Gene TK9 (Sea Urchin)

TK9

Species: Sea Urchin
Alias: SPU_000806, Spk269, TK9
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
TK9.AA Protein None 764 None Fasta, JSON
TK9.kin_dom Protein Kinase Domain None 272 None Fasta, JSON

Protein domain

Protein domains of TK9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF_2 TK9.AA EGF_2 16-43 33 5.7e-05 19.04 Pfam 1-29 (29) Show / Hide 
Range on Protein: 16-43
Range on HMM: 1-29/29
Sequence Identity: 33% (11 aa)

CSTGGCFN-GGTCA---NGICQCTEF-YTGEFC
|    | . .|||     |.|||.   ..|  |
C----CNGHHGTCNNQGCGKCQCDDGWWQGDHC
EGF TK9.AA EGF 16-42 30 0.000978 15.55 Pfam 1-36 (36) Show / Hide 
Range on Protein: 16-42
Range on HMM: 1-36/36
Sequence Identity: 30% (11 aa)

CSTG--GCFNGGTCANG----ICQCTEF---YTGEF
|.    .| ..||| ..     |||..    |||..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF TK9.AA EGF 15-44 36 0.069345 10.53 SMART 1-32 (32) Show / Hide 
Range on Protein: 15-44
Range on HMM: 1-32/32
Sequence Identity: 36% (13 aa)

TCSTGGCFNG-----GTCANGICQCT-EFYTGEFCE
 |.  .| .|     |||    | |  . |||  ||
ECA--PCHHGGCEQHGTCISYTC-CPGPGYTG-RCE
EGF TK9.AA EGF 50-80 30 1.9e-07 27.92 Pfam 1-36 (36) Show / Hide 
Range on Protein: 50-80
Range on HMM: 1-36/36
Sequence Identity: 30% (11 aa)

CSSG--VCQNGGTCIDSGTTAYCVCPQD---VTGVF
|..    |...|||.|.... .| ||.     || .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF TK9.AA EGF 49-82 35 3e-06 27.99 SMART 1-32 (32) Show / Hide 
Range on Protein: 49-82
Range on HMM: 1-32/32
Sequence Identity: 35% (14 aa)

MCSSGVCQNG-----GTCIDSGTTAYCVCP-QDVTGVFCE
 |.   |..|     ||||    . .| || .  ||  ||
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF_CA TK9.AA EGF_CA 46-82 42 0.000127 11.97 SMART 5-38 (34) Show / Hide 
Range on Protein: 46-82
Range on HMM: 5-38/34
Sequence Identity: 42% (17 aa)

DISMCSSGVCQNGG---TCIDSGTTAYCVCPQDVTGVFCE
||  |   .|||||   |||.     .| ||.  |   ||
DIDEC---PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE
EGF_2 TK9.AA EGF_2 50-81 26 0.000212 17.25 Pfam 1-29 (29) Show / Hide 
Range on Protein: 50-81
Range on HMM: 1-29/29
Sequence Identity: 26% (9 aa)

CSSGVCQN-GGTCIDSGTTAYCVCPQD-VTGVFC
|    |.. .|||... ..  |.|..   .|  |
C----CNGHHGTCNNQ-GCGKCQCDDGWWQGDHC
EGF TK9.AA EGF 86-132 28 1.8e-07 32.07 SMART 1-32 (32) Show / Hide 
Range on Protein: 86-132
Range on HMM: 1-32/32
Sequence Identity: 28% (15 aa)

ACFYGPCVNG-----GSCVPLPSSSTSAPTSTPDPGSYYCQCP-SGYSGYNCD
 |   || .|     | |.                 ||.| ||  ||.| .| 
ECA--PCHHGGCEQHGTCI-----------------SYTC-CPGPGYTG-RCE
EGF TK9.AA EGF 87-130 32 1e-06 25.2 Pfam 1-36 (36) Show / Hide 
Range on Protein: 87-130
Range on HMM: 1-36/36
Sequence Identity: 32% (16 aa)

CFYG--PCVNGGSCVPLPSSSTSAPTSTPDPGSYYCQCPSG---YSGYN
|.    || ..| ||..|             |.|.|||| |   |.| .
CNPNNNPCHHHGTCVDTP-------------GGYTCQCPPGYLGYTGKR
EGF_CA TK9.AA EGF_CA 87-132 34 0.002119 2.1 SMART 5-34 (34) Show / Hide 
Range on Protein: 87-132
Range on HMM: 5-34/34
Sequence Identity: 34% (17 aa)

CFYGPCVNGG---SCVPLPSSSTSAPTSTPDPGSYYCQCPSGYSGYNCD
|   || |||    |.  |             |||.| || ||.  .|.
C---PCQNGGPTGTCIN-P-------------GSYRC-CPPGYT-RHCE
EGF_2 TK9.AA EGF_2 120-131 46 0.701942 6.24 Pfam 17-29 (29) Show / Hide 
Range on Protein: 120-131
Range on HMM: 17-29/29
Sequence Identity: 46% (6 aa)

CQCPSG-YSGYNC
|||..| ..|  |
CQCDDGWWQGDHC
EGF_2 TK9.AA EGF_2 87-99 28 27.41145 1.26 Pfam 1-10 (29) Show / Hide 
Range on Protein: 87-99
Range on HMM: 1-10/29
Sequence Identity: 28% (4 aa)

CFYGPCVN-GGSCV
|    | . .|.|.
C----CNGHHGTCN
EGF TK9.AA EGF 137-169 34 8.1e-09 32.53 Pfam 1-36 (36) Show / Hide 
Range on Protein: 137-169
Range on HMM: 1-36/36
Sequence Identity: 34% (13 aa)

CIPD--PCLNNGVCTPGDGMPSYTCECTSG---FTGRD
| |.  ||...| |....  ..|||.|. |   .||..
CNPNNNPCHHHGTCVDTP--GGYTCQCPPGYLGYTGKR
EGF TK9.AA EGF 136-171 35 1.7e-08 35.5 SMART 1-32 (32) Show / Hide 
Range on Protein: 136-171
Range on HMM: 1-32/32
Sequence Identity: 35% (15 aa)

PCIPDPCLNN-----GVCTPGDGMPSYTCECT-SGFTGRDCE
.|   || ..     |.|.      |||| |   |.||  ||
ECA--PCHHGGCEQHGTCI------SYTC-CPGPGYTG-RCE
EGF_CA TK9.AA EGF_CA 137-171 39 0.000105 12.64 SMART 5-34 (34) Show / Hide 
Range on Protein: 137-171
Range on HMM: 5-34/34
Sequence Identity: 39% (15 aa)

CIPDPCLNNG---VCTPGDGMPSYTCECTSGFTGRDCE
|   || |.|   .|.      ||.| |  |.| | ||
C---PCQNGGPTGTCIN---PGSYRC-CPPGYT-RHCE
EGF_2 TK9.AA EGF_2 137-170 22 0.000327 16.66 Pfam 1-29 (29) Show / Hide 
Range on Protein: 137-170
Range on HMM: 1-29/29
Sequence Identity: 22% (9 aa)

CIPDPCLN-NGVCT-PGDGMPSYT---CECTSG-FTGRDC
|    | . .|.|  .       .   |.|..| ..| .|
C----CNGHHGTCNNQ-------GCGKCQCDDGWWQGDHC
Adeno_E3_CR2 TK9.AA Adeno_E3_CR2 182-221 32 5e-06 22.7 Pfam 1-39 (39) Show / Hide 
Range on Protein: 182-221
Range on HMM: 1-39/39
Sequence Identity: 32% (13 aa)

LSQTTIGIIAGSVAAVVIVVIIIIAIACCCCRKKRDDDKE
 ....|.||.. |....|..|| . .  || || |  .| 
IPKSMIAIIVA-VVVGMIIIIICMMCYACCYRKHRAHNKM
Kinase TK9.AA TK-Unique 272-353 44 3.5e-31 104.84 In-house 1-81 (294) Show / Hide 
Range on Protein: 272-353
Range on HMM: 1-81/294
Sequence Identity: 44% (37 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKT-IVAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDADTQNPPM
|......|.|.|  |...|. ||.... |. .|||| ||| ||. ||.|. ||......|..|||||..|||||. |  .|.|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWM
Kinase TK9.AA TK 272-353 26 8.9e-23 72.52 In-house 1-131 (486) Show / Hide 
Range on Protein: 272-353
Range on HMM: 1-131/486
Sequence Identity: 26% (35 aa)

LTLLNKLGSGSFA---DVYKAEALGII--------------------TKEQKTIVAVKRLK--DTATENDKSD--------------LSKELSLYMY-LD
.||..|||.| |    .|||.|. |..                    ....|| |||| ||  |....... |              .  |... .. | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNIVNILGCCTDADT---------QNPPM
 |||||...|.||. ..         | |.|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWM
Kinase TK9.AA Pkinase_Tyr 272-347 36 5.2e-22 75.17 Pfam 1-78 (270) Show / Hide 
Range on Protein: 272-347
Range on HMM: 1-78/270
Sequence Identity: 36% (29 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKRLKDTATEND--KSDLSKELSLYMYLDPHPNIVNILGCCT-DAD
.|.. |||.|.| .|||... |   ...|. |||| ||..|.. .  . |. .|... . |  |||||. .|.|| . .
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGE
Kinase TK9.AA FGFR 272-344 46 4.3e-21 68.6 In-house 1-75 (293) Show / Hide 
Range on Protein: 272-344
Range on HMM: 1-75/293
Sequence Identity: 46% (35 aa)

LTLLNKLGSGSFADVYKAEALGIITK--EQKTIVAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCT
|||   || | |  | .||| ||  .  |....|||| ||. .|. | |||  |.        |.||.| |||||
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCT
Kinase TK9.AA VEGFR 272-344 45 1.8e-14 51.12 In-house 1-73 (332) Show / Hide 
Range on Protein: 272-344
Range on HMM: 1-73/332
Sequence Identity: 45% (33 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCT
| |   || | |  | .|.| ||   |  |.||||.|| .||   .  |  || .   .  | | || |||||
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCT
Kinase TK9.AA PDGFR 272-344 45 4.5e-14 41.22 In-house 1-73 (358) Show / Hide 
Range on Protein: 272-344
Range on HMM: 1-73/358
Sequence Identity: 45% (34 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKTI-VAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCT
| .   |||| |  |  | | |.. |.| .. |||| || ||    |  |  ||    .| .| |||| || ||
LQFGKTLGSGAFGKVVEATAYGLS-KSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACT
Kinase TK9.AA Tie 281-343 37 4.8e-13 35.38 In-house 2-61 (267) Show / Hide 
Range on Protein: 281-343
Range on HMM: 2-61/267
Sequence Identity: 37% (24 aa)

GSFADVYKAEALGIITKEQKTI-VAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCC
| |  | ||     | |.   . ||.|..|. | |.|. |   || .   .  ||||.|..| |
GNFGQVMKA----MIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGAC
Kinase TK9.AA UTK 272-345 24 8e-12 36.74 In-house 1-81 (296) Show / Hide 
Range on Protein: 272-345
Range on HMM: 1-81/296
Sequence Identity: 24% (20 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKRLKDTATENDKSD----LSKELS---LYMYLDPHPNIVNILGCCTD
. |...||.| | .|.||..  .   ... .|||| .. .|. .....    . .|     ...... |||... .| ||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQ
Kinase TK9.AA CTKA 272-344 32 3.3e-09 26.92 In-house 1-79 (290) Show / Hide 
Range on Protein: 272-344
Range on HMM: 1-79/290
Sequence Identity: 32% (26 aa)

LTLLNKLGSGSFADVYKAEALGIIT--KEQK---TIVAVKRLKDTATENDKSDLSKELSLYM--YLDPHPNIVNILGCCT
.    |.|.| . .|..|   .     | |.   . |||| ||| ||| |      |  .     .. |||..  || ||
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFH-HPNVLRLLGVCT
Kinase TK9.AA Pkinase 272-345 32 1.9e-07 27.41 Pfam 1-71 (293) Show / Hide 
Range on Protein: 272-345
Range on HMM: 1-71/293
Sequence Identity: 32% (25 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKRLKDTATENDKSDLSK---ELSLYMYLDPHPNIVNILGCCTD
.... |.|||||. |||.   |        |||||..|   .. .|        |...   |  ||||| ......|
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED
Kinase TK9.AA Fer 272-317 29 3e-06 17.24 In-house 1-51 (283) Show / Hide 
Range on Protein: 272-317
Range on HMM: 1-51/283
Sequence Identity: 29% (15 aa)

LTLLNKLGSGSFADVYKAE-ALGIITKEQKT----IVAVKRLKDTATENDK
 || .|||.| | .|||.. .| .. . . .     |.||..| ...  ..
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQ
Kinase TK9.AA Src 272-347 25 1.5e-05 14.78 In-house 1-67 (255) Show / Hide 
Range on Protein: 272-347
Range on HMM: 1-67/255
Sequence Identity: 25% (19 aa)

LTLLNKLGSGSFADVYKAEALGIITKEQKTIVAVKRLKDTATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDAD
..|. |||.| | .|...      .  ..| |||| ||      .  .. .|  .   |. |...|...  |.. .
IKLCRKLGQGQFGEVWMG------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEE
Adeno_E3_CR2 TK9.AA Adeno_E3_CR2 357-396 32 8e-06 22.02 Pfam 1-39 (39) Show / Hide 
Range on Protein: 357-396
Range on HMM: 1-39/39
Sequence Identity: 32% (13 aa)

LSQTTIGIIAGSVAAVVIVVIIIIAIACCCCRKKRDDDKD
 ....|.||.. |....|..|| . .  || || |  .| 
IPKSMIAIIVA-VVVGMIIIIICMMCYACCYRKHRAHNKM
Kinase TK9.AA TK-Unique 447-721 50 1.2e-157 530.0 In-house 1-294 (294) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-294/294
Sequence Identity: 50% (148 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKT-IVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSD-PWYIIMEYLPNNNLQGYLRQIR
|......|.|.|  |...|..||.....|. .|||| ||. ||. ||.|. ||......|..|||||..|||||.|| ||.|||||.|. |||.|||. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

TG--ES-------MTADYRNVKKQKD-IPPNDLLTFGVQIARGMEYLAS--RQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTYEMK-SQGRVPV
 .  ..       ....... |.... | | ||..|..|||.|||||||  ....||||.|||.||.|..|||..|||.|||..... |.|. ||||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMSPESLL--HNTY-TSQSDVWSFAILIWEIVTLGSHPYPGMSSKQVVKEISAGYRLPKPEHC-SQDIYNLMKECWAYEAEERPTFSQVKVRL
|||.||||.  |..| |..||||||..|.|||.|||..|||||..|.....| .|||.|.|||| |...|||||.|| .|.||||.|.|.| ||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TK9.AA Pkinase_Tyr 447-721 44 4.3e-131 444.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-270/270
Sequence Identity: 44% (125 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATEND--KSDLSKELSLYMYLDPHPNIVNILGCCT-DSDP--WYIIMEYLPNNNLQGYLR
.|.  |||.|.| .|||... |   ...|. |||| |||.|.. .  . |. .|... . |  |||||. .|.|| ...|  .||.||| |. .|  |||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QIRTGESMTADYRNVKKQKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTY-EMKSQGRVPVRWMSPESLL
. |              .. ... ||| . .|||.|||||.|..||||||||||.|..|. |.|..|||||||...  .|  ... |..|..||.||.. 
KHR------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

HNTYTSQSDVWSFAILIWEIVTLGSHP-YPGMSSKQVVKEI-SAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRL
.. .|..|||||| .|.|||.|.|  | |||||  .|.. |   |||.|.||.|...||.|||.||.|..|.|||||..  .|
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TK9.AA TyrKc 447-721 39 4e-129 436.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-280/280
Sequence Identity: 39% (120 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYMYL-DPHPNIVNILGCCTDS-------DPWYIIMEYLPNNNLQG
.||  |||.| |  |||...         . |||| ||| |    . |. .|... . |   |||||...|.||..       .| .|.||| |. .|. 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRQIRTGESMTADYRNVKKQKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDG-------QTYEMKS--QGR-
|||  |                 ... ||| | .|||.|||||.|..||||||||||.|.||....|.|||||.||..|.       ..| .|.  .|. 
YLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-VPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPG-----MSSKQVVKEISAGYRLPKPEH--------CSQDIYNLMKECWAYEAEERPTF
 .|.|||.||.. ....|..|||||| ...||| |.|  ||||     || ..|.. . .|||.|.|..        |....|..||.||....|.||||
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

SQVKVRL
|... ..
SEIHECF
Kinase TK9.AA TK 447-721 25 2.9e-122 411.93 In-house 1-486 (486) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-486/486
Sequence Identity: 25% (125 aa)

LTLFNKLGSGSFA---DVYKAEAVGII--------------------TKEEKTIVAVKRLKETATENDKSDLS----------------KELSLYMY-LD
.|| .|||.| |    .|||.|. |..                    ....|| |||| |||.......  .                  |... .. | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNIVNILGCCTDS------------DPWYIIMEYLPNNN----LQGYLRQIRTG------------------------------ESMTADYRNVKKQK
 |||||...|.||..             ||.|.||| |. .    |. |||. | .                              ... .... . .|.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

D-------------------------------IPPNDLLTFGVQIARGMEYLASR------QCIHRDLAARNILLGEGYV-----------CKVSDFG--
.                               ... .|| . .|||.|||||.|.      ...||||||||.|.||..|           ||..|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARDLEDGQTYEMKS------------------------QGRVPVRWMSPESLL---------HNTYTSQSDVWSFAILIWEIVTLG-SHPYPG
      ||||..... |  ||                        .|..|.|||.||.|.         ....|..|||||| .|.|||.|.|   .|.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

MSS---------KQVVKEISAG--------------YRLPKPEHCS--------------QDIYNLMKECWAYEAEERPTFSQVKVRL
||.         ..|.. . .|              .|.|.|.||.              ...| ||..||.|..|.||||||.. .|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TK9.AA FGFR 447-721 43 1.3e-109 370.44 In-house 1-293 (293) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-293/293
Sequence Identity: 43% (126 aa)

LTLFNKLGSGSFADVYKAEAVGIITK--EEKTIVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGYLRQIR
|||   || | |  | .|||.||  .  |....|||| ||. .|. | |||  |.        |.||.| |||||   | |.| || .  ||  .||. |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

TGE-SMTADYR-------NVKKQK-------DIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTYEMKSQGRV
 ..     |             |.       ..   ||  .  |.|||||||||| ||||||||||.| ...|| |..|||||||  .   |  .. || 
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPGMS-SKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRL
|. || ||.|  . ||.||||||. .|.||| |.|  |||.     .  |    |.|. ||..|||.|| .| .||  ....|||| |.   |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TK9.AA UTK 447-721 33 2e-103 349.92 In-house 1-296 (296) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-296/296
Sequence Identity: 33% (103 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSD----LSKELS---LYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGY
. | ..||.| | .|.||... .   ... .|||| ....|. .....    . .|     ...... |||... .| ||.. ||.|..|| .| .|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRQIRTGESMTADYRNVKKQKDIPPND-LLTFGVQIARGMEYLASRQCIHRDLAARNILLGEG-------YVCKVSDFG---LARDLE---------DGQ
||  |              . ..  .. .| . ..|||||.||.|....||||||||.|...        .|||..|||   ..|..          . .
LRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESY

TYEMKSQGRVPVRWMSPESLLHN-TYTSQSDVWSFAILIWEIVTLGSHPYPGMSSKQVVKEISAG--YRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQ
 | . .|.|.|.|||.||.| |. ..|..|||||| .. |||.| |. ||||||  ||......|  ||.|.|..|. ..|.||..||.|. .|||.| .
YYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFED

VKVRL
.  ..
LVQQM
Kinase TK9.AA Src 447-721 35 3.8e-96 325.71 In-house 1-255 (255) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-255/255
Sequence Identity: 35% (98 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGYLRQIRTG
..|  |||.| | .|...      .   .| |||| ||.     .  .. .|  .   |. |...|...  |.. .| ||. ||  ...|. ||..    
IKLCRKLGQGQFGEVWMG------YWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLR-HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

ESMTADYRNVKKQKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDG-QTYEMKSQGRVPVRWMSPESLLHNTYT
          .. . .. ..|. .. |.|.||.|| |.. |||||||||.| ||. |||| |||||| ....   |....  ..|..|. || ......|
---------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFT

SQSDVWSFAILIWEIVTLGSHPYPGMSSKQVVKEISAGYRLPKPEHCSQDIYN-LMKECWAYEAEERPTFSQVKVRL
  |||||| ||..|||| |  |||||. ..|......|||.|.|..| . .|. .|..||  ..|.||||      |
IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TK9.AA Tie 456-721 42 2.5e-92 281.26 In-house 2-267 (267) Show / Hide 
Range on Protein: 456-721
Range on HMM: 2-267/267
Sequence Identity: 42% (116 aa)

GSFADVYKAEAVGIITKEEKTI-VAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGYLRQIRTGESMTADYR
| |  | ||     | |.   . ||.|..|| | |.|. |   || .   .  ||||.|..| | .    |. .|| |  ||  .||. |. |.  |  |
GNFGQVMKA----MIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAR

NVKK------QKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTYEMKSQGRVPVRWMSPESLLHNTYTSQS
.            .  . .| |   .||||.||. .||||||||||||| .| ||||..||||.|  |    |  |  ||.|||||  |||    || .|
EHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDE---VYVKKTMGRLPVRWMAIESLNYSVYTTKS

DVWSFAILIWEIVTLGSHPYPGMSSKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRL
||||. .|.||||.||  || ||   .. . .  |||. .|  |  ..|.||..||     |||.|.|. |.|
DVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase TK9.AA Fer 447-722 34 3.2e-86 292.77 In-house 1-283 (283) Show / Hide 
Range on Protein: 447-722
Range on HMM: 1-283/283
Sequence Identity: 34% (103 aa)

LTLFNKLGSGSFADVYKAE-----AVGIITKEEKTIVAVKRLKET-ATENDKSDLSKELSLYMY-LDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGY
 || .|||.| | .|||..       |     .|. |.||..|.. ||.  . .. .|  . .  .| |||.| . | |.|  | .|.||. .. .|. |
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD-HPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LRQIRTGESMTADYRNVKKQKD-IPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGE-GYVCK--VSDFGLARD-LEDGQTYEMK-SQGRVPVRW
|.               |.... .. |... .  |.|.||||| |..|||||.||||.|... . ..|  .||||..|.  ..| .|.||  . .||.||
LK---------------KNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRW

MSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPG----MSSKQV----VKE-ISAGYRLPKPEHCSQDIYNLMK-ECWAYEAEERPTFSQVKVRLE
..||..   .|.. .||||| ...||| | | .||||    |  ..|    .|  | .||..| |.|.  .|...|.  ||... |.|||..... .|.
LAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase TK9.AA PDGFR 566-721 52 3.4e-75 240.76 In-house 202-358 (358) Show / Hide 
Range on Protein: 566-721
Range on HMM: 202-358/358
Sequence Identity: 52% (82 aa)

DLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTYEMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGS
||| |  |.|.|||.|||  |.||||||||.|| .| | |. |||||||      |  |   | || || |||.  . || ||||||. || ||| .||.
DLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGG

HPYPGMS-SKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRL
 |||||   ..  | |  |||  .|.| ...||  |..||. . | ||||.|.   |
NPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase TK9.AA VEGFR 566-721 49 9.1e-72 244.73 In-house 174-332 (332) Show / Hide 
Range on Protein: 566-721
Range on HMM: 174-332/332
Sequence Identity: 49% (78 aa)

DLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARD-LEDGQTYEMKSQ-GRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTL
||. .  |.|||||.|||| ||||||||||||| | .| | .||||||. . ..  |  | . || | .||.|||.  . ||..|||||.... ||| .|
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSL

GSHPYPGMS-SKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRL
|  |||| .      . . .|||. .|. | . ||  | .||  | ||||.||   ..|
GGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase TK9.AA CTKA 573-721 44 3.1e-69 231.77 In-house 139-290 (290) Show / Hide 
Range on Protein: 573-721
Range on HMM: 139-290/290
Sequence Identity: 44% (67 aa)

QIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDG-QTYEMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSHPYPGM
||| ||.|||..  .|||||.||.||| . . |..|||..| |. . | | . ||.. |||||.|| |  ......||||.| .|.||| . |  |. .|
QIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHM

SSKQVVKEISAG--YRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRL
| . |.. . ..   ||| |  | | .| .|.|||  |  .|||| ...  |
SDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase TK9.AA Pkinase 447-721 23 7.4e-47 166.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 447-721
Range on HMM: 1-293/293
Sequence Identity: 23% (76 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSK---ELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNN----NLQGY
...  |.|||||. |||.  .|        |||||..|   .. .|        |...   |  ||||| ......|.|  |..|||...      |  |
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRQIRTGESMTADYRNVKKQKDI--PPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVC----KVSDFGLARDLEDGQTYEMKSQGRVPVRW
..               .... .  .....  .  ||.||.||. |. .|||||   |||. . ...    |..|||||. ..    ..  .   .  ..
IST--------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWY

MSPESLL-HNTYTSQSDVWSFAILIWEIVTLGSHPYPGM------SSKQVVKEISA-GYRLPKPEHCS-------------------QDIYNLMKECWAY
|.|| .. .. |.. .|.||. ....| .. |  |.||       . .|....|    .. . |. ||                   ..   ..| |...
MAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

EAEERPTFSQVKVR--L
  ..|||. |..    .
DPKKRPTAEQILQHPWF
Kinase TK9.AA S_TKc 447-725 24 3.8e-45 157.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 447-725
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPN--NNLQGYLRQIR
 .. .|.|.|.|. |||.  ..      . |||.|..|         .. .|... .    |||||...... | |  |..|||...   .|  |... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

TGESMTADYRNVKKQKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSDFGLARDLEDGQTYEMKSQGRVPVRWMSPESLLHNTY
..          .... .|. .   .  ||....||. |.. |||||   |||| |  . |..|||||| |         .   .   .|.|| |    |
RH----------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GY

TS-QSDVWSFAILIWEIVTLGSHPYPGMSSKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKV-----RLENML
.   .|.||. ....| .. |  |.|    ... | |            |..  .... |. .. |.|||  ..       ..   .
GKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TK9.AA VEGFR 447-544 43 1.2e-19 70.89 In-house 1-101 (332) Show / Hide 
Range on Protein: 447-544
Range on HMM: 1-101/332
Sequence Identity: 43% (44 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCT---DSDPWYIIMEYLPNNNLQGYLRQI
| |   || | |  | .|.|.||   |  |.||||.|||.||   .  |  || .   .  | | || |||||      |  .|.|| .  ||. |||  
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

R
|
R
Kinase TK9.AA PDGFR 447-530 45 2e-19 58.72 In-house 1-84 (358) Show / Hide 
Range on Protein: 447-530
Range on HMM: 1-84/358
Sequence Identity: 45% (38 aa)

LTLFNKLGSGSFADVYKAEAVGIITKEEKTIVAVKRLKETATENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEY
| .   |||| |  |  | | |..  .    |||| ||.||    |  |  ||    .| .| |||| || || . | ||| ||
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEY
Kinase TK9.AA CTKA 447-541 31 4.8e-16 50.28 In-house 1-101 (290) Show / Hide 
Range on Protein: 447-541
Range on HMM: 1-101/290
Sequence Identity: 31% (32 aa)

LTLFNKLGSGSFADVYKAEAVGIIT-----KEEKTIVAVKRLKETATENDKSDLSKELSLYM--YLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGY
.    |.|.| . .|..|   .        .   . |||| ||. ||| |      |  .     .. |||..  || || . ||. |||...   |. |
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFH-HPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCY

LR
||
LR