVHKVHGDVAVK
.   | |||| ||..  . |||||||
MTRIGSGSFGTVYRG--HWHGDVAVK
Kinase ANKK1.AA TKL-Unique 49-90 33 0.001892 8.24 In-house 2-41 (290) Show / Hide 
Range on Protein: 49-90
Range on HMM: 2-41/290
Sequence Identity: 33% (14 aa)

GCHLGGGSFGEVYKAVHKVHGDVAVKLAKPGKEDQVVLMYQK
.  .|.|..|.|||....   .||.|  .| .||.   | |.
WNKIGEGGYGQVYKGKWRGY-PVAIKQFHP-NEDSSNEMMQE
Kinase ANKK1.AA LRRK 46-63 36 0.010555 5.37 In-house 1-19 (351) Show / Hide 
Range on Protein: 46-63
Range on HMM: 1-19/351
Sequence Identity: 36% (7 aa)

EHEGCHLGGGSFG-EVYKA
  ..  .| |.|| .||.|
LKIEEQIGRGGFGTFVYRA
Kinase ANKK1.AA Dicty4 52-82 41 0.01266 4.77 In-house 7-36 (277) Show / Hide 
Range on Protein: 52-82
Range on HMM: 7-36/277
Sequence Identity: 41% (13 aa)

LGGGSFGEVYKAVHKVHGDVAVKLAKPGKED
.|.||||||||.  .   .||||...  ...
IGKGSFGEVYKGTWRGK-EVAVKKLNNHNQN
Death ANKK1.AA Death 1164-1241 30 3.7e-10 36.34 Pfam 1-83 (87) Show / Hide 
Range on Protein: 1164-1241
Range on HMM: 1-83/87
Sequence Identity: 30% (26 aa)

LGIEQLI-----PGKAVKSLGRHLGLDHVRIENIVYENQNET-SSEIAYQLLREWIQQNGHQATKAVLANALWKAECCEAAESV
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QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKI