Gene RETa (Sea Urchin)

RETa

Species: Sea Urchin
Alias: Spk284, SPU_000667, RETa
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
RETa.AA Protein None 1297 None Fasta, JSON
RETa.kin_dom Protein Kinase Domain None 293 None Fasta, JSON

Protein domain

Protein domains of RETa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RETa.AA TK-Unique 711-1003 44 4e-151 508.36 In-house 1-294 (294) Show / Hide 
Range on Protein: 711-1003
Range on HMM: 1-294/294
Sequence Identity: 44% (136 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCT-IQDPICLLVEH
..||||.|||||||| .| |.|..              ........||||||.. | ||.||.||.||..|||||.|||.|..|||||  ..| ... |.
LEVGDVIGEGAFGQVWRGEVWGIW--------------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEY

CYYGDLLHFLRNRRPQMFDQ-------FKTGRAPRTPSKDALRPLDLLSFARQIAMGMEYISQ--KGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDD
|..|.|.|.||..||.|...       |.....|..|..... | ||..|| |||.||||...  |..|||||.||||....||..||.|||..|.||..
CPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTN

KVYVNRRG-GKLPVKWMSLEAIY--DQIF-TTKGDVWSYGVVLFEIVTLGAAPYPGISNKDMPKLLKGGYRMEKPDNC-SPQIFSLMESTWCDDPELRPG
.||.. .. |..|..||..|...  .... |||.||||.||...||.|||| ||||...||. .... ||||..|..| |.....||.|.|...|| || 
GVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPS

FTEIRNKL
|..|...|
FRQIKHRL
Kinase RETa.AA Pkinase_Tyr 711-1003 43 6.4e-135 457.56 Pfam 1-270 (270) Show / Hide 
Range on Protein: 711-1003
Range on HMM: 1-270/270
Sequence Identity: 43% (130 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQ--KQEFLREIELMKELGYHPNVVSLLGCCT-IQDP--ICL
|. | .|||||||.| ||   |                   .... ||||||   | . |  ...|.||...||.||.|||.|.|.|.||  ..|  |..
ITFGKKLGEGAFGEVYKGTWKG----------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYI

LVEHCYYGDLLHFLRNRRPQMFDQFKTGRAPRTPSKDALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDDKVY-V
 .|.. .||||..||..|               ..|..| . |||....|||.|||| ..|...||||||||..|.... |||.||||.|..|.|  | .
VMEYMPHGDLLDYLRKHR---------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYR

NRRGGKLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLGAAP-YPGISNKDMPKLL-KGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRNK
 | |||||.|||..|.| . .|||| ||||.||...||.|.|. | |||.|| .. ... . ||||..|.||.. | .|| . |  ||| || |.||...
KRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ

L
|
L
Kinase RETa.AA TyrKc 711-1003 38 5.3e-131 442.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 711-1003
Range on HMM: 1-280/280
Sequence Identity: 38% (125 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQKQEFLREIELMKELG-YHPNVVSLLGCCTIQ-------DP
|. |..|||||||.| ||                          . ||||||.. |    ...|.||...|..||  |||.| |.|.|| |       .|
ITLGKKLGEGAFGEVYKGTWK-----------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEP

ICLLVEHCYYGDLLHFLRNRRPQMFDQFKTGRAPRTPSKDALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDD--
.....|.. .|||...||..||.                  | . |||||. ||| ||||...|...||||||||..|.... |||.||||.|..|||  
LMIVMEYMPHGDLKDYLRKHRPK------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQ

-----KVYVNRR--GGK--LPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLGAAPYPG-----ISNKDMPKLLKGGYRMEKPDN--------CSPQI
     ..|. .   |||  ||..||..|.| . .|||| ||||.||...|| |.|. ||||     .||... ...| ||||..|.|        |.. .
QGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM

FSLMESTWCDDPELRPGFTEIRNKL
...|.. |  ||| || |.||. ..
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase RETa.AA TK 711-1003 25 6.2e-121 407.37 In-house 1-486 (486) Show / Hide 
Range on Protein: 711-1003
Range on HMM: 1-486/486
Sequence Identity: 25% (123 aa)

IKVGDVLGEGAFG---QVLKGLVVGRIWSHQSSLSAIVP-----REATHGEHTVVAVKMLHKFAEDTQKQEFL----------------REIELMKE-LG
|..|..||||.||   .| ||.. ||. .. .  ..  .     .... |..| ||||||.. ....|...|.                .|...|.. ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

YHPNVVSLLGCCTIQ------------DPICLLVEHCYYGD----LLHFLRNRRPQMFDQFKTGR--------------------------APRTPSKD-
 |||.|.|.|.|| .             |.....|.. .||    |...||..|| ....  ..                            |. |... 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-----------ALRPLDLLS-------------------FARQIAMGMEYISQK------GFVHRDLAARNVMVADDKN-----------VKIGDFG---
           .|.  |||.                   ...||| ||||...|      .||||||||||..|.....           .||.|||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTRYVYDDKVYVNRR------------------------GGKLPVKWMSLEAIYDQI---------FTTKGDVWSYGVVLFEIVTLGAAPYPG-I
     |.|..|.|. |. ..                        |||||..||. |.. |..         |||| ||||.||...||.|.|..||.| .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------KDMPKLLKGG--------------YRMEKPDNCS--------------PQIFSLMESTWCDDPELRPGFTEIRNKL
||         ... ..|. |              .||..|..|.              . .. || . |  ||| || |......|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RETa.AA KIN6 711-1003 37 6.6e-113 374.52 In-house 1-305 (305) Show / Hide 
Range on Protein: 711-1003
Range on HMM: 1-305/305
Sequence Identity: 37% (116 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQDPICLLVEHC
|     ||.|||. | || ..| .  .|   ..    |.   ..  .||||| ..| .  ...|..||..|| ||.|| .|..||| |  .. ||.||.|
IHKDHKLGHGAFCNVYKGKIKGKSPIMQWINRVNMRIEMMRYQDCQCAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYC

YYGDLLHFLRNRRPQMF----------DQFKTGRAPRTPSKDALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDK---NVKIGDFGLTRYV
  .|||..||||.  |           ..     ..|      .|  ||..|| ||. ||||...|...||||||||| |         ||.|||| || 
CHMDLLKYLRNRCQYMMNLDDLGINYHCPDE---NSRYDDMMCIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYP

YDDKVYVNRRGGK-LPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLGAAPYPGIS-NKDMPKLLKGGYRMEKPDNCSPQIFSLMESTWCDDPELRPG
|.|.   . .||. ||.|||..|..    | .| ||||.||..||. .||  |||..    .|   ...| |...|..|. .|.  | | |  .|. || 
YMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPE

FTEIRNKL
|.|.|...
FNEMRMQF
Kinase RETa.AA FGFR 711-1003 40 7.3e-95 321.46 In-house 1-293 (293) Show / Hide 
Range on Protein: 711-1003
Range on HMM: 1-293/293
Sequence Identity: 40% (125 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQDPICLLVEHC
  .| .||||.|||| .. ..|           |..  .   . . |||||| . . |.      .|.| ||  | |.|.. |||||| . |   .|| |
LTLGKMLGEGCFGQVWMAEAKG-----------IDCDRPE--KEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYC

YYGDLLHFLRNRRPQMFDQFKTGR-----APRTPSKD-------ALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVY
  | |  ||| |||   |. | .       ||.|..         |   || |.| |.| ||||   .  .||||||||| | ||   || |||| | . 
HHGNLRDFLRARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIH

DDKVYVNRRGGKLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLGAAPYPGIS-NKDMPKLLKGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFT
.   |  .  | ||.||| .||  |...|.. ||||||| | || |.|  |||.|    .. |.|| |.||||| |||  |. .| . |   |. || |.
CIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFK

EIRNKL
..   |
QLVEYL
Kinase RETa.AA Src 748-1003 36 2e-82 279.86 In-house 17-255 (255) Show / Hide 
Range on Protein: 748-1003
Range on HMM: 17-255/255
Sequence Identity: 36% (94 aa)

EATHGEHTVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQDPICLLVEHCYYGDLLHFLRNRRPQMFDQFKTGRAPRTPSKDALRPL
...   .| |||| | .     . . ||.|...||.|  |...|.|.  |.  .||    |    | || .|..                ..   .|.  
MGYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----------------DGEGRHLHLP

DLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVY-DDKVYVNRRGGKLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLG
.|...| |.| ||.|.... ..||||||||| | ..  .|..|||| | .  || .|. | | |.|.||.  |||  . ||.| ||||.|. | |||| |
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYG

AAPYPGISNKDMPKLLKGGYRMEKPDNCSPQIFS-LMESTWCDDPELRPGFTEIRNKL
  |||| .|..  . .. |||| .|.|| ....  .|   |. ||| || |  ....|
RVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RETa.AA UTK 751-1003 34 2.1e-82 280.08 In-house 26-296 (296) Show / Hide 
Range on Protein: 751-1003
Range on HMM: 26-296/296
Sequence Identity: 34% (97 aa)

HGEHTVVAVKMLHKFAEDTQKQE----FLREIE---LMKELGYHPNVVSLLGCCTIQDPICLLVEHCYYGDLLHFLRNRRPQMFDQFKTGRAPRTPSKDA
|..  .|||| . . | ..|..|    |..|     .|| .  ||||. |.| || . |.....|..  |||...||. ||. .           .  ..
HMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP-----------ACPHW

LRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADD-------KNVKIGDFG---LTRYVY---------DDKVYVNRRGGKLPVKWMSLEAIYDQ
|.  ..|..|..|| ||.|....|||||||||||. |...         .||.|||   ..|.|.         ..  |  .  ...|..||. ||....
LTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH

-IFTTKGDVWSYGVVLFEIVTLGAAPYPGISNKDMPKLLKGG--YRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRNKL
  |||| ||||.|||..||.| |..||||.|| .  . .  |  |||..|. |. ... || . |  ||. || | ... ..
TRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RETa.AA Ret 848-1005 51 9.6e-78 264.59 In-house 136-293 (293) Show / Hide 
Range on Protein: 848-1005
Range on HMM: 136-293/293
Sequence Identity: 51% (82 aa)

DLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDDKVYVNRRGGKLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLGA
...||| ||  || |.|    |||||||||| ||. .  || |||||| || |  || |  ...|||||  |. || ..||| ||||.|| . ||||.||
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

APYPGISNKDMPKLLKGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRNKLEE
 |||||       ||| ||||. |.|||  ....|   | . |. || |  |   .| 
NPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase RETa.AA InsR 711-1005 37 6.7e-77 257.81 In-house 1-278 (278) Show / Hide 
Range on Protein: 711-1005
Range on HMM: 1-278/278
Sequence Identity: 37% (112 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATH-GEHTVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQDPICLLVEH
|  .  .|.|.|| |  |.           . .||| |.   |.   .|.| .   | .. . ||| | . |||   | .|| ||| |.   |     | 
IVLIRECGQGSFGMVYEGI-----------AKGIVPDEEWRFGR---CAIKTVNENASMRERIEFLNEASVMKEFNCH-HVVRLLGVCSRGQPMYVVMEM

CYYGDLLHFLRNRRPQMFDQFKTGRAPRTPSKDALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDDKVYVNRRGG
  ||||  .|| ||| . .     . ...  ..   . .... | .|. || |   | |||||||.|| ||..|  |||||||.|| .|.   |   ..|
MTYGDLKSYLRSRRPEEEF----NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG

KLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTLGAAPYPGISNKDMPKLL-KGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRNKLEE
.||| ||. | . | .|||. ||||.||||.|.||||. || | ||    |   ..|  ...|.||... . ||   |   | .|| |..| . | .
MLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase RETa.AA VEGFR 848-1003 46 3.4e-70 239.5 In-house 174-332 (332) Show / Hide 
Range on Protein: 848-1003
Range on HMM: 174-332/332
Sequence Identity: 46% (74 aa)

DLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRY-VYDDKVYVNRRG-GKLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEIVTL
||.... |.| |||. . .  .||||||||. .. .. ||| |||| |   |.|  || . . |.|| |||..|.| | ..||. |||||||.| || .|
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL

GAAPYPGIS-NKDMPKLLKGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRNKL
|. ||||.. . .  . || ||||..|| | |.|   | . |  .|| || | |   .|
GGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase RETa.AA PDGFR 843-1003 46 1.1e-60 193.45 In-house 197-358 (358) Show / Hide 
Range on Protein: 843-1003
Range on HMM: 197-358/358
Sequence Identity: 46% (76 aa)

ALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDDKVYVNRRGGKLPVKWMSLEAIYDQIFTTKGDVWSYGVVLFEI
.|   |||.|. |.| |||.   |  |||||||||| ..  | |||.|||| | .  |  || .    ||||||  | |.| ..||. ||||||. | ||
VLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEI

VTLGAAPYPGIS-NKDMPKLLKGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRNKL
 .||  ||||.  ..   |. | ||||..|.  .  |.. | . |  ||| || | ..   |
FSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase RETa.AA S_TKc 711-1007 21 3.1e-40 140.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 711-1007
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

IKVGDVLGEGAFGQVLKGLVVGRIWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQDPICLLVEHC
 ......|.||||.| |.  ..                     . .||.|...        . ..|||...|.   |||.| |....   | ...  |.|
YEILRKIGKGAFGKVYKCRHKK--------------------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYC

YY--GDLLHFLRNRRPQMFDQFKTGRAPRTPSKDALRPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNVKIGDFGLTRYVYDDKVYVNRRG
    |||......|...  ..              . . .  ....||. ..||. ..|..||||   |... .  ..||.|||| | .         . 
DGDLGDLFDYIKKRGRHGLRF-------------PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TT

GKLPVKWMSLEAIYDQIFTT-KGDVWSYGVVLFEIVTLGAAPYPGISNKDMPKLLKGGYRMEKPDNCSPQIFSLMESTWCDDPELRPGFTEIRN-----K
      .|. | .    ... | |.|| |..|.| .. |  |.|     .| ...|           ||.  ....  .. ||| ||.  |. .     |
FCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

LEEMM
. . .
CHPWF
Kinase RETa.AA Pkinase 711-893 25 3.9e-24 86.43 Pfam 1-158 (293) Show / Hide 
Range on Protein: 711-893
Range on HMM: 1-158/293
Sequence Identity: 25% (51 aa)

IKVGDVLGEGAFGQVLKGLVVGR-IWSHQSSLSAIVPREATHGEHTVVAVKMLHKFAEDTQK-QEFLR--EIELMKELGYHPNVVSLLGCCTIQDPICLL
...| ..|.|.||.| |.  .|  .                     .|||| . |  |. .| |. .|  ||..||.|. |||.| |.....  | |.. 
YHIGRKIGSGSFGCVYKCHHKGTGK---------------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMV

VEHCYYG----DLLHFLRNRRPQMFDQFKTGRAPRTPSKDAL--RPLDLLSFARQIAMGMEYISQKGFVHRDLAARNVMVADDKNV----KIGDFGL
 |.|  |    || ....                   .. ..   . .. ....||. |.||. ..|..||||   |... .. ..    ||.||||
MEYCEGGLYVMDLFDYIST-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL
Kinase RETa.AA PDGFR 757-826 44 2.6e-20 61.6 In-house 32-101 (358) Show / Hide 
Range on Protein: 757-826
Range on HMM: 32-101/358
Sequence Identity: 44% (31 aa)

VAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQDPICLLVEHCYYGDLLHFLRNRRPQM
||||||   |. . |.    |   |  || | |.| ||| ||.  || .  | | ||||| .|. .| ..
VAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHSF
Kinase RETa.AA VEGFR 755-823 38 2.5e-17 62.07 In-house 30-101 (332) Show / Hide 
Range on Protein: 755-823
Range on HMM: 30-101/332
Sequence Identity: 38% (28 aa)

TVVAVKMLHKFAEDTQKQEFLREIELMKELGYHPNVVSLLGCCTI---QDPICLLVEHCYYGDLLHFLRNRR
|.||||||   |    . . . |..... .| | |||..|||||.   . |    || | .| |. .||  |
TTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKR
Kinase RETa.AA Ret 755-823 44 1.3e-15 49.77 In-house 30-100 (293) Show / Hide 
Range on Protein: 755-823
Range on HMM: 30-100/293
Sequence Identity: 44% (32 aa)

TVVAVKMLHKF-AEDTQKQEFLREIELMKELGYHPNVVSLLGCCTIQD--PICLLVEHCYYGDLLHFLRNRR
| |||||| .  |        | | .| |..  ||.|. |.| |. .|  | || || | || |  |||  |
TTVAVKMLKRNTANSSEYHDLLSEFQLLKQVN-HPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLSR
Kinase RETa.AA Pkinase 927-1003 16 6.3e-11 39.72 Pfam 190-293 (293) Show / Hide 
Range on Protein: 927-1003
Range on HMM: 190-293/293
Sequence Identity: 16% (18 aa)

TTKGDVWSYGVVLFEIVTLGAAPYPGI----SNKDMPKLLKGGYRMEKPDNCS-----------------------PQIFSLMESTWCDDPELRPGFTEI
..| |.||.|..|.| .. |  |.||     .  |. ....   . . . ...                       .   ..... .| ||. ||....|
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

RNK--L
 .   .
LQHPWF
Kinase RETa.AA VEGFR 711-728 55 8e-06 18.24 In-house 1-18 (332) Show / Hide 
Range on Protein: 711-728
Range on HMM: 1-18/332
Sequence Identity: 55% (10 aa)

IKVGDVLGEGAFGQVLKG
.| | .||.||||||...
LKLGKMLGRGAFGQVHEA
Kinase RETa.AA Ret 711-728 55 4.6e-05 13.18 In-house 1-18 (293) Show / Hide 
Range on Protein: 711-728
Range on HMM: 1-18/293
Sequence Identity: 55% (10 aa)

IKVGDVLGEGAFGQVLKG
   .|.|||| ||||.|.
LQLDDTLGEGHFGQVVKA
Kinase RETa.AA UTK 711-728 50 0.00083 8.91 In-house 1-18 (296) Show / Hide 
Range on Protein: 711-728
Range on HMM: 1-18/296
Sequence Identity: 50% (9 aa)

IKVGDVLGEGAFGQVLKG
.. |. ||.||||.| |.
VQLGRQLGQGAFGEVHKA
Kinase RETa.AA PDGFR 711-728 44 0.004296 5.36 In-house 1-18 (358) Show / Hide 
Range on Protein: 711-728
Range on HMM: 1-18/358
Sequence Identity: 44% (8 aa)

IKVGDVLGEGAFGQVLKG
 . | .|| ||||.|  .
LQFGKTLGSGAFGKVVEA
Kinase RETa.AA Src 711-729 47 0.046606 2.73 In-house 1-19 (255) Show / Hide 
Range on Protein: 711-729
Range on HMM: 1-19/255
Sequence Identity: 47% (9 aa)

IKVGDVLGEGAFGQVLKGL
||  . ||.| || | .|.
IKLCRKLGQGQFGEVWMGY