Gene LRRKb (Sea Urchin)
LRRKb
Sequence
Protein domains of LRRKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRR_1 | LRRKb.AA | LRR_1 | 1504-1524 | 22 | 14.379053 | 2.64 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1504-1524 Range on HMM: 1-26/26 Sequence Identity: 22% (6 aa) CIKFVDLSA-N--NVS-DLTP--LSRA .. ||| | |.. .. | . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1651-1674 | 54 | 0.00036 | 21.1 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1651-1674 Range on HMM: 1-24/24 Sequence Identity: 54% (13 aa) LQLLKILDLSNNKLTTLTPVFLHG | |. ||||||.||.| | ..| LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | LRRKb.AA | LRR_1 | 1558-1579 | 29 | 0.003819 | 15.32 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1558-1579 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) ELQELNLRS-N--GIT-ELPTH-LLSL ||.|.|.. | .| ..| . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRRKb.AA | LRR_1 | 1653-1675 | 33 | 0.009235 | 13.96 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1653-1675 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) LLKILDLSN-N--KLT-TLTPVFLHGC |..||||. | .|| .. | . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1579-1607 | 37 | 0.017449 | 14.26 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1579-1607 Range on HMM: 1-24/24 Sequence Identity: 37% (11 aa) LSKLTLLDLSHNQIKDLNKTRPGDTAFKL |..|. ||||.||.. | . || LPNLRELDLSNNQLTHLP-----PGAFQG |
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| LRR_1 | LRRKb.AA | LRR_1 | 1534-1555 | 33 | 0.019237 | 12.83 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1534-1555 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) FLEKLDLSD-N--GLT-EFPKE-LTDY |..||||. | || ..|.. . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1556-1578 | 37 | 0.020481 | 13.69 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1556-1578 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) MPELQELNLRSNGITELPTHL-LS .|.|.||.| .| .|.|| . . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1532-1555 | 37 | 0.04411 | 10.96 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1532-1555 Range on HMM: 1-24/24 Sequence Identity: 37% (9 aa) FRFLEKLDLSDNGLTEFPKELTDY . |..||||.| ||. | .. . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1628-1650 | 25 | 0.050339 | 10.49 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1628-1650 Range on HMM: 1-24/24 Sequence Identity: 25% (6 aa) VPSLQRLSLASNKIETIPDK-PLA |.|..|.| .|.....|. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | LRRKb.AA | LRR_1 | 1630-1651 | 29 | 0.109641 | 10.15 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1630-1651 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) SLQRLSLAS-N--KIE-TIPDK-PLAL .||.|.| . | ... .||. .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRRKb.AA | LRR_1 | 1581-1595 | 31 | 0.870206 | 6.96 | Pfam | 1-19 (26) | Show / Hide |
Range on Protein: 1581-1595 Range on HMM: 1-19/26 Sequence Identity: 31% (6 aa) KLTLLDLSH-N--QI-KDL .|. ||||. | .. ... NLQHLDLSGCNCCNLTGHI |
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| LRR_1 | LRRKb.AA | LRR_1 | 1606-1627 | 25 | 6.264471 | 3.92 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1606-1627 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) KLVELDLSY-N--ATV-RFPSW-LSMF .| .||||. | . .|.. . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRRKb.AA | LRR_1 | 1677-1698 | 22 | 0.322205 | 8.49 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1677-1698 Range on HMM: 1-26/26 Sequence Identity: 22% (6 aa) ALEQLCASN-N--QI-DSLPGD-LDNI |. | |. | .. ...| . . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1727-1750 | 41 | 0.220104 | 5.24 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1727-1750 Range on HMM: 1-24/24 Sequence Identity: 41% (10 aa) LPLLRDIDLSDNGIIDIPPPSEWK || || |||.| . .|| . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | LRRKb.AA | LRR_1 | 1729-1749 | 29 | 3.251566 | 4.93 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1729-1749 Range on HMM: 1-26/26 Sequence Identity: 29% (8 aa) LLRDIDLSD-N--GII-DIPP--PSEW |. .|||. | . .||| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRRKb.AA | LRR_1 | 1701-1727 | 28 | 3.35886 | 4.88 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1701-1727 Range on HMM: 1-26/26 Sequence Identity: 28% (9 aa) KLKILKLAK-N--QL-GLPEHPFIPKF-VLHL .|..| | | .| | ||. .| NLQHLDLSGCNCCNLTGH-----IPPSCF-NL |
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| LRR_1 | LRRKb.AA | LRR_1 | 1778-1799 | 33 | 0.000674 | 17.99 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1778-1799 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) KLERLILSH-N--KLT-KVPKE-LGQL .|..| ||. | .|| ..|.. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | LRRKb.AA | LRR_1 | 1801-1823 | 37 | 0.00461 | 15.03 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1801-1823 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) LLASLDLSH-N-RSIT-TIPDE-LGQL | .||||. | ..| .||.. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1799-1823 | 40 | 0.016542 | 14.45 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1799-1823 Range on HMM: 1-24/24 Sequence Identity: 40% (10 aa) LTLLASLDLSHNRSITTIPDELGQL |. | .||||.|. .|..|... | LPNLRELDLSNNQ-LTHLPPGAFQG |
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| LRR_TYP | LRRKb.AA | LRR_TYP | 1776-1798 | 33 | 0.130141 | 7.11 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 1776-1798 Range on HMM: 1-24/24 Sequence Identity: 33% (8 aa) WSKLERLILSHNKLTKVPKEL-GQ ..|..| ||.|.|| .| .. . LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | LRRKb.AA | LRR_1 | 1753-1776 | 13 | 5.325923 | 4.17 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 1753-1776 Range on HMM: 1-26/26 Sequence Identity: 13% (4 aa) TLREVILSR-N--KI-KKLTLGDN-LKSW .|.. ||. | .. .. . .. . . NLQHLDLSGCNCCNLTGH--IPPSCF-NL |
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| COR | LRRKb.AA | COR | 1992-2362 | 16 | 2.3e-62 | 200.95 | In-house | 1-434 (434) | Show / Hide |
Range on Protein: 1992-2362 Range on HMM: 1-434/434 Sequence Identity: 16% (77 aa) LNEKIKGQPI-------FGQMIPYSYLRLEQLLQEQ--VRRLKSEGQPPVMLHKQVIKMIREND---------LQLDDNELSQAVRFLHETGVLLHYD-- . . .| ... .|..| |.....| |.| .....| |.| |..... .|. ...|..|| .....||..|...|.. IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEK--PWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIW DPSQQLRNVYFIEPQWLCKVMARVITVREINPLV--SKEGI-MKVKDISLLFND---GD-------VPKQLIPQYLKLLERFEVSLPVSD---------- |. .|.......|||.|..|.......|.... . || ....|.. ..|. .. .|. . .....|.|.||...|... DHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQET DKILLPCKVPIQKPNIT-LPIS------DATQDLLLRYYDM------PYIPLGLWSRMILRLLLFSKHMMNGEEDHAETIPIWHMPVLNTQGSAVSTHRQ . | |. .| ..|.. .. .. . | | |.. ...| |.|.| . ||. |...|.. TTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC---------------------------- FRMRSHEEPETVFWREGIYVCWSEE--AFFLIEPLKKGADTLKITVPKTKQ-----GYRLLGLVSDHLDDLIEEWF--PGLC----ELDPRLGRPLVQRL |. || .|...|| |.. |... ...|.. . . ..||| . ...|.... .|.... ..|. ||| .. .. . FYERSC--CEWMYWRNGMVLKWEGHNKNEALVKCDN-HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW-------VCREW VPCVMC-------EGRPHLHDLSELLEQSETS-DTITCPNHP-------------------------TR-KVPL .|| .| .. . . ..... | . |...||. . .. IPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD |
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| ROC | LRRKb.AA | ROC | 1864-1941 | 32 | 2.3e-30 | 99.13 | In-house | 1-93 (215) | Show / Hide |
Range on Protein: 1864-1941 Range on HMM: 1-93/215 Sequence Identity: 32% (30 aa) YNRMKLMVVGYGGRGKSTLLSRMQGQKFDKK-------GDNIATVGVV-VKEWVIQIR-------KKDFCLSTWDFAGQEDFYSTHPCFLTDH .|.|||| .|.|| ||..|.... ..||. . |.. .|.|. ...||.... .... .. |||.||| ...|| ||| | CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNH |
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| Miro | LRRKb.AA | Miro | 1868-1943 | 17 | 2e-08 | 32.29 | Pfam | 1-96 (140) | Show / Hide |
Range on Protein: 1868-1943 Range on HMM: 1-96/140 Sequence Identity: 17% (17 aa) KLMVVGYGGRGKSTLLSRMQGQKFD----------KKGDNIATVGVVVKEWVIQIRKKD--------FCLSTWDFAGQEDFYSTHPCF--LTDHAA |..|.| | |||...... | .|. . .. . ...|.. .... .. . .. ||..|.|.....|. | ... | KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADA |
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| RAB | LRRKb.AA | RAB | 1867-1993 | 20 | 0.000218 | -87.88 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 1867-1993 Range on HMM: 1-172/172 Sequence Identity: 20% (36 aa) MKLMVVGYGGRGKSTLLSRMQGQKFDKKGDNIATVGVVVKEWVIQIRKKDFCLSTWDFAGQEDFYSTHPCF----------------------------L .|....| | ||| ||.| ||. . ..|.|| | .|... | | || |||| | | . . . FKIILIGDSGVGKSCLLHRFTDDKFSE--QYKHTIGVDFKTKTIEVDGKRVKLQIWDTAGQERFRSITSSYYRGAHGCILVYDITNRESFENVKNWLKEI TDHAAD------FI-----SDMEM-RVLEVCRSPGF----PTIKGYINL---SAVTDSGGINELRGMIENVILN .|| . .. .|.| |. . | | . || | . . . ... .. . RMHANPPPENVVIMLVGNKCDLEHQRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR |
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| ROC | LRRKb.AA | ROC | 1962-1986 | 25 | 0.173171 | 1.5 | In-house | 181-215 (215) | Show / Hide |
Range on Protein: 1962-1986 Range on HMM: 181-215/215 Sequence Identity: 25% (9 aa) FPTI----------KGYINLSAVTDSGGINELRGM || | .| .. .. |.. ||..||.. FPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH |
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| Kinase | LRRKb.AA | LRRK | 2389-2646 | 27 | 9.80000000001e-132 | 443.94 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 2389-2646 Range on HMM: 1-351/351 Sequence Identity: 27% (98 aa) QRAENLLGDGSFG-SVYKGTYRD----------------------------KPVAVKVFSKG---------------------------------GESHP .. |...|.|.|| .||....|. ..||.|.. .. . .. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA HRLLRQEVTVLRHLQHPSLVSMEGVGLNPRILVMELAPLGSLNTLLA---SGR-----IK-NRNLQHRIAMQVAEGLAFLHKNR--IVYRDLKPDNVLIF .|..|.||....||.||..||. |....|...|||.||.|.|...| . . .. ...|...||.|.|.|...||... |..||||..|.|.. FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW SL-------ALGTLQNAKISDYGISR--FATPYG-LKSSEGTPGYRAPEVIR--GTSNYNTEVDIYSFGILLYELVSEGHRPFEEMEFR-----TEIDEA |. .... ..|||.|.|||| .....| .| ..|.||..|||..| |...|...||.||||..|.||.. .|.||.|..|. .|..| SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED VIKGQHLPPIS---QGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKLSS |.... |.|. .....||...|.||.|| .| |..||.... ...||. KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | LRRKb.AA | TKL | 2395-2644 | 23 | 2.2e-78 | 266.74 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 2395-2644 Range on HMM: 1-364/364 Sequence Identity: 23% (87 aa) LGDGSFGSVYKGTYRD----------KPVAVKVFSKGG--------------------------ESHPHRLLRQEVTVLRHLQHPSLVSMEG-------- .| |.|| ||||..| |.||||.|.. |. ...|. ... |.|| .|.. | IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG -VGLNP------RILVMELAPLGS-LNTLLASGRIKNRNLQHRIAMQVAEGLAFLHKNR--------IVYRDLKPDNVLIFSL---------ALGTLQNA | ..| .|||..| || |..|. .. .|.|...| |...|| .. |..||||..|.|... . .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KISDYGISRFATPYG--------------------LKSSEG-TPGYRAPEVIRGT---------------SNYNTEVDIYSFGILLYELVSEGHRPFEEM ||.|.|.||| .. | ..... ||.. ||||.||. . |.. .|.|||||.|.|... . |.... KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDY EFRT--------EIDEAVIKGQHLPPIS---------QGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL ... |. . |.. .. ||| . .|.. .|. .| .| ||.||..|| ..| PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | LRRKb.AA | S_TKc | 2389-2650 | 24 | 5.7e-57 | 196.49 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2389-2650 Range on HMM: 1-231/231 Sequence Identity: 24% (67 aa) QRAENLLGDGSFGSVYKGTYRD--KPVAVKVFSKGGESHPHRLLRQEVTVLRHLQHPSLVSMEGVGL-NPRILVMELAPL--GSLNTLLASGRI------ . ...| |.||.|||.. .. . ||.|. . . .|.|. .|.. .|| .| . .| . .|||... |.| ... . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP KNRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFATPYGLKSSEGTPGYRAPEVIRGTSNYNT-EVDIYSFGILLY . ... |....|...|...|..|||||.|.|. . . ||.| |..|. .. ||| |.||||. |.. ..|..|.|..|| FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY ELVSEGHRPFEEMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFE---KLSSAEML |... | ||. . . .. . |.. ..|..| . || |||| ||.. . . . . EMLC-GYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | LRRKb.AA | Pkinase | 2395-2644 | 25 | 5.3e-46 | 163.74 | Pfam | 7-293 (293) | Show / Hide |
Range on Protein: 2395-2644 Range on HMM: 7-293/293 Sequence Identity: 25% (76 aa) LGDGSFGSVYKGTYRDKP--VAVKVFSKGGESH--PHRLLR-QEVTVLRHLQHPSLVSMEGVGL-NPRIL-VMELAPLG----SLNTLLA---SGRI--K .| ||||.|||.. .. . ||||...| .|.. . ...| .|. ....|.|| | . .. ...| |||... | .| ... .|.. IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS NRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIF-SLALGTLQNAKISDYGISRF--ATPYGLKSSEGTPGYRAPEVIRGTSNYNTEVDIYSFGILL . ... .. |...||...|...|..|||||.|.|| ... ||.| |.... ...... |||.|.||||||| . | ..||..|.|..| EWECKF-YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL YELVSEGHRPFEEM-EFRTEIDEAVIKGQHLPPISQGGVAPW---------------------PDLQELIDHCTEHVPESRPTAQEAFEK--L ||... |. || . . .|. .. . ..|. | ......|. | . |..||||..... . YEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | LRRKb.AA | TK | 2389-2644 | 16 | 2.7e-45 | 149.36 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 2389-2644
Range on HMM: 1-486/486
Sequence Identity: 16% (82 aa)
QRAENLLGDGSFG---SVYKGTYRDK---------------------------PVAVKVFSKG-GESHPHRLL---------------RQEVTVLRH--L
. .. || | || ||||..|.. |||||. .| ..| ... .| ...| .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
QHPSLVSMEG----VGL----------NPRILVMELAPLGS----LNTLLASGRIKNRN-----------------------------------------
.|| .|.. | .. | ..|||..|.|. | . | . | | ..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-----------------------------------LQHRIAMQVAEGLAFLHKN------RIVYRDLKPDNVLIFSLALGTLQN------AKISDYGISR
.. ...|.|.|...||.. ..| ||| |.|... . . .||.|.| ||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
FAT-----------PYGLKSSEGTPG-------------------------YRAPEVIRG--------TSNYNTEVDIYSFGILLYELVSEG-HRPFEEM
. | |||.||.. . |||.... . . |. |..|||.|..|... | . ..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
EF--------RTEIDEAVIKG--------------QHLPPISQGG----------VAPWPDLQELIDHCTEHVPESRPTAQEAFEKL
.|. | . .| .|. . .| .....|. | .. || ||| .. |.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | LRRKb.AA | TKL-Unique | 2393-2644 | 28 | 6.8e-45 | 155.47 | In-house | 3-290 (290) | Show / Hide |
Range on Protein: 2393-2644 Range on HMM: 3-290/290 Sequence Identity: 28% (83 aa) NLLGDGSFGSVYKGTYRDKPVAVKVFSKGGESHPHRLLRQ----EVTVLRHLQ-HPSLVSMEGVGL----NPR--ILVMELAPLGSLNTLLAS------- |..| |..|.||||..| .|||.|.|.. .. .. ..| ||... |. || .| |. | ..||| |.|||. .|. NKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN -GRIKNRNLQHRIAM--QVAEGLAFLHKNR--IVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFAT-----PYGLK------SSEGTPGYRAPEVIRG . .. |.| |. | ..| |. .|| . | ||||. |.|. . |.||.| |.|.|.. ... . . .|.. ..||||.|. NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM T-SNYNTEVDIYSFGILLYELVSEGHR------PFEEMEFR--TEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL . |.. .|.||||| |.|... ... |...|.. |. . .... |||.. .....||. | | |. ||. .| ..| NFCQYSEKSDVYSFGIVLWEIAT-RKITKTYKKPYQGMDQEQWCEMVHYMEENYR-PPIPNHCP---KEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | LRRKb.AA | MLK | 2389-2644 | 27 | 2.6e-43 | 148.14 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 2389-2644 Range on HMM: 1-291/291 Sequence Identity: 27% (84 aa) QRAENLLGDGSFGSVYKGTYRDKP-----VAVKVFS-----KGGESHPHRLLRQEVTVLRHLQHPS----LVSMEGVGLNP---RILVMELAPLGSLNTL . . .| ||||.|.||..| | |||| . |. .. . ...|. ||.|.|| . || |.| .||| .. |||... IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LASGRIKNR---NLQH-----------RIAMQVAEGLAFLHKNR---IVYRDLKPDNVLIFS----LALGTLQNAKISDYGISRFATPYGLK---SSEGT |...|.| . | ..|.|.|.|...||.. |. ||||. |.|| .. ||| ||.| |.||. . . . | || LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL---KICDFGTSRDWHQMC-TNMMSNAGT PGYRAPEVI---RGTSNYNTEVDIYSFGILLYELVSEGHRPFE-EMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEK . ..||||| |. . |. .|..|.|..|.|... . |.. ... . . ... .|...| .|. .| . . .|. | . |..||. .. .. YAWMAPEVIQQFRC-EKYSEKCDVWSWGVVLWEMLT-REVPYKQHYDPMAIAWWVAYNGLRPPIPST---CP-EHWKKLMKQCWNQDPHKRPSFRQIVQH L | L |
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| Kinase | LRRKb.AA | STE | 2389-2639 | 18 | 1.3e-38 | 133.93 | In-house | 1-350 (359) | Show / Hide |
Range on Protein: 2389-2639
Range on HMM: 1-350/359
Sequence Identity: 18% (66 aa)
QRAENLLGDGSFGSVYKGTYRDKP-----------------VAVKVFSKGGES----------------HPHRLLRQEVTVLRHLQ--HPSLVSMEGVGL
.. .| |.||.|||. ..... .|.|. .. .. . . .|. ...... || | | .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
---------NPRILVMELAPLGSLNTLLASGRIKNR-------------NLQH-RIAMQVAEG-LAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISD
. ..||. . ||| .. . .... | .|. |. .| |..||...|. ||.||.|.|. .|..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD
YGISRFATP------------------YGLKSSEGTPGYRAPEVIRG-----TSNYNTEVDIYSFGILLYELVSEGHRPFEEMEFRTEIDEAVIKG----
|.. |. .. ||| . |||||.. . |.| .||.|.|... |.. .|. |. .| . .. ...
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA-TGKPPWHDMHPMRAMFMIPFNYHMQQ
---------QHLPPISQ----------GGVAPW---------PDLQELIDHCTEHVPESRPTAQE
.. ||. . | . |.... |..| . |. ||||..
QFEQLCIVNGPPPPLPDHLSQNEMISYG-G--SGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
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| Kinase | LRRKb.AA | CAMK | 2394-2640 | 18 | 3e-37 | 117.07 | In-house | 1-419 (425) | Show / Hide |
Range on Protein: 2394-2640
Range on HMM: 1-419/425
Sequence Identity: 18% (76 aa)
LLGDGSFGSVYKGTYRDKP--------------VAVKVFSKGG---------------------------ESHPHRLLRQEVTVLRHLQ-------HPSL
|| |||| |.... . . ||.|. .| . . . .|.|. ....|| || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VSMEGVGLNPR---------------------ILVM---ELAPLG----S-LNTLLASGR---------IKNRN------LQHRIAMQVAEGLAFLHKNR
... | .|. ..|| |... | .. . . |. | .. .|. |........|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN
IVYRDLKPDNVLIFSLALGTL------------QNAKISDYGISRFATPYG-------------------------LKSSEGTPGYRA-PEVIRG-----
|| |||||.|.|. . .. | ||.| | ... .| .| . |||.| | |||..|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------TSNYNTEVDIYSFGILLYELVSEGHRPFEEM---EFR---------TEIDEAVIKGQHL-PPISQGGVAP------WP------------DL
|. ..|. | |..|| ... |. ||.. | . |. | ..||. || .. . | .
MQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC
QELIDHCTEHVPESRPTAQEA
. || .. . || |.|....
KDLIRKMLQVDPEKRMTIEQC
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| Kinase | LRRKb.AA | TyrKc | 2389-2644 | 25 | 2.7e-36 | 127.79 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2389-2644 Range on HMM: 1-280/280 Sequence Identity: 25% (76 aa) QRAENLLGDGSFGSVYKGTYRDKPVAVKVFSKGGESHPHRLLRQEVTVLRHL--QHPSLVSMEGVGL---------NPRILVMELAPLGSLNTLLASGR- . . || | || |||||.. .||||. .. .. ...| ....| .|| .| . || . | .|||..|.|.|. | . | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -IKNRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFATPY-------GLKSSEGTPGYR--------APEVIRGTS .... | . .. |.|.| ..||..... ||| |.|. . .|||| | ||. . . ... .. | . |||.| KLCMKDL-LSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY N-YNTEVDIYSFGILLYELVSEGHRPFEE-----MEFRTEIDEAVIKGQHLPPISQ-----GGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL . ..|. |..|||....|. . | | .. |. . |. | | .| .|. | ... ... | .. ||.||| .| |.. GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | LRRKb.AA | Dicty4 | 2390-2579 | 31 | 3e-36 | 118.51 | In-house | 2-211 (277) | Show / Hide |
Range on Protein: 2390-2579 Range on HMM: 2-211/277 Sequence Identity: 31% (69 aa) RAENLLGDGSFGSVYKGTYRDKPVAVKVF--SKGG-ESHPHRLLRQEVTVLRHLQHPSLVSMEGVGL----NP--RILVMELAPLGSLNTLLAS------ |...|.||||.||||| | | ||||.. . . .. .|.||. . ..|| .. | . .| |.|. | |.| .|| . NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ GRIKNR-NLQHR---IAMQVAEGLAFLHK-N-RIVYRDLKPDNVLIFSLALGTLQNAKISDYGISR----FATPYG-LKSSEGTPGYRAPEVIRGTSNYN .|| | | .| .| |.. || | .|. ||||..| |. ..|..| |.|. . ... |||.. |||| .. . || QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV-----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YN TEVDIYSFGILLYELV .| |||||.|.|.. EKADVYSFGIVLWEIL |
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| Pkinase_Tyr | LRRKb.AA | Pkinase_Tyr | 2385-2589 | 27 | 2e-35 | 120.57 | Pfam | 1-219 (270) | Show / Hide |
Range on Protein: 2385-2589 Range on HMM: 1-219/270 Sequence Identity: 27% (64 aa) LNFTQRAENLLGDGSFGSVYKGTYR------DKPVAVKVFSKGGESHP---HRLLRQEVTVLRHL-QHPSLVSMEGVGL---NP--RILVMELAPLGSLN . | . || |.||.|||||.. . |||||. | | .|. .. . .|. ....| .|| .|.. || . | ..|||..|.|.| ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL TLLAS----GRIKNRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFATP---YGLKSSEGTPG---YRAPEVIRGT . | . .. . ...|.|.|...|. .... ||| |.|. . .. .||.| | .| .. | .....|.. |||.|. DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYG SNYNTEVDIYSFGILLYELVSEGHRP-FEEM ..|. |..|||.|..|... | | ...| K-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM |
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| Kinase | LRRKb.AA | Dicty4-Unclassified | 2390-2644 | 28 | 3.3e-35 | 117.99 | In-house | 2-263 (263) | Show / Hide |
Range on Protein: 2390-2644 Range on HMM: 2-263/263 Sequence Identity: 28% (77 aa) RAENLLGDGSFGSVYKGTYRDKPVAVKVFSKGGESHP---HRLLRQEVTVLRHLQHPSLVSMEGVGLNP------RILVMELAPLGSLNTLLA---SGRI . .| | | |.|| . | |||| | . . . || .| .||| || . | .|| . |||. . | | . | . QIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ KNRNLQH----RIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISR-FATPYGLKSSEGTPGYRAPEVIRGTSNYNTEVDIYSFG . | ..|. .| |...|| .. ||.| |.|. |.|| | |||| . . ||| .||. .. | || |.||.. QPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILM-----DKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSYA ILLYELVSEGHRPFEEMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL ..||||. | |. | .. | | |. . . .. || | | ||| . ..| MMLYELAT-GDEPYQEIQSIMNAARSVCDKKLRPKIPD-NCDNF--WKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | LRRKb.AA | TK-Unique | 2389-2644 | 23 | 1.5e-33 | 113.1 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 2389-2644
Range on HMM: 1-294/294
Sequence Identity: 23% (72 aa)
QRAENLLGDGSFGSVYKGTYR--------DKPVAVKVFSKGGESHPHRLLRQEVTVLRHLQ-HPSLVSMEGVGL---NPRILVMELAPLGSLNTLLASGR
. ....|.|.|| |..|... .| |||| .. . .. . .| ....| || .|...|. .| ..|| .| |.| ..| . |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR
---------------------IKNRN-LQ----HRIAMQVAEGLAFLHK--NRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISR---FATPYGLKSSE
..... .. ..| |.| |...|.. .||.||| |||. . ..||.|.|..| ..| . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQ
GTPGYR--APEVIR--GTSNYNTEVDIYSFGILLYELVSEGHRPFEEMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAF
|. .| |||... . ..|. |..|||.|..|... | .|. .| . | |.. .| .| | . ... .|. |. ..||.||. .
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMP---QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIK
EKL
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HRL
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| Kinase | LRRKb.AA | Dicty4 | 2617-2646 | 31 | 0.024669 | 3.79 | In-house | 246-277 (277) | Show / Hide |
Range on Protein: 2617-2646 Range on HMM: 246-277/277 Sequence Identity: 31% (10 aa) PDLQELIDHCTEHVPESRPTAQEAFEK--LSS | . .|| | .| |..||. .| .. | . PSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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