Gene Met (Sea Urchin)
Met
Sequence
Protein domains of Met.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Sema | Met.AA | Sema | 43-496 | 18 | 8.5e-47 | 162.71 | SMART | 1-532 (532) | Show / Hide |
Range on Protein: 43-496 Range on HMM: 1-532/532 Sequence Identity: 18% (101 aa) LQHMIVNKETG--DLYLGGINFIYHLT-SNLSL------VDEQ-SSLTAD-------ITNFCSTGDSGCILPPDWGENENKVLLIDEDN---DFLIACGS ..||......| ||.|. | || |. .|||. . .. . . ... . |. | ...| .| ..||... |. . |..||. YNHMLLDEDRGNWRLYVGARNHIYQLSLPNLSKEWEHVTGPVIDWPSCPEPNEKCIKCQECQMKGKHFCPHNETWCDNYIRVLQPYNDHYYDTHLYVCGT AFNGT---CVLHHLNSITT-------VQSRVHDLV--HHEEASLGIGDSVVAFYGPSTVNTDGQQA-MGTALFVGASFNPLFNDTLIRQHAVS---TKLL | | .|.| . .. .|. .|.. .|.. |.|.... ..||. .. .. |. |..| . . . |.| .. . NAFGPDVMCWYHNLGNHEPWDEMEQEDQIFTHCPHSKQHNRSESGCGKCPYDPLHNSTSVFVDGYNPDGGELYSGTVADFSG-------VAQSYHRSDPI LQRNSRWTFDLAYQELRFGRYTYIDVREEHAHNYPIKYINGFTF-----EGFSYLTTVQKEDVD-----SEN--YHSRLVRICNKD--------SAYYSY |. . | . .. .. | .. | . . |.......|. | | ... . . ... ||||..|.| .| . ..|| IYRRLGMFQDGFHFWFHPSRTDQYDSKWG-YDLYEPHFVHAFEIPESNDGDFVYFFFRERAHEHMNRDCGYEKHYHSRVARVCKNDMGGQRLLQKKWTSY TEVPLKCRSYASGR----TYNLLQAAHVSSAGVELARDLNMKVGDMALFGLFAESSPDAP---DQPTSNMAMCIFTLKKITKKVRDGVQNCFFG------ ....| |. . || .|.||...|. .| ||.|.. .| |.| |..... .|... |.|.|..|.| . ..|.. |. | LKARLNCSVPDKGRRPEFYFNELQDVFVLPPGA-LAQDWGW-EQDDVLYGVFTQGQQWSSRDAANPWPGSAVCAFSMKDINRVFNEGPFKCYEGPNHQWH -YGSQGLSQFSDNLLC--------SYSTYRNVDD--SFCGTGDLHPIQAQTTVNAYDYLTGGGHGRHYTSLSTLTMGR-------DTVAVMGTKSGRIHK |.. .. .. ... ... | ... ....| . . . . ... . . ..|.. .... ||. .|| .||||| PYNGNKVPWPRPGTCPSNHFREQRNCCHTKDLPDDVLCFIKHHPLMDEAVQPIHGRPLFVKTNTDYRFTHIAVDRVHNLDGHHNWYTVMFLGTDDGRIHK FVIDPLSIDFVRRDYPLKPYKDLKLDTEG-PVLRDMPLDSEQ .|... . .. . .| . .. .| ...||| ....| VVVWRSRHNQSWHGWESHVYEEFQVFPHGSEPIRDMQFSHKQ |
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| Sema | Met.AA | Sema | 258-359 | 22 | 3.8e-05 | 19.18 | Pfam | 213-329 (484) | Show / Hide |
Range on Protein: 258-359 Range on HMM: 213-329/484 Sequence Identity: 22% (26 aa) TVQKEDVDS----ENYHSRLVRICNKDSAYYSYTE---------VPLKCRSYA--SGR-TYNLLQAAHVSSAGVELARDLNMKVGDMALFGLFAESSPDA ..... .| . .|||..|.| .|. .| | . |.| .. . . .| ||...| ... ||..| . ..|.|. .... FRETAVEYSMNCGKTIHSRVARVCKNDMGGHRYLEMNKWCTFLKARLNCSVPGPDGYPFYFNELQDVFVLPTDNWLAHELGISWRNPVIYGVFTTPWNI- PDQPTSNMAMCIFTLKKI .|. | |.| |... | FRGPMHNSAVCAFHMNDI |
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| Sema | Met.AA | Sema | 43-146 | 25 | 0.00062 | 14.79 | Pfam | 1-111 (484) | Show / Hide |
Range on Protein: 43-146 Range on HMM: 1-111/484 Sequence Identity: 25% (28 aa) LQHMIVNKETGDLYLGGINFIYHL-TSNLSLVDEQSSLTADIT---NFCSTGDSGCILPPDWGENENKVLLIDEDND-FLIACGS-AFNGTCVLHHLNS- .... .. ....|| |. | .| | . |||.. .. .. .. |. .. .|| | |. | ..... .|| |..||. ||...| .| | . FHTLLHDEDRDRLYVGARNHVYVLNLNNLSER-CYQKIHWPSSHGCEHCEECYMKGKDPPVWTECQNYIRVLHPYNDTHLYVCGTNAFHPVCWYHNLGHH -ITTVQSRVHDL . . |...| | HTADHQAEEHCL |
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| PSI | Met.AA | PSI | 514-575 | 23 | 2.9e-10 | 33.6 | Pfam | 1-57 (57) | Show / Hide |
Range on Protein: 514-575 Range on HMM: 1-57/57 Sequence Identity: 23% (16 aa) TCEHYIHCSACVTSRDPNGCGWCGG--VCTTEE-----ECDGADGPSGEIPETELDSEDDPDWVTDACS .|... ||.|. .||| .||||.. ||... .|.... ... .|... | NCSQHTSCSSCLSARDPFYCGWCSSQHRCTRGHAYTYGQCPRWWQ--------WMWW----SWSQSQCP |
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| TIG | Met.AA | TIG | 633-709 | 25 | 6e-09 | 32.64 | Pfam | 7-82 (82) | Show / Hide |
Range on Protein: 633-709 Range on HMM: 7-82/82 Sequence Identity: 25% (20 aa) HP-LVGPMFGRTMITLFGEGL-HAGNNPEVTVAGVPCHIHSVTPTKIHCVTRNSSELTTGPVILNLDSLQLISTLEFTY .| || | |.||. |... . .. ... |.|| ......| | |.| ... |..|.. .. . ... ||| SPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPG-THNVSV-VNGQWSSNPTTFTY |
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| TIG | Met.AA | TIG | 576-630 | 32 | 2.7e-07 | 27.08 | Pfam | 1-50 (82) | Show / Hide |
Range on Protein: 576-630 Range on HMM: 1-50/82 Sequence Identity: 32% (18 aa) PAIYEVSP-VFGPLQGDTTVNIIGDSLVADAAVNANSTLEVIIAGQPCHVDLSSSN | |. .|| . || .| ||. |.|. . |.. .. . . |.|| | .||. PTITSISPNTTGPPSGGTTITITGQNF-----GNDS-DTKCYFGGTPCTVIWWSST |
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| PSI | Met.AA | PSI | 514-575 | 24 | 4e-06 | 27.6 | SMART | 1-56 (56) | Show / Hide |
Range on Protein: 514-575 Range on HMM: 1-56/56 Sequence Identity: 24% (17 aa) TCEHY--IHCSACVTSRDPNGCGWC--GGVCTTEEECDGADGPSGEIPETELDSEDDPDWVT---DACS .|.|| ||.|. .||| .|||| .. ||.. ... ... .|. . |. NCSHYGVTSCSECLSARDPYRCGWCSWQHRCTHR-------------HRCDERRFWRQNWEHGPHKQCP |
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| IPT | Met.AA | IPT | 625-710 | 21 | 0.000565 | 20.45 | SMART | 1-111 (111) | Show / Hide |
Range on Protein: 625-710 Range on HMM: 1-111/111 Sequence Identity: 21% (24 aa) DLSSSNITHPLVGPMFGRT-MITLFGEGLHA-GNNPEVTVA------GVPCHIHSV------TPTKIHCVTRNSS----ELTTGPV----ILNLDSLQLI |.. . || || | | ||. | ... .. . |.| .|||.. .. .|.| |.| .. ..|| . ... . DPVIT-RIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVR S----TLEFTYA . .. ||| TQLSWPQPFTYV |
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| TIG | Met.AA | TIG | 713-822 | 21 | 0.003214 | 13.26 | Pfam | 1-82 (82) | Show / Hide |
Range on Protein: 713-822 Range on HMM: 1-82/82 Sequence Identity: 21% (25 aa) PFITHFSP-TKSYLSGGNNLQISGFNLHLGQNVQLEVSALTDSGHRVIKSQGCTVPWHSSDDTIPSGTLENSLTCTTPDLSDEELNPTPDQPFIANLTIK | || .|| | . |||... |.| |. . . . . .. ||| .|...| .|||| .. | |... PTITSISPNTTGPPSGGTTITITGQNF----------GNDS-DTKCYFGGTPCTVI-WWSSTQI---------VCTTPPHT----------PGTHNVSV- FNK---NILVPMSY |. . .. .| VNGQWSSNPTTFTY |
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| IPT | Met.AA | IPT | 712-825 | 16 | 0.014361 | 6.78 | SMART | 1-111 (111) | Show / Hide |
Range on Protein: 712-825 Range on HMM: 1-111/111 Sequence Identity: 16% (22 aa) NPFITHFSPTKSYLSGGN-NLQISGFNLHLGQNVQLEVSALTDSGHRVIKSQGCTVP-----WHSSDDTIPSGTL----ENSLTCTTPDLSDEELNPTPD .| || ..|.....||| . | | |.. |... ..| |... .|. .....|.|| ... .| DPVITRIHPNCGPCSGGTERITICGKNFDS-----------------DIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSP--IPG QPFI----ANLTIKFNKNILV----PMSYDGQ | . |.|. . |... QVPVRVTQEVQF--CNDNVRTQLSWPQPFTYV |
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| TIG | Met.AA | TIG | 856-930 | 22 | 8.5e-11 | 38.91 | Pfam | 18-82 (82) | Show / Hide |
Range on Protein: 856-930 Range on HMM: 18-82/82 Sequence Identity: 22% (17 aa) NTVLIRGEYLDLVSRKEDISVTVGSQPCAIQEFASTYIVCQVPSSLQQSGNGSGIYEVKVTMGDNQAHNVGLLQV .|. |.|... . . |.....|..||.. || |||..|.. .| ..|.| ..... .| . ... TTITITGQNF--GNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHT------PGTHNVSV-VNGQWSSNPTTFTY |
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| IPT | Met.AA | IPT | 838-925 | 19 | 0.008731 | 9.13 | SMART | 1-111 (111) | Show / Hide |
Range on Protein: 838-925
Range on HMM: 1-111/111
Sequence Identity: 19% (22 aa)
DPILEQFEDHIYLLDLTSNTVLIRGEYLDLVSRKEDISVTVG----SQPCAIQEF------ASTYIVCQVPSSLQQS-GNGSGIY----EVKVTMGDNQA
||. .... . . ....|.| ..| . ..|.|| ..|| .| .| ||| .|... || ..|.. ||...... ..
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVRT
--------HNV
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QLSWPQPFTYV
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| Kinase | Met.AA | Met | 1048-1298 | 56 | 7e-201 | 664.75 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 1048-1298 Range on HMM: 1-271/271 Sequence Identity: 56% (153 aa) AVGKVLGQGHFGCVFAGKLHQ-DGEEHQVAVKSLH---QGTLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKNGDILTFVRDPSNE ....|.||||||||..|..|. ||.||..|.|||| ......||.|||||||||.|.|.|||||||.|......||.||||.||.||..||.|.|.|. HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN LTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDI-YERSYYSAKDRTA--KLPVRWMALECLE--------RNI-YNTRT ...|.|.|||.|.|.||||.|..||||||||.||||||....|||.||||.||. |...|||....|. .|||.|||.|||. ... ..|.. PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKS DVWSFGVVMWELLTRGIVPYPSVDN-VDILTFLHGG--RRLSQPEHCPDHVY-EVMLSCWSVSPIDRPSFC ||||||||||||.|||..|||.||| .||...||.| |||.|||.||||.| .|||.||...|.|||.| DVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS |
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| Pkinase_Tyr | Met.AA | Pkinase_Tyr | 1047-1304 | 42 | 1.8e-123 | 418.83 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 1047-1304 Range on HMM: 1-270/270 Sequence Identity: 42% (114 aa) IAVGKVLGQGHFGCVFAGKLH--QDGEEHQVAVKSLHQGTLNE---ISNFLREGIMMKDF-KHRNVLSLIGVCI-ISDTNMPYVVLPFMKNGDILTFVRD | ||.||.|.|| |. |... .|... .||||.| .|. | . |.|| .|| . .| |...|.|||. .. | .|.|...|..|| |.. |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK P---SNELTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLERNIYNTRTDVWSF . . || .||..|.|||.|| ||. ...|||||||||......|||..||||.||||. .||. | .|||..|||.||. ....| .||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF GVVMWELLTRGIVP-YPSVDNVDILTFL-HGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVDNL ||.|||..|.| | || ..| ... .. |.|. .||.||| .|..|..|| | |||.| .. | GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| TyrKc | Met.AA | TyrKc | 1047-1304 | 37 | 2.6e-120 | 406.93 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1047-1304 Range on HMM: 1-280/280 Sequence Identity: 37% (108 aa) IAVGKVLGQGHFGCVFAGKLHQDGEEHQVAVKSLHQGTLNEISNFLREGIMMKDF--KHRNVLSLIGVCIIS-----DTNMPYVVLPFMKNGDILTFVRD | ||.|| |.|| |. |.. |||||.|. .. . |.|| .|. . .| |.. |.|||. . ...|. .|..|| . . |. ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK PSNELTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYER-------SYYSAKD-RTAK--LPVRWMALECLERNIYNT . ..|. ..||.|| |||.|| ||. ...|||||||||..... .||..|||||||||. .||..| . .| ||.||||.||. ....| HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT RTDVWSFGVVMWELLTRGIVPYPS-----VDNVDILTFLHGGRRLSQPEH--------CPDHVYEVMLSCWSVSPIDRPSFCLLVDNL .|||||||.|||..|.| ||| ..| ... .. |.|. ||.. ||| .|..|..|| | |||.| ... . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Met.AA | TK | 1047-1304 | 23 | 9.80000000001e-111 | 372.58 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 1047-1304
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)
IAVGKVLGQGHFG---CVFAGKLHQ-----------------------DGEEHQVAVKSLHQGTLNEISN--------------FLREGIMMKDFK----
| .||.||.|.|| |. |.... .|....|||| |. |. .. ||.| .|| ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HRNVLSLIGVCIISDT----------NMPYVVLPFMKNGD----ILTFVRDPSNE--------------------------------------------
| |...|.||| ... ...|. .|..|| ... |. ...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LTARQLLEFCRQIAEGMMYLAGL------KFVHRDLAARNCMLDKDMV-----------VKVGDFG---
|| .||| .|.|||.|| ||. . .|||||||||||......| .|..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LSRDIYERSYYSAKDR-----------------------TAKLPVRWMALECLE---------RNIYNTRTDVWSFGVVMWELLTRG-IVPYPSV
|.||||....| .|. .|||.|||| |||. ... | .|||||||.|||..|.| .|. .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
DN---------VDILTFLHGG--------------RRLSQPEHCP--------------DHVYEVMLSCWSVSPIDRPSFCLLVDNL
.| ... .| | |. ||.||| . .|..|..||. | |||.| |.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | Met.AA | Axl | 1047-1302 | 47 | 1.5e-98 | 333.74 | In-house | 1-267 (267) | Show / Hide |
Range on Protein: 1047-1302 Range on HMM: 1-267/267 Sequence Identity: 47% (127 aa) IAVGKVLGQGHFGCVFAGKLHQ-DGEEHQVAVKSL--HQGTLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDT----NMPYVVLPFMKNGDILTF--- ...||.||.| || | |.|.| || .|||| . | || .||.| . ||.|.| ||. |||||| . | |.||||| ||. || FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY --VRDPSNELTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLERNIYNTRTDVW . | | |. | || || ||. .|.||||||||||| || | | |||||. ||. || . . ||.||.|.|.| | ..| . ||| SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYY-RQGCIAKMPVKWIAIESLADRVYTSKSDVW SFGVVMWELLTRGIVPYPSVDNVDILTFLHGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVD .||| |||. ||| ||| |.| .. .| .| || ||| | | .|..| .||.. | ||||| | AFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE |
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| Kinase | Met.AA | UTK | 1047-1304 | 35 | 6.4e-93 | 315.01 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 1047-1304 Range on HMM: 1-296/296 Sequence Identity: 35% (107 aa) IAVGKVLGQGHFGCVFAGKLHQDG---EEHQVAVKSLHQGTL--NEIS---NFLREGI---MMKDFK-HRNVLSLIGVCIISDTNMPYVVLPFMKNGDIL .. |. ||||.|| |. ... |. .| .|||| . . | |..| ||| |. |.||| |.||| . ...|. .|.||| . VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLR TFVRDPSNE-------LTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKD-------MVVKVGDFG---LSRDIYE--------RSYYSAKDRT ...|. . . || .|.|.....||.|| ||.. .||||||||||| .... ||.|..||| .||... |||. .. SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ AKLPVRWMALECLERN-IYNTRTDVWSFGVVMWELLTRGIVPYPSVDNVDILTFLHGG--RRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVDNL ..|.|||| |.| . . | .||||||||.||..|.| .||| |........ | .|. .|..||. ||..|..|| .| .||.| ||. . DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | Met.AA | TK-Unique | 1047-1304 | 35 | 8.2e-92 | 311.32 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 1047-1304
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)
IAVGKVLGQGHFGCVFAGKLHQDG---EEH-QVAVKSLH-QGTLNEISNFLREGIMMKDFK-HRNVLSLIGVCIISDTNMPYVVLPFMKNGDILTFVR--
. ||.|.|.| ||.|. |.. .. ... .|||| |. |. . ..||.| ||| . | |.....|.|. || . .. ..... .|. ... |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC
----------------------DPSNE-LTARQLLEFCRQIAEGMMYLAG--LKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLP
.|..| .. ..|. |. ||| ||.|||. |.|||||.|||..| | |.|..|||..||.| . || ... ..|
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP
VRWMALECLE--RNIY-NTRTDVWSFGVVMWELLTRGIVPYPSVDNVDILTFLHGGRRLSQPEHC-PDHVYEVMLSCWSVSPIDRPSFCLLVDNL
.||||.| | ...| .|..|||||||.|||..| | |||.... ||.. . | |. ||||| .. .|..| |||. .| .|||| ... |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
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| Kinase | Met.AA | InsR | 1047-1306 | 38 | 4.3e-81 | 272.1 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 1047-1306 Range on HMM: 1-278/278 Sequence Identity: 38% (108 aa) IAVGKVLGQGHFGCVFAG---KLHQDGEEH--QVAVKSLHQG-TLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKNGDILTFVR-- |. .. .||| || | | . .|.|. ..|.|.. . .. | .|| | || |.. .| | ||| | ||| .|. || .. | IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVC--SRGQPMYVVMEMMTYGDLKSYLRSR --DPS-NELTAR---------QLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLERNI . |.. |... .|. || ||| .||||||||.|||| ..| ||.||||. ||||| || | . .||||||| | | . RPEEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYY-RKGGKGMLPVRWMAPESLKDGV YNTRTDVWSFGVVMWELLTRGIVPYPSVDNVDILTFL-HGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVDNLDG . | ||||||||.|| | | || | .| . .| | .|| ||. ..|.| || .| .||.| ....| FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD |
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| Kinase | Met.AA | Src | 1047-1304 | 37 | 1.4e-76 | 259.73 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 1047-1304 Range on HMM: 1-255/255 Sequence Identity: 37% (98 aa) IAVGKVLGQGHFGCVFAGKLHQDGEEHQVAVKSLHQGTLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMP-YVVLPFMKNGDILTFVR--DPSNE | . ||||.|| |. |. . . .||||.| .||. . ||.| || ..| ....| || . | | | .|..| |.. . . . IKLCRKLGQGQFGEVWMGYWNG---NTKVAVKTLKPGTM-SPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE---PIYIVTEYMSHGSLLDYLKKDGEGRH LTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYE--RSYYSAKDRTAKLPVRWMALECLERNIYNTRTDVWSFGVVMW | .||... |.||||.|| ...|||||||| ... |.||.|||| | . . |.|. ||.|..|.| |.. .. ... .||||||. .. LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARH-GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLT ELLTRGIVPYPSVDNVDILTFLHGGRRLSQPEHCPDHVYE-VMLSCWSVSPIDRPSFCLLVDNL |. |.| |||| .| . |. . | |. .|..||| .|| .|| || .| .|| | | . | EIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | Met.AA | Sev | 1047-1304 | 39 | 6.3e-75 | 249.03 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 1047-1304
Range on HMM: 1-277/277
Sequence Identity: 39% (110 aa)
IAVGKVLGQGHFGCVFAGKLHQDG----EEHQVAVKSLHQG-TLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKNGDILTFVR---
. || | || |. | . || .||.|.| | | | ||.| .| ||| |.. ..||| |. |... | || |...|
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCL--DNEPQYIIMEHMEGGDLLCYLRAAR
-----DPS--NELTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCML-------DKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLER
.|. || |.| | |. | || . |||||||.||| .. |||.||||| |||| || | ||||||| | |
MTTFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYY-RKEGEGLLPVRWMAPESLMD
NIYNTRTDVWSFGVVMWELLTRGIVPYPSVDNVDILTFLHGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVDNL
.. | |||.||. .|| .|.| ||| |...| . | ||.||. ||| .. |. || .| .|||| . . |
GYFTTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
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| Kinase | Met.AA | EGFR | 1047-1305 | 36 | 1.5e-74 | 246.94 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 1047-1305 Range on HMM: 1-258/258 Sequence Identity: 36% (96 aa) IAVGKVLGQGHFGCVFAGKLHQDGEEHQ--VAVKSLHQGT-LNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKNGDILTFVRDPSNE . .|||| | || |..| .||. . ||.| |.. | . .|.| .| .| ... |.|||. |. . .|. | .| .|| .. LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPY---GCLLDYVRQHKDN LTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLERNIYNTRTDVWSFGVVMWEL . ...|| .| ||| ||.|| . ||||||||| .. . ||. ||||.. . | . . .|.|..||||||... .| . ||||.|| .||| IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAK-LLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL LTRGIVPYPSVDNVDILTFLHGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVDNLD .| | || . .| .| | ||.||. | || ||..|| . . || | |. .. MTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | Met.AA | Abl | 1047-1304 | 40 | 5.3e-73 | 242.75 | In-house | 1-252 (252) | Show / Hide |
Range on Protein: 1047-1304 Range on HMM: 1-252/252 Sequence Identity: 40% (105 aa) IAVGKVLGQGHFGCVFAGKLHQDGEEHQVAVKSLHQGTLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKNGDILTFVRDPSNE-LT | . . || | .| |. | . .. ||||.|. |. |. .||.| .||. ||.|. |.||| |.. || .| .| ..|. . | |. IMMKHKLGGGQYGEVYEGVWKR--HDCTVAVKTLKEDTM-EVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPF--YIITEFMCYGNLLDYLRECDREELP ARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLERNIYNTRTDVWSFGVVMWELLT | || ||| || || .|.|||||||||.. . .||| ||||.| . . | |. || |..| | | | | . .. ||| |||..||. | AVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLAR-MMKDDTYTAH-AGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIAT RGIVPYPSVDNVDILTFLHGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVDNL |. |||..| .. | | |. .|| ||..|||.|. || |. ||||| . .. YGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
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| Kinase | Met.AA | S_TKc | 1047-1308 | 20 | 2.1e-44 | 154.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1047-1308
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)
IAVGKVLGQGHFGCVFAGKLHQDGEEHQVAVKSLHQGTLNEISNFLREGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKN--GDILTFVRDPSNE-
.....|.| ||.|. .. . ..||.| .. ...|| ..| .| |. |..|. . |.|. .. . || ... .. .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LTARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVVKVGDFGLSRDIYERSYYSAKDRTAKLPVRWMALECLERNIYNT-RTDVWSFGV
.. . ...||.... |. ....|||| | .||. ..|..||||.| . .| .|| | | |.. . |.||.|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC
VMWELLTRGIVPYPSVDNVDILTFLHGGRRLSQPEHCPDHVYEVMLSCWSVSPIDRPSFCLLVD-----NLDGIL
...|.|. | |.| ... . . | .. . . . |. . | .||. . ... .
ILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Met.AA | Pkinase | 1047-1304 | 18 | 2.8e-35 | 125.8 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 1047-1304 Range on HMM: 1-293/293 Sequence Identity: 18% (57 aa) IAVGKVLGQGHFGCVFAGKLHQDGEEHQVAVKSLHQGTLNE---ISNFL-REGIMMKDFKHRNVLSLIGVCIISDTNMPYVVLPFMKNG----DILTFVR . .|...|.| ||||. .. . .|. .|||| . . .. ..... .| .|| ..| |.. |.... . .|.|.... .| | .... YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS -DPSNEL--TARQLLEFCRQIAEGMMYLAGLKFVHRDLAARNCMLDKDMVV----KVGDFGLSRDIYERSYYSAKDRTAKLPV---RWMALECLE-RNIY . .. . . ... ...||..|. |. ...|||| |...|..... |..||||.. .. ... .. .. ..|| | . .. | TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYY NTRTDVWSFGVVMWELLTRGIVPYPSV----DNVDILTFLHGGRR----LSQPEHCP-------------------DHVYEVMLSCWSVSPIDRPSFCLL .. |.||.|....|.|. | |.|. . .| . . .. . |. |. . ... .|. . | .||.. . GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI VDN--L . . LQHPWF |
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