Gene TK10 (Sea Urchin)
TK10
Sequence
Protein domains of TK10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Sushi | TK10.AA | Sushi | 27-86 | 21 | 8.7e-07 | 26.95 | Pfam | 1-65 (65) | Show / Hide |
Range on Protein: 27-86 Range on HMM: 1-65/65 Sequence Identity: 21% (15 aa) CD-IPS---LPS--HLKSTSATCNAGSNIEYATTCEFDCQAGFTLMGM--HQLSCNTEGQLTGDLPT-C |. .|. .|. ...| .... .. ..... |..|...||. . | .|| |. .|| | CPFDPPDPNIPHGHVIHTTKWR-CYRN-YQFGSKVYYECDPGYQMMGQGSNTITC--NGQWTPPFPTPC |
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CCP | TK10.AA | CCP | 27-86 | 18 | 1.3e-05 | 25.88 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 27-86 Range on HMM: 1-79/79 Sequence Identity: 18% (15 aa) CDIPS---LPSHLKSTSATCN----AGSNIEYATTCEFDCQAGFTLMG-----------MHQLSCNTEGQLTGDL----PTC |. | | . . |. .. . . .| .|... |. |.||.| . | .. ||| CP-PPPHIDPENGYVTCSNSQFTSTFKDTYSYGDTVTYSCNPGYTLIGGRQPEKSQEYHSSTITCQNN--WSPPPWGPLPTC |
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Kinase | TK10.AA | TK-Unique | 242-479 | 44 | 5.6e-114 | 384.96 | In-house | 1-263 (294) | Show / Hide |
Range on Protein: 242-479 Range on HMM: 1-263/294 Sequence Identity: 44% (118 aa) HLTKNLIDGGSFGRVYRVEAVGIMEGQDTT-IVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPNQSLRHCLTQMA ...|. |.|| |.| |..||....| . .||||||.|.|||.||. |..|.|.|.|...||||...||... |....|||||||...|.|.| ... LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR KENRQQ----NVN--------------VSSEQLLRFCVQIAKAMEHIAQ--KKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEYIMM-SRGRVPV .. ||. |.. .|...|..|..|||..||..|. ||||||||.||||||. ...||..|||.||.|.....|.|| |.||.|. PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI RWMAPESLR--HDVY-STKSDVWSFAVLMWEILTLGARPYTGMESGQVKMAVETDIVMDDFDG ||||||||. | .| .||||||||.||||||.||||.||.|| . .. ... |..... RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH |
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Kinase | TK10.AA | Pkinase_Tyr | 251-459 | 40 | 1.5e-91 | 310.73 | Pfam | 10-219 (270) | Show / Hide |
Range on Protein: 251-459 Range on HMM: 10-219/270 Sequence Identity: 40% (87 aa) GSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLD--KDSFTNELQIMREIPCHPNIIRLLGYSIAEDGS--TYIIMEYCPNQSLRHCLTQMAKENRQQ |.||.||. .. | ...... ||||||...|.. . ...| .|..||.... ||||.||.| . .... ||.|||.|. .|.. | . . GAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR----ED NVNVSSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEY-IMMSRGRVPVRWMAPESLRHDVYSTKSDVWSFAVLM . ... ..|| .|.||||.||. ..|...||||||||.|.. . .|..|||||| . .|..| . . |..|..|||||.... ...|||||||| ||| KQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLM WEILTLGARP-YTGM |||.|.|. | | || WEIFTYGEQPTYPGM |
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Kinase | TK10.AA | TK | 251-459 | 24 | 3.1e-86 | 289.0 | In-house | 10-399 (486) | Show / Hide |
Range on Protein: 251-459 Range on HMM: 10-399/486 Sequence Identity: 24% (94 aa) GSFG---RVYRVEAVGIM--------------------EGQDTTIVAVKMLRDSATDLDKDSFT----------------NELQIMRE-IPCHPNIIRLL | || .||. |. |.. ... .| ||||||.. ... ... | .|...|.. . ||||.||. GQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLY GYSIAEDGS-----------TYIIMEYCPNQS----LRHCLTQMAKENRQ-------------------------------------------------- |.. .... .|.|||.|. . ||. | . .. .. GVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHP ------------------QNVNVSSEQLLRFCVQIAKAMEHIAQK------KIVHRDLAARNVLLGPRLE-----------CKVADFG--------LARR .. ... .||| .|.|||..||....| ..|||||||||.|.| .. ||.|||| |||. PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARD VNDDEEYIMMS------------------------RGRVPVRWMAPESLRHDV---------YSTKSDVWSFAVLMWEILTLG-ARPYTGM ...|..| .| .|..|.||||||.|.. | ..|||||||| ||||||.|.| . .| || IYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM |
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TyrKc | TK10.AA | TyrKc | 241-490 | 30 | 5.7e-79 | 269.57 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 241-490 Range on HMM: 1-280/280 Sequence Identity: 30% (92 aa) LHLTKNLIDGGSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLDKDSFTNELQIMREI-PCHPNIIRLLGYSIAE------DGSTYIIMEYCPNQSLR ..| | . | ||.||. .. . ||||||...| . | .|..||... . ||||.||.|. . . .. .|.|||.|. .|. ITLGK-KLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK HCLTQMAKENRQQNVNVSSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDD------EEYIMMS---RGR--VPVRWM . | .. .. ..|| ||.|||. ||....|...||||||||.|.| .. .|..||||.| . || ..|.... |. .|.||| DYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM APESLRHDVYSTKSDVWSFAVLMWEILTLGARPYTG-----MESGQVKMAVETDIVMDDFDG--------TDSEYMP-------------------TSDL |||.... ...|||||||| |.||||.|.|. || | |. .| |.. |. . .| ... APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | TK10.AA | UTK | 241-459 | 33 | 9.6e-72 | 244.66 | In-house | 1-244 (296) | Show / Hide |
Range on Protein: 241-459 Range on HMM: 1-244/296 Sequence Identity: 33% (83 aa) LHLTKNLIDGGSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLDKDS----FTNELQ---IMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPNQSLR ..| . | | || |.. ... . | . .|||| .. .|.. .. | .| . .| .|||..||.|. .| . ..|..||..| .|| VQLGRQLGQG-AFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLR HCLTQMAKENRQQNVNVSSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPR-------LECKVADFG---LARRVN---------DDEEYIMMSR ..| ... ... . ....|.| ....|| .|........|||||||||.|.. . ||.|||| ..|||| ....| . .. SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ GRVPVRWMAPESLRHD-VYSTKSDVWSFAVLMWEILTLGARPYTGM .|.|.||||||.| | ..|||||||| |..|||.| |..|| || DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM |
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Kinase | TK10.AA | Tie | 251-459 | 42 | 4.8e-64 | 193.55 | In-house | 2-217 (267) | Show / Hide |
Range on Protein: 251-459 Range on HMM: 2-217/267 Sequence Identity: 42% (94 aa) GSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPNQSLRHCL---------TQMAK | || | . | ||.||... | . |. | || .| . ||||| |.| . | |. .|| | | | |. GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVG-ACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAR ENRQ-QNVNV----SSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEYIMMSRGRVPVRWMAPESLRHDVYSTKS |. ||| ||.|.|.| .|. |....||...||||||||.| . . ||.|||||.| || |. ||.|||||| ||| || ||| EHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKS DVWSFAVLMWEILTLGARPYTGM ||||. ||.|||..|| || || DVWSYGVLLWEIVSLGGTPYCGM |
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Kinase | TK10.AA | FGFR | 241-456 | 37 | 2.6e-63 | 214.63 | In-house | 1-239 (293) | Show / Hide |
Range on Protein: 241-456 Range on HMM: 1-239/293 Sequence Identity: 37% (91 aa) LHLTKNLIDGGSFGRVYRVEAVGIMEG--QDTTIVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPNQSLRHCLTQ | | | | | ||.| . ||.|| . . ...|||||| ...|| | . |. .| | |.|||.||| .| |.| |||. || | . LTLGKMLGE-GCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLG-CCTQEGPLYVIVEYCHHGNLRDFLRA ---MAKENRQQNV-------NVSSEQ-------------LLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEYIMMSRG ... .. ...| | .. |.|. || | .|..|||||||||| . . |..|||||| ... . | . | RRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNG RVPVRWMAPESLRHDVYSTKSDVWSFAVLMWEILTLGARPY | |. |||||.| || ..|||||. ||.|||.|.| || RLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPY |
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Kinase | TK10.AA | Src | 268-469 | 36 | 3.5e-58 | 196.24 | In-house | 21-214 (255) | Show / Hide |
Range on Protein: 268-469 Range on HMM: 21-214/255 Sequence Identity: 36% (75 aa) QDTTIVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAEDG-STYIIMEYCPNQSLRHCLTQMAKENRQQNVNVSSEQLLRFCVQIAKAM ...| |||| |. .. . | | ||| . |.....| | . .. ||. || . || | . ... ... .||. . |.|. | NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQL--YAVCSQEEPIYIVTEYMSHGSLLDYLKK-----DGEGRHLHLPQLIDMAAQVAEGM EHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVN-DDEEYIMMSRGRVPVRWMAPESLRHDVYSTKSDVWSFAVLMWEILTLGARPYTGMESGQVK . . .....|||||||||| | . |||||||||| . ||.|| . . ..|..|.||| ... ....||||||| .|..|| | | || ||. .| AYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVL MAVE .|| QQVE |
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Kinase | TK10.AA | KIN6 | 273-460 | 33 | 5.5e-55 | 180.06 | In-house | 47-255 (305) | Show / Hide |
Range on Protein: 273-460 Range on HMM: 47-255/305 Sequence Identity: 33% (70 aa) VAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPNQSLRHCLTQMAKENR-----------QQNVN-------VSSEQ .||||| |.. .. | | |. || .. .||. ... . ... ||| . | . | . .. . . .. . CAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGC-VTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKD LLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRL---ECKVADFGLARRVNDDEEYIMMSRGR-VPVRWMAPESLRHDVYSTKSDVWSFAVLMWEILT |. | .||. || ...| ..||||||||||. . ||. ||||.| .|. || |..|||||.|.| .|.||||||| |||.|. . LYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFS LGARPYTGME || || .|. LGDVPYPEMQ |
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Kinase | TK10.AA | RTKB | 351-465 | 49 | 1.2e-48 | 162.18 | In-house | 107-220 (264) | Show / Hide |
Range on Protein: 351-465 Range on HMM: 107-220/264 Sequence Identity: 49% (57 aa) SSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEYIMMSRGRVPVRWMAPESLRHDVYSTKS-DVWSFAVLMWEIL ...||. || |||. | . |....||||.|||||.. |.||..|||.|| . |.|.| | |..||||||. | |.||| ||||| | |||| KQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI-DHECYETTCT-RLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEIF TLGARPYTGMESGQVK .||. || . |... SLGGTPYQQYRNGDIF |
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Kinase | TK10.AA | Ret | 361-458 | 58 | 3.7e-47 | 159.1 | In-house | 143-240 (293) | Show / Hide |
Range on Protein: 361-458 Range on HMM: 143-240/293 Sequence Identity: 58% (57 aa) QIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEYIMMSRGRVPVRWMAPESLRHDVYSTKSDVWSFAVLMWEILTLGARPYTG || | | .. |.|||||||||||. . ||. |||| | | | |. |..|.|| |||.||| || |||||||| ||.||| |.|| || | QICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPG |
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Kinase | TK10.AA | VEGFR | 352-456 | 48 | 1.5e-42 | 147.72 | In-house | 172-278 (332) | Show / Hide |
Range on Protein: 352-456 Range on HMM: 172-278/332 Sequence Identity: 48% (52 aa) SEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARR-VNDDEEYIMMSR-GRVPVRWMAPESLRHDVYSTKSDVWSFAVLMWEIL .| |. . |.|. || | .|..||||||||.|| | |||||| .| | . || | .||||||.. ||.|.|||||..|..||| MEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIF TLGARPY .||. || SLGGSPY |
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Kinase | TK10.AA | Pkinase | 251-450 | 28 | 8.5e-39 | 138.27 | Pfam | 10-207 (293) | Show / Hide |
Range on Protein: 251-450 Range on HMM: 10-207/293 Sequence Identity: 28% (60 aa) GSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLDKD-SFTN--ELQIMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPNQ----SLRHCLTQMAKEN ||||.||. .| . ||||| .. . .. .|| . .. |.|||... .||||.||... ... |..||||.. .| . .. GSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST----- RQQNVNV--SSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLEC----KVADFGLARRVNDDEEYIMMSRGRVPVRWMAPESLR-HDVYSTKS ... .. | ... ... ||....|.. ...|.|||| |.|. . .. |..|||||. .. . |. . ..|||| .| . |..|. -WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV DVWSFAVLMWEILT |.||. ....| |. DMWSCGCILYEMLC |
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Kinase | TK10.AA | S_TKc | 242-485 | 22 | 4.1e-31 | 110.6 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 242-485 Range on HMM: 1-231/231 Sequence Identity: 22% (60 aa) HLTKNLIDGGSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAEDGSTYIIMEYCPN--QSLRHCLTQM ..| |.||.||.. .. . |||.|... ... .|.||... ||||..|... .. |..||||.. .|.. . .. YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR AKENRQQNVNVSSEQLLRFCVQIAKAMEHIAQKKIVHRDLAARNVLLGPRLECKVADFGLARRVNDDEEYIMMSRGRVPVRWMAPESLRHDVYST-KSDV .. . .. . . ... ||..|.|.. ...|.|||| |.|| . |..||||||.. . . .|||| | |.. |.|. GRHGL--RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW WSFAVLMWEILTLGARPYTGMESGQVKMAVETDIVMD------DFDGT--------D-------SEYM ||. ....| |. | |. . |. . .. . | ..| . ... WSCGCILYEMLC-GYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | TK10.AA | VEGFR | 241-328 | 35 | 3.5e-11 | 38.6 | In-house | 1-89 (332) | Show / Hide |
Range on Protein: 241-328 Range on HMM: 1-89/332 Sequence Identity: 35% (32 aa) LHLTKNLIDGGSFGRVYRVEAVGIMEGQDTTIVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIA--EDGSTYIIMEYCP |.| | | | || | .|.|| .. .|.|||||| || . . || .. | | | .|| | .|.|||. LKLGKMLGR-GAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCC |
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Kinase | TK10.AA | Ret | 241-333 | 34 | 6.5e-09 | 26.53 | In-house | 1-93 (293) | Show / Hide |
Range on Protein: 241-333 Range on HMM: 1-93/293 Sequence Identity: 34% (33 aa) LHLTKNLIDGGSFGRVYRVEAVGIMEGQDTTIVAVKMLRDS-ATDLDKDSFTNELQIMREIPCHPNIIRLLGYSIAED-GSTYIIMEYCPNQSLR | | . | | ||.| . | | | |||||| |. |.|. ... ||..|.|.| | .| | .| ||| .|| LQLDDTLGE-GHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLR |
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Kinase | TK10.AA | RTKB | 241-311 | 27 | 7.7e-07 | 19.12 | In-house | 1-69 (264) | Show / Hide |
Range on Protein: 241-311 Range on HMM: 1-69/264 Sequence Identity: 27% (20 aa) LHLTKNLIDGGSFGRVYRVEAVGIMEGQD-TTIVAVKMLRDSATDLDKDSFTNELQIMREIPCHPNIIRLLG ..| . | | || |.. | ... . ..|.| |. .| ... | |. .| |. |||.| ..| VWLGEKLGN-GAFGEVFQ--AWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIG |