Gene TK1 (Sea Urchin)

TK1

Species: Sea Urchin
Alias: Spk249, SPU_026272, TK1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Sp1

Sequence

Name Sequence Type Origin Length Description Download
TK1.AA Protein None 806 None Fasta, JSON
TK1.kin_dom Protein Kinase Domain None 319 None Fasta, JSON

Protein domain

Protein domains of TK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TK1.AA TK-Sp1 411-680 84 8.99999999999e-244 816.13 In-house 1-270 (270) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-270/270
Sequence Identity: 84% (227 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHFLWKCRED
|||||||||||||||||||||||||||||||||||||||||||||.||||||||||..|||||.|||||||||||||.|.|||.||||||||||||||||
LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMKEDFLNEIKLMFELGQHPHILQIIGCCTVHEPHYMITEMMKYGDLLHFLWKCRED

KYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGYKRLAPDKKRPVKWVSLETNTIGRCTIQSDVW
|..|||.|.|||...|.||||||.||||||.|||||||||||||||||.||..|.|||||||||||.|||||||..|||||||||||||.|.||||||||
KHIRQDPIYDLTDTQQYQICRQIARGMEYISKTRYYHGDLAARNVLVGKGLMCKISDFGLADDIYQRGYKRLAPERKRPVKWVSLETNTQGKCTIQSDVW

SFGIVMYEIYTLGGVPYPGMDGREIISKLQEGYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRL
|||||||||||.||.|||||||||.|||||.||||.|||.|||||||.|.||||..|..||||..||...
SFGIVMYEIYTNGGMPYPGMDGREVISKLQDGYRMEKPDNCPEDVYDMMRACWHEHPHHRPTFKNIFNFF
Kinase TK1.AA Pkinase_Tyr 411-680 44 1.2e-121 412.57 Pfam 1-270 (270) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-270/270
Sequence Identity: 44% (125 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGM--EEDFLNEIKLMIDLGQHPNILQIIGCCT-VHEP--NYLITEYMKYGDLLHFLW
... |.||.|.|| |||. ..|  . .. .|||||.|. .|..     |||..|.|.|  ||.||||.. .|.||   ||   |...|||..||||..| 
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KCREDKYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGYK-RLAPDKKRPVKWVSLETNTIGRCT
| |       ..   ||    ||.|.||..||||    .. | ||||||.||.|.. ||..||||| |||  .|  | . . | |.|| ..|    |..|
KHR-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT

IQSDVWSFGIVMYEIYTLGGVP-YPGMDGREIISKL-QEGYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRL
..|||||||..|.||.|.|. | ||||.  |.. .. ..|||||.|. ||...||.|| |||..|..||||. |  .|
TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TK1.AA TyrKc 411-680 39 8.3e-120 405.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-280/280
Sequence Identity: 39% (118 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLG-QHPNILQIIGCCTVH-------EPNYLITEYMKYGDLLH
.. .|.|| |.||.|||. .         ..||||.|. .|    .|||..|...|  || .||||....|.|| .       || ....|||..|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLWKCREDKYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQS-------GYKRLA--PDKK--RPVK
.| |.|..          |. .  |..| ||..||||. . .. | ||||||.||||.. ||.|||||. |||          |.| .   ..|   |..
YLRKHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

WVSLETNTIGRCTIQSDVWSFGIVMYEIYTLGGVPYPG-----MDGREIISKLQEGYRMPKPDQ--------CPEDVYDIMKACWHANPSERPTFTTIFK
| ..|.   |..|..|||||||..|.||.|.|. ||||     |. .|.| ....|||||.|.         ||...|.||| |||..|..||||..| .
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

RL
..
CF
Kinase TK1.AA TK 411-680 24 4e-115 387.56 In-house 1-486 (486) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)

LKIEKELGAGQFG---IVYKAFAFGLN--------------------GIKEYVPVAVKSLRVNATPGMEEDFL----------------NEIKLMID-LG
....|.||.||||    |||. ..|.|                    . .. .||||| |.  ..  .|| |.                .|.|.|   ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNILQIIGCCTVH------------EPNYLITEYMKYGD----LLHFLWKCREDKYRRQDSIF-----------------------------------
.||||....|.|| .            || ....|||..||    |...|.|||...   ||..                                    
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------DLTQANQLQ-------------------ICRQISRGMEYIFKT------RYYHGDLAARNVLVGEGLE-----------VKVSDFG----
          .||.. .||                   .|.||..||||. .       .. |.||||||.||||..            .|..|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LADDIYQSGYKRLAP------------------------DKKRPVKWVSLETNT---------IGRCTIQSDVWSFGIVMYEIYTLG-GVPYPGMD
    || |||.... . .                         . | |..| . |. .          |..|..|||||||..|.||.|.| . .|.||.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

G---------REIISKLQEG--------------YRMPKPDQCP--------------EDVYDIMKACWHANPSERPTFTTIFKRL
          .|.. .|..|              .|||.|..||              |..||.|. |||..|..||||... ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TK1.AA TK-Unique 411-680 38 1.1e-102 347.42 In-house 1-294 (294) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-294/294
Sequence Identity: 38% (112 aa)

LKIEKELGAGQFGIVYKAFAFGLN-GIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVH-EPNYLITEYMKYGDLLHFLWKCR
|......| |.|| |... ..|.. .  . . |||| |. |||.  . |||.||..|  ||.||||.|..||||   || ..| ||. .|.|.|.|..||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

EDKYRR-------------QDSIFD--LTQANQLQICRQISRGMEYIFKTRY--YHGDLAARNVLVGEGLEVKVSDFGLADDIYQ-SGYKRLAPDKKRPV
 .. .               |. ..  ..    .... || .||||. . |.   |.||.|||||..|....|..|||.|.|.|    | .    .. |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWVSLETNT--IGRC-TIQSDVWSFGIVMYEIYTLGGVPYPGMDGREIISKLQEGYRMPKPDQC-PEDVYDIMKACWHANPSERPTFTTIFKRL
.| ..|      | . |..|||||||..|.|| |||. |||||. ..|. ....|||||.|..| ....| .|| ||. .|.|||.|..| .||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TK1.AA Src 411-680 39 3.9e-93 315.73 In-house 1-255 (255) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-255/255
Sequence Identity: 39% (110 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHFLWKCRED
.| ...||.|||| |...        .  ..||||.|.        |.|| |...|  | .|....|.   |.  || | .||||. | || .| |    
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

KYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLA------DDIYQSGYKRLAPDKKRPVKWVSLETNTIGRCT
    ..    |   ... .  |...||.|. . .| | |||||||||||.. .|| |||||      ||.| .       . | |.||   |  . || |
----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH-----GAKFPIKWTAPEAINYGRFT

IQSDVWSFGIVMYEIYTLGGVPYPGMDGREIISKLQEGYRMPKPDQCPEDVYD-IMKACWHANPSERPTFTTIFKRL
| |||||||| ..|| | | ||||||. .| . ... |||||.|..||. .|. ||. |||. | .|||| .... |
IKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TK1.AA UTK 411-680 33 9.8e-87 294.46 In-house 1-296 (296) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-296/296
Sequence Identity: 33% (101 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNAT-PGMEE---DFLNEIK---LMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHF
... ..||.|.||.|.|| .   ... . . |||| ... |. .  .|   ||..| .   .|  .  |||.|. .| ||  || ...||||. |||...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LWKCREDKYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEG-------LEVKVSDFG---LADDIY---------QSGYKRLAP
| ..|..     .  . ||   .|. ...|.|||.|.   .. |.||||||.||..        . .|..|||   .. ...         .| | . ..
LRRHRPTPP---ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

DKKRPVKWVSLETNTIG-RCTIQSDVWSFGIVMYEIYTLGGVPYPGMDGREIISKLQEG--YRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRL
... |..| . |  | . | |..|||||||.|..||.| | .|||||  ....  . .|  ||||.|..||..||..|..|||..|.|||.| .. ...
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase TK1.AA FGFR 411-680 37 7.3e-74 251.13 In-house 1-293 (293) Show / Hide 
Range on Protein: 411-680
Range on HMM: 1-293/293
Sequence Identity: 37% (110 aa)

LKIEKELGAGQFGIVYKAFAFGLNGI--KEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHFLWKCR
| . | || | || | .| |.|.     .. . |||| |  |.|     |   |.  |   |.|.||.  .||||   | | | || . | |  || . |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

--EDKYRRQDS------------------IFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGYKRLAPDKKR
  . .|..  .                  | .|||    ..  |. |||||    .  | |||||||||... . |..||||| || .  | |   .   
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWVSLETNTIGRCTIQSDVWSFGIVMYEIYTLGGVPYPGMD-GREIISKLQEGYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRL
|.||  .|       | ||||||.|. . || |.|| |||.     |. . |.||.|| || .|....| .|  |||..|..||||...   |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase TK1.AA Frk 411-684 38 1.7e-73 250.44 In-house 1-260 (260) Show / Hide 
Range on Protein: 411-684
Range on HMM: 1-260/260
Sequence Identity: 38% (105 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHFLWKCRED
... ..||.|||| |.             .||||| |.  .     .||| | ..| .| .|| ..|.   ||| || |.||| |. | |...|      
IQLIRRLGSGQFGEVWEGL------WNNTTPVAVKTLKPGTM--DPNDFLREAQIMKKL-RHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAI---

KYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGY--KRLAPDKKRPVKWVSLETNTIGRCTIQSD
   .. .   ..|  ....  |.  || |. .  | | |||||||||||.. .|. |||||  . .          . . |.||   |     . ||.||
--NDKGRQCQMQQ--LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSD

VWSFGIVMYEIYTLGGVPYPGMDGREIISKLQEGYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRLDDML
||||||...|| | | .||||| ..|..  ...|||||.|  ||. .|.||  |||..| .|||| |.  .|.| .
VWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase TK1.AA SFK-Src 532-684 42 2.4e-62 183.34 In-house 104-259 (259) Show / Hide 
Range on Protein: 532-684
Range on HMM: 104-259/259
Sequence Identity: 42% (67 aa)

QISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGY----KRLAPDKKRPVKWVSLETNTIGRCTIQSDVWSFGIVMYEIYTLGGVPY
|.  || |     . | ||||||||||.   .|| |||..  . |       . .|   | |.||   |  .. |  | |||||||| |.|| |.| .||
QVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGA---KFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMDGREIISKLQE--GYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRLDDML
|||   |.. ..    |||||.|  ||.  | || .||  .|..|||| .   ...|  
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase TK1.AA Src-Unclassified 532-680 44 3.8e-60 204.92 In-house 127-284 (284) Show / Hide 
Range on Protein: 532-680
Range on HMM: 127-284/284
Sequence Identity: 44% (72 aa)

QISRGMEYIFKTRYYHGDLAARNVLVGEGL-----EVKVSDFGLA------DDIYQSGYKRLAPDKKRPVKWVSLETNTIGRCTIQSDVWSFGIVMYEIY
|. .||.|    .| | ||||||||.|.       .||| |||||      ||.|    ..   . . |.||   |  . |  .| |||||.||  .|| 
QVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCM--RT---GAMFPWKWMAPECFIYGNFSIKSDVWSYGILLWEIM

TLGGVPYPGMDGREIISKLQEGYRMPKP--DQCPEDVYD-IMKACWHANPSERPTFTTIFKRL
|.| .|||||. || .  .  |||||||    ||. .|. ||| |||. |  |||| | .. .
TKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase TK1.AA VEGFR 532-680 43 1e-53 184.8 In-house 181-332 (332) Show / Hide 
Range on Protein: 532-680
Range on HMM: 181-332/332
Sequence Identity: 43% (66 aa)

QISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADD-IYQS-GYKRLAPDKKRPVKWVSLETNTIGRCTIQSDVWSFGIVMYEIYTLGGVPYPG
|. ||||.       |.||||||.|. |   || .||||| . ||.   |.|     . | || ..|.      |..|||||.|... || .|||.||||
QVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPG

MD-GREIISKLQEGYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFKRL
 .   | ...| .|||| .|| |.  .|.||  ||| .| |||.|    ..|
VQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase TK1.AA S_TKc 411-684 20 9.1e-33 116.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 411-684
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKY--GDLLHFLWKCR
 .| ...| | || |||.   .         ||.| ..        |....||...    .|||| ......   .  |...||.    |||....   .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI---K

EDKYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEVKVSDFGLADDIYQSGYKRLAPDKKRPVKWVSLETNTIG-------
. .... .. |.  .|    ...|| ...||. . .  | ||   |.|. |  ..|..|||||  .                      |  .|       
KRGRHGLRFPFPE-HA--RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAP

---RCTI-QSDVWSFGIVMYEIYTLGGVPYPGMDGREIISKLQEGYRMPKPDQCPEDVYDIMKACWHANPSERPTFTTIFK-----RLDDML
     .   .|.||.|...|| .. |  |.|  .  ... |.            .... |... |.. .|..|||   ...     ...  .
EVLGYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TK1.AA SFK-Src 411-504 45 1.2e-20 57.41 In-house 1-85 (259) Show / Hide 
Range on Protein: 411-504
Range on HMM: 1-85/259
Sequence Identity: 45% (43 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLLHFL
 . || ||.|||| |.|      |.  |   |||| |.  |.   .| ||.|  .|  | .|||  |    ||  || | ||| |||| || .|
IRLEKKLGSGQFGDVWKGR---WNNTTE---VAVKTLKPGAM--SAEEFLQEAQVMKKL-RHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYL
Kinase TK1.AA VEGFR 411-504 37 3.4e-19 69.17 In-house 1-97 (332) Show / Hide 
Range on Protein: 411-504
Range on HMM: 1-97/332
Sequence Identity: 37% (36 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGMEEDFLNEIKLMIDLGQHPNILQIIGCCTV--HEPNYL-ITEYMKYGDLLHFL
||. | ||.| || | .| |||... .    |||| |  .||       . |.|..| .|.| |     ||||     . .. | || ..| |. .|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYL
Kinase TK1.AA Pkinase 411-571 26 3.4e-15 54.8 Pfam 1-159 (293) Show / Hide 
Range on Protein: 411-571
Range on HMM: 1-159/293
Sequence Identity: 26% (45 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLR-VNATPGMEEDFLN--EIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYG----DLLHF
..|.. .|.| || |||.   | .       |||| .. ... .....  ..  ||..|  | .||||........ .   |...||.  |    || ..
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LWKCREDKYRRQDSIFDLTQANQLQICRQISRGMEYIFKTRYYHGDLAARNVLVGEGLEV----KVSDFGLA
.        .|. ..  ..      ...|| ||.||. . .  | ||   |.|. .  ..    |..|||||
IST------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase TK1.AA Src-Unclassified 411-504 33 1.4e-14 46.4 In-house 1-96 (284) Show / Hide 
Range on Protein: 411-504
Range on HMM: 1-96/284
Sequence Identity: 33% (34 aa)

LKIEKELGAGQFGIVYKAFAFGLNGIKEYVPVAVKSLRVNATPGM-EEDFL--------NEIKLMIDLGQHPNILQIIGCCTVHEPNYLITEYMKYGDLL
..  ..|| |||| |...        .  | ||||..|      |  | ||         | ..|  . .|.|. .  . |.  || | |||||  | ||
VHLLRKLGRGQFGEVWYGK------WRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKC-RHQNLVHLYAVCSQEEPYYIITEYMINGSLL

HFL
 .|
QWL
Kinase TK1.AA Pkinase 607-680 20 2.2e-11 41.3 Pfam 193-293 (293) Show / Hide 
Range on Protein: 607-680
Range on HMM: 193-293/293
Sequence Identity: 20% (21 aa)

SDVWSFGIVMYEIYTLGGVPYPGM----DGREIISKLQEGYRMPKPDQCP-----------------------EDVYDIMKACWHANPSERPTFTTIFKR
.|.||.|...|| .. |  |.||     . .. . ....  . | . ..|                       |.  |..| |.. .|..|||.. |.. 
VDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF