Gene Shark (Sea Urchin)

Shark

Species: Sea Urchin
Alias: Shark, SPU_015545, Spk251
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Syk

Sequence

Name Sequence Type Origin Length Description Download
Shark.AA Protein None 683 None Fasta, JSON
Shark.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of Shark.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank Shark.AA Ank 62-94 33 4.9e-07 29.63 Pfam 1-33 (33) Show / Hide 
Range on Protein: 62-94
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

EGRTALHEAAALGEENIIFRLLEKSANINSKDS
.|.|.|| |.  | ....  ||.. |..| .| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank Shark.AA Ank 95-127 33 6e-06 25.77 Pfam 1-33 (33) Show / Hide 
Range on Protein: 95-127
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

NGVTPLYTACSSNQPRACQFLMQKGADPTLRHP
.| |||  ||...... ...|.|.|||. ..  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank Shark.AA Ank 129-161 39 4e-06 26.4 Pfam 1-33 (33) Show / Hide 
Range on Protein: 129-161
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

TGWVPLHEAAMKGHAGCVKELIMHGAPCHPRSA
 |. ||| |...||. .||.|. |||  . .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank Shark.AA Ank 162-182 52 1.233029 6.55 Pfam 1-21 (33) Show / Hide 
Range on Protein: 162-182
Range on HMM: 1-21/33
Sequence Identity: 52% (11 aa)

DNDTPLDLARRYEHSHVVMYL
| .||| || |. |  || .|
DGFTPLHLACRCGHTEVVKML
SH2 Shark.AA SH2 195-279 32 1.9e-25 91.77 SMART 1-87 (87) Show / Hide 
Range on Protein: 195-279
Range on HMM: 1-87/87
Sequence Identity: 32% (29 aa)

KPWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEINTKM-ESFYIDD--GPYFDTLEQLIDHYSRYDDG
 ||.|| ..|..| .  ...| .|| ||.| | ..|   |||.  .| | .. |...   ..|||.  ...|..| .|..||..  .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 Shark.AA SH2 197-273 30 2.1e-24 73.47 Pfam 1-81 (81) Show / Hide 
Range on Protein: 197-273
Range on HMM: 1-81/81
Sequence Identity: 30% (25 aa)

WFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANG---TVFNFEINTKMES-FYIDDGPYFDTLEQLIDHY
|.||.. |..| .  .. | .|| ||.| | ..|   .||   .|    |  . |..  .  .|| ....|..| .|..||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase Shark.AA Syk 409-656 59 7.1e-204 683.59 In-house 1-257 (257) Show / Hide 
Range on Protein: 409-656
Range on HMM: 1-257/257
Sequence Identity: 59% (152 aa)

IERGNEIGQGEFGSVLEGKYKEK-----DRWVKVALKTLHADHLQTG-QKEFLREAKVMCGLDHPCIVKLMGVCLGPPMMLVQELVSQGALLDFLQND--
....||||.|.||||..|.|..|     ..|.|||.|.|.|||.|.. ..||.|||.|||.|||||||...|.|....||.|.|....|.....||..  
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

SITA-SDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVTLW
.||| ..|.||.||.|.||.|||.|.||||||||||.||.|...|||||||.|.|.||...||..||.|.|||||||||.|||..|||.||||.||||.|
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMW

EMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFS
||.|.|..||||..|.||.|.||||||.|.|.||||..||.|||||.||.|.||||.
EMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase Shark.AA TyrKc 409-662 39 1.3e-130 441.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-280/280
Sequence Identity: 39% (114 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCGL--DHPCIVKLMGVCLG--------PPMMLVQELVSQGALLDFLQ
|. | ..| |.|| | .|..|     ..|| |.|..|.    ...|.|||..|| |  .||.||.| |||.         .|.|.| |... |.|.|.|.
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NDS--ITASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGAN------NDYYRSTT--GGR--WPVKWYAPESIYYGTFS
.    .. .||  ...|||.|| ||. |...||||||||.|. .....|||||||||. .         ||||...  ||.  .|..|.|||.| ||.|.
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

HSSDVWGFGVTLWEMNSRGAQPYGE-----KTGAEVIKQIENGHRLNRPEG--------CPQNVYQIMNKCWSYKPCNRPTFSQLNDMF
. |||| |||..||. ..|.||| .     .. .|||.....|.|. .|.         ||. .|||| .|| ..| .|||||.. . |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Shark.AA Pkinase_Tyr 409-662 43 1.8e-130 442.46 Pfam 1-270 (270) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-270/270
Sequence Identity: 43% (119 aa)

IERGNEIGQGEFGSVLEGKYK--EKDRWVKVALKTL--HADHLQTGQKEFLREAKVMCGL-DHPCIVKLMGVCL--GPP--MMLVQELVSQGALLDFLQN
|. | ..|.|.||.| .|..|  ...  ..|| |.|  .|.| |  ...|.||||.|. | .|| ||.|.|||.  | |  ...| |..  | |||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D-----SITASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYY-RSTTGGRWPVKWYAPESIYYGTFSHSSDVWG
      ..| .||  ...|||.|| ||| |...||||||||.|.......||.||||.|.   | ||| |...||..|.||.|||.| || |.. |||| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVTLWEMNSRGAQP-YGEKTGAEVIKQI-ENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMF
|||..||. ..|.|| | . . .||...| |.|.|. .||.||. .|..| .|| |.| .|||||..  ..
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Shark.AA TK 409-662 22 1.2e-111 375.66 In-house 1-486 (486) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-486/486
Sequence Identity: 22% (108 aa)

IERGNEIGQGEFG---SVLEGKYKEKDRW-----------------------VKVALKTLH--ADHLQTGQKE--------------FLREAKVMCG--L
|. |...|.|.||    | .|.......|                       ..|| |.|.  ... |. ...              ...|.|.||   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPCIVKLMGVCLG-------------PPMMLVQELVSQGA----LLDFLQNDS----------------------------------------------
.|| ||.| |||.              .|.|.| |... |     |.|.|.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ITASDLKLWATQIASGMMYLEGK------KFVHRDLAARNILLENKGQ-----------AKISDFG---
                               .|  .|  .. |||.|| ||. |      .||||||||||.|. ....           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRATGANNDYYRST-----------------------TGGRWPVKWYAPESIY---------YGTFSHSSDVWGFGVTLWEMNSRG-AQPYGEK
     |.|. . . ||||..                       .||..|..|.|||..          ||.|.. |||| |||..||. ..| ...||. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TG---------AEVIKQIENG--------------HRLNRPEGCP--------------QNVYQIMNKCWSYKPCNRPTFSQLNDMF
.          .||......|              .|. .|..||              . .|..| .||.|.|  ||||||| ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Shark.AA Ack 409-662 43 2.3e-103 349.53 In-house 1-266 (266) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-266/266
Sequence Identity: 43% (117 aa)

IERGNEIGQGEFGSVLEGKYKE-KDRWVKVALKTLHADHLQTG--QKEFLREAKVMCGLDHPCIVKLMGVCLGPPM-MLVQELVSQGALLDFLQNDSI--
| .. ..|.|.||.|  |  .      . || | |  | .| .  . .||||. .|  |||| .|.| || |. || |.| ||   |.||| |  .    
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

--TASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENK-GQAKISDFGLSRATGANNDYYRSTTGG--RWPVKWYAPESIYYGTFSHSSDVWGFGVT
  . . |  .. |||.|| ||| | ..|||||||||||  .   .||.||||.|| | | ||||.        |  | |||.. ...||| |||| ||||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

LWEMNSRGAQPYGEKTGAEVIKQIE-NGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMF
|||| | | .|.   .|......|. .| || ||. ||. .||.| .||  .|  |||||.. | .
LWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase Shark.AA UTK 409-662 32 7.8e-100 337.97 In-house 1-296 (296) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-296/296
Sequence Identity: 32% (95 aa)

IERGNEIGQGEFGSVLEGKYKEKD---RWVKVALKTLHADHL-QTGQK---EFLREAK---VMCGLD-HPCIVKLMGVCL-GPPMMLVQELVSQGALLDF
...|...|||.|| | ...... .     ..||.|.. ...  |. .    .|..||.   .|  .. || ...| |||. . |.|.| |. ..| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQNDSITAS---------DLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKG-------QAKISDFG---LSRATGA--------NNDYYRSTTGGR
|.. . |.          ..  .| .||.|| ||....||||||||||.|.   .       ..||.|||   .||. ..        . .||...  .|
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

WPVKWYAPESIYYG-TFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENG--HRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMF
||..|.|||..... .|...|||| |||..||. ..|..||.. . ..|..|..||  .|...|..|| .||..|..|| | | .||.| .| . .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Shark.AA TK-Unique 409-662 34 2.4e-93 316.44 In-house 1-294 (294) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-294/294
Sequence Identity: 34% (100 aa)

IERGNEIGQGEFGSVLEGKYKE----KDRWVKVALKTLHADHLQTGQKEFLREAKVMCGLD-HPCIVKLMGVCL-GP-PMMLVQELVSQGALLDFLQ---
.| |..||.|.|| |  |....     |. ..||.|.|.... .| ...||.|...|  |. || ||...|.|     |.|.. | ...| |...|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

------------------------NDSITASDLKLWATQIASGMMYLEG--KKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPV
                        ...|.  ||  .| |||.||.||..  ||.|||||.|||.|| .....||.|||..| . .|..| .... || |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWYAPESIY--YGTF-SHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGC-PQNVYQIMNKCWSYKPCNRPTFSQLNDMF
.| ||||..  .|.. .  |||| |||..||. . ||.||..   ......|..|.|...||.| .. .|..|  ||...|  ||.|.|. ...
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Shark.AA Src 409-662 39 1.5e-91 310.5 In-house 1-255 (255) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-255/255
Sequence Identity: 39% (103 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCGLDHPCIVKLMGVCLGP-PMMLVQELVSQGALLDFLQ----NDSIT
| .  ..||| || | .|... .   .||| ||| .....  .. ||.||..|  |.|. .|.|  ||    |   |.|. |.| |||.|.      .. 
IKLCRKLGQGQFGEVWMGYWNGN---TKVAVKTLKPGTMS--PEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLH

ASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNS
  .|   |.|.|.||.||| ....||||||||.|  ..  .|. |||| | .  . | | . .| . |.|| ||| | ||.|.  |||| ||. |.|. .
LPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVT

RGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQ-IMNKCWSYKPCNRPTFSQLNDMF
.|  ||   | .||..|.|.| |. .|..||...|. || .||  .|  ||||  |.. .
YGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Shark.AA Csk 409-662 43 5.9e-85 288.55 In-house 1-251 (251) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-251/251
Sequence Identity: 43% (112 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCGLDHPCIVKLMGVCLGPP--MMLVQELVSQGALLDFL---QNDSIT
.. | .||.|||| |. |.|. .    |||.| .  |   . |. || ||.|| .| ||  |.|.|| |. .  . .| | .| | |.|.|       ||
LHLGECIGHGEFGDVMQGEYQNR----KVAVKCIKCDGNGMAQA-FLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVIT

ASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNS
 ..|   |  ...|| |||.||||||||||||||.     ||.|||||...   . |    .|.|. |.|| |||    . ||  |||| ||. |||  |
RRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQD---DSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEIYS

RGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMF
 |  ||     ..| |..| | |   ||||| .||..|..||   | .|||| |.    
FGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Shark.AA EGFR 409-663 39 5.8e-84 278.65 In-house 1-258 (258) Show / Hide 
Range on Protein: 409-663
Range on HMM: 1-258/258
Sequence Identity: 39% (102 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVK--VALKTLHADHLQTGQKEFLREAKVMCGLDHPCIVKLMGVCLGPPMMLVQELVSQGALLDFLQN--DSITA
. ..   | | || |  | .  .   ||  || | |.    .  ..|.|.||.|| ..|||..|.|.|||... |.||  .   |.|||....  | | .
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

SDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVTLWEMNSR
 .| .|..|||.||.||| .. |||||||||.|.    . || ||||..   .... |.   ||. |.|| | |.| .. . | |||| .|||.||.   
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYH-AQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTF

GAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMFR
|..||     .|.   .|.| ||  |. | . ||..| |||   .  |||| .|   |.
GQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase Shark.AA Src-Unclassified 409-662 36 8e-82 278.14 In-house 1-284 (284) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-284/284
Sequence Identity: 36% (105 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQT-GQKEFL--------REAKVMCGLDHPCIVKLMGVC-LGPPMMLVQELVSQGALLDFLQ
. .  ..|.| || |  ||.. |   | || ||. ..|  |     ||        .||..|  ..|. .|.| .||    |   ..|. . | ||..|.
VHLLRKLGRGQFGEVWYGKWRGK---VDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLR

NDSITASDLKLW---------------ATQIASGMMYLEGKKFVHRDLAARNILLENKG-----QAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPE
 .  .   ...                |.|.|||||||| || |||||||||.|   .       .|. |||| | .    | |   || . |.|| |||
EGGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPE

SIYYGTFSHSSDVWGFGVTLWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRP--EGCPQNVYQ-IMNKCWSYKPCNRPTFSQLNDMF
 . ||.||  |||| .|. |||.   |  ||      ||....| | |. .|  ..|| ..|. || |||   |  ||||  |.  |
CFIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Shark.AA Eph 409-662 40 2e-81 273.3 In-house 1-264 (264) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-264/264
Sequence Identity: 40% (106 aa)

IERGNEIGQGEFGSVLEGKYK--EKDRWV---KVALKTLHADHLQTGQKEFLREAKVMCGLDHPCIVKLMGV-CLGPPMMLVQELVSQGALLDFLQNDSI
|     || |||| | .|  |  ...| |    || ||| | .    . .||.|| .|   ||| |..| ||   . |.| | |    |.| .|| .   
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

TASDLKLWATQ--IASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANN---DYYRSTTGGRWPVKWYAPESIYYGTFSHSSDVWGFGVT
  . ..| . .  ||||| ||    .|||||||||||.. .   |.|||||||    .    . | .. ||. |..| ||| | |..|. .|||| .|. 
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTR-GGKIPIRWTAPEAIAYRKFTSASDVWSYGIV

LWEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLNDMF
.||  | |  ||.. .. .||| || | ||  | .||.  .|.| .|| . . .||.|.|.  ..
MWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase Shark.AA S_TKc 409-662 23 5.4e-45 156.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQKEFLREAKVMCGLDHPCIVKLMGVCLGPPMMLVQELVSQ--GALLDFLQNDS-----
 | ...||.| ||.|  .. |.     .||.| ..        . ..|| ...   .|| |||| .|.    . .| |....  | |.|....       
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--ITASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQAKISDFGLSRATGANNDYYRSTTGGRWPVKWYAPESIYYGTFSH-SSDVWGFGVTL
  ..  . . .. ||.... |.  ....||||   |||| .  . ||.||||.|         ..  | .|   . ||| .    ... ..|.| .|..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPW---YMAPEVL---GYGKCKCDWWSCGCIL

WEMNSRGAQPYGEKTGAEVIKQIENGHRLNRPEGCPQNVYQIMNKCWSYKPCNRPTFSQLND---------MF
.|| . |  |.   . ....|.|            .. . ....||. . | .|||  ..            |
YEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Shark.AA Pkinase 409-662 24 5.5e-41 145.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 409-662
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

IERGNEIGQGEFGSVLEGKYKEKDRWVKVALKTLHADHLQTGQ-KEFLR--EAKVMCGLDHPCIVKLMGVCL-GPPMMLVQELVSQG----ALLDFLQ--
...|  ||.| ||.| ... |   .  .||.|..  .|   .. .. .|  |...|  |.||.||.| ...  .. . .|.|..  |     | |...  
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-NDSI--TASDLKLWATQIASGMMYLEGKKFVHRDLAARNILLENKGQA----KISDFGLSRAT-GANNDYYRSTTGGRWPVKWYAPESIY-YGTFSHSS
 . ..  .  ..| ...||..|. |.  ....||||   |||. |.|.     ||.||||..     ||  . . .| .|   . ||| |  .   ....
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKV

DVWGFGVTLWEMNSRGAQPYGEK------TGAEVIKQIEN-GHRLNRPEGCP-------------------QNVYQIMNKCWSYKPCNRPTFSQLNDM--
|.|..|..|.|| . |  |. ..      .  ..|..|     . ..|. |.                   ..  .....|. ..|  |||. |.     
DMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

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