Gene MLK (Sea Urchin)
MLK
Sequence
Protein domains of MLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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SH3 | MLK.AA | SH3 | 91-151 | 36 | 1.1e-19 | 72.61 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 91-151 Range on HMM: 1-58/58 Sequence Identity: 36% (23 aa) SLCTAMHDYESTADDELTIHRGDLVEIISKDHAVSGDDGWWMGKVG--DQQGIFPNNYVSDSQ . |..||... .|||....|| .....|| ||||| |... |.|.|| ||| . PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID |
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SH3_1 | MLK.AA | SH3_1 | 94-144 | 32 | 4.6e-13 | 47.07 | Pfam | 1-49 (49) | Show / Hide |
Range on Protein: 94-144 Range on HMM: 1-49/49 Sequence Identity: 32% (17 aa) TAMHDYESTADDELTIHRGDLVEIISKDHAVSGDDGWWMGKVGD--QQGIFPN .| .||. . .|||.. .|| ...|.|... ..|| |.. . |.|.|| VALYDYQAQQPDELSFKKGDIIHVIEKSDD----WDWWKGRCNNTGQEGWFPS |
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SH3_2 | MLK.AA | SH3_2 | 92-150 | 22 | 1.3e-08 | 33.01 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 92-150 Range on HMM: 1-68/68 Sequence Identity: 22% (16 aa) LCTAMHDYES-TADDE-----LTIHRGDLVEIISKDHAVS--GDDGWWMG-KV--GDQQ--GIFPNNYVSDS .. .. ||.. | .| |....||....|. .. .|.|| . . | . | ||...|. YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVID----NGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC |
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Kinase | MLK.AA | MLK | 170-433 | 65 | 4.8e-182 | 606.75 | In-house | 1-280 (280) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-280/280 Sequence Identity: 65% (186 aa) IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVR-STIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMP ... |.||.||||||.|..|.||||||||...|||.| . ...|||||.|| |.||||| |||.||..|| |.||||.||||||| . || . | LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK--RIP PNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVE-----------------HSNMYNIQLKITDFGLAREMYKTTRMSAAGTYAWMAPEVI |.|||||| ||| |||||| |||.|.|||||||||||. .|.. | .| | ||||||||||||..||||||||||||||||||| PHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVI KSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL |.|..||.|||||.|.||||||||||||.|||.||||||.|.|||||||||||||...|.. ||||.|||.||.||||.||| KESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL |
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Kinase | MLK.AA | MLK | 170-433 | 45 | 3.7e-150 | 505.13 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-291/291 Sequence Identity: 45% (133 aa) IQLNELIGVGGFGKVFRGSWRGEE-----VAVKAAKHDPEEDDNV-RSTIDNVRQEAKLFSLLSHPN----IISLRGACLREPH-VCIVMEYARGGSLNR ||. | ||.|.||||..| ||... ||||....... | . . ......|..... ||||| || ..|.||..|. .||||||..||||.. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN LLFGKK-------------MAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKT-T-RMSAAGTY .| |.. ... ...|||.|.| ||.||| .|| |.|||||||.|||.|. ..| .| . .|||.|||..|..... | .||.|||| VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY AWMAPEVI---KSSLFSKSSDVWSFGILLWELLTGEVPYK-GIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL |||||||| ... .|...||||.|..|||.||.||||| ..| .|.|...|.|.|..||||||||...|.. .||| |||.||.|..|.|.| AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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Kinase | MLK.AA | TKL | 176-433 | 29 | 7.89999999999e-108 | 364.53 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 176-433 Range on HMM: 1-364/364 Sequence Identity: 29% (111 aa) IGVGGFGKVFRGSWRG----------EEVAVKAAKHDPEEDDNVRS---------------------TIDNVRQEAKLFSLLSHPNIISLRGACLREPH- || ||||.|..| ||| ..|||| | . . .. | . ..|... | |.||||... |.|...|. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------VCIVMEYARGGS-LNRLLFGKKMAMPPNVLVNWAYQIADGMNYLHWEAP-----IPLIHRDLKSSNILLDQKVEH------SNMYNIQ ||||||. ||| |..|. ......||..|| |||||| . | |.|||||||.|||.|.. .. . ... CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC LKITDFGLAREM---------------------YKTTRMSAAGTYAWMAPEVIKSS----------------LFSKSSDVWSFGILLWELLTGEVPYKGI .||.||||.|.| ...|.|. ||..||||||.. . .|...||.||||.|||.||...||... CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY DTLAVA---------YGIAVNKLTLPIP------------STCPEIFSKMLLDCWNYDPHERPTFSEIMQQL . . .......| .||| ..||. ..| . |||..||..||.|.||...| PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | MLK.AA | TyrKc | 170-433 | 31 | 9.9e-90 | 305.32 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-280/280 Sequence Identity: 31% (94 aa) IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLL--SHPNIISLRGACLRE-------PHVCIVMEYARGGSLNRLL |.|.. .| | ||.|..| |. ..|||| |.| . ..||.. . | .||||. | |.|. . . ..|||||. .|.|. | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL FGKKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKT---------TRM----SAA--GTYAW .. .. |.....|||.||.||| ..||||| |.|.. . . ||.||||.|. | |. .. . | RKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW MAPEVIKSSLFSKSSDVWSFGILLWELLT-GEVPYKGI----DTLAVAYGIAVNKLTLPIPST--------CPEIFSKMLLDCWNYDPHERPTFSEIMQQ ||||.|. . |. |||||||...||..| |. || |. . . .. . .|.| ||. .. ..||..||..||||||| .. MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC L . F |
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Kinase | MLK.AA | TKL-Unique | 172-433 | 35 | 5.1e-84 | 285.44 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 172-433 Range on HMM: 1-290/290 Sequence Identity: 35% (104 aa) LNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLS-HPNIISLRGACL----REPHVCIVMEYARGGSLNRLLF----- ..|| ||.|.|..| |||..||.| . | . | . ... . | .. . | |||| . |.| .|. |||||| ||||. .| FWNKIGEGGYGQVYKGKWRGYPVAIKQFH--P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN ----GKKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKTTRMSAA-----------GTYAWM ... ..... |. | .||.||.||| . | |||||||||.|.|.. || .. || ||||.. | ..|.. |.. || NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNN---SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM APEVIKS--SLFSKSSDVWSFGILLWELLTGEV------PYKGIDTLAVAYGIAV--NKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL ||||... ...|..|||.|||| |||..|... ||.|.| ... ... .. .|||. ||..... . .||. || .||.|.|| | APEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | MLK.AA | Dicty4 | 170-435 | 35 | 1e-83 | 279.09 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 170-435 Range on HMM: 1-277/277 Sequence Identity: 35% (101 aa) IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACL----REPHVCIVMEYARGGSLNRLLFG--- |. ..|| |.||.|..|.||| ||||| .. . . .| ... |.|... . ..||||. . |||. . .|||.|| |.| .|| INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFD--ENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS ---KKMAMP-PNVLV--NWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR----EMYKTT-RMSAAGTYAWMAPEVI .. .. | .. | .| |||.|| |. |||||||.|.| |. | . |..||||.. . ... |.|.|| .|||||| EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM KSSLFSKSSDVWSFGILLWELLTGEVPYK--GIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQ--LKD . . ..|| ||||.|||.||.. || .... .. ... || .|||. || ... . .||. || ||.|.|| |. | MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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Kinase | MLK.AA | Pkinase_Tyr | 170-433 | 35 | 6.1e-80 | 271.36 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-270/270 Sequence Identity: 35% (102 aa) IQLNELIGVGGFGKVFRGSWR------GEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLL-SHPNIISLRGACL-REPH--VCIVMEYARGGSLNRL |.... .| | ||.|..| |. . .|||| |.. ...| .. .|||. . | .||||..| |.|. .. . ..|||||. .|.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY LFGK---KMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREM-----Y-KTTRMSAAGTYAWMAPEV | . | . .. |.....|||.||.||. ...||||| |.|.. | . ||.|||||| . | ... . |||||. LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPEC IKSSLFSKSSDVWSFGILLWELLT-GEVP-YKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL |. . |. |||||||.|.||..| || | |.|.. | |. . .|.| ||. .....||.||| .||||||| .|| INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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Kinase | MLK.AA | LZK | 170-433 | 41 | 8.2e-79 | 265.34 | In-house | 1-241 (241) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-241/241 Sequence Identity: 41% (111 aa) IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMPP |. . .| | | |||| .|.|.|||| . | | | |. | ||||| ..| | . | ||.||| | | | .. ..| ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETD------IKHLRK-------LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVL-RERRTITP NVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKT--TRMSAAGTYAWMAPEVIKSSLFSKSSDVWSFGI . .|.| |||.||.||| ||||||| ||| .| .|| ||| ... . |.|| .|| ||||||||. | |.||||. QLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI--------SHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGV LLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL |||.||.|.||| .| |. .|. | | ||.|||||| | .. ||. | || |. |.. . VLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW |
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Kinase | MLK.AA | Pkinase | 170-433 | 27 | 3e-77 | 267.74 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-293/293 Sequence Identity: 27% (84 aa) IQLNELIGVGGFGKVFRGSWRGEE--VAVKAAKHDPEEDDNVRST---IDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGG----SLNRLL ... . || |.||.|... ..|.. |||| | . .|..... | . .|... |.||||. |.... ...|...||||..|| .| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI F---GKKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR---EMYKTTRMSAAGTYAWMAPEVIK-S .... ...... ...|||. |..|.| . ||||||..|||.|.. . . .||.|||||. . .. .. .||. .||||||. . STWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG SLFSKSSDVWSFGILLWELLTGEVPYKGI------DTLAVAYGIAVNKLTLPIPSTCP-------------------EIFSKMLLDCWNYDPHERPTFSE . ....|.||.|..|.|.|.|. |..| | ... . | .| ..| .|. | . . . .|...||..|||. . QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ IMQQ--L |.| . ILQHPWF |
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Kinase | MLK.AA | DRK | 170-435 | 36 | 3.2e-77 | 261.07 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 170-435 Range on HMM: 1-258/258 Sequence Identity: 36% (98 aa) IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMPP | || |..| ||||.||| .|||| .. . ..| | . ..|. | . | ||||. |.|. | .||.||| ||| . | .. | IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENF---LNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDW NVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR----EMYKTTRMSAAGTYAWMAPEVIKSSLFSKSSDVWSF . . .| ||.||| || ||||||| | | | . | |. ||||. ... | . || | |||| . . ||.|| PLMKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDE--------HWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSF GILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQLKD .| |||..| . || |. |. | . .. .|.| || . . . |||| || ||.. |... | AIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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Kinase | MLK.AA | LRRK | 170-435 | 29 | 1.2e-73 | 250.96 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 170-435 Range on HMM: 1-351/351 Sequence Identity: 29% (106 aa) IQLNELIGVGGFG-KVFRGSWRG----------------------------EEVAVKAAKHDP-----------------------------EEDDNVRS . .|.||.|||| .|.|. ||| ..||.| . || ...| |. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA TIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKK-MA-------MPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSN |.|. . | | ||||.|| | |.. . |.|||||. |.|...|. || .. ...... |.|||.||.||| | |.||||||| | -FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPN ILL-DQKVEHSNM---YNIQLKITDFGLAR--EMYKTT-RMSAAGTYAWMAPEVIK---SSLFSKSSDVWSFGILLWELLTGE-VPYKGID---TLAVAY ||| . .|| .. || |||. | .... .. |. |||||... . .. .|. |||..||||||.. |. ..| . . ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME GIAV---NKLTLPIPST-CPE-----IFSKMLLDCWNYDPHERPTFSEIMQQLKD | ..| .||.. ||. ... . .||. || .||.||.| ..|.. QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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Kinase | MLK.AA | TK | 170-433 | 19 | 3.4e-73 | 244.51 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 170-433 Range on HMM: 1-486/486 Sequence Identity: 19% (97 aa) IQLNELIGVGGFG---KVFRGSWRG---------------------------EEVAVKAAKHDPEEDDNVRST--ID---------NVRQEAKLFS--LL |.| . .| | || .|..| ||| ..|||| | . ..... . .. . .|.|... |. ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG SHPNIISLRGACLRE------------PHVCIVMEYARGGS----LNRLLFGKKMA-------------------------------------------- ||||..| |.|... ....|||||. .|. | | .. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------------------------MPPNVLVNWAYQIADGMNYLHWEAPI----PLIHRDLKSSNILLDQKVEHS---NMYNIQLKITDFG-- ... |. ...|||.|| ||| . .. ..|||| |.|.... .. . ||.||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH-SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS ------LAREMYKTTRMSAAGTYA----------------------------WMAPEVIKSSL---------FSKSSDVWSFGILLWELLT-GEVPYKGI |||..|. . ....| |||||.... |. |||||||.|.||..| |..|| | RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG DTL---------AVAYGIAVN--------------KLTLPIPSTCP--------------EIFSKMLLDCWNYDPHERPTFSEIMQQL . . . .. .. .| | || |.. ....||.||| .|||||.. .|| MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | MLK.AA | S_TKc | 170-442 | 27 | 3.7e-70 | 240.32 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 170-442 Range on HMM: 1-231/231 Sequence Identity: 27% (79 aa) IQLNELIGVGGFGKVFRGSWRG--EEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARG--GSLNRLLFGKKM .. ..|| |.||||... ... ..||.| | ...|.| .. . ||||. | ... |...||||. | |.| ... .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR A-----MPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKTTRMSAAGTYAWMAPEVIKSSLFSK-S .|. . ..|||.....|.| |||||| .|||||. ..||.||||||.. .. || .|||||. ..| . HGLRFPFPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCK SDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQLKDISESPFI .|.||.|..|.|.|.|. |. .... . . . .. . .. |...|| .||| |..| || |.. CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | MLK.AA | ZAK | 170-432 | 36 | 1.7e-67 | 230.57 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 170-432 Range on HMM: 1-257/257 Sequence Identity: 36% (102 aa) IQLNELIGVGGFGKVFRGSWRGEE-----VAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPH-VCIVMEYARGGSLNRLLFGK ||. . .||| || |.|. | .||| . . || | ..| ||| | |. | || ||| ||| IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKK--------------VFKIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSN K---MA-------MPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR-EMYKTTRMSAAGTYAWMAPEVI- . |. | .. . || ||| || ||| .|| ||||||| |. .| | .|| ||| | .| || || .|||||.| RSQEMDSSSGGNSM--DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDK--------NGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMIL KSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQ | . ||||.|. |||.|| |||||. . . .. | .| ||. || | ... .|| || .|| . | QSEPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI |