Gene KSR1 (Sea Urchin)
KSR1
Sequence
Protein domains of KSR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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C1 | KSR1.AA | C1 | 251-300 | 24 | 1.7e-08 | 35.46 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 251-300 Range on HMM: 1-61/61 Sequence Identity: 24% (15 aa) HRFSKKTSMKPQSCDYCHEKIVILQ-------RYKCKDCKYICHSNCKFHAEK-----VPSC |...... || |..|...| .. |.| .||| || .|. .. . . .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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C1_1 | KSR1.AA | C1_1 | 251-304 | 27 | 2e-08 | 34.62 | Pfam | 1-55 (55) | Show / Hide |
Range on Protein: 251-304 Range on HMM: 1-55/55 Sequence Identity: 27% (16 aa) HRFSKK-TSMKPQSCDYCHEKI---VILQRYKCKDCKYICHSNCKFHAEKVPSCGLPR |.. . . .| .|..| | . ..| .|| .|.| || | ..|||.. . HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRC---HMKVPPECGCN |
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Kinase | KSR1.AA | KSR | 482-672 | 62 | 3e-146 | 492.16 | In-house | 78-272 (272) | Show / Hide |
Range on Protein: 482-672 Range on HMM: 78-272/272 Sequence Identity: 62% (121 aa) LCKG-QTLYTHIHLRKDRFNINRTIQIATQITQGMSYLHHKGIVHKDLKSKNIFIEN-GKVVLTDFALFSIGRLSKQKTRKDSLVIPDGWLCYLAPELIT |||| ||||.|||.|......|||.|||.||.|||.|||.|||.||||||||||.|| ||||.|||.||||.||.....|.|.|.||.|||||||||||. LCKGSQTLYHHIHVRREKLDMNRTMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIR SLKINTDGTQDMELPFSEKSDVYSFGTIWYELLAGEWPFHKQPVETVIWQVGKG--LKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKKTI ....|.|..|.|.||||..||||.|||||||...|||||..|..|..|||...| ..|.|...|..|..||||||||||.|..||.||.|.|.. AMRPNYDEYQCMCLPFSHHSDVYAFGTIWYEMICGEWPFKYQCAESIIWQMCQGEGMRQVLRNVQCGREMKEILMMCWSYEPQERPTFQDIMKML |
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Kinase | KSR1.AA | RAF | 481-672 | 52 | 1.8e-124 | 419.84 | In-house | 78-275 (275) | Show / Hide |
Range on Protein: 481-672 Range on HMM: 78-275/275 Sequence Identity: 52% (103 aa) NLCKGQTLYTHIHLRKD-RFNINRTIQIATQITQGMSYLHHKGIVHKDLKSKNIFIENGKV-VLTDFALFSIGRLSKQKTRKDSLVIPDGWLCYLAPELI ..|||.|||.||| .|. .|..|.|||||.||.|||.|||.|.|.|.||||||||..|||| |.|||.||.. |....|.||..| .|.||.|..|||.| QWCKGSTLYHHIHVQKTEKFDMNWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVI TSLKINTDGTQDMELPFSEKSDVYSFGTIWYELLAGEWPFH-KQPVETVIWQVGKG---LKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKKTI .......|..|....|||..||||.|||.||||.|||||.. .|..|..||.|..| ........|.....||.||.||||.|..||.||.|.|.| RMMRPDWDEYQCDCNPFSFQSDVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI |
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Kinase | KSR1.AA | RAF | 481-674 | 33 | 2.3e-57 | 184.45 | In-house | 80-282 (282) | Show / Hide |
Range on Protein: 481-674 Range on HMM: 80-282/282 Sequence Identity: 33% (68 aa) NLCKGQTLYTHIHLRKD--RFNINRTIQIATQITQGMSYLHHKGIVHKDLKSKNIFIENG-KVVLTDFALFSIGRLSKQKTRKDSLVIPDGWLCYLAPEL . | . .|| ||| . .|... .|.|. |. |||.||| | |.| ||||.||| ... .|. .||.| . .. . .. . .| .| ..||| QWCEHSSLYHHIHVQETREKFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPR-GNQQFEQPTHWILWMAPEV ITSLKINTDGTQDM--ELPFSEKSDVYSFGTIWYELLAGEWPF--HKQPVETVIWQVGKGLKQPLNHLQAS---RDVKEILMMCWSYSPDSRPIFQHIKK | | |. | | |.|.| .|||||||.. |||.... |. | . . .|. .|.|. .| . . . .. . ||.. .. ||.||.| | IRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILK TILR .| RITV |
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Kinase | KSR1.AA | TKL | 467-672 | 21 | 2e-53 | 183.84 | In-house | 87-364 (364) | Show / Hide |
Range on Protein: 467-672 Range on HMM: 87-364/364 Sequence Identity: 21% (61 aa) ILDLIG-----------------TGRFGAVHNLCKGQTLYTHIHLRKDRFNINRTIQIATQITQGMSYLHH--------KGIVHKDLKSKNIFIE-NGK- |. ..| .| .. | .|.| .|. ..| .......| .| .||.||| ..|.| |||||||.. |.. IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN -------------VVLTDFALFSIGRLSKQKTRKD--------------SLVIPDGWLCYLAPELITSLKINT-----DGTQDMELPFSEKSDVYSFGTI . ..|| | |..... . . |.....|||.. .| |. .......|||.|||||| . VSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIV WYELLAGEWPFHKQPVETVI---------WQVGKGLKQPLNH------------LQASRDVKEILMMCWSYSPDSRPIFQHIKKTI ..|.|....|....| ...| ..|.. ..|. .. ...|.....||.. |..|| || |.|.. LWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | KSR1.AA | Pkinase_Tyr | 488-672 | 25 | 2.2e-24 | 83.21 | Pfam | 94-270 (270) | Show / Hide |
Range on Protein: 488-672 Range on HMM: 94-270/270 Sequence Identity: 25% (48 aa) LYTHIHLR---KDRFNINRTIQIATQITQGMSYLHHKGIVHKDLKSKNIFIE-NGKVVLTDFALFSIGRLSKQK-TRKDSLVIPDGWLCYLAPELITSLK |... . . |..... . .|...|| .||.||. |...| || .|. .. |..| .|| | . . ... .| |. ||| | | LLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM---APECINYGK INTDGTQDMELPFSEKSDVYSFGTIWYELLA-GEWP-FHKQPVETVIWQVGKGLKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKKTI |..||||.||| ..|.. || | . . | |. .... . .. .. .....|| | |. || |. | . ------------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | KSR1.AA | TKL-Unique | 487-672 | 23 | 4.8e-23 | 78.23 | In-house | 86-290 (290) | Show / Hide |
Range on Protein: 487-672 Range on HMM: 86-290/290 Sequence Identity: 23% (52 aa) TLYTHIH---------LRKDRFNINRTIQIATQITQGMSYLHHKG--IVHKDLKSKNIFIENG------KVVLTDFALFSIGR--LSKQKTRK----DSL .|| ..| .. .| .. ...| .| ||| ||||.. | | ||||.|. . |. .. . || | . . . .... .. SLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQT VIPDGWLCYLAPELITSLKINTDGTQDMELPFSEKSDVYSFGTIWYELLAGEW------PFHKQPVETVIWQVGK---GLKQPL-NHLQASRDVKEILMM .. | . ..|||..... .||||||||||.. .|.. .. |... | .. | . .. |. ||. . .... . RC--GSFRWMAPEVLRMNF----------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKE--YRDLIQQ CWSYSPDSRPIFQHIKKTI || |. || |. | . . CWHHDPSQRPSFDEIIHRL |
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Kinase | KSR1.AA | Ciliate-E2-Unclassified | 482-618 | 24 | 1.6e-21 | 71.42 | In-house | 102-270 (352) | Show / Hide |
Range on Protein: 482-618 Range on HMM: 102-270/352 Sequence Identity: 24% (43 aa) LCKGQTLYTHIHLRKD----------------RFNINRTI-----QIATQITQGMSYLHHKG-IVHKDLKSKNIFIENG----KVVLTDFALFS-IGRLS .|.|..| .| || .| . .. ... || || .|||||. |.| |.| ||.. |. .. ..|| ... .. . YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN KQKTR--------KDSLVIPD-GWLCYL----APELITSLKINTDGTQDMELPFSEKSDVYSFGTIWYELLAGEWPF ...|. |. . | ..|. |||.. . . .. .|.|..|.| | ||.| |..|| NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--------YKCDIWSLGVILYEMLFGYYPF |
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Kinase | KSR1.AA | Ciliate-E2 | 482-618 | 21 | 5.4e-21 | 68.78 | In-house | 115-296 (365) | Show / Hide |
Range on Protein: 482-618 Range on HMM: 115-296/365 Sequence Identity: 21% (42 aa) LCKGQTLYTHIHLRKD----------RFNINRTIQIATQITQ---------------GMSYLHHKG-IVHKDLKSKNIFIENGKVVLTDFALFS------ .|.|..|. .| .| .|... ..| .||.| .. ||| |. |.| |.| ||.. . ..|| | YCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDN ---IGRLSKQKTRKDSL----VIPD---------------GWLCYLAPELITSLKINTDGTQDMELPFSEKSDVYSFGTIWYELLAGEWPF .. .. .| .. . | | . |.||| . . |.... . . ..|.|..|.| | ||.| |..|| QNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF |
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Kinase | KSR1.AA | RIPK | 510-672 | 25 | 1.8e-20 | 66.46 | In-house | 115-290 (290) | Show / Hide |
Range on Protein: 510-672 Range on HMM: 115-290/290 Sequence Identity: 25% (47 aa) QITQGMSYLHHKG--IVHKDLKSKNIFI-ENGKVVLTDFALFSIGRLSKQKT-RK-----DSLVIPD--GWLCYLAPELITSLKINTDGTQDMELP---F .| || ||| .. | |.||| || . | | . || | . . |.... |. .| . | | |..||.. | | . EISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR---------TDNKKPIKVV SEKSDVYSFGTIWYELLAGEWPFHK-QPVETVIWQVGKGLKQPLNHLQASRD-------VKEILMMCWSYSPDSRPIFQHIKKTI ..|.|||||. . .|.|.. |. . .. . . .| .|. . ... .| . ||.. |..|| || .. . TPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT |
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Kinase | KSR1.AA | MLK | 592-672 | 26 | 4.9e-16 | 52.22 | In-house | 210-291 (291) | Show / Hide |
Range on Protein: 592-672 Range on HMM: 210-291/291 Sequence Identity: 26% (22 aa) ELPFSEKSDVYSFGTIWYELLAGEWPFH-KQPVETVIWQVGKGLKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKKTI . ..|||.||.|.| . .|.|..| |.. . ...|.|. . | .... |. ...||. | .|| |..| . CEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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S_TKc | KSR1.AA | S_TKc | 465-673 | 18 | 3.7e-13 | 16.02 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 465-673 Range on HMM: 1-231/231 Sequence Identity: 18% (51 aa) LEILDLIGTGRFG----AVHNL----------------------------------------------CKG--QTLYTHIHLRKDR-----FNINRTIQI |||..|| | || ..|. | | .|...|. |. . |. .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY ATQITQGMSYLHHKGIVHKDLKSKNIFIENGKVVLTDFALFSIGRLSKQKTRKDSLVIPDGWLCYLAPELITSLKINTDGTQDMELPFSE-KSDVYSFGT . || ... |.| .||.| ||| ||.. . . ..|| | . .... . |.|||.. ... |.|..|.| MYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGT---PWYMAPEVL---------------GYGKCKCDWWSCGC IWYELLAGEWPFHKQPVETVIWQVGKGLKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKK--------TIL | ||.|.|. ||. . ..... . |...|.... |. . |. || . . . ILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | KSR1.AA | Pkinase | 482-545 | 31 | 1.1e-12 | 45.87 | Pfam | 81-156 (293) | Show / Hide |
Range on Protein: 482-545 Range on HMM: 81-156/293 Sequence Identity: 31% (24 aa) LCKGQ----TLYTHIH-LRKDRF--NINRTIQIATQITQGMSYLHHKGIVHKDLKSKNIFIE-NGKV----VLTDF .| | |...|. |. .| . . ...|| .|. |.| .||.| |||. ||.| || . ..|| YCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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Kinase | KSR1.AA | TyrKc | 465-672 | 20 | 1e-11 | -33.39 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 465-672 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) LEILDLIGTGRFGAVH-----------------------------NL-------------CKG--------QTLY----------THIHLRKDR--FNIN .. .. .| | || |. .| | . |. . .||| | .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK RTIQIATQITQGMSYLHHKGIVHKDLKSKNIFIENGK-VVLTDFALFSIGRLSKQKTRK-------DSLVI---PDGW----LCYLAPELITSLKINTDG .....|| .||.|||.|...| || |. . ... | .|| ||. . . | . .| . .||| | DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG------LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--------- TQDMELPFSEKSDVYSFGTIWYELLA-GEWPFHK-----QPVETVIWQVGKG--LKQPLNHL-----QASRDVKEILMMCWSYSPDSRPIFQHIKKTI .. |..||||.||| .|.. |. | . . || .| .| ..|| |.. .. .. .| .|| . |..|| |. |.. . ---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | KSR1.AA | MLK | 505-545 | 37 | 1.6e-10 | 32.85 | In-house | 127-177 (291) | Show / Hide |
Range on Protein: 505-545 Range on HMM: 127-177/291 Sequence Identity: 37% (19 aa) IQIATQITQGMSYLHHKG---IVHKDLKSKNIFIE-------NGKVVLTDF ...|.|. .||.||| . |.| ||||.|| | .|... .|| MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF |
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Kinase | KSR1.AA | TK-Unique | 595-672 | 27 | 9.5e-10 | 29.92 | In-house | 216-294 (294) | Show / Hide |
Range on Protein: 595-672 Range on HMM: 216-294/294 Sequence Identity: 27% (22 aa) FSEKSDVYSFGTIWYELLA-GEWPFHKQPVETVIWQVGKGLKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKKTI ...||||.||| . .|.. |. |... | . .. .. .| .|. .|... ... ||...|..|| | ||. . HTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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Kinase | KSR1.AA | TK-Unique | 505-547 | 39 | 9.6e-09 | 26.4 | In-house | 134-179 (294) | Show / Hide |
Range on Protein: 505-547 Range on HMM: 134-179/294 Sequence Identity: 39% (18 aa) IQIATQITQGMSYLHH--KGIVHKDLKSKNIFIENGKVV-LTDFAL ...| || .||.||. |.|||.|| ..|... ..||. ..|| . YHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGM |
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Kinase | KSR1.AA | Pkinase | 572-672 | 17 | 1.2e-05 | 21.09 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 572-672 Range on HMM: 177-293/293 Sequence Identity: 17% (22 aa) YLAPELITSLKINTDGTQDMELPFSEKSDVYSFGTIWYELLAGEWPFHKQ----PVETVIWQVGKGLK-QPLNHLQAS---------------------R |.|||.| . . |.|..|.| | ||.| |. || . . . .. . . .. .. . . . . YMAPEVIR-----------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE DVKEILMMCWSYSPDSRPIFQHIKKT--I . |... |. . | .|| ...|.. . ECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | KSR1.AA | KSR | 465-480 | 56 | 0.000134 | 11.6 | In-house | 1-16 (272) | Show / Hide |
Range on Protein: 465-480 Range on HMM: 1-16/272 Sequence Identity: 56% (9 aa) LEILDLIGTGRFGAVH |... .|| |||| || LKYGECIGQGRFGKVH |
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Kinase | KSR1.AA | RAF | 465-480 | 50 | 0.000181 | 11.24 | In-house | 1-16 (275) | Show / Hide |
Range on Protein: 465-480 Range on HMM: 1-16/275 Sequence Identity: 50% (8 aa) LEILDLIGTGRFGAVH ..|. ||.|||| |. VQIGERIGQGRFGTVY |
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Kinase | KSR1.AA | TK-Unique | 465-480 | 56 | 0.000593 | 9.66 | In-house | 1-16 (294) | Show / Hide |
Range on Protein: 465-480 Range on HMM: 1-16/294 Sequence Identity: 56% (9 aa) LEILDLIGTGRFGAVH ||..|.||.|.|| |. LEVGDVIGEGAFGQVW |
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Kinase | KSR1.AA | MLK | 465-480 | 37 | 0.007305 | 5.92 | In-house | 1-16 (291) | Show / Hide |
Range on Protein: 465-480 Range on HMM: 1-16/291 Sequence Identity: 37% (6 aa) LEILDLIGTGRFGAVH .... || | ||.|. IQFHEWIGSGSFGKVW |
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Kinase | KSR1.AA | RAF | 465-479 | 40 | 0.018811 | 3.42 | In-house | 1-15 (282) | Show / Hide |
Range on Protein: 465-479 Range on HMM: 1-15/282 Sequence Identity: 40% (6 aa) LEILDLIGTGRFGAV ... ||.|.|| | VMVMTRIGSGSFGTV |
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Kinase | KSR1.AA | TKL-Unique | 467-479 | 38 | 0.376452 | 0.03 | In-house | 1-13 (290) | Show / Hide |
Range on Protein: 467-479 Range on HMM: 1-13/290 Sequence Identity: 38% (5 aa) ILDLIGTGRFGAV .. .||.| .|.| FWNKIGEGGYGQV |
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Kinase | KSR1.AA | Pkinase | 465-479 | 46 | 1.139264 | 3.45 | Pfam | 1-15 (293) | Show / Hide |
Range on Protein: 465-479 Range on HMM: 1-15/293 Sequence Identity: 46% (7 aa) LEILDLIGTGRFGAV ..|. || | || | YHIGRKIGSGSFGCV |
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Kinase | KSR1.AA | Pkinase_Tyr | 465-480 | 31 | 1.635664 | 2.36 | Pfam | 1-16 (270) | Show / Hide |
Range on Protein: 465-480 Range on HMM: 1-16/270 Sequence Identity: 31% (5 aa) LEILDLIGTGRFGAVH .... .| | || |. ITFGKKLGEGAFGEVY |