Gene Irak2 (Sea Urchin)

Irak2

Species: Sea Urchin
Alias: Irak2, Spk304, SPU_028724
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
Irak2.AA Protein None 1035 None Fasta, JSON
Irak2.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of Irak2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death Irak2.AA Death 18-99 25 4.6e-12 42.76 Pfam 1-87 (87) Show / Hide 
Range on Protein: 18-99
Range on HMM: 1-87/87
Sequence Identity: 25% (23 aa)

QQLCDLL-DDISGLKNWKHLAGLLGFTNDDIAMFQRCMLRPGG---SPTDEMLTTWDYE---NHTIEELYLKLYEIKHARCMMFLKDFV
|.||.|| .|    |.|..|| .||.....|  ....  ....   |.| .||. |      |.|...|.  | .... .|.  ... .
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD--QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase Irak2.AA IRAK 332-619 36 2.5e-137 462.51 In-house 1-317 (317) Show / Hide 
Range on Protein: 332-619
Range on HMM: 1-317/317
Sequence Identity: 36% (115 aa)

FSAARRLGSGAFGEVFHAQLDMID--VAIKKIIKNENVKFNESMIRGDQ-IKEIEALTKYRHKNIVSLTAYSFGEDCICLIFDFMKNGSLEYQLEGRAPQ
|....|.|.|.||.|...|.....  .|.||.........||...|..| ..|.......||.|||.|..|.....|.||....|.|||||..|.....|
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GP---LEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLARPG-PTQGKEYTTI---KTSVVFGTKAYLAPEFMRDPKRK
.|   |.||.|..|..|.|.|||.||......|.||.||||||||||..|.|||.||||.|.| |...||..|.   .||.|.||..|..|||.|||...
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSKKLDVYSFGVVLLELVTGEKAGQAKKRFGTHEILWRSVDKIMYANE------------------GNPQAA--AKILQDPKCLVWPSKYMMELVELAMD
|.||.||||||.||||..||..  .....   |. |   .. ||                        | ..   ... |..   .|..   |.  .|  
LTKKTDVYSFGIVLLEVLTGCR--AVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACC

CLKD-FKFRPEMEKVILTL
|.    . |..|..|  .|
CGHHRANRRCDMAWVMQQL
Kinase Irak2.AA TKL 338-619 21 7.9e-69 234.98 In-house 1-364 (364) Show / Hide 
Range on Protein: 338-619
Range on HMM: 1-364/364
Sequence Identity: 21% (84 aa)

LGSGAFGEVFHAQLDM----------IDVAIKKIIKNENVKFNESM---------------------IRGDQIKEIEALTKYRHKNIVSLTAYSFGEDC-
.|||.||||.....             |||.||. .... .|....                     .|   ..||  . . || |||.. .|.. ..| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ICLIFDFMKNGSLEYQLEGRAPQGPLEWHRRHMIAEGAALGIQYLHTADS----AVPLIHQDIKSANILLDENFV-------------
            .|.. .....|||...|          ||.|. .| ..|.|..|||. .       |.|| |.||.|||.|||.              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKIADFGLARPG----PTQGKEYTTI----------KTSVVFGTKAYLAPEFMRDP--------------KRKLSKKLDVYSFGVVLLELVTGEKAGQA
 .||.||||.|        .  ..|.           .|. . ||....||| .|.               ... |.| ||||||.|| |..|...    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

KKRFGTHEILWRSVDKIMYANEGNPQAA---------AKILQ---DPKCL---------VWPSKYMMELVELAMDCLKD-FKFRPEMEKVILTL
                  |.......           ... .    | .          ....  . .. .|..|| .   . || ..... .|
-----------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Irak2.AA RIPK 338-544 30 4.1e-35 117.1 In-house 1-227 (290) Show / Hide 
Range on Protein: 338-544
Range on HMM: 1-227/290
Sequence Identity: 30% (69 aa)

LGSGAFGEVFHAQ-LDMIDVAIKKIIKNENVKFN-ESMIRGDQIKEIEALTKYRHKNIVSLTAYSFGEDC------ICLIFDFMKNGSLEYQLEGRAPQ-
.|.|.||||| |.  .  |...||. .  ...   ..  | .|. | ... | |...||..      |.       . .   .|.||||.  |  . |. 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-GPLEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLARPGPTQ--GKEYT-----TIKTSVV-FGTKAYLAPEFMRDPK
  |. |  |  .    ..| .|||  .   |.|| | | .|||.| ||  ||||||||    .   ...        . .|    || .|..||  |.  
HHPDPWPLRCRMIHEISCGMCYLHSMNP--PIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDN

RKL----SKKLDVYSFGVVLLELVTGEKA
.|     ..| |||||..|. |. |. ..
KKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase Irak2.AA Pkinase 332-542 25 1e-33 120.26 Pfam 1-209 (293) Show / Hide 
Range on Protein: 332-542
Range on HMM: 1-209/293
Sequence Identity: 25% (57 aa)

FSAARRLGSGAFGEVFHAQLDMID--VAIKKIIKNENVKFNESM---IRGDQIKEIEALTKYRHKNIVSLTAYSFGEDCICLIFDFMKNG----SLEYQL
.   |..|||.||.|....       ||.|.| | .. .  .     .      ||. . . .|.||| |  .   .| |....... .|    .|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

EGRAPQGPL--EWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVP----KIADFGLARPGPTQGKEYTTIKTSVVFGTKAYLAPEFMR
..   .|..  ...   ...   . |..|.|        || |.|..|||.|.| ..    ||.|||||.       .     .... ||  |.|||  |
ST-WRHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIR

DPKRKLSKKLDVYSFGVVLLELVTGE
   .. ..| |..|.|..| |...|.
-GGQYYGPKVDMWSCGCILYEMLCGR
Kinase Irak2.AA TKL-Unique 334-542 27 2.8e-32 111.19 In-house 1-225 (290) Show / Hide 
Range on Protein: 334-542
Range on HMM: 1-225/290
Sequence Identity: 27% (63 aa)

AARRLGSGAFGEVFHAQLDMIDVAIKKIIKNENVKFNESMIRGDQIKEIEALTKYR-HKNIVSLTAYSF----GEDCICLIFDFMKNGSLEYQLE-----
    .|.|..|.|...    ..||||.. .|| .   .. .. . ..|.  . | . |.||| . .|..     .   |.. ...  |||   |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDS---SNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

--GRAPQGPLEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDEN-----FVPKIADFGLARPGPTQGKEYTTIKT-------SVVFGTKAY
    ..  .| . .|  .|. .|.|  |||. .     || |.|| |.|.|.|     .  ||.||||..   .. |. .....       ... |.  .
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP--IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK---FNSKINKMTNNEHKGTRNQTRCGSFRW

LAPEFMRDPKRKLSKKLDVYSFGVVLLELVTGE
.||| .|..  . |.| ||||||.|| |..|..
MAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase Irak2.AA MLK 332-542 27 2.9e-30 102.23 In-house 1-233 (291) Show / Hide 
Range on Protein: 332-542
Range on HMM: 1-233/291
Sequence Identity: 27% (67 aa)

FSAARRLGSGAFGEVFHAQLDMID-----VAIKKII-KNENVKFNESMIRGDQIKEIEALTKYRHKN----IVSLTAYSFGEDC-ICLIFDFMKNGSLEY
.   . .|||.||.|. ..    |     ||.|..    .  |  .. .. |  .|.. | . .|.|    |. . . .  . |  |..  .. .|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

QLEGRAPQGP-----------LEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDE------NFVPKIADFGLARPGPTQGKEYTTI---KT
 | |. ...               .    .|   | |..||| ..  .|.|| |.|| |||.||      . . ||.|||..|       . ...   ..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH-SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR-------DWHQMCTNMM

SVVFGTKAYLAPEFMRD-PKRKLSKKLDVYSFGVVLLELVTGE
|   || |. |||     .  | |.| ||.|.|||| |..|.|
S-NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase Irak2.AA TK 332-540 15 1.1e-27 89.22 In-house 1-389 (486) Show / Hide 
Range on Protein: 332-540
Range on HMM: 1-389/486
Sequence Identity: 15% (61 aa)

FSAARRLGSGAFG---EVFHAQLDM---------------------------IDVAIKKIIK--NENVK-FNESMIRGDQ---------IKEIEALT--K
    . ||.|.||   ||. ... .                           ..||.| . .  ... . | . ...  .           |.. .   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSL

YRHKNIVSLTAYSFGEDC------------ICLIFDFMKNGS----LEYQLEGRAP--------------------------------------------
..|.|||.| .... ...            ....  .|..|.    |   |  . |                                            
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

-----------------------------QGPLEWHRRHMIAEGAALGIQYLHTAD-SAV--PLIHQDIKSANILLDENFV-----------PKIADFGL
                             ...|  |... ..  .| | .|||    .     ..| |.   |.|..|| |            |||||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

AR-------PGPTQGKEYTTIKTSVVF-------------------GTKA---YLAPEFMRDP-------KRKLSKKLDVYSFGVVLLELVT
.|           ....|.. ..  .                    |.|    ..||| ..|        ..| . | ||.||||.. |..|
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase Irak2.AA Pkinase_Tyr 332-543 28 2.2e-27 93.38 Pfam 1-213 (270) Show / Hide 
Range on Protein: 332-543
Range on HMM: 1-213/270
Sequence Identity: 28% (64 aa)

FSAARRLGSGAFGEVFHAQLD------MIDVAIKKIIKNENVKFNESM-IRGDQIKEIEALTKY-RHKNIVSLTAYSF-GEDC--ICLIFDFMKNGSLEY
 .  . ||.||||||... ..       |.||.|.. |.   .  ..  .| | ..|.. .... .|.|||.| .     ..   |.... .|..|.|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

QLEGR-APQGPLEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLARPGPTQGKEYT-TIKTSVVFGTKAYLAPEFMRDP
 |  .  ...||  ..   ..   | | .||.       .|| |.   |.|..||.| ||.||||||    . ..|  . ...        .||| ... 
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGK-LPIKWMAPECINYG

KRKLSKKLDVYSFGVVLLELVT-GEK
|   . | ||.||||.. |..| ||.
K--FTTKSDVWSFGVLMWEIFTYGEQ
Kinase Irak2.AA STE 332-542 22 2.8e-26 89.88 In-house 1-265 (359) Show / Hide 
Range on Protein: 332-542
Range on HMM: 1-265/359
Sequence Identity: 22% (65 aa)

FSAARRLGSGAFGEVFHAQLDM---ID--------------VAIKKI-IKNENVKFNE-----------SMIRGDQIKEIEALTKYR--HKNIVSLTAYS
.   ...|.||||.|. |       |.              .|||.. ..|.| |  |           .... . .|||. . |..  |.|||    . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

FGE-------DCICLIFDFMKNGSLEYQLE-GRAPQGPL-----------EWHRRHMIAEGAALG-IQYLHTADSAVPLIHQDIKSANILLDENFVPKIA
| |       | ....  .| .|||.  ..    ...||           |   .... .    |  .|||        || |||.|||||      |..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQ-ILKGLLYYLHSHH----IIHRDIKPANILL-----VKLC

DFGLAR-----------------PGPTQGKEYTTI-KTSVVFGTKAYLAPEFMRDPKRK----LSKKLDVYSFGVVLLELVTGE
|||..                          .|.  |.  . ||  . ||| ..  ...     . | |..|.| ...|..||.
DFGVCGQLTDSMANIQSNNIIDCI-------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase Irak2.AA TKL-ciliate1 336-539 25 5.8e-26 85.86 In-house 5-213 (279) Show / Hide 
Range on Protein: 336-539
Range on HMM: 5-213/279
Sequence Identity: 25% (55 aa)

RRLGSGAFGEVFHAQLDMIDVAIKKIIKNENVK--FNESMIRGDQIKEIEALTK-YRHKNIVSLTAYSFGEDCICLIFDFMKNGSLEYQLEGRAPQ--GP
.  ||| |..|.       ||||...  .   .   |.        .||... |   | | ..| . ||...   .|  .   |..   .  | ..   .
QKIGSGHFCNVYKGRCNSYDVAIMNMNYFNSQESFINQKEF----QREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTM-FDICHRKHSQIYM

LEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLARP---GPTQGKEYTTI-KTSVVFGTKAYLAPEFMR---DPKRKLS
. |  |  .    | |.||||      |||| |.|. |||.|| . .|| .|.       . ..      .   . . .|  . ||| |.    | .  .
IKWQHRMRWCKDIAQGMQYLHMRQN--PLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPIN

KKLDVYSFGVVLLELV
 | |.|..|.|. .|.
EKIDIYAYGIVMYILC
Kinase Irak2.AA Dicty4 430-542 33 2.1e-24 78.48 In-house 105-214 (277) Show / Hide 
Range on Protein: 430-542
Range on HMM: 105-214/277
Sequence Identity: 33% (40 aa)

PLEWHRRHM---IAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLAR---PGPTQGKEYTTIKTSVVFGTKAYLAPEFMRDPKRKLS
.|.| ..     .|  ||.|...||. .. .  || |.||.|.| |.|.. |..||||..   .. ...   .| .     || .. ||| |.  ..   
KLDWPLIKRAMRMAFDAARGMNWLHCCNPVI--IHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC-----GTPCWMAPEVMM--HQPYN

KKLDVYSFGVVLLELVTGE
 | |||||| || |..|..
EKADVYSFGIVLWEILTRQ
Kinase Irak2.AA Ciliate-E2-Unclassified 332-542 20 1.8e-23 78.26 In-house 1-267 (352) Show / Hide 
Range on Protein: 332-542
Range on HMM: 1-267/352
Sequence Identity: 20% (56 aa)

FSAARRLGSGAFGEVFHAQL---DMIDVAIKKIIKNENVK-------FNESMIRGDQIKEIE-------------ALTKYRHKNIVSLTAYSFGEDCICL
.   . .|.|.||.|...|    .    |.| ..|. ..|         | |   .......              |    | .|| .  .   ...|..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IFDFMKNGSLEYQLEGRAP----QGPLEWHRRH---------------MIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDEN---FVPKIADFGLAR
. .....|.|.. .. |      .. |  ....                ..    .|..|||        || |||  |||.|.|   . .||.|||...
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN---NIIHRDIKPENILFDNNGKNYYIKIIDFGISK

-PGPTQGKEYTT----------IKTSVVFGTKAYL----APEFMRDPKRKLS--KKLDVYSFGVVLLELVTGE
 ..  .... |.           ... . ||  |.    ||| ..  .   |  .| |..|.||.| |...|.
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase Irak2.AA S_TKc 332-617 23 5.2e-23 83.68 SMART 1-220 (231) Show / Hide 
Range on Protein: 332-617
Range on HMM: 1-220/231
Sequence Identity: 23% (68 aa)

FSAARRLGSGAFGEVFHAQLDM--IDVAIKKIIKNENVKFNESMIRGDQIKEIEALTKYRHKNIVSLTAYSFGEDCICLIFDFMKN--GSLEYQLEGRAP
.   | .|.||||.|. ..       ||||.|               . ..||. | | .|.||| |  .    |......... .  |.|   .. | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

QGP---LEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLARPGPTQGKEYTTIKTSVVFGTKAYLAPEFMRDPKRKLSK
.|.   .   .   ..   .....|.|        || |.| .||||||  . ||.||||||              . . ||  |.||| .     . .|
HGLRFPFPE-HARFYMYQICCALEYCHSHG----IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL-----GYGK

-KLDVYSFGVVLLELVTGEKAGQAKKRFGTHEILWRSVDKIMYANEGNPQAAAKILQDPKCLVWPSKYMMELVELAMDCLK-DFKFRPEMEKVIL
 | |..|.|..| |...|.   .          . .  .||.                            |. .. . ||. | . ||   ..  
CKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase Irak2.AA TyrKc 332-619 21 2.3e-17 58.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 332-619
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

FSAARRLGSGAFGEVFHAQLDMIDVAIKKIIKNENVKFNESMIRGDQIKEIEALTKY--RHKNIVSLTAYSFGE-------DCICLIFDFMKNGSLEYQL
 .  . ||.||||||...... |.||.|.. ..          | | ..|.. ..|.  .|.||| | ..   .       . ..... .|..|.|   |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

EGRAPQGPLEWHRRHMIAEGAALGIQYLHTADSAVPLIHQDIKSANILLDENFVPKIADFGLARPGPTQ-----GKEYTTIKT--SVVF-GTKAYLAPEF
  . |.  | .   . ..  .| | .|||      ..|| |.   |.|..||.. ||.||||.| .         |.| . |.  .  .      .||| 
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

MRDPKRKLSKKLDVYSFGVVLLELVTGEKAGQAKKRFGTHEILWRSVDKIMYANE----GNPQAAAKILQDPKCLVWPSK--------YMMELVELAMDC
.   ..| . | ||.||||.. |. |                      .  | ..     ..| . . ... . .  |             |. ..  .|
I--NYGKFTTKSDVWSFGVCMWEIFTYG--------------------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC

LKD-FKFRPEMEKVILTL
 .   . || .. ..  .
WHEDPEDRPTFSEIHECF
Kinase Irak2.AA Dicty4 332-374 37 5e-05 12.9 In-house 1-42 (277) Show / Hide 
Range on Protein: 332-374
Range on HMM: 1-42/277
Sequence Identity: 37% (16 aa)

FSAARRLGSGAFGEVFHAQLDMIDVAIKKIIKNENVKFNESMI
     |.|.|.||||. .    ..||.||  .| |..| |.|.
INIEQRIGKGSFGEVYKGTWRGKEVAVKKL-NNHNQNFDENML