Gene JAK2 (Sea Urchin)
JAK2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| JAK2.kin_dom2 | Protein Kinase Domain | None | 268 | None | Fasta, JSON |
| JAK2.AA | Protein | None | 829 | None | Fasta, JSON |
| JAK2.kin_dom | Protein Kinase Domain | None | 157 | None | Fasta, JSON |
Protein domains of JAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| B41 | JAK2.AA | B41 | 31-248 | 15 | 2e-06 | 21.7 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 31-248
Range on HMM: 1-232/232
Sequence Identity: 15% (37 aa)
GMEPDIVEVRTYMCGNLVLPWRERLTVEQVCIKAAKLCGIPRLTSNLFALYDKTN---KKWLCPKAQVFSRRQR----KSEQLEYRVRFHTAT-MCPSGD
.| . |... . | . . |....| .... ||| .. ...|.|. . ..|| . . .. . . ...| .||.| . . ..
SPKPRFCRVYFMDGTTLEFEVDSSTTGQDLCDHVCRHCGISPREHWYFGLWYEDPHEDRHWLDHWKTIMKQDVKWHKSEPWTLHFRVKFYPPDWHG----
AQGFMLLEENVVN-YMFCQYRESFLNDEFMGLSTEESLGLMVLDFMQHVKEDGTS-------LTNLNGRLRFGRFLPKSLNE------GLSWWDKRKLRR
.| |.... |...| |. .|.... ..||.|.| .|... . ... . .. . . .. |||||.... . . . ..|.
-FPNQLQEDPTRYNYFYLQCRHDILQGRHPCPHEEECLQLAALQVQIEYGDYDPEETNNKKMTKHVQKYKSYKRFLPKQWIDSIKQSFMHYQMHHKEWRK
KVRTALTDFRDDPRETFAFRVMFLVSLSEEMKQEWGTEQF
... . ... .| .. . .. . .. |.| |
RIMEWHKNHCGMTPEEAKLKYLQIC---QRWPPMYGVEHF
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| SH2 | JAK2.AA | SH2 | 357-445 | 24 | 8.4e-12 | 46.46 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 357-445 Range on HMM: 1-87/87 Sequence Identity: 24% (22 aa) KNRCHGPIPLSKAKQKIEETGRQEGVYLIRQNPEDHYSYCLTVRIHANQELKNFKINCYEDDDQVGLDN--QRRFNCLRSFVEFYRSRENS . .||.|. ..| |. | ..| .|.|. . ..|.|.|| . .. |...|.. .| ... .| |.|..| |..|. . QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK--GKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| Kinase | JAK2.AA | Jak | 498-761 | 28 | 7.8e-87 | 294.79 | In-house | 2-299 (299) | Show / Hide |
Range on Protein: 498-761 Range on HMM: 2-299/299 Sequence Identity: 28% (86 aa) TNWRHLDDGDFTEVWAADLRKKV------GNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEG-----IGAGYMLVMEYASEGPLDHY . .|| |.|. | .. . .. .. |..| .... .....|......||.|.||||....| ....|..||||...||||.| KWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDY LRSLLENERKRLGL--NSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPN-----MHIKLADPMLGVYYHSLEMTSRPKLERVRWTAPELLAT- |....|........ ..... |.|......|||..|..||.|.|.|.|| |.... ...||.||. .......||..| ||..|.|||.|.. LHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDR--DERIPWYAPECLTNC NSEPTLAGDKFSYA-ITLWQIM----------------SHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDVNS ....|||.||.|.. .|||.|. . | .| . | | || .|. |..|. .| ||. .|..||| | ..||.|. KFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLNQ |
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| Kinase | JAK2.AA | TK | 506-759 | 15 | 6e-52 | 172.04 | In-house | 10-486 (486) | Show / Hide |
Range on Protein: 506-759
Range on HMM: 10-486/486
Sequence Identity: 15% (75 aa)
GDFT---EVWAADLRKKVGNRPRK-------------------MRVAIKCPKMDAPQSVQQKFS----------------QSVDLMSS--WVHKHIIRFE
| | ||. . .| . ...... ..||.|. | ....| ...| . .|.. |..|.|.
GQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLY
G---IGAG------------YMLVMEYASEGP----LDHYLRSLLENERK--------------------------------------------------
| |.. .|.||||.. | |..|||. .....
GVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHP
---------------------RLGLNSQLHAAFQLIDALEYLESR------RIVHGNVSAHNTLVLRPAPN--------MHIKLADPMLG----------
.| . .| ..|. ...|||.|. ..||... |.| || . .. ...|.|| |
PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARD
-----VYYHSL-EMTSR------------------PKLERVRWTAPELLATNS--------EPTLAGDKFSYAITLWQIMSHG-AIPAENLSD-------
|| . . |.| .||.||| |... | . | .|. ...| |...| . .....|.
IYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG
--EXXXXXYRHG--------------VRLDAPPGCP--------------QELLKIMEACWSHNPRNRPSCRGVLRDV
. | | |. .||.|| .|. .| ||...|. ||. . ...
DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | JAK2.AA | Pkinase_Tyr | 506-759 | 25 | 3e-38 | 130.16 | Pfam | 10-270 (270) | Show / Hide |
Range on Protein: 506-759 Range on HMM: 10-270/270 Sequence Identity: 25% (67 aa) GDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSV--QQKFSQSVDLMSSW-VHKHIIRFEGIGA----G--YMLVMEYASEGPLDHYLRSLLENERK | | ||. . .. |. ||.|. | .| .. ...| . . .|.. |..|.|. |. ...||||. | |..|||. .... GAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQ RLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADP--MLGVYYHSLE-MTSRPKLERVRWTAPELLATNSEPTLAGDKFSYAI .| . |. ..| ...|||||....| . | | || . |...| .| . .| . .. ..|.||| .... | . | |. . PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGV TLWQIMSHGAIP-AENLSDEXXXXXY-RHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV ..| |.. |..| ...|.| ..| |...|..||.|. ..| || ..| .||. . .... LMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | JAK2.AA | TK-Unique | 497-759 | 23 | 1.2e-34 | 116.93 | In-house | 1-294 (294) | Show / Hide |
Range on Protein: 497-759 Range on HMM: 1-294/294 Sequence Identity: 23% (71 aa) RTNWRHLDDGDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWV-HKHIIRFEGIGA--G--YMLVMEYASEGPLDHYLRSLL .. . ...| | .|| ...... ... .. .||.| | .| . .|.| . .|.. |..|....|. . |..|||.. | |.||||. LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR -E-----------------NERKR---LGLNSQLHAAFQLIDALEYLES--RRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYY-----HSLEMTSRP . ....| . . . .| |.|. ..|||.| ..|||....|.| |. . . .|..| .| . . ..|. . PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICD--FGMARDVYTNGVYSMMCSQ KLERVRWTAPELLA-TNSEP-TLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGC-PQELLKIMEACWSHNPRNRPSCRGVLRDV . .|| ||| | . | .| |.....| |.. || | ..... | |.|.. |..| ..|. ..|. ||...| |||.| .. GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | JAK2.AA | TKL | 503-759 | 18 | 3.6e-27 | 94.9 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 503-759
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)
LDDGDFTEVWAADLRKKVGNRPRK----MRVAIKCPKMDA--------------------------PQSVQQKFSQSVDLMSSWVHKHIIRFEG--IGAG
. | | ||. . .| | . . ||.| |.. .. .... . . .||. | .|..| | . .
IGSGGFGEVYKGKWRGWGG-KC-PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP
--------------YMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRR--------IVHGNVSAHNTLVL-----------RP
...||||.. | | ||| .. .. | . ...|| |.. |.| . .| || .|
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP
APNMHIKLADPMLGVYYH---SLEMTSRP-------------KLERV---RWTAPELLATN---------------SEPTLAGDKFSYAITLWQIMSHGA
. . ..|..| | . . ..|. . .. || |||.| . .| . . | .|..| || |..
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
IPAENLSDEXX---------XXXYRHGVRLDAP------------PGCPQELLKIMEACWSHNPRNRPSCRGVLRDV
... ... . .| |. | | ||... |.|. ||.|.|..|||. .|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | JAK2.AA | UTK | 668-759 | 26 | 1.2e-24 | 81.21 | In-house | 203-296 (296) | Show / Hide |
Range on Protein: 668-759 Range on HMM: 203-296/296 Sequence Identity: 26% (25 aa) VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHG--VRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV .||.||| |. .. .|.. | .|. ...| |...|. | ...|.. . | |. .|..|| .. ..| .|| .|..||... .. . IRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | JAK2.AA | Abl | 571-759 | 27 | 1.5e-20 | 64.87 | In-house | 70-252 (252) | Show / Hide |
Range on Protein: 571-759 Range on HMM: 70-252/252 Sequence Identity: 27% (52 aa) YMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYYHSLEMTSRPKLE-RVR . .. |. . | | ||| |..|. | |. | |. ...|||.| .| . | | || . . .|.|| | . | . .. FYIITEFMCYGNLLDYLR---ECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLV---GEHHIVKVADFGLARMMKDDTYTAHAGAKFPIK WTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV ||||| || | . | . . . || | | | . . .| |.. |.|||.. ..| .|| .. ||| . . . . WTAPESLAYN-KFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
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| Kinase | JAK2.AA | Frk | 572-763 | 27 | 4.2e-19 | 62.55 | In-house | 70-260 (260) | Show / Hide |
Range on Protein: 572-763 Range on HMM: 70-260/260 Sequence Identity: 27% (54 aa) MLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGV-YYHSLE--MTSRPKLE-R ... | .| | .||... .. |. . .. .. | |. . ||||. .| . | | || . .|.|| | | || YIITELMRHGSLQEYLQAINDKGRQ-CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV---GEHNICKIADFGLARVLMKDNEDIYESRHGARFP VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDVNSFL ..||||| .|. |. | .|. | | |. .| .| . . || |. ||.|||.| .|| || ..|..|| . .. .. IKWTAPEAANYNKF-TIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | JAK2.AA | TyrKc | 497-759 | 23 | 1.2e-17 | 62.66 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 497-759 Range on HMM: 1-280/280 Sequence Identity: 23% (71 aa) RTNWRHLDDGDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSW--VHKHIIRFEGIGAG----------YMLVMEYASEGPLD | . | | | ||. . .. . ||.|. | || .. | . .|.. |..|.|. |. .|.||||.. | |. ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK HYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYYHSL-------EMTSR--PKLER----VRWT .|||. .. | . |. ..| . |||.|....| | | || .. ..| .| | . .. .. . | .. .||. DYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM APELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAEN-----LSDEXXXXXYRHGVRLDAPPG--------CPQELLKIMEACWSHNPRNRPSCRGVLRD ||| . .. | . | .|. ...| |.. |. | .. .|.. ..| |.. || ||.|. .||. || ..| .||. . . .. APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC V F |
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| Kinase | JAK2.AA | Musk | 668-759 | 30 | 5.3e-17 | 52.51 | In-house | 192-282 (282) | Show / Hide |
Range on Protein: 668-759 Range on HMM: 192-282/282 Sequence Identity: 30% (28 aa) VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDV .||..|| . | |.. | .| . || | | . | ... | | | .| | |||.. ..| ||. || .||. . . . IRWMPPESIWYN-QFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI |
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| Kinase | JAK2.AA | FAK | 523-647 | 32 | 3.2e-16 | 50.68 | In-house | 48-167 (285) | Show / Hide |
Range on Protein: 523-647 Range on HMM: 48-167/285 Sequence Identity: 32% (41 aa) RPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEGI--GAGYMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESR || |. |||| | . .... || | | | ||.. || ..|| . | | || |. ....| . . . ..|| |. ||||. RPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWIIMELCKYGELRHY----LQRNKNSLKHATLILYCYQLCMAMAYLESK RIVHGNVSAHNTLVLRPAPNMHIKLAD . || . | | || . . .||.| KFVHRDIAARNVLV---SSPDCVKLGD |
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| Kinase | JAK2.AA | Eph | 668-763 | 34 | 3e-13 | 40.72 | In-house | 174-264 (264) | Show / Hide |
Range on Protein: 668-763 Range on HMM: 174-264/264 Sequence Identity: 34% (33 aa) VRWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLRDVNSFL .|||||| .| | | | || | .| .|| | | ..|. | || .|..||. | ..| || . .|| .. |.| IRWTAPEAIAYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPH----FQQIVSIL |
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| Kinase | JAK2.AA | S_TKc | 497-763 | 17 | 9.5e-11 | -19.28 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 497-763 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) RTNWRHLDDGDFTEVWAADLRKKVGNRPRKMRVAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEGIGA--GYMLVMEYASE--GPLDHYLRSLLE . |.. | | .|. . .| . .||||. | ... . ...... |..|... .. . .||||.. | | .|... YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGR -NERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLVLRPAPNMHIKLADPMLGVYYHSLEMTSRPKLERV---RWTAPELLATNSEPTL-AGD |... . . |...||||. |..|.| . | |. . |||..| |. . . . |||.| . . | HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICD--FGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCD KFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRPSCRGVLR-----DVNSFL | ..|. .. | | . ... . ..|.. ... |. .|..||.. .|. .. WWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | JAK2.AA | UTK | 572-634 | 33 | 2.9e-09 | 27.84 | In-house | 86-151 (296) | Show / Hide |
Range on Protein: 572-634 Range on HMM: 86-151/296 Sequence Identity: 33% (22 aa) MLVMEYASEGPLDHYLRSLLEN---ERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVSAHNTLV |.|.||...| |..|||. .. .. | | ..|. | . ....||.|...||... | | || MIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV |
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| Kinase | JAK2.AA | Eph | 506-588 | 33 | 1e-06 | 18.21 | In-house | 10-96 (264) | Show / Hide |
Range on Protein: 506-588 Range on HMM: 10-96/264 Sequence Identity: 33% (29 aa) GDFTEVWAADLRKKVGNRPRKMR-VAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEGI---GAGYMLVMEYASEGPLDHYLR |.| || |... | | .. |||| | .. . . | .| | .||| ||. . | | || |.|| .|| GEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLR |
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| Kinase | JAK2.AA | FAK | 683-750 | 30 | 1e-06 | 18.38 | In-house | 204-271 (285) | Show / Hide |
Range on Protein: 683-750 Range on HMM: 204-271/285 Sequence Identity: 30% (21 aa) TLAGDKFSYAITLWQIMSHGAIPAENLSDEXXXXXYRHGVRLDAPPGCPQELLKIMEACWSHNPRNRP | | | ... .| |...| | . . | || || || | .| ||. .| || TTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRP |
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| Kinase | JAK2.AA | Musk | 529-589 | 31 | 0.000428 | 9.17 | In-house | 32-95 (282) | Show / Hide |
Range on Protein: 529-589 Range on HMM: 32-95/282 Sequence Identity: 31% (20 aa) VAIKCPKMDAPQSVQQKFSQSVDLMSSWVHKHIIRFEG---IGAGYMLVMEYASEGPLDHYLRS ||.| | || . .|. | .| | |.. | .| | .|| ..| |. .|.| VAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHS |
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| Kinase | JAK2.AA | Pkinase | 669-759 | 10 | 0.003224 | 12.46 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 669-759 Range on HMM: 176-293/293 Sequence Identity: 10% (13 aa) RWTAPELLATNSEPTLAGDKFSYAITLWQIMSHGAIPAENL----SDEXXXXXYRHGVRLDAPPGCP-----------------------QELLKIMEAC .. |||.. .... . . | .|. ..|.. .. . . . .. . . . .| .|...... | WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC WSHNPRNRPSCRGVLRD--V . .| ||... .| . . LCKDPKKRPTAEQILQHPWF |
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| Kinase | JAK2.AA | Pkinase | 573-624 | 24 | 0.025408 | 9.29 | Pfam | 77-131 (293) | Show / Hide |
Range on Protein: 573-624 Range on HMM: 77-131/293 Sequence Identity: 24% (14 aa) LVMEYASEG----PLDHYLRSLLENERKRL--GLNSQLHAAFQLIDALEYLESRRIVH .||||. | | .|.. ..... . . . |.. .|||. |..|.| MVMEYCEGGLYVMDLFDYIST---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH |
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