Gene SFK3 (Sea Urchin)

SFK3

Species: Sea Urchin
Alias: Spk291, SFK3, SPU_005419
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Echino2

Sequence

Name Sequence Type Origin Length Description Download
SFK3.AA Protein None 474 None Fasta, JSON
SFK3.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of SFK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 SFK3.AA SH3 28-85 39 6.2e-25 90.07 SMART 1-58 (58) Show / Hide 
Range on Protein: 28-85
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

ERYKALYDYEARTADDLTFRKGEILIITNKSDPNWWLASSVVSKREGYVPRNYIEPAD
....|||||.|...|.|.|.||.|.....|.|..|| .    . .||..| ||.|. |
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 SFK3.AA SH3_1 31-78 40 5.9e-22 76.92 Pfam 1-49 (49) Show / Hide 
Range on Protein: 31-78
Range on HMM: 1-49/49
Sequence Identity: 40% (20 aa)

KALYDYEARTADDLTFRKGEILIITNKSDP-NWWLASSVVSKREGYVPR
.|||||.|...|.|.|.||.|... .|||  .|| . .  ...||..| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 SFK3.AA SH3_2 29-84 22 1.3e-13 50.61 Pfam 1-68 (68) Show / Hide 
Range on Protein: 29-84
Range on HMM: 1-68/68
Sequence Identity: 22% (15 aa)

RYKALYDYEA-RTADD-----LTFRKGEILIIT---NKSDPNWWLA-SSVVSKRE--GYVPRNYIEPA
.|... ||.. . ...     |.|.||... ..   .|...|||..  .   .|.  |..|....|. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 SFK3.AA SH2 92-174 53 3.9e-46 137.29 Pfam 1-81 (81) Show / Hide 
Range on Protein: 92-174
Range on HMM: 1-81/81
Sequence Identity: 53% (44 aa)

WFFEKMTRKDAEKQLQLTSNSRGTFLVRGSETSPGAYSLSVLDHDDTRGYNVKHYRIRTLDNGGYYISTRITFKTLRDLVEHY
|.. |..|..||..|. . | .|||||| ||..|| |.|||.| ..  |..||||||...|||||||..| .| .| .|||||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 SFK3.AA SH2 90-180 41 2.5e-34 121.27 SMART 1-87 (87) Show / Hide 
Range on Protein: 90-180
Range on HMM: 1-87/87
Sequence Identity: 41% (39 aa)

EDWFFEKMTRKDAEKQLQLTSNSRGTFLVRGSETSPGAYSLSVLDHDDTRGYNVKHYRIRTLDNGGYYIST--RITFKTLRDLVEHYQSQADG
. |.. ...|..||. |.  ..  |.|||| ||..||.|.||| ..       |||||||..|.|.||| .  | .| .| .||.|||  ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SFK3.AA Src 211-462 68 6.2e-193 647.24 In-house 1-255 (255) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-255/255
Sequence Identity: 68% (177 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLH-DGEGRHLKEPE
|||.|.||.|||||||.|.||....|||||||.| |.|.||||||.|||||||.|||.|.|.||..   |||||||.|.||.||.||. |||||||. |.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

LIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIE--D-EYIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGR
|||..|||..|||||||....||||||||.||||.  |||||||| |.|.  | || ||.|||.|||||||||||.|.|||||||||||||..|..|.||
LIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR

VPYPGMVNREVLDQVSRGYRMPKPVECPEQLYD-IMRQCWDAQPEKRPTFDFLHSFL
|||||| |.|||.||.||||||.| .||..||. ||.|||...||.||||..|..||
VPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SFK3.AA SFK-Src 211-466 60 5.8e-176 526.51 In-house 1-259 (259) Show / Hide 
Range on Protein: 211-466
Range on HMM: 1-259/259
Sequence Identity: 60% (157 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHDGEGRHLKEPEL
|.| ..|| ||||.|| |.||.| .||||||| |||    ||||| .|||||||.|. | |.|  |  |||||.||||  | || |||. .|| |. | |
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDG--EPIYIITELMKYGSLLDYLHEPHGRSLRMPQL

IDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIEDEYI---AREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRV
.| .|||  |||||| | ||||||||||.|||.   |||.|||.||..... .   |.|||| ||||||||| |  .| |||||||||||..|..| ||.
VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI

PYPGMVNREVLDQVSR--GYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFLDDFY
||||| | ||| || |  |||||.|  ||...| ||..||  .|. ||||. |   ..||.
PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase SFK3.AA Src-Unclassified 211-462 50 5.3e-158 531.2 In-house 1-284 (284) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-284/284
Sequence Identity: 50% (144 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEG---AMDPTAFL--------QEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHD
..|.| || ||||||| | |   | |||||...|    | |.|||        |||.||||.||..||.|.|.||.   ||.||.||.|. | |||.|  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQ--EEPYYIITEYMINGSLLQWLRE

GEGRHLKEPEL------------IDITAQVSDGMAYLESQRFVHRDLAARNILVGEHR-----NCKVADFGLSR---IIEDEYIAREGAKMPIKWTAPEA
| |. |  ...            .|| |||  || |||| . |||||||||.|.|.         ||.|||| |   . .|.|..| ||. |.||.|||.
GGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPEC

INFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLDQVSRGYRMPKP--VECPEQLYD-IMRQCWDAQPEKRPTFDFLHSFL
.  |.|.|||||||.||| .|. |||..||||| ||||| .|.||||||||    ||...|. || .||...|..|||||.|  ..
FIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase SFK3.AA SrcA 211-462 66 2.5e-156 497.85 In-house 1-250 (250) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-250/250
Sequence Identity: 66% (167 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHDGEGRHLKEPEL
|.| ||||.|.||||| | || |  ||.|||| | | | |||.|| ||||||| ||| | |. ||   |||||||| |..| || .| |.||..|| |.|
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSE---EPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQL

IDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIED-EYIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPY
.|..||| .||||.|   ..|||| | ||||||.  ||.||||| |.||| || || ||| |||||||||  .|.|||||||||||||. |..|||||||
VDMAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPY

PGMVNREVLDQVSRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFL
|||.|||||.|| |||.|| | .||| |...| |||  .|| ||||..| |||
PGMNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase SFK3.AA Pkinase_Tyr 211-462 49 7.1e-151 511.6 Pfam 1-270 (270) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-270/270
Sequence Identity: 49% (133 aa)

IKLVRRLGNGQFGEVWEGVWN-----DTVNVAVKTLKEGAMDP----TAFLQEANIMKKL-RHPKLVALLAICSEGAAEP--IYIVTELMTHGCLLQYLH
|.. . || |.||||..|.|.     ... ||||.||||||..     .|..||.|||.| .||..| |...|.    ||  ||||.|.| ||.|| ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYLR

DG--EGRHLKEPELIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRII--EDEY-IAREGAKMPIKWTAPEAINFGKFTIKSDVWS
.   ....|. ..|... .|...||.||||....||||||||.||.| . .|..||||.| |  .|.|  .|.|.|.||||.|||.||.||||.||||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGILIYEVITKGRVP-YPGMVNREVLDQV-SRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFL
||.|..|..| |. | |||| | ||....  .|||||.|  ||. .||.|.|||...||.||||  .|..|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SFK3.AA Frk 211-466 62 3.2e-145 488.76 In-house 1-260 (260) Show / Hide 
Range on Protein: 211-466
Range on HMM: 1-260/260
Sequence Identity: 62% (164 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLH--DGEGRHLKEP
|.|.|||| ||||||||| || |. ||||||| |.|||. ||.|| ||||||||||. | |.|     |||||.|||| || |..||   ...||... .
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCT--VEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQ

ELIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSR--IIEDE--YIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITK
.|.|..|||  |||||||| ..||||||||.|||||  ||.||||| |  . ..|  | .| ||..|||||||||.|  ||||||||||||||..|.|| 
QLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITY

GRVPYPGMVNREVLDQVSRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFLDDFY
||.||||| |.|||..|..|||||.| .||.|||.|| .|| ..|.|||||. |.  |.|..
GRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SFK3.AA SrcB 211-463 62 2.8e-142 478.98 In-house 1-251 (251) Show / Hide 
Range on Protein: 211-463
Range on HMM: 1-251/251
Sequence Identity: 62% (159 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHDGEGRHLKEPEL
.|||..|| ||||||| | .|. . |||||.|.|.| | |||.|||.||.| | .|| | |. .    |||||.|| | .|||| .|   || .|. | |
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTK---EPIYIITEYMAKGCLLDFLKTDEGSKLSLPKL

IDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIED-EYIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPY
||..||...||||.| . ..|||| | |||| |   ||.||||| ||||| || |||||| ||||||||||||| |||||||||||||..|..| ||.||
IDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPY

PGMVNREVLDQVSRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFLD
||| | ||. ...||||||.| .||| ||.||..||  .|| |||||.|.| ||
PGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase SFK3.AA TyrKc 211-462 44 7e-141 475.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-280/280
Sequence Identity: 44% (128 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKL--RHPKLVALLAICSEG-----AAEPIYIVTELMTHGCLLQYLHDGEGR
|.| . ||.|.||||..|.|.  ..||||.|||.|    .|..||.||.||  .|| .|.|...|...      .||..||.|.| ||.|..||.. ...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

HLKEPELIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIEDE---------YIARE--GAK--MPIKWTAPEAINFGKFTIKSD
 |. ..|...  |...||.||.|....||||||||.|||| . .|..|||||| |.|.         | ..|  |.|  .||.|.|||.||.||||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILIYEVITKGRVPYPG-----MVNREVLDQVSRGYRMPKPVE--------CPEQLYDIMRQCWDAQPEKRPTFDFLHSFL
|||||....|. | |  ||||     | |.||. .| .|||||.| .        ||. .|.||.|||...||.||||  .|...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SFK3.AA Src-Echino1 211-462 58 2.5e-130 439.28 In-house 1-252 (252) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-252/252
Sequence Identity: 58% (148 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHDGEGRHLKEPEL
 .. ...|.|..||||.||||   .||||||||..| | .|| |||.|||.||  .| . |.||.   |||||||||| .| |..|| .|...|.| ..|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSD--KEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTL

IDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIE-DEYIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPY
||. |..  || ||.|. .|||||||||.|||.   ||.||||| |... |.|....|||.|||||||||. .|.|||||||||||||. |..| ||.||
IDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPY

PGMVNREVLDQVSRGYRMPKPVECPEQLYDI-MRQCWDAQPEKRPTFDFLHSFL
||| |||||||| |||||||. .||. ||.. | .||   | .||||.|||.|.
PGMMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase SFK3.AA TK 211-462 27 1.7e-127 429.79 In-house 1-486 (486) Show / Hide 
Range on Protein: 211-462
Range on HMM: 1-486/486
Sequence Identity: 27% (134 aa)

IKLVRRLGNGQFG---EVWEGVWNDT--------------------------VNVAVKTLKEG-AMDPTA--------------FLQEANIMKKLR----
|.|.. || ||||   ||..| |..                           . ||||.|||| ||....              ||.||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKLVALLAICSEGAA----------EPIYIVTELMTHGC----LLQYLH--DGEGRH-----------------------------------------
 || .| |...|..|.           ||..||.|.| ||.    |..||.  .....|                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LKEPELIDITAQVSDGMAYLESQ------RFVHRDLAARNILVGEHRN-----------CKVADFG---
                               |  ..|. . .|...||.||.|.      .||||||||||.||||. .           ||.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRIIED--EYIARE------------------------GAKMPIKWTAPEAIN---------FGKFTIKSDVWSFGILIYEVITKGRVPYPG-M
     |.| |..  .| ...                        |.|.||.|.|||..|         .||||.||||||||.|..|. | |..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VN---------REVLDQVSRG--------------YRMPKPVECP--------------EQLYDIMRQCWDAQPEKRPTFDFLHSFL
 |         .||.... ||              .|||.|. ||              | .||.|.|||...||.||||. ||..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SFK3.AA SRM 212-463 50 1.7e-127 428.62 In-house 2-253 (253) Show / Hide 
Range on Protein: 212-463
Range on HMM: 2-253/253
Sequence Identity: 50% (128 aa)

KLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGA-MDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHDGEGRHLKEPEL
 | |.|| | ||||||| | . | ||.|  |    |  . . .|   |||||| ....| |.|| |  .|.||.||||  | |.||| | ... |. |.|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVG--DPVYIITELMRKGNLQQYLRDSDEKALPIPHL

IDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRII-EDEYIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPY
.|.  ||  ||.|||.|...||||||||.|||.   |||.|||| | | .| |    . . |.|||||||.| . . .|||||||||| .|. |.| .||
LDFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPY

PGMVNREVLDQVSRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFLD
||| | | . |..|||||| |.||| . .  | .||   ||.||.|  |   | 
PGMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase SFK3.AA Tec 211-464 45 6.9e-115 387.99 In-house 1-254 (254) Show / Hide 
Range on Protein: 211-464
Range on HMM: 1-254/254
Sequence Identity: 45% (116 aa)

IKLVRRLGNGQFGEVWEGVWNDTVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHGCLLQYLHDGEGRHLKEP-E
..... ||.|||| |  | |     ||.|..|||.|    |..|| .|.|| ||||| |  .||.    ||||||| |.||||| ||   ...  |.   
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQ--QRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAI

LIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSR-IIEDEYIAREGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVP
|.... .|. ||||||.. |.|||||||| |||.    ||.|||..| .. |.|.   |.| |.|| .||  .. ..  |||||.||.|  || . |..|
LLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMP

YPGMVNREVLDQVSRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHSFLDD
|. | | || ..||.|.|. .|  |....|.|| .||  .||.||||  | . . .
YENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase SFK3.AA S_TKc 211-466 23 5.8e-57 196.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 211-466
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

IKLVRRLGNGQFGEVWEGVWND-TVNVAVKTLKEGAMDPTAFLQEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTH--GCLLQYLHDGEGRH---
 ...| .| | ||.|. .....    ||.| .|        ...| .|.|| .|| .| |. .. .   . .|.|.|.. .  | |..|...  ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LKEPELIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNCKVADFGLSRIIEDEYIAREGAKMPIKWTAPEAINFGKFTI-KSDVWSFGILIYEVI
 . | .   ...|. ....|. |....||||   |||. |  . |..||||.|..               . ||| .   ...  |.|.||.|...|| .
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TKGRVPYPGMVNREVLDQVSRGYRMPKPVECPEQLYDIMRQCWDAQPEKRPTFDFLHS-----FLDDFY
. |. |.|     ......            .... |..|.|..  ||||||   .        .. . 
C-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SFK3.AA Pkinase 211-461 25 4.5e-45 160.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 211-461
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

IKLVRRLGNGQFGEVWEGVWNDTVN-VAVKTLKEGAMDP----TAFL-QEANIMKKLRHPKLVALLAICSEGAAEPIYIVTELMTHG----CLLQYLHDG
....|..| | ||.|..... .|   ||||..|    ..    |... .|. |||.|.||  | |. .. .     ||.|.|.. .|     |  |..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

EGRHL--KEPELIDITAQVSDGMAYLESQRFVHRDLAARNILVGEHRNC----KVADFGLSRIIEDEYIAREGAKMP---IKWTAPEAIN-FGKFTIKSD
... .   | |....  |.  |..|. |....||||   |||. .. ..    |..||||.. ..  |   . .. .   . . ||| |.   . . |.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VWSFGILIYEVITKGRVPYPGM------VNREVLDQVSR-GYRMPKPVECP-------------------EQLYDIMRQCWDAQPEKRPT-FDFLHS--F
.||.|...||... || |.||         ....... .  .. . | .|.                   | . |... |..  |.||||  . |..  |
MWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF