Gene ROS (Sea Urchin)
ROS
Sequence
Protein domains of ROS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FN3 | ROS.AA | FN3 | 72-152 | 18 | 4.3e-07 | 30.81 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 72-152 Range on HMM: 1-69/69 Sequence Identity: 18% (18 aa) IGQPSS---PQPSNMGTT------SLTLSWTAASHQDVRYLVQWRYVEGGGEAWNYYGSGEPISETTLDITDLIPY----ALYQFRVVWV----ITPR | |. .. .. ..| |.||||.. |..| .|.| |. |.|||. | . PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| FN3 | ROS.AA | FN3 | 172-255 | 18 | 9.4e-11 | 42.97 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 172-255 Range on HMM: 1-69/69 Sequence Identity: 18% (18 aa) STAPII---TSIVSSSPT------TISLTWDPPPFPNGPIIGYTIAVQNFFNETGIVLDVDGSTTEATVVDSSLRAL----TLYAVSVRARNM--EGGG .| .... ..| ...|.|.|| |.||. .. . |.. | | ..|||.| | | PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| LY | ROS.AA | LY | 258-299 | 19 | 0.034169 | 8.64 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 258-299 Range on HMM: 1-51/51 Sequence Identity: 19% (10 aa) DMVNVTTGAEPEN-VAVDYWEN--FIFISDSDG-------RIHRRTIDPANL . . |. .|||. |. ... .|. .| | ..| | RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| LY | ROS.AA | LY | 305-345 | 17 | 0.012402 | 12.32 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 305-345 Range on HMM: 1-51/51 Sequence Identity: 17% (9 aa) EVLYTNQSTAPTK-LDVDWLNE--QLYFVQGT--------EILRCDLNVSGC ... ... | ..|||... ||.. . | ||... ... RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| LY | ROS.AA | LY | 346-387 | 15 | 0.062799 | 6.43 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 346-387 Range on HMM: 1-51/51 Sequence Identity: 15% (8 aa) SVAVANLGSVPVE-MKVDPFSG--YLFWSERDVG-------IRRTSLTSSTV . . . | . ||...| .|.|. |.| ... ... RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| FN3 | ROS.AA | FN3 | 541-621 | 19 | 2.9e-08 | 34.68 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 541-621 Range on HMM: 1-69/69 Sequence Identity: 19% (19 aa) IGQPSS---PQPSNIGTT------SLTLSWTAASHQDVRYLVQWRYVEGGGEAWNYFGSGEPISETTLDITDLIPY----TLYQFRVVWV----ITPR | |. .. .....| |.||||.. |..| .|.| |. | |.|||. | . PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| FN3 | ROS.AA | FN3 | 641-724 | 19 | 3.5e-12 | 47.73 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 641-724 Range on HMM: 1-69/69 Sequence Identity: 19% (19 aa) STAPTI---TSIVSSSPT------TISLTWDPPPFPNGPIIGYTIAVQNFFNEARIVLGVGGSTTEATVVDSSLRAS----TLYAVSVRARNM--EGEG .|. .... ..| ...|.|.|| |.||. .. . |.. | | ..|||.| ||| PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| LY | ROS.AA | LY | 783-824 | 17 | 0.064552 | 6.33 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 783-824 Range on HMM: 1-51/51 Sequence Identity: 17% (9 aa) IHTVDNENSTISD-VAVDYWEN--FIFISDSDG-------RIHRRTIDPANL ... .. .|||. |. ... .|. .| | ..| | RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| LY | ROS.AA | LY | 830-875 | 19 | 0.245439 | 1.48 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 830-875 Range on HMM: 1-51/51 Sequence Identity: 19% (10 aa) EVLYTDQSTAPTK-LDVDWLNE--QLYFVQGTEKLS---PQLALAAVCGTFS ... ... | ..|||... ||.. ... | | . ||. RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| LY | ROS.AA | LY | 899-940 | 15 | 0.055786 | 6.86 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 899-940 Range on HMM: 1-51/51 Sequence Identity: 15% (8 aa) SVAVANLGSVPVE-MKVDPFSG--YLFWSEQDVG-------IRRTSLTSSTV . . . | . ||...| .|.|. . |.| ... ... RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| FN3 | ROS.AA | FN3 | 1079-1149 | 18 | 0.035671 | 9.85 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1079-1149 Range on HMM: 1-69/69 Sequence Identity: 18% (16 aa) PAFPPTD--LQVLFTEGE------EAWEEWLYEILLTNLQIGNTVTLTGLQEDSALVDNLNGS----TEYSVQVRAYSI--GGLG | || . |.| . . .| .. . . |..| |||...|||.. .| | PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP--IVGYR--------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| LY | ROS.AA | LY | 1229-1272 | 20 | 5.8e-05 | 23.74 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 1229-1272 Range on HMM: 1-51/51 Sequence Identity: 20% (11 aa) LTFVPPGVRSSVDA-IAVDWLSE--FIYWADRDQN------QIIRGRLSNQSS | . .... |||||... ..||.| .. | | .. . RTIISE-DL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| LY | ROS.AA | LY | 1277-1317 | 19 | 0.087151 | 5.24 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 1277-1317 Range on HMM: 1-51/51 Sequence Identity: 19% (10 aa) PTSINAFANDVQD-IAIDSVQA--YIYWTSSS--------SVEGSRLNGESP | |. . ||.| . ..||| .. . | ....| RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| FN3 | ROS.AA | FN3 | 1451-1526 | 10 | 0.0128 | 13.71 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1451-1526 Range on HMM: 1-69/69 Sequence Identity: 10% (10 aa) EISPSS---IQVTGTWDD-------FNITWQASTEVNYGIVFYTIAVTAPEQTYTETVQSASYNIKNLTPF----QSLDITISPYT---YWAT .|. ..|| . .. ....|.. || |. | ...|.| . .... .. . PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| FN3 | ROS.AA | FN3 | 1541-1630 | 18 | 4.1e-05 | 24.25 | SMART | 1-69 (69) | Show / Hide |
Range on Protein: 1541-1630 Range on HMM: 1-69/69 Sequence Identity: 18% (18 aa) PSVPLN---PRAFAIDSTDIMTGTTMYSAEFRWSEPAEINGVFEGYNVSWGTDVEQLTVFNVSVDVDVFSFANLTAN----TTYFFQVEGFTS--VGSG |. | | .|. ...|| . . ..|.. .|..| || . . .|... |.| |.| ... .|.| PGPPPNPTHLRVTDVTSTSTSD---WHSVTLSWKPP------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG |
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| LY | ROS.AA | LY | 1668-1710 | 15 | 0.04342 | 7.77 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 1668-1710 Range on HMM: 1-51/51 Sequence Identity: 15% (8 aa) EIPLLGGIAISV--VAFVASED--KVFFVETSGD-----LEIYRSKLDGSDR .. . .. .|. |. ..... . | |.|...||..| RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| LY | ROS.AA | LY | 1760-1802 | 17 | 0.03216 | 8.86 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 1760-1802 Range on HMM: 1-51/51 Sequence Identity: 17% (9 aa) ETPLLGGIAISV--VAFVASED--KVFFVETSGD-----LEIYRSKLDGSDR .| . .. .|. |. ..... . | |.|...||..| RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR |
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| Kinase | ROS.AA | Sev | 1911-2146 | 70 | 4.7e-215 | 720.74 | In-house | 37-277 (277) | Show / Hide |
Range on Protein: 1911-2146 Range on HMM: 37-277/277 Sequence Identity: 70% (170 aa) TLRKGATDEDKQEFLKEATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAPTNSK----ITLMDQIEIILDTVKGCEHLEELHFV |||||.||..||||||||..|.||||||||..|||||||.|||||.|.|||||||||.|||||....|.. .||||..|...|..||||.||..||| TLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMTTFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFV HRDLAARNCLVSTKSYEAH-ERVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFV |||||.||||||.|.|..| .||||||||||||||||||||||||||||||||||||.||||||..||||||||||.||.|..|.|||||.||.|||..| HRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYFTTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHV EAGGRLSQPDQCPDEIYMMMRRCWERSTEDRPSFKMLKEMI .|||||.||..|||...||||.||......||||.|...|. QAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML |
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| Kinase | ROS.AA | Pkinase_Tyr | 1911-2146 | 46 | 8.20000000001e-119 | 403.01 | Pfam | 35-270 (270) | Show / Hide |
Range on Protein: 1911-2146 Range on HMM: 35-270/270 Sequence Identity: 46% (114 aa) TLRKGATDED--KQEFLKEATVMGKF-KHPNIVLLMGVCL-DNDP--QYIIQELMEGGDLLCYIRAARMPAPTNSKITLMDQIEIILDTVKGCEHLEELH .|. ||..|. ...|..|| .| .. .||||| |.|||. . .| ||. |.|..|||| | |. | . . ..|. | ... .. ||.|.||. . MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKN FVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDIYKNDYY-RKEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQP-YPARSNVEVL ..|||||||||||. ..||||.|||||||||. ||| || |.| ||..||||| ...| |...||||.||.||||....|.|| || || ||. CIHRDLAARNCLVTE------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY RFV-EAGGRLSQPDQCPDEIYMMMRRCWERSTEDRPSFKMLKEMI ... | |.|. .|. ||||||..|..||. ||||.|. . |.. EYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | ROS.AA | ALK | 1911-2148 | 46 | 5.6e-107 | 361.7 | In-house | 36-273 (273) | Show / Hide |
Range on Protein: 1911-2148 Range on HMM: 36-273/273 Sequence Identity: 46% (111 aa) TLRKGATDEDKQEFLKEATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAP--TNSKITLMDQIEIILDTVKGCEHLEELHFVHR ||. . .| |..|| .||||.|.|.| . |.|.. | .|. |.|||||.. ..| | |..| | . . .| .|| ||| ||.|| TLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHPESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHR DLAARNCLVSTKSYEAHERVVKIGDFGLARDI-YKNDYYRKEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFVEA | |||||| ..| ||.||.||| |||| |. ||||| | ..|| || || .||| | .|||.||.|.||..| | ||| |.| ||. || . DIAARNCLLTCK---GPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTE GGRLSQPDQCPDEIYMMMRRCWERSTEDRPSFKMLKEMIQD |||. | || .| .|. || ||||.| . | ||. GGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY |
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| Kinase | ROS.AA | TK | 1911-2146 | 25 | 1.5e-100 | 337.83 | In-house | 59-486 (486) | Show / Hide |
Range on Protein: 1911-2146 Range on HMM: 59-486/486 Sequence Identity: 25% (109 aa) TLRKGATDEDKQ-------------EFLKEATVMGKFK-----HPNIVLLMGVCLDN------------DPQYIIQELMEGGD----LLCYIRAARMPAP .|..|....... .||.|| .| ... ||||| | |||... | .|. |.|..|| |. | |. | .. MLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQ T---------------------------------------------------------------------NSKITLMDQIEIILDTVKGCEHLEEL---- . ....|. ... . .. .|.|.|... HEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF --HFVHRDLAARNCLVSTKSY-----EAHERVVKIGDFG--------LARDIYK------------------------NDYYRKEGEGLLPVRWMAPEGL .|||||||||||||. . . ..|.||.||| ||||||. ||||.. | ||.|||||| | IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECL M---------DGYFSVQSDVWAFGILMWEVMSRGQQPYPA-RSN---------VEVLRFVEAGGRL--------------SQPDQCP------------- . .| |. .||||.||.||||....||.||. || ||......|||| ||..|| NDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCP -DEIYMMMRRCWERSTEDRPSFKMLKEMI .|.| .|..||.. ||||.|. |.|.. PEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| TyrKc | ROS.AA | TyrKc | 1888-2146 | 36 | 4.4e-100 | 339.72 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1888-2146
Range on HMM: 1-280/280
Sequence Identity: 36% (108 aa)
LSLEHMSEHGSYKMLNVLILQLM-----TLRKGATDEDKQEFLKEATVMGKF--KHPNIVLLMGVCLDN-------DPQYIIQELMEGGDLLCYIRAARM
..|... .| . .. . .|...| ...|..|| .| |. .||||| | |||.. .| .|. |.|..|||. |.|. |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP
PAPTNSKITLMDQIEIILDTVKGCEHLEELHFVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDIYKN-------DYYRK----EGEGLLPVRWMAPE
... | ... .. .|.|.|.. ...|||||||||||. . .|||.||||.|||| ||||| | ..||.||||||
K------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE
GLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPA-----RSNVEVLRFVEAGGRLSQPDQ--------CPDEIYMMMRRCWERSTEDRPSFKMLKEMI
...| |. .||||.||..|||....|||||| || ||...|..|.|. ||. ||||.|..|..||.. ||||.|. ..| .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | ROS.AA | UTK | 1911-2145 | 35 | 8.3e-90 | 304.66 | In-house | 36-296 (296) | Show / Hide |
Range on Protein: 1911-2145 Range on HMM: 36-296/296 Sequence Identity: 35% (94 aa) TLRKGATDEDKQE----FLKEAT---VMGKFK-HPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAP-TNSKITLMDQIEIILDTVKGCEHLE .....|......| |..||. .|..|. |||.. | |||.. | .|. |.||.|||..| | .| .| || .... .| | ..|. VCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH ELHFVHRDLAARNCLVSTK-SYEAHER--VVKIGDFG---LARDIY---------KNDYYRKEGEGLLPVRWMAPEGLMDG-YFSVQSDVWAFGILMWEV . .||||||||||||| . | . |.||.||| ..|... .||.. . . .|.|||||| | .. |. .||||.||...||. SCGFVHRDLAARNCLVHMHRM-MWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEI MSRGQQPYPARSNVEVLRFVEAGG--RLSQPDQCPDEIYMMMRRCWERSTEDRPSFK-MLKEM ...|..||| ||..|. .|..|| |. .|..||...|..|.|||. . ..||.|. ....| WTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | ROS.AA | InsR | 1911-2148 | 40 | 1.5e-88 | 297.58 | In-house | 38-278 (278) | Show / Hide |
Range on Protein: 1911-2148 Range on HMM: 38-278/278 Sequence Identity: 40% (100 aa) TLRKGATDEDKQEFLKEATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAP-----TN---SKITLMDQIEIILDTVKGCEHLEE |. .|..... |||.|| || .|.. ..| | ||| | |.. |.|. ||| | |. | . | . ..| . .. . | |. TVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAA LHFVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVL . |||||||.|||.| .|. |||||||..|||| |||||.| |.||||||||| | || |. .|||| ||...||. . | ||| || .|| KKFVHRDLACRNCMV------NHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVL RFV-EAGGRLSQPDQCPDEIYMMMRRCWERSTEDRPSFKMLKEMIQD ... .|. | .|. ||. . .|..|| . .||.|. . ....| KYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD |
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| Kinase | ROS.AA | Src | 1911-2146 | 38 | 1.6e-79 | 269.83 | In-house | 30-255 (255) | Show / Hide |
Range on Protein: 1911-2146 Range on HMM: 30-255/255 Sequence Identity: 38% (91 aa) TLRKGATDEDKQEFLKEATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAPTNSKITLMDQIEIILDTVKGCEHLEELHFVHRDL ||..| . . ||.|| .| |..|...| | || . .| ||..|.|. | || | .. .. ... | ..|.. .| . ||. ..|||| TLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDL AARNCLVSTKSYEAHERVVKIGDFGLARDIYK--NDYYRKEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFVEAG |||| ||.... |.|..|||||| . | | | . . .|..|.||| . | |.. |||| ||||..|....|. ||| .| |||. ||.| AARNVLVGENN------VCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERG GRLSQPDQCPDEIYM-MMRRCWERSTEDRPSFKMLKEMI |. .|..||||.|. |..||... |.|| |. | . YRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | ROS.AA | Met | 1923-2140 | 37 | 6.6e-79 | 258.29 | In-house | 47-271 (271) | Show / Hide |
Range on Protein: 1923-2140
Range on HMM: 47-271/271
Sequence Identity: 37% (88 aa)
EFLKEATVMGKFKHPNIVLLMGVCLDNDP--QYIIQELMEGGDLLCYIRAARMPAPTNSKITLMDQIEIILDTVKGCEHLEELHFVHRDLAARNCLVSTK
.||.|. .| |.|||. |.|.||| . ... . |..|||. .|| . .. | || .. || . . ...|||||||.|||. . .
QFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNP------QNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEH
SYEAHERVVKIGDFGLARDI-YKNDYYRKEGEGL---LPVRWMAPEGLM--------DGY-FSVQSDVWAFGILMWEVMSRGQQPYPARSN-VEVLRFVE
..||..||||.||. | || . . |||.||||| | . |. .|||| ||..||| | || ||| .| . .. . .
------FTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLH
AG--GRLSQPDQCPDEIY-MMMRRCWERSTEDRPSFK
| ||.|| ||| .| | .||. . ||||.|
QGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
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| Kinase | ROS.AA | TK-Unique | 1911-2146 | 35 | 1.4e-78 | 267.34 | In-house | 37-294 (294) | Show / Hide |
Range on Protein: 1911-2146 Range on HMM: 37-294/294 Sequence Identity: 35% (95 aa) TLRKGATDEDKQEFLKEATVMGKFK-HPNIVLLMGVCLDND-PQYIIQELMEGGDLLCYIRAARMP-----------------APTNSK--ITLMDQIEI .|...|||.|||.||||. .| . . ||||| ..|.| ..| |..|| | ...|.|. |.| |.. ..... |.. | . . MLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHF ILDTVKGCEHLEE--LHFVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDIYKNDYYRKE-GEGLLPVRWMAPEGLM--DGYF-SVQSDVWAFGILMW . . .| |.|.. ..|||||.|||.|.. |.||.|||.|||.|.| | .. ..| .|.|||||| | .| . . .||||.||.||| AWQIACGMEYLASQRKKIVHRDLCARNVLLTE------DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMW EVMSRGQQPYPARSNVEVLRFVEAGGRLSQPDQC-PDEIYMMMRRCWERSTEDRPSFKMLKEMI |... |..||| .. .... ...| |. ||..| ..|.| |..|| .. |.|||| .| .. EIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | ROS.AA | Trk | 1914-2146 | 37 | 1.3e-72 | 245.48 | In-house | 38-275 (275) | Show / Hide |
Range on Protein: 1914-2146 Range on HMM: 38-275/275 Sequence Identity: 37% (91 aa) KGATDEDKQEFLKEATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRA----ARMPAPTNS-----KITLMDQIEIILDTVKGCEHLEELH | |... ...| .|| .. . .|..|| . ||| |.|| .. | |. ||| | |. | . | . |. . |. . | . ..| KDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQH FVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDIYK-NDYYRKEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLR |||||.|.||||| ... .|||||||. ||.| |||| .. . ||.||| || | |.. |||| ||. |||... |.||. || || FVHRDMATRNCLV------GQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIE FVEAGGR-LSQPDQCPDEIYMMMRRCWERSTEDRPSFKMLKEMI .. .| | .| .|| |.| .|. || | . | . | . ..| CIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII |
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| Kinase | ROS.AA | HMTK | 1911-2145 | 39 | 6.7e-70 | 238.53 | In-house | 58-291 (291) | Show / Hide |
Range on Protein: 1911-2145 Range on HMM: 58-291/291 Sequence Identity: 39% (95 aa) TLRKGATDEDKQEFLKEATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAPTNSKITLMDQIEIILDTVKGCEHLEELHFVHRDL .|| .|..||. ||| ||.|| ..|||.| | |||. .| . | |. ||| ...| | . |. .|. .. . .|.. . . ..||.|| MLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPWLCVLEYMQYGDLRNVLKTCRE---KNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDL AARNCLVSTKSYEAHERVVKIGDFGLARDIY-KNDYYRKEGEG-LLPVRWMAPEGLM--DGYFSVQSDVWAFGILMWEVMSRGQQPYP--ARSNVEVLRF |||||||. .. .|||.||||.| . ||.. .. . ||..|||||.. ...|| .|||||||..|||... | |||. | || | AARNCLVGHNN------QVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRH VEAGGRLS-QPDQ-CPDEIYMMMRRCWERSTEDRPSFKMLKEM | .|.||. .|. |||... .|. ||.. . ||.|. |. | VREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM |
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| Kinase | ROS.AA | Pkinase | 1913-2146 | 20 | 4.4e-28 | 100.38 | Pfam | 34-293 (293) | Show / Hide |
Range on Protein: 1913-2146 Range on HMM: 34-293/293 Sequence Identity: 20% (57 aa) RKGATDEDKQEFLK--EATVMGKFKHPNIVLLMGVCLDNDPQYIIQELMEGG----DLLCYIRAARMPAPTNSKI--TLMDQIEIILDTVKGCEHLEELH .... .. .|. .. |. .| ...||||| | ... |.| |...|..||| || ||.. . .. . . . ... ...| |.. . KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMG FVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDI-YKNDYYRKEGEGLLPVRWMAPEGLM-DGYFSVQSDVWAFGILMWEVMSRGQQPYPAR----SN ..|||| |.|.. . . . |||.|||||. . | |. . | . ..|||| .. . | . .|.|..|....|... |. |.| . . IIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN- VEVLRFVEAGGR----LSQPDQCP-------------------DEIYMMMRRCWERSTEDRPSFKMLKEM--I .. . .. .. . | |. .| ...|... ..||... ... . HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | ROS.AA | S_TKc | 1853-2146 | 18 | 5.5e-24 | 86.94 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1853-2146
Range on HMM: 1-231/231
Sequence Identity: 18% (57 aa)
YEAPE-------GNTVEGISVNPHGKMAIRQENSNYAVTSEKLSLEHMSEHGSYKMLNVLILQLMTLRKGATDEDKQEFLKEATVMGKFKHPNIVLLMGV
|| . | .. .. . ..|| . . . ...| .. | .||||| | .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------EHIRREIQILKK-HHPNIVKLYDV
CLDNDPQYIIQELMEG--GDLLCYIRAARMPAPTNSKITLMDQIEIILDTVKGCEHLEELHFVHRDLAARNCLVSTKSYEAHERVVKIGDFGLARDIYKN
. | | |.. |...| |||. ||. . . ....... . .. .... |.. .....|||| | |... ..||.|||||| .
FQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH-GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL---
DYYRKEGEGLLPVRWMAPEGLMDGYFSV-QSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFVEAGGRLSQPDQCPDEIYMMMRRCWERSTEDRPSFKML
.|||| | .. .|.|..|....| .. |. |.| .... . ..| ..|.|... |.||. .
------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EA
KE---------MI
. .
LQDEWDIKCHPWF
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