Gene SFK1 (Sea Urchin)

SFK1

Species: Sea Urchin
Alias: Spk294, SPU_013522, SFK1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
SFK1.AA Protein None 511 None Fasta, JSON
SFK1.kin_dom Protein Kinase Domain None 87 None Fasta, JSON

Protein domain

Protein domains of SFK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 SFK1.AA SH3 63-119 48 5.3e-26 93.63 SMART 1-58 (58) Show / Hide 
Range on Protein: 63-119
Range on HMM: 1-58/58
Sequence Identity: 48% (28 aa)

HPYTALYDYDARSEDDLDFKKGDILDVTKT-EGDWWLARSQKTGKEGYIPSNYVAPVD
  . |||||.|...|.| ||||||. |..  ...|| .| ..||.||..|||||...|
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 SFK1.AA SH3_1 66-112 51 2.9e-23 81.32 Pfam 1-49 (49) Show / Hide 
Range on Protein: 66-112
Range on HMM: 1-49/49
Sequence Identity: 51% (25 aa)

TALYDYDARSEDDLDFKKGDILDVTK-TEG-DWWLARSQKTGKEGYIPS
.|||||.|...|.| ||||||. | . ... ||| .|.. ||.||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 SFK1.AA SH3_2 64-118 26 1.2e-14 54.2 Pfam 1-68 (68) Show / Hide 
Range on Protein: 64-118
Range on HMM: 1-68/68
Sequence Identity: 26% (18 aa)

PYTALYDYDA-RSEDD-----LDFKKGDILDVT----KTEGDWWLA-RSQKTGKE--GYIPSNYVAPV
.| .. ||.. .....     |.|||||.. |.    |  ..||.. .. ..|..  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 SFK1.AA SH2 126-209 51 3.4e-37 111.02 Pfam 1-81 (81) Show / Hide 
Range on Protein: 126-209
Range on HMM: 1-81/81
Sequence Identity: 51% (43 aa)

WYFGKCARKDAEKKLIAIGINKGQFIVRDGEANPGTFSLSVRDNDPQKGDHVKHYRIRKMDGGNGFFITQRSVFPTLSELVRHY
||.||  |..||. | ..|   | |.||. | .|| ..|||||..|  ||.||||||...|.| |..|| |  |..|.||| ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP--GDRVKHYRIQRTDNG-GYYITGRHKFCSLQELVEHY
SH2 SFK1.AA SH2 124-215 44 2.6e-28 101.27 SMART 1-87 (87) Show / Hide 
Range on Protein: 124-215
Range on HMM: 1-87/87
Sequence Identity: 44% (42 aa)

EDWYFGKCARKDAEKKLIAIGINKGQFIVRDGEANPGTFSLSVRDNDPQKGDHVKHYRIRKMDGGNGFFITQ--RSVFPTLSELVRHYQSNIDG
. ||.|.. |..||..| . |   | |.||| | ||| ..||||..     ..|||||||. |  ....|..  |  ||.| |||.||| | .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK-----GKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase SFK1.AA Src 246-496 74 1.1e-199 669.64 In-house 1-255 (255) Show / Hide 
Range on Protein: 246-496
Range on HMM: 1-255/255
Sequence Identity: 74% (191 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLK-DGTGKDTKLTTHV
... |.|| |||||||.|.|||||.|||||||.|||||.|||.||..|||.|||.|||||||||. ||||||||.||.|||||||| ||.|.  .|.. .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIE--EDEYMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIP
||.||.|.|||||||||..|||||||||||||.||.|||||||||||.  .||| || |||||||||||||...|||||||||||||||.|||||.||.|
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMTNREVLDQVDLGYRMPKMHHCPDSLYE-IMLKCWHKDPQQRPTFEFLHFCL
||||||.|||.||. |||||..|.|||.||| |||.||||||.||||||.|.  |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase SFK1.AA SFK-Src 246-500 64 7.79999999999e-194 580.5 In-house 1-259 (259) Show / Hide 
Range on Protein: 246-500
Range on HMM: 1-259/259
Sequence Identity: 64% (166 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGTGKDTKLTTHVD
 |. ..|| ||||.||.|.||. | ||||||| |.||   ||.|| |||| ||..|.|||||| | |||||.|||| .|||||||..  |.  .. . ||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIE-EDE-YMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIPY
|.||.|.||||||  |||||||||||||||. ||.||.|||..| .. .|| | |. |||||||||||||..  || ||||||||||||.||||.|||||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMTNREVLDQVDL--GYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCLDDYF
||||| ||| |||   |||||.   ||| .|.||. || . |  ||||| | . ..|.|
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase SFK1.AA Src-Echino1 246-495 78 3.3e-179 601.63 In-house 1-252 (252) Show / Hide 
Range on Protein: 246-495
Range on HMM: 1-252/252
Sequence Identity: 78% (198 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGTGKDTKLTTHVD
|||....|.|..||||.||||||||||||||||.|||||.||||||||||.||| .||.||||||.|||||||||||||.|.||||.| .|..|.|| .|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEEDEYMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIPYPG
|||.||||| ||.| |.|||||||||||||.|||.|.|||||||....|.|... |||.|||||||||||.||||||||||||||||||.|||||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MTNREVLDQVDLGYRMPKMHHCPDSLYEI-MLKCWHKDPQQRPTFEFLH-FC
|.|||||||||.|||||||||||||||.. |.||||||||||||||||| | 
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase SFK1.AA SrcA 246-496 69 7.79999999999e-169 538.04 In-house 1-250 (250) Show / Hide 
Range on Protein: 246-496
Range on HMM: 1-250/250
Sequence Identity: 69% (174 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGTGKDTKLTTHVD
.|. ||||.|.||||| | |||.| ||.|||| ||||| ||| || .|||.||..||||||| |. |||||||| |. |||||.|||..||. ||   ||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSE-EPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

MGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEEDEYMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIPYPG
| ||.|.||||.| ||..|||| | |.||||  . |.||||||||||..|| || |||||||||||||||.|||||||||||||||.||.|| ||.||||
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG

MTNREVLDQVDLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCL
| |||||.||. ||.||    || ||.|.| .||.|||. |||||.|   |
MNNREVLEQVERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase SFK1.AA Src-Unclassified 246-495 55 4e-167 561.51 In-house 1-284 (284) Show / Hide 
Range on Protein: 246-495
Range on HMM: 1-284/284
Sequence Identity: 55% (158 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEG---TMSPAAFL--------AEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGT
..  | || ||||||| | | |   |||||...|   ||||.|||        .||..||| || .||.||||||. ||.||.||.|.|||||..|. |.
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GKDTKLTTH------------VDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGN-----VVKVADFGLA--RLIEEDEYMARVGAKFPIKWTAPEAAL
|.   .               ||. ||.|||| ||||   |||||||||||.|. |     ||||.|||||  .|...|.| .| ||.||.||.|||...
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

HGRFTIKSDVWSFGILMTEIVTFGRIPYPGMTNREVLDQVDLGYRMPKM--HHCPDSLYE-IMLKCWHKDPQQRPTFEFL-HFC
 | |.|||||||.|||  || | |..||||| ||||| .| .||||||   | |||..|| ||.||||||||.||||..| |. 
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase SFK1.AA Frk 246-500 65 3.7e-156 525.07 In-house 1-260 (260) Show / Hide 
Range on Protein: 246-500
Range on HMM: 1-260/260
Sequence Identity: 65% (170 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLK--DGTGKDTKLTTH
... |||| ||||||| | || .||||||||| ||| |  ||.|| .|||.|| .|.||||||   |||||.|||| .|||..||.  ...|.  .... 
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLAR-LIEEDE--YMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGR
||| ||.|.|||||||.|..|||||||||||||.|..|.||||||| |. ..|  | .|.||.|||||||||||   .|||||||||||||.|||.|.||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

IPYPGMTNREVLDQVDLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCLDDYF
.|||||||.|||..|| |||||.   ||  ||||||.|||.||..||||| |.. |.|||
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase SFK1.AA Pkinase_Tyr 246-496 50 3.2e-151 512.76 Pfam 1-270 (270) Show / Hide 
Range on Protein: 246-496
Range on HMM: 1-270/270
Sequence Identity: 50% (135 aa)

LRMTRRLGHGQFGEVWQGVWN-----GNTPVAVKTLKEGTMSP----AAFLAEANVMKKV-RHERLVQLYAVCS-DREP--IYIVTELMSNGSLLDYLKD
... . ||.|.||||..|.|.     ...|||||.||||.|..    ..|..||..||.  .|. .|.||.||. ..||  ||||.|.| .|.|||||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

G--TGKDTKLTTHVDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLI-EEDEY-MARVGAKFPIKWTAPEAALHGRFTIKSDVWSF
    ..  .. . ..| .|||.||.||||.|..||||||||.||.|.||||..||||||.| ..|.|  .| |.|.||||.|||.  .|.||.|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILMTEIVTFGRIP-YPGMTNREVLDQV-DLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCL
|.|| ||.|.|..| ||||.| ||.... . |||||. ..||| .|..|..|||.||..||||. .| .|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase SFK1.AA SrcB 246-497 62 6.8e-144 484.34 In-house 1-251 (251) Show / Hide 
Range on Protein: 246-497
Range on HMM: 1-251/251
Sequence Identity: 62% (157 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGTGKDTKLTTHVD
|.. ..|| ||||||| | .|... |||||.|.||||| ||||||||||.. |.|||.|||| . .|||||.|| | .|.|||.||   |   .|   .|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVT-KEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEEDEYMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIPYPG
| |||| ||||.| ||..|||| | |.|| |  . |.|||||||.||..|| || |||||||||||||  .| |||||||||||||..||||.|||||||
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPG

MTNREVLDQVDLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCLD
||| ||. ... |||||..  ||. ||.|| .||.. | .||||..|.  ||
MTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase SFK1.AA TyrKc 246-496 43 1.1e-142 481.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 246-496
Range on HMM: 1-280/280
Sequence Identity: 43% (125 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKV--RHERLVQLYAVCSDR-------EPIYIVTELMSNGSLLDYLKDGTGK
... . ||.|.||||..|.|.  ..||||.|||..   ..|. ||..|.|.  .|. .|.||.||..        ||..||.|.|..|.|.|||..  .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

DTKLTTHVDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEED--------EYMARV--GAK--FPIKWTAPEAALHGRFTIKSD
  .. . ...  |||.||.||.|.|..||||||||.||||...||..||||.| |..|         |...   |.|  .||.|.|||.  .|.||.|||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGILMTEIVTFGRIPYPG-----MTNREVLDQVDLGYRMPKMHH--------CPDSLYEIMLKCWHKDPQQRPTFEFLHFCL
|||||..| || |.|  ||||     |.|.||. .|. |||||....        ||| .|.||..||| || .||||. .| |.
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SFK1.AA TK 246-496 27 4.2e-127 428.44 In-house 1-486 (486) Show / Hide 
Range on Protein: 246-496
Range on HMM: 1-486/486
Sequence Identity: 27% (135 aa)

LRMTRRLGHGQFG---EVWQGVWNGN--------------------------TPVAVKTLKEG-TMSPAAFLA--------------EANVMKKVR----
... . ||.||||   ||..| |.|                           ||||||.|||| .||...|..              ||..||. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HERLVQLYAVCSDR------------EPIYIVTELMSNGS----LLDYLK--DGTGKD-----------------------------------------
 |. .|.||.||..             ||..||.|.|..|.    |.|||.  ......                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------TKLTTHVDMGAQIASGMAYLESM------NFVHRDLAARNVLVGEGNV-----------VKVADFG---
                                 . . . | .|||.||.||.|.      |||||||||||.||||.||           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARLIE-------------------------EDEYMARVGAKFPIKWTAPEAAL---------HGRFTIKSDVWSFGILMTEIVTFGRIPYPG-M
     ||| |.                         .|.|... |.|.||.|.|||. .         .|.||.||||||||.|| ||.|.|. ||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------REVLDQVDLG--------------YRMPKMHHCP--------------DSLYEIMLKCWHKDPQQRPTFEFLHFCL
.|         .||....  |              .|||.  |||              . .|..|..|||.||..||||. || .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SFK1.AA SRM 246-497 49 4.6e-123 413.56 In-house 1-253 (253) Show / Hide 
Range on Protein: 246-497
Range on HMM: 1-253/253
Sequence Identity: 49% (126 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGT-MSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGTGKDTKLTTHV
  . |.|| | ||||| | | |  .||.|  |    |  . . .|   ||| ||.... |.||||  .|.||.||||  |.|. ||.|  .|  ..   .
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEEDEYMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIPYP
|.  |.| ||.|||. |..||||||||||||..|. ||.|||||||| .| |    . . |.||||||||  . . .||||||||||. |. | | .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMTNREVLDQVDLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCLD
|||| | . |.| |||||    || . .  ||.|| .||.|||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase SFK1.AA Tec 246-498 47 2.2e-120 406.23 In-house 1-254 (254) Show / Hide 
Range on Protein: 246-498
Range on HMM: 1-254/254
Sequence Identity: 47% (120 aa)

LRMTRRLGHGQFGEVWQGVWNGNTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNGSLLDYLKDGTGKDTKLT-THV
| . . || |||| |  | | ..  ||.|..|||.||   |. || ||.|  |..||||| ||| . ||||||| |..|.||.||.   ..  | .    
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEEDEYMARVGAKFPIKWTAPEAALHGRFTIKSDVWSFGILMTEIVTFGRIPYP
.|  ..  ||||||. .|.|||||||| |||. .||||.|||..| .  |.|   ||.|||.|| .||     |.  |||||.||.|| |. . |..||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GMTNREVLDQVDLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLHFCLDD
 |.| || ..|  |.|. . |.|....|.|| .|||  | .||||. |   . .
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase SFK1.AA S_TKc 246-500 25 4.2e-54 186.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 246-500
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

LRMTRRLGHGQFGEVWQGVWNG-NTPVAVKTLKEGTMSPAAFLAEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSN--GSLLDYLKDGTGKD----T
 .. | .|.| ||.|....... .  ||.| .|        .. | ...|| .|. .|.|| |. | . .|.|.|....  |.|.||.|.  ..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

KLTTHVDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVVKVADFGLARLIEEDEYMARVGAKFPIKWTAPEAALHGRFTI-KSDVWSFGILMTEIVT
   .   . .||.....|. |....||||   |.|. |  ..|..||||||..                . |||      ..  |.|.||.|... | ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

FGRIPYPGMTNREVLDQVDLGYRMPKMHHCPDSLYEIMLKCWHKDPQQRPTFEFLH----FCLDDYF
 |. |.|  .  ......            .... ... ||..|||..||| | |.      .. .|
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase SFK1.AA Pkinase 246-500 23 2.6e-43 154.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 246-500
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

LRMTRRLGHGQFGEVWQGVWNGN-TPVAVKTLKEGTMSP----AAFL-AEANVMKKVRHERLVQLYAVCSDREPIYIVTELMSNG----SLLDYLK---D
..  |..| | ||.|..... |.   ||||..|  . ..    .... .|. .||...|.  |.|| .. |.  ||.|.|.. .|    .| ||..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GTGKDTKLTTHVDMGAQIASGMAYLESMNFVHRDLAARNVLVGEGNVV----KVADFGLARL--IEEDEYMARVGAKFPIKWTAPEAAL-HGRFTIKSDV
|.       .  ..  ||..|..|. ||...||||   |.|. . ...    |..|||||..  .  .... ..|  .   . |||  . .   . |.|.
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPW---YMAPEVIRGGQYYGPKVDM

WSFGILMTEIVTFGRIPYPGM----TNREVLDQVDLGYRMPKMHHCP-----------------------DSLYEIMLKCWHKDPQQRPTFEFLHFCLDD
||.|... | .. || |.||     . .. .  ...  . | . ..|                       ... ... .|..|||..|||  . . . ..
WSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHP

YF
.|
WF