Tesk

Species: Sea Urchin
Alias: Spk305, SPU_005626, Tesk
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: TESK

Sequence

Name Sequence Type Origin Length Description Download
Tesk.AA Protein None 598 None Fasta, JSON
Tesk.kin_dom Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of Tesk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Tesk.AA TESK 18-295 67 3.1e-228 728.65 In-house 13-292 (292) Show / Hide
Range on Protein: 18-295
Range on HMM: 13-292/292
Sequence Identity: 67% (189 aa)

KIRHKADGRVMVAKIGKQKIWRANQHKMIQELELLNKLQHPNVVRYMGACVKDGHIHPVLEYVSGGCLTDILADESLALSWRQKGDLATDIARGMTYLHS
|.||.|.|.|||.|..||||||||.|.|..|..|.|||||||..|.||.||..|..|...||..||||...|||..|.|||.||..||.||||||.||||
KVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSELHLSWTQKIHLAYDIARGMSYLHS

QNVCHRDLTSANCLVRQKPNNVLEAILTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDVPR-KMSVVGTAFWMAPEVLRGEE
..|.||||||.||||||..||..||...|||||||||||||||||||||||||||||||||||||||..||..|||... ||.|||...||||||||||.
KGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGSPYWMAPEVLRGEW

YTRQVDVFSFGIVVCEIVARITANPDDLPRTGKFGLDLQLFKEKCP-GIPEPFLQIAEDCCSMDPRDRPVFAELVRRFEI
|....||||||||.|||.|||.|.||..|||.|||||.|.|||.|| ..||||||.|..||.|||.|||||.|.....|.
YDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLEW

Kinase Tesk.AA LISK 18-293 42 1.1e-166 545.82 In-house 12-296 (296) Show / Hide
Range on Protein: 18-293
Range on HMM: 12-296/296
Sequence Identity: 42% (124 aa)

KIRHKADGRVMVAKIGKQK----IWRANQHKMIQELELLNKLQHPNVVRYMGACVK-DGHIHPVLEYVSGGCLTDILADESL---ALSWRQKGDLATDIA
|..|...|.||. |  ...    .....|..|..|......|.|||.|..||.|.. ||..|.| ||..||.|...|.|...    |.|.|. ..|.|||
KGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIA

RGMTYLHSQNVCHRDLTSANCLVRQKPNNVLEAILTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDVPR-KMSVVGTAFWMA
.||.||||.|..||||.| |||||...||. .....|||.||.. |....|.|.||..||. |.   ..|..||...||..||.... .|...||..|||
CGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESD-PC---MDNDMPMKRKIPKKCMNQRKRRMTICGTPYWMA

PEVLRGEEYTRQVDVFSFGIVVCEIVARITANPDDLPRTG--KFGLDLQLFK-EKCPG-IPEPFLQIAEDCCSMDPRDRPVFAELVRRF
||.|.|..|....||||||||.|||..|..|.||..|||.  .||||...|. . ||  .|.|||... |||..||..||.|.|.|...
PEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL

Kinase Tesk.AA TKL 46-293 25 1.3e-68 234.28 In-house 73-364 (364) Show / Hide
Range on Protein: 46-293
Range on HMM: 73-364/364
Sequence Identity: 25% (80 aa)

IQELELLNKLQHPNVVRYMG---------ACVK----DGHIHPVLEYVSGGC-LTDILADESLALSWRQKGDLATDIARGMTYLHSQN--------VCHR
..|. ....|.|||.|..||         .|..    .|... | ||..||. | ...        | |. ..| |||||| ||||.|        . ||
EEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHR

DLTSANCLVRQKPN----------NVLEAILTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDVPRKMSVVGTAFWMAPEVLR
||.|.|.|| .. .          .   . ..||||.|..  . .   ..  ..|  .  .          .   .. .   ..|...||  ||||||||
DLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME--S--A----------E---HQ-NNRKTTMTQCGTPRWMAPEVLR

GE----------------EYTRQVDVFSFGIVVCEIVARITANPDDLPRT--------GKFGLDLQLFKEKCPG--------------IPEPFLQIAEDC
|.                ||. ..||.||||| .||..| .   |. ...          | .. . ..   .               .|... ....||
GQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDC

CSMDPRDRPVFAELVRRF
...||..|| | |.. |.
WDHDPEKRPSFQEILKRL

Kinase Tesk.AA LISK-DD1 48-293 26 1.3e-51 177.84 In-house 44-290 (290) Show / Hide
Range on Protein: 48-293
Range on HMM: 44-290/290
Sequence Identity: 26% (76 aa)

ELELLNK---LQHPNVVRYMGACVK-------------DGHIHPVLEYVSGGCLTDILADE------------SLALSWRQKGDLATDIARGMTYLHSQN
|.. |     ..|||.|.. |.|..             .. .. | |...|| | ..| .             .  ..|  .  .| ||| .| |||| |
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

VCHRDLTSANCLVRQKPNNVLEAILTDFGLARVLGCM--PDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDVPRKMSVVGTAFWMAPEVLRGEEY
. |||| | | ||         . . |||.||..                                           .|.|. .||  ||||||. |..|
IIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ-----------------------------------NNRHMTICGTDNWMAPEVILGMSY

TRQVDVFSFGIVVCEIVARITANPDDLPRT--GKFGLDLQLFKE-KCPG---IPEPFLQIAEDCCSMDPRDRPVFAELVRRF
   .||||||.|  |.  |    .. ..|.   .|..|.  |.  | |.   .|..|.  . .||. || .|| | | | . 
DWSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL

Kinase Tesk.AA TKL-Unique 46-234 29 8.6e-44 151.81 In-house 43-222 (290) Show / Hide
Range on Protein: 46-234
Range on HMM: 43-222/290
Sequence Identity: 29% (63 aa)

IQELELLNKLQ-HPNVVRYMGACV----KDGHIHPVLEYVSGGCLTDILA---------DESLALSWRQKGDLATDIARGMTYLHSQN--VCHRDLTSAN
. |. ...||. |||.|.|||.|.    . ..   |.||..|| | | |.          ... |.. |. ..| |||.|| |||. .  . ||||.| |
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSN

CLVRQK-PNNVLEAILTDFGLARVLGCMPDPPPNSP---RTPESPEPDIIDAPNGGPMLPRIPSACMDVPRKMSVVGTAFWMAPEVLRG--EEYTRQVDV
 || .. . . . . . ||||....  . . . | .   |                               . ...|...||||||||.  . |....||
FLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR-------------------------------NQTRCGSFRWMAPEVLRMNFCQYSEKSDV

FSFGIVVCEIV
.|||||. ||.
YSFGIVLWEIA

Kinase Tesk.AA LIMK 200-293 52 1.4e-43 146.3 In-house 192-287 (287) Show / Hide
Range on Protein: 200-293
Range on HMM: 192-287/287
Sequence Identity: 52% (50 aa)

VVGTAFWMAPEVLRGEEYTRQVDVFSFGIVVCEIVARITANPDDLPRTGKFGLDLQLFKEKCP--GIPEPFLQIAEDCCSMDPRDRPVFAELVRRF
|||...||||| ..| .|  .||||||||| |||. |. | ||..|||. |||. |.| |||     |.|| .|.  || |||  || | .|  ..
VVGNPYWMAPEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPRTMDFGLNQQEFWEKCCPDQCPPPFFPIMFMCCDMDPDMRPCFDKLHQWL

Kinase Tesk.AA TK 47-293 16 3.6e-39 128.44 In-house 90-486 (486) Show / Hide
Range on Protein: 47-293
Range on HMM: 90-486/486
Sequence Identity: 16% (69 aa)

QELELLN--KLQHPNVVRYMGACVKD------------GHIHPVLEYVSGGC----LTDILADESLA---------------------------------
.|.....  ...|||.||  |.|...            ...  |.||...|.    | | | . .                                   
EEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHE

------------------------------------------LSWRQKGDLATDIARGMTYLHSQ------NVCHRDLTSANCLVRQKPN-------NVL
                                          |. .|.   . .||.|| ||||.      |. ||||   |||| .. .       ...
SNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGP

EAILTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDVP-----RKMSVVGTAF-------------------------WMAPE
 . ..||||.|.                                      . |..     ...|  ||.                          |||||
VCKIADFGLSRQGS-G--------------------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPE

VLRGEE---------YTRQVDVFSFGIVVCEIVARITANPDD----------------LPRTGKF-----------GLDLQLFK-EKCP----------G
.|.. .         .| . ||.|||... ||. .  . .                  . .  .            |  ... . . ||           
CLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPH

IPEPFLQI-AEDCCSMDPRDRPVFAELVRRF
 |......   .|.. ||.||| |..|....
CPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase Tesk.AA Pkinase 18-293 20 1.3e-38 137.6 Pfam 17-293 (293) Show / Hide
Range on Protein: 18-293
Range on HMM: 17-293/293
Sequence Identity: 20% (66 aa)

KIRHKADGRVMVAKIGKQKIWRANQHKMIQ---ELELLNKLQHPNVVRYMGACVKDGHIHPVLEYVSGG----CLTDILA-DESLAL--SWRQKGDLATD
| .|| .|.. . || | .  . ....      |......|.|||.||. ...  ..||. |.||. ||     | |..  ... ..  |...  . .. 
KCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQ

IARGMTYLHSQNVCHRDLTSANCLVRQKPNNVLEAI-LTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDVPRKMSVVGTAFW
|.||. |.||....|||| ..|.|.  . ... . . ..|||||...                                         .  ....|| ..
ILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------------------------------------Y-NNS-MTTFCGTPWY

MAPEVLR-GEEYTRQVDVFSFGIVVCEIVARITANPDD-----------LPRTGKFGLDLQLFKE----------------KCPGIPEPFLQIAEDCCSM
|||||.| |..|.. ||..|.|... | . . .  |..           . |...  |. . ...                . . ..|..... ..|. .
MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCK

DPRDRPVFAELVRR--F
|| .|| .....    |
DPKKRPTAEQILQHPWF

S_TKc Tesk.AA S_TKc 10-296 20 1.3e-36 128.9 SMART 1-231 (231) Show / Hide
Range on Protein: 10-296
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

KQREE--------SKTKIRHKADGRVMVAKIGKQKIWRANQHKMIQELELLNKLQHPNVVRYMGACVKDGHIHPVLEYVSG--GCLTDILADESLA----
 .  .        .  | ||| .||..  || |         ....|...| | .|||.|.. ....  .|.. |.||..|  | | |.. .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSWRQKGDLATDIARGMTYLHSQNVCHRDLTSANCLVRQKPNNVLEAILTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSACMDV
 ..  .   ..  |.... |.||....||||  .| |. .      .  ..||||||.|                                         
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------------------------------

PRKMSVVGTAFWMAPEVLRGEEYTR-QVDVFSFGIVVCEIVARITANPDDLPRTGKFGLDLQLFKEKCPGIPEPFLQIAEDCCSMDPRDRPVFAELVR--
   ....|| ..||||||    |..  .|. |.|... | ... .  |           . ..||  .   ....... . |. .||..||   |. .  
---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDE

----RFEII
      . .
WDIKCHPWF

Kinase Tesk.AA LIMK 18-153 39 5.5e-29 95.83 In-house 17-147 (287) Show / Hide
Range on Protein: 18-153
Range on HMM: 17-147/287
Sequence Identity: 39% (55 aa)

KIRHKADGRVMVAKIGKQKIWRAN---QHKMIQELELLNKLQHPNVVRYMGACVKDGHIHPVLEYVSGGCLTDILADESLALSWRQKGDLATDIARGMTY
|. |.. | ||| |       |.    |   . |   .  | ||.|  . |   ||   . | ||. |||| .|. |    . | |.  .| ||| || |
KVTHRQTGEVMVMK----ELHRCDEETQRTFLKEVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQPFPWQQRVRFARDIACGMSY

LHSQNVCHRDLTSANCLVRQKPNNVLEAILTDFGLARVL
||| .. |||| | |||||    .|   .  ||||||..
LHSMCIIHRDLNSHNCLVRED-RSV---VVADFGLARLM

Kinase Tesk.AA DRK 47-132 40 1.6e-27 90.33 In-house 46-133 (258) Show / Hide
Range on Protein: 47-132
Range on HMM: 46-133/258
Sequence Identity: 40% (36 aa)

QELELLNKLQHPNVVRYMGACVKDGHIHPVLEYVSGGCLTDILADESLALSWRQKGDLATDIARGMTYLHSQN--VCHRDLTSANCLV
.| .|. .| |||.. .||.|     |  . || . | |  || |||. ..|     .. |.|.||.|||. |  . |||| | | ||
REINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLV

Kinase Tesk.AA Pkinase_Tyr 41-153 32 5.9e-27 91.91 Pfam 44-161 (270) Show / Hide
Range on Protein: 41-153
Range on HMM: 44-161/270
Sequence Identity: 32% (40 aa)

N--QHKMIQELELLNKL-QHPNVVRYMGACV-KDGH--IHPVLEYVSGGCLTDILADE---SLALSWRQKGDLATDIARGMTYLHSQNVCHRDLTSANCL
.  . ....|.... .| .|||.||..|.|. ....  |  |.||. .|.| | | .      .|.  .. . ...||.|| ||.|.|  ||||   |||
QNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCL

VRQKPNNVLEAILTDFGLARVL
|       . .  .|||||| .
VTE----NNVVKICDFGLARDI

Kinase Tesk.AA MLK 29-151 26 1.6e-23 78.53 In-house 26-181 (291) Show / Hide
Range on Protein: 29-151
Range on HMM: 26-181/291
Sequence Identity: 26% (42 aa)

VAKIGKQKIWR----------ANQHKMIQELELLNKLQHPN----VVRYMGACVKDGH-IHPVLEYVSGGCLTDILADES-------------LALSWRQ
|||| . |..|          . | .. .| ..|..|.|||    ... .|.| ....    |.||..||.| ..|....                .  .
VAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDH

KGDLATDIARGMTYLHSQN---VCHRDLTSANCLVRQ--KPNNVLEAILTDFGLAR
. . |...|||| ||||.    . |||| | | |. .  .. . . .  .|||..|
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR

Kinase Tesk.AA Dicty4 47-132 36 2.3e-22 71.57 In-house 47-147 (277) Show / Hide
Range on Protein: 47-132
Range on HMM: 47-147/277
Sequence Identity: 36% (37 aa)

QELELLNKLQHPNVVRYMGACV----KDGHIHPVLEYVSGGCLTDILAD------ESLALSWRQKGD---LATDIARGMTYLHSQN--VCHRDLTSANCL
.| ... |..|||..  ||||     . | .  | ||.. | |  .| |      .|  |.|        .| |.||||..||. |  . |||| |.| |
KEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLL

V
|
V

TyrKc Tesk.AA TyrKc 1-293 23 2.2e-19 71.67 SMART 1-280 (280) Show / Hide
Range on Protein: 1-293
Range on HMM: 1-280/280
Sequence Identity: 23% (80 aa)

MNIDEKL-----------TAKQREESKTKIRHKADGRVMVA-KIGKQKIWRANQHKMIQELELLNKL--QHPNVVRYMGACVKD-------GHIHPVLEY
   ..||           |.|                ..|| |  |       .  ...|.... ||  .|||.||  |.|...       . .  |.||
ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

VSGGCLTDILADESLALSWRQKGDLATDIARGMTYLHSQNVCHRDLTSANCLVRQKPNNVLEAILTDFGLARVLGCM---PDPPPNSPRTPESPEPDIID
...|.| | | .    |..... . ...||.|| ||||.|. ||||   ||||  .      .  .||||.| ..                   . | ..
MPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG------------ESKDYYR

A---PNGGPMLPRIPSACMDVPRKMSVVGTAFWMAPEVLRGEEYTRQVDVFSFGIVVCEIVARITANPDD-----LPRTGKFGLDLQLFKEKCPGI----
.    .|  |||                    |||||...  ..| . ||.|||..  ||  .    . .     .. .  . .  | .  ..|      
KKEHKGGKTMLP------------------IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPM

-----PEPFLQIAEDCCSMDPRDRPVFAELVRRF
     |.   || ..|.  || ||| |.|....|
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase Tesk.AA Dicty4 198-229 53 1.5e-15 48.47 In-house 175-206 (277) Show / Hide
Range on Protein: 198-229
Range on HMM: 175-206/277
Sequence Identity: 53% (17 aa)

MSVVGTAFWMAPEVLRGEEYTRQVDVFSFGIV
|...||. ||||||.....|.  .||.|||||
MTACGTPCWMAPEVMMHQPYNEKADVYSFGIV

Kinase Tesk.AA MLK 197-236 46 2.4e-13 42.78 In-house 190-232 (291) Show / Hide
Range on Protein: 197-236
Range on HMM: 190-232/291
Sequence Identity: 46% (20 aa)

KMSVVGTAFWMAPEVL---RGEEYTRQVDVFSFGIVVCEIVAR
.||  ||. ||||||.   |.| |.. .||.|.|.|  |...|
MMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR

Kinase Tesk.AA DRK 198-236 53 5.2e-13 40.45 In-house 160-198 (258) Show / Hide
Range on Protein: 198-236
Range on HMM: 160-198/258
Sequence Identity: 53% (21 aa)

MSVVGTAFWMAPEVLRGEEYTRQVDVFSFGIVVCEIVAR
|  .||  | |||||| . ||   ||.||.||  |.| |
MTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR

Kinase Tesk.AA Pkinase_Tyr 205-234 43 1e-06 23.28 Pfam 179-208 (270) Show / Hide
Range on Protein: 205-234
Range on HMM: 179-208/270
Sequence Identity: 43% (13 aa)

FWMAPEVLRGEEYTRQVDVFSFGIVVCEIV
.|||||...  ..| . || |||..  ||.
KWMAPECINYGKFTTKSDVWSFGVLMWEIF

Kinase Tesk.AA MLK 262-293 28 1e-06 18.98 In-house 260-291 (291) Show / Hide
Range on Protein: 262-293
Range on HMM: 260-291/291
Sequence Identity: 28% (9 aa)

PGIPEPFLQIAEDCCSMDPRDRPVFAELVRRF
...||.. .  ..| ..||..|| |.. |  .
STCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase Tesk.AA DRK 265-295 35 5.7e-05 12.82 In-house 228-258 (258) Show / Hide
Range on Protein: 265-295
Range on HMM: 228-258/258
Sequence Identity: 35% (11 aa)

PEPFLQIAEDCCSMDPRDRPVFAELVRRFEI
| .. |   || . ||  || . | . | | 
PPKYIQLMNDCWNEDPQHRPSMQECLERLEA

Kinase Tesk.AA Pkinase_Tyr 274-293 40 0.03003 8.24 Pfam 251-270 (270) Show / Hide
Range on Protein: 274-293
Range on HMM: 251-270/270
Sequence Identity: 40% (8 aa)

DCCSMDPRDRPVFAELVRRF
.|   || ||| |.|.....
QCWHYDPEDRPTFSEIHEQL

Kinase Tesk.AA TKL-Unique 264-293 30 0.039687 3.52 In-house 261-290 (290) Show / Hide
Range on Protein: 264-293
Range on HMM: 261-290/290
Sequence Identity: 30% (9 aa)

IPEPFLQIAEDCCSMDPRDRPVFAELVRRF
.|. .  . ..|.  || .|| | | . | 
CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase Tesk.AA Dicty4 273-295 36 0.117246 1.5 In-house 253-277 (277) Show / Hide
Range on Protein: 273-295
Range on HMM: 253-277/277
Sequence Identity: 36% (9 aa)

EDCCSMDPRDRPVFAELVRR--FEI
..| . ||  || |.| . |   | 
QWCWDHDPQHRPSFEEIIQRRILEH