Gene LRRKc (Sea Urchin)

LRRKc

Species: Sea Urchin
Alias: SPU_021858, Spk307, LRRKc
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRKc.AA Protein None 2185 None Fasta, JSON
LRRKc.kin_dom Protein Kinase Domain None 325 None Fasta, JSON

Protein domain

Protein domains of LRRKc.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRRKc.AA LRR_1 270-292 25 0.420495 8.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 270-292
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

VLSTINLSQ-N--SLF-SVPEGLLWGL
 | ...||  |  .|  ..|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 294-314 29 0.199267 9.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 294-314
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLRRLNLSQ-N--SLQ-LLPS--PKSH
||..|.||  |  .|.  .|.    . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 321-342 25 1.259999 6.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 321-342
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RLRSLSLYQ-N--ELL-SVPAE-LFML
.|..|.|   |   |  ..| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 378-399 29 0.026617 12.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 378-399
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLVNLDLSQ-N--KLS-SLPRQ-MDAC
.|  ||||  |  .|. ..|     ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 447-468 37 0.000616 18.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 447-468
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

TLRFLNLSY-N--RLT-EIPTA-ICQL
.|. |.||. |  .|| .||   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 401-421 22 0.645497 7.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 401-421
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SLITINLSE-N--SFN-EIPR--PWAC
.| ...||  |  ..  .||     ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 422-446 19 7.761146 3.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 422-446
Range on HMM: 1-26/26
Sequence Identity: 19% (6 aa)

PLEILNISK-N--MVQ-SASGDLPK--FWHR
 |..|..|  |   .. .    .|.  | . 
NLQHLDLSGCNCCNLTGH----IPPSCF-NL
LRR_1 LRRKc.AA LRR_1 470-485 40 1.472491 6.15 Pfam 1-20 (26) Show / Hide 
Range on Protein: 470-485
Range on HMM: 1-20/26
Sequence Identity: 40% (8 aa)

SLSELDLSH-N--VL-RCFP
.| .||||. |   | ...|
NLQHLDLSGCNCCNLTGHIP
LRR_1 LRRKc.AA LRR_1 494-505 46 1.444084 6.18 Pfam 1-15 (26) Show / Hide 
Range on Protein: 494-505
Range on HMM: 1-15/26
Sequence Identity: 46% (7 aa)

KLQHLNLAY-N--QL
.||||.| . |  .|
NLQHLDLSGCNCCNL
LRR_1 LRRKc.AA LRR_1 595-616 37 0.067368 10.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 595-616
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLYVLKLSH-N--ALE-DVPPS-VCKL
.| .| ||. |   |. ..|||   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRRKc.AA LRR_1 618-640 29 0.383953 8.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 618-640
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ALYDLDISC-N-PDLH-KLPEA-LSTL
 |  ||.|. | . |  ..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC LRRKc.AA ROC 687-830 26 1.3e-12 39.15 In-house 1-157 (215) Show / Hide 
Range on Protein: 687-830
Range on HMM: 1-157/215
Sequence Identity: 26% (45 aa)

YHSMKLMIMGPAKSGKTTLLGSLMNDTSG----RVLDMALHVTEWELQDPVIEGRGCS-LTQKV-KEKFSKEKEIVEGPAITFFSWDMKGGDLYENVHQC
...||||..| ...|||.|. .|| | .      ..          . .      |   . |.| ..|. ..  .     |.|  ||  | . |   || 
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC----------DKGNHPTTHGIEPIQQWVLDCKDMMF--RKKEDEIKFNVWDFGGQEIYHATHQF

FVTA-KTLYLLVWDMSE----GMDG----AHK--LSSLLLNISSRSSD--------FGIVIVGTHHDVV
| |  . .|||||| ..    | .       .  |   | .|.||...          ..||||| |.|
FLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKV
COR LRRKc.AA COR 876-1278 15 4.9e-31 97.66 In-house 1-434 (434) Show / Hide 
Range on Protein: 876-1278
Range on HMM: 1-434/434
Sequence Identity: 15% (79 aa)

LKRVIYETAM-QMKVHHKRPVCVEKLIGRKVPQPYFNLKKRISQEVEVRQKADPPILPIMTETELAQIVQLIPDSG-------LHTPEELQEAINFLHEI
. .....  . || .          .... ||| .. .|. . .. . .. .  .  | |. .|..||.|   ..        .. ..||. .. .||. 
IRKTAKKIKHKQMFED---------YMCQPVPQSWWKCKQKLEEMRKWMNRH--NEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDL

GSIVHFT--DHLNGLNDLYFIDPVWLACTLQRVTALPIGS-----LKGGK-VHVETLRELSKKS----------RIGEDKFEQYLQLLARFEIVVPISHH
|.|.||   ||  .|.|....|| |..  . ..             ..|. .... | .. ...          |      |....|. .||. .||.  
GHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPD

W----------FLVPARLPRDNPGVM-LSLHNT---DDAPFYYLRRVYKM------PYLPPGFWIRLVSRLLADLQMHDKKKKISPARNERKICRSKSAK
|          .|.|..|| |.|.   ..  .     ..  .||||.|..      ..||.||| |.  ||.  ..... |                   
WTHFWHQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLH-HFIHDMFKC------------------

SSISKGIRFLQTESI----YWREGIFFRHKTG---QILVRSTVFPSTDKSPGVDILISCQEG-----HFSAMGCVVDQIEGLIKDWY--PGLC--ASIYD
         .  .|     ||| |... .. .   ..|| . .     .  . .| .. ..      .   .. . . |... ..|.  |||   . .  
---------FYERSCCEWMYWRNGMVLKWEGHNKNEALVKCDN-----HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW-

SLQPKVQRLVPCPICVIHGPDDLEPVTENLP-HCY--T--VEELAQKLARGETHITACANSKE------------------------KLI-PISV
    ..  ..||| |          ......  |.  .   ...... ..|.   .  .. ..                        . | .|| 
----VCREWIPCPHC----------IQDHWDTCCDICYYQYDWCIRAEEMGM--DSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD
Kinase LRRKc.AA LRRK 1302-1623 34 4.7e-166 557.96 In-house 1-351 (351) Show / Hide 
Range on Protein: 1302-1623
Range on HMM: 1-351/351
Sequence Identity: 34% (126 aa)

MVSGQSLGQGGFG-EVFRAKFRGETVAAKTMFPSRLLKNQMYSSPSEGYASCASTPSSTSNMTGESTSTENDSCD-------------------SLEAAM
.......|.|||| .|.|||.||..|....|....|... ||......|..|.... .. |.... |.. || |.                   ......
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPY-MYQGARNSYDMCQWVAIKKWNRDPM-TID-ND-CNNSNNNNNLNNNNSEQVEDMDQNHED

LMDSFHKLRNEVAIMVKLDHPCIVNLVGVSIRHLCFAMDYAPLGDLQSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGFLHSKD--IIY
.. .|...|.||.|| .|.||.||.|.|..|..||..|.|||.|||...|....|... ||.|      ...|.||..||.||.|.....|||..  ||.
CCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGF-HFMK------AHISWMLKLKIALQIAKGMEYLHSHNPPIIH

CDLKTDNILLFSSD-------VNEDVNIKLTDYGISR--KYDLMG-AMGMAGPPGFCAPEILQG---KVFDEKVDWFSYGMFLYHLMTGLVPYYDQHS--
.|||..||||.||.       .|..|..|. |.||||  ....|| |.|. |.||..||||...   ....||||..|.||.|..|.|......|.|.  
RDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFF

-----RIEIQLAVNEGRKPTFNFHEYKMPPRQVFPALGALMESCWQDKPGKRPHGKTILQLLSE
     ...|.....||..||...| | .||.|... . .|...||| .| ||||  .|.. ||.
DHMQWMEQIEDKIIEGLRPTIPQH-Y-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRKc.AA TKL 1308-1621 21 1e-75 257.89 In-house 1-364 (364) Show / Hide 
Range on Protein: 1308-1621
Range on HMM: 1-364/364
Sequence Identity: 21% (88 aa)

LGQGGFGEVFRAKFRG----------ETVAAKTMFPSRLLKNQM----------YSSPSEGYASCASTPSSTSNMTGESTSTENDSCDSLEAAMLMDSFH
.|.||||||...|.||          ..|| |..      .. .          |                            .|   .|.. ...  . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNY----------------------------SD-M-QLNDPEASWFRF

KLRNEVAIMVKLDHPCIVNLVGVSIRH---------------LCFAMDYAPLGDLQSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGFL
....|. .| .|.|| || ..|....                ||. |.|.| |.| .||                         .. ...|..|... .|
FEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------------WHQRCRWALDIARGMNYL

HSKD--------IIYCDLKTDNILLFSS---------DVNEDVNIKLTDYGISRKYDLMG---------------------AMGMAGPPGFCAPEILQGK
||..        ||..|||..|||...          ..|.|...|..|.|.||  . .|                      |   | |...|||.|.|.
HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ

----------------VFDEKVDWFSYGMFLYHLMTGLVPYYDQHSR---------IEIQLAVNEGRKPTFNFHEYK----MPPRQVFPALGALMESCWQ
                 ..||.| .|.|. |. ..|. .||||....         ... .....|..|.   .       .|. .. | .  ||. ||.
MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWD

DKPGKRPHGKTILQLL
 .| |||  ..||. |
HDPEKRPSFQEILKRL
Kinase LRRKc.AA Pkinase 1302-1621 18 1e-45 162.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1302-1621
Range on HMM: 1-293/293
Sequence Identity: 18% (68 aa)

MVSGQSLGQGGFGEVFRAKFRGET--VAAKTMFPSRLLKNQ------MYSSPSEGYASCASTPSSTSNMTGESTSTENDSCDSLEAAMLMDSFHKLRNEV
 . |. .|.|.||.|.... .|.   || |..  ..  ...                                                        .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------------------------------------------------SEI

AIMVKLDHPCIVNLVGVSI--RHLCFAMDYAPLG----DLQSYLFAEHQSARPHFVKRNIVLEPVL--SRMLTYKISLQVASAVGFLHSKDIIYCDLKTD
.|| .|.||.|| | ..    .|... |.|.. |    || .|. .                . ..  |     .. .|..... ..||. ||..||| .
QIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE

NILLFSSDVNEDVNIKLTDYGISRK--YDLMGAMGMAGPPGFCAPEILQ-GKVFDEKVDWFSYGMFLYHLMTGLVPYYDQ---HSRIEIQLAVNEGRKPT
|||. . .....  .|..| |....  |   .... .| |...|||... |.  . |||..|.|  || ...|  |....   .. .. .  ... ..| 
NILIDNNGHIDA-CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP

FNFHEYKMPPRQVF---------------PALGALMESCWQDKPGKRPHGKTILQL--L
. |....  ..  |               ...  ....|.. .| |||  . |||   .
LHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LRRKc.AA S_TKc 1302-1626 21 7.5e-41 142.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 1302-1626
Range on HMM: 1-231/231
Sequence Identity: 21% (72 aa)

MVSGQSLGQGGFGEVFRAKFRG--ETVAAKTMFPSRLLKNQMYSSPSEGYASCASTPSSTSNMTGESTSTENDSCDSLEAAMLMDSFHKLRNEVAIMVKL
   .. .|.|.||.|.... ..  . || | .                                                        ..|.|..|. | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------------------------EHIRREIQILKK-

DHPCIVNLVGVSI-RHLCFAMDYAPL--GDLQSYLFAEHQSARPHFVKRNIVLEP-VLSRMLTYKISLQVASAVGFLHSKDIIYCDLKTDNILLFSSDVN
.|| ||.| .|    ||.. |.|..   ||| .|.           .||.    . ...   . ..  |...|. ..||. ||..||| .|||| .    
HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYI-----------KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----

EDVNIKLTDYGISRKYDLMGAMGMAGPPGFCAPEILQGKVFDE-KVDWFSYGMFLYHLMTGLVPYYDQHSRIEIQLAVNEGRKPTFNFHEYKMPPRQVFP
   .||..| |..|..     . . | | ..|||.|    ..  |.|| | |  || ...|  |..  .    ... .                     |
---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------SP

ALGALMESCWQDKPGKRPHGKTILQ----LLSEPSF
 .  ... |.|  | |||    .||      . | |
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRRKc.AA AGC 1302-1585 17 1.2e-36 91.0 In-house 1-353 (395) Show / Hide 
Range on Protein: 1302-1585
Range on HMM: 1-353/395
Sequence Identity: 17% (72 aa)

MVSGQSLGQGGFGEVFRAKFR--------GETVAAKTMFPSR---LLKN-QMYSSPSE------GYASCASTPSSTSNMTGESTSTENDSCDSLEAAMLM
      .|.|.||.|. .. .        |.  | | .  ..   ..|  ..    .|      ||                                  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY----------------------------------

DSFHKLRNEVAIMVKLD----------HPCIVN-LVGVSIR--H--LCFAMDYAP--------LGDLQSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYK
     ...|  |..|..          || ||. |        |  |.| |.|.|         |.. ..|   ..        |    | ...   .  
-----VWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR--------R---KEGRFDEERARF

ISLQ-------VASAVGFLHS-KDIIYCD-LKTDNILLFSSDVNEDVNIKLTDYGISRKYDLMG------------------------------------
.  .       ...|. .||| ..||. | || .|||| .       .||||| | . .    |                                    
YAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQR

----------------AMGMAG--PPGFCAPEILQGKVFDEKVDWFS--YGMFLYHLMTGLVPYYDQH---------SRIEIQLAVNEGR-----KPTFN
                .  . |   | . |||||     .  .|| |  .| ..| ..||. |.|..          .. |.   . .||     |..|.
NNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFP

FH--------EY
|.        ..
FPEDPQFPEDRW
Kinase LRRKc.AA TK 1302-1621 15 8.6e-32 103.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 1302-1621
Range on HMM: 1-486/486
Sequence Identity: 15% (80 aa)

MVSGQSLGQGGFG---EVFRAKFRG---------------------------ETVAAKTMFPSRLLKNQMYSS-------PSEGYASCASTPSSTSNMTG
 . |. ||.| ||   ||.... ||                           ..|| |.. .      ..             |                
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG--G----------------

ESTSTENDSCDSLEAAMLMDSFHKLRNEVAIMV--KLDHPCIVNLVGVSIRH--------------LCFAMDYAPLGD----LQSYLFAEHQSARPHFVK
                 .   | .. .| ..|   ...|| ||.|.||. ..              ..  | |.|.||    |..|| . .  ....  .
-----------------E--DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDC

RNIVLEPV----------------------------------------LSRMLTYK-------------------ISLQVASAVGFLHSKDI------IY
   . ...                                        |.    .                    ...|.|..  .|||| .      . 
PDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVH

CDLKTDNILLFSSDV------NEDVNIKLTDYGISR--------------KYDLMGAMGMAGPPGF-----------------------CAPEILQGKV-
 || . |.|.....|      .    .|..|.| ||               |  ..  |...|.                         .||| |...| 
RDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVF

--------FDEKVDWFSYGMFLYHLMT-GLVPYYDQHSR---------IEIQLAVNEGRKPTFN--FHE-----YKMPPRQVFP--------------AL
        | .| | .|.| ... ..| | .||| ..|           |.   . .|... .   . .     . ||. .  |              ..
SEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGL-NEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEE

GAL-MESCWQDKPGKRPHGKTILQLL
 .. | .||. .| .||  ..... |
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRRKc.AA Ciliate-E2 1302-1626 17 2.7e-30 101.18 In-house 1-365 (365) Show / Hide 
Range on Protein: 1302-1626
Range on HMM: 1-365/365
Sequence Identity: 17% (77 aa)

MVSGQSLGQGGFGEVFRA-------------------------KFRGETVAAKTM----FPSRLLKNQMY-----SSPSEGYASCASTPSSTSNMTGEST
    . .|||.|| |...                         |. .  .| |.|      . . .....                              
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCF------------------------

STENDSCDSLEAAMLMDSFHKLRNEVAIMVKLDHPCIVNLVGVSI----RHLCFAMDYAPLGDLQSYL------FAEHQSARPHFVKRNIVLEPVLSRML
                  . |. ||  |. .|.|| |.... . .     .. . |.|.  |||..|.      . ....            .    .. 
------------------YKKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------K-D-KYFT

TYKIS---LQVAS---------------AVGFLHSKD-IIYCDLKTDNILLFSSDVNEDVNIKLTDYGISRKYDLM-------GAMG-------------
 ..|.    |...               |. .||||  ||. |.| .|||.          ||..| |.|.|||           ..             
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPG

-------------MAGPPGFCAPEILQ---------GKVFDEKVDWFSYGMFLYHLMTGLVPYYDQHSRIEIQLAVNEGRKPTFNFHEYKMPPRQ-----
              .| ||. |||||.         .|  |.|.|..| |. || ...|  |.          .  ..  |  |.. |.  .  |     
YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKD-TQCIQCK

------VFPALGALMES----CWQDKPGKRPHGKTILQLLSEPSF
      . .    |.      . | .| ||.    . |.|  | |
WKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase LRRKc.AA Dicty5 1461-1625 30 1.3e-27 92.15 In-house 109-260 (260) Show / Hide 
Range on Protein: 1461-1625
Range on HMM: 109-260/260
Sequence Identity: 30% (50 aa)

ISLQVASAVGFLHSKDIIYCDLKTDNILLFSSDVNEDVNIKLTDYGISRKYDLMGAMGM-AGPPGFCAPEILQGKVFDEKVDWFSYGMFLYHLMTGLVPY
. . .| .  .|||. ||  |||  |.|     ..|.  ||. |.|.||  |.   | |  | . . |.|. .|. ...|.| .|.|  |. ..|   | 
MAIDIAQSMRHLHSMNIIHRDLKSMNFL-----ITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP-

YDQHSRIEIQLAVNEGRKPTFNFHEYKMPPRQVFPALGALMESCWQDKPGKRPHGKTILQLLSEPS
||   ...| . |  |  ||         |  .      | ..|||.|| .||  | |.. .   .
YDNINNWNIPVMVMKGERPTI--------PKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase LRRKc.AA MLK 1391-1621 27 3e-27 91.67 In-house 57-291 (291) Show / Hide 
Range on Protein: 1391-1621
Range on HMM: 57-291/291
Sequence Identity: 27% (68 aa)

NEVAIMVKLD-HPCIVNLVGVSIRH---LCFAMDYAPLGDLQSYLFAE--HQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGFLHSKD---IIYCD
....|. ..  ||||. ..||....   .|  | |.. | | ..| ..  . ... |  | | .   | .  .  ...||.|... .|||..   ||  |
RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK-NDR---VYDHDHAMNWALQCARGMHYLHSMAPKPIIHRD

LKTDNILLF---SSDVNEDVNIKLTDYGISRKYDLM-G-AMGMAGPPGFCAPEIL---QGKVFDEKVDWFSYGMFLYHLMTGLVPYY-DQHSRIEIQLAV
||  |||.    . | ....  | .| |.||.   |    |..|| . . |||..   ..  ..||.| .|.|. |. ..|. |||  .. .   .  ..
LKSHNILIDEICH-DMHHGT-LKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVA

NEGRKPTFNFHEYKMPPRQVFPALGALMESCWQDKPGKRPHGKTILQLL
..|  |.         | .  . .  ||. ||...|.|||  . |.| |
YNGLRPPI--------PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase LRRKc.AA Ciliate-E2-Unclassified 1303-1626 17 7.9e-27 90.11 In-house 2-352 (352) Show / Hide 
Range on Protein: 1303-1626
Range on HMM: 2-352/352
Sequence Identity: 17% (75 aa)

VSGQSLGQGGFGEVFRAKFRGET--VAAKTMFPSRLLKNQMY----------------------SSPSEGYASCASTPSSTSNMTGESTSTENDSCDSLE
  .. .||||||.|.... . .    | |.|  ..  | . .                      .                                   
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRK-----------------------------------

AAMLMDSFHKLRNEVAIMVKLDHPCIVNLVGVSI--RHLCFAMDYAPLGDLQSYL----------------------FAEHQSA---RPHFVKRNIVLEP
         |. ..  |.. ..||.||... .     .... |.|.. |||. |.                      | | |..                
-------YNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA------------

VLSRMLTYKISLQVASAVGFLHSKD-IIYCDLKTDNILLFSSDVNEDVNIKLTDYGISRKYDL-----------------MGAMGMAGPPGFC----APE
        ..  |. ..  .||.|  ||. |.| .|||. ..      .||..|.|||.||.                  . .  ..| |..     |||
-------KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE

ILQGKVFD----EKVDWFSYGMFLYHLMTGLVPYYDQHSRI---------------EIQLAVNEGRKPTFNFHE----YKMPPRQ---VFPALGALMESC
.|||.  |    .|.|..| |. || ...|  |.||. . .               ...   ...    ..| .    .. .| .   .      |. ..
VLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN----DLLQKM

WQDKPGKRPHGKTILQLLSEPSF
 . .|.||.   |. |.|  | |
LKKNPNKRI---TFEQILNHPWF
Kinase LRRKc.AA Dicty4 1472-1559 31 6.8e-21 66.58 In-house 128-217 (277) Show / Hide 
Range on Protein: 1472-1559
Range on HMM: 128-217/277
Sequence Identity: 31% (30 aa)

LHSKD--IIYCDLKTDNILLFSSDVNEDVNIKLTDYGISR----KYDLMG-AMGMAGPPGFCAPEILQGKVFDEKVDWFSYGMFLYHLMTGLVPY
||. .  ||  |||..|.|     | .. ..| .| |.|.      |.   .|...| |.  |||..... ..||.| .|.|. |. . |.  ||
LHCCNPVIIHRDLKSHNLL-----VDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPY
Kinase LRRKc.AA TyrKc 1302-1621 21 1e-17 63.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 1302-1621
Range on HMM: 1-280/280
Sequence Identity: 21% (77 aa)

MVSGQSLGQGGFGEVFRAKFRGETVAAKTMFPSRLLKNQMYSSPSEGYASCASTPSSTSNMTGESTSTENDSCDSLEAAMLMDSFHKLRNEVAIMVKL--
 . |. || | ||||.... . ..|| |.. ..                                                      ...|  || ||  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------------------------------------------------REDFMREARIMCKLGG

DHPCIVNLVGVSI---------RHLCFAMDYAPLGDLQSYL-FAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGFLHSKDIIYCDLKTDNILL
.||.||.|.|| .           |.  | |.|.|||..||   ...                |.     ....|.|.   .|||| .|  || . |.|.
HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV

FSSDVNEDVNIKLTDYGISRKY----------DLMGA----MGMA-GPPGFCAPEILQGKVFDEKVDWFSYGMFLYHLMT-GLVPYYDQ----HSRIEIQ
 .        .| .| | ||.           |   .     | .  |   .||| .. ..| .| | .|.|  .. ..| |  ||...     | .|. 
GENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI

LAVNEGRKPTFNFHEYKMPPRQ----VFPALGALMESCWQDKPGKRPHGKTILQLL
  | .|. .    . |   |        ...  .|..||. .| .||  ..| ...
EYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LRRKc.AA TKL-Unique 1459-1559 25 1.6e-15 51.33 In-house 113-234 (290) Show / Hide 
Range on Protein: 1459-1559
Range on HMM: 113-234/290
Sequence Identity: 25% (31 aa)

YKISLQVASAVGFLHSKD--IIYCDLKTDNILLFSSDVNEDVNIKLTDYGISRKYD--LMGAMGMA---------GPPGFCAPEILQG--KVFDEKVDWF
.|. ...|..  .||...  || .|||. |.|. .      .|||. | |.|.  .  . .  ..          | .   |||.| .  . ..||.| .
VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVY

SYGMFLYHLMTGLV------PY
|.|. |. . |. .      ||
SFGIVLWEIATRKITKTYKKPY
Kinase LRRKc.AA Pkinase_Tyr 1383-1561 25 3.8e-15 51.92 Pfam 41-218 (270) Show / Hide 
Range on Protein: 1383-1561
Range on HMM: 41-218/270
Sequence Identity: 25% (49 aa)

MDS---FHKLRNEVAIMVKL-DHPCIVNLVGVSI---RH--LCFAMDYAPLGDLQSYLFAEHQSARPHFVKRNIVLEPVLSRMLTYKISLQVASAVGFLH
|..     .. .|..|| .| .|| ||.|.|| .   ..  ..  | |.|.||| .|| .                .. |.     ....|.|..  .|.
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR------------EDKQPLTMKDLLQMCWQIAKGMEYLE

SKDIIYCDLKTDNILLFSSDVNEDVNIKLTDYGISRKY-----D-LMGAMGMAGPPGFCAPEILQGKVFDEKVDWFSYGMFLYHLMT-GLVP-YYD
|| .|  || . |.|. .     .  .| .| | .|          ..  |.  |   .||| .. ..| .| |  |.|  .. ..| |  | |..
SKNCIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG
Kinase LRRKc.AA TKL-Unique 1388-1431 35 7.4e-08 23.99 In-house 41-91 (290) Show / Hide 
Range on Protein: 1388-1431
Range on HMM: 41-91/290
Sequence Identity: 35% (18 aa)

KLRNEVAIMVKLD-HPCIVNLVGVSI------RHLCFAMDYAPLGDLQSYL
...||| .| ||. || || ..|...       ..|. |.| |.| | ..|
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL
Kinase LRRKc.AA Dicty4 1302-1332 38 4.1e-07 19.96 In-house 1-31 (277) Show / Hide 
Range on Protein: 1302-1332
Range on HMM: 1-31/277
Sequence Identity: 38% (12 aa)

MVSGQSLGQGGFGEVFRAKFRGETVAAKTMF
 . .| .|.|.||||.... ||  || | ..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLN
Kinase LRRKc.AA MLK 1302-1330 27 4e-06 17.4 In-house 1-29 (291) Show / Hide 
Range on Protein: 1302-1330
Range on HMM: 1-29/291
Sequence Identity: 27% (8 aa)

MVSGQSLGQGGFGEVFRAKFRGETVAAKT
    . .| |.||.|.....|.... ||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKI
Kinase LRRKc.AA TKL-Unique 1304-1340 35 4e-06 17.75 In-house 1-40 (290) Show / Hide 
Range on Protein: 1304-1340
Range on HMM: 1-40/290
Sequence Identity: 35% (14 aa)

SGQSLGQGGFGEVFRAKFRGETVAAKTMFP---SRLLKNQ
 . ..|.||.|.|...|.||. || |. .|   |.. . |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQ
Kinase LRRKc.AA Pkinase_Tyr 1302-1331 30 0.00463 10.99 Pfam 1-36 (270) Show / Hide 
Range on Protein: 1302-1331
Range on HMM: 1-36/270
Sequence Identity: 30% (11 aa)

MVSGQSLGQGGFGEVFRAKFR------GETVAAKTM
 . |. ||.| ||||.... .      . .|| |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML
Kinase LRRKc.AA TKL-Unique 1599-1621 34 0.005275 6.65 In-house 268-290 (290) Show / Hide 
Range on Protein: 1599-1621
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

LMESCWQDKPGKRPHGKTILQLL
|.. || . | .||   .|.  |
LIQQCWHHDPSQRPSFDEIIHRL
Kinase LRRKc.AA Dicty4 1389-1409 47 0.019308 4.15 In-house 45-65 (277) Show / Hide 
Range on Protein: 1389-1409
Range on HMM: 45-65/277
Sequence Identity: 47% (10 aa)

LRNEVAIMVKLDHPCIVNLVG
.|.||.|| |. || |. . |
FRKEVHIMCKIRHPNICLFMG
Kinase LRRKc.AA Pkinase_Tyr 1599-1621 39 0.026571 8.42 Pfam 248-270 (270) Show / Hide 
Range on Protein: 1599-1621
Range on HMM: 248-270/270
Sequence Identity: 39% (9 aa)

LMESCWQDKPGKRPHGKTILQLL
|| .||. .| .||  . |.. |
LMKQCWHYDPEDRPTFSEIHEQL
Kinase LRRKc.AA Dicty4 1589-1623 29 0.030465 3.48 In-house 241-277 (277) Show / Hide 
Range on Protein: 1589-1623
Range on HMM: 241-277/277
Sequence Identity: 29% (11 aa)

PRQVFPALGALMESCWQDKPGKRPHGKTILQL--LSE
| .. | . .|.. ||   | .||  . |.|   | .
PDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH