Gene JAK1 (Sea Urchin)

JAK1

Species: Sea Urchin
Alias: Spk275, SPU_022495, JAK1
External Links: Sea Urchin Project Link
Annotation: Secondary Group: TK,

Classification

Group: TK
Family: Jak

Sequence

Name Sequence Type Origin Length Description Download
JAK1.AA Protein None 355 None Fasta, JSON
JAK1.kin_dom Protein Kinase Domain None 267 None Fasta, JSON
JAK1.kin_dom2 Protein Kinase Domain None 140 None Fasta, JSON

Protein domain

Protein domains of JAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase JAK1.AA Jak 71-336 34 2.3e-108 366.31 In-house 1-299 (299) Show / Hide 
Range on Protein: 71-336
Range on HMM: 1-299/299
Sequence Identity: 34% (105 aa)

LKKEERLGSGHFGMVFRGVLMPRQ------GIPAE---IVAKVIKND---SRSDQFQQEIRAMSYCDHKNIVKVLG-YCEDNSNRLSLVMEYFPLGSLEK
||..|.||.||||||.|......|      ....|    |.|.....   ..|..|..||..||...||.|||. | .|..  . . .|||| ..|.| .
LKWHEHLGEGHFGMVYRCRYDWIQDMTDDEDQWHEQKQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDD

YLR----EKKDRVSH--KTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENE---VKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRH
||.     .|..|.|  .....| .|||.||.|| |... .|.|..|||.|| .|.    |||..|.|.    . |.|||....    .| ||||| |. 
YLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYL-EDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPWCSDKEYYREMMDR-DERIPWYAPECLTN

QKYQK--ESDVWSLG-IVLWEMF-SYGQDPI---------YQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSMIVRLG
.|  .  ..|.|| | ..|||.. .|.  .          ......|...|...|.|.|.|.||.||.||...|...|..||..|| .||.|...|..|.
CKFYLTLAMDKWSFGRVTLWEICNCYCDESHSPYAIFLCMIGCCPQRQMDHCRKLNFYENGHRLPHPDSCWDEIYNLMQQCWHYDPNQRPSFRTIIRDLN

I
.
Q
Kinase JAK1.AA Pkinase_Tyr 71-334 35 1.1e-98 334.89 Pfam 1-270 (270) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-270/270
Sequence Identity: 35% (100 aa)

LKKEERLGSGHFGMVFRGVLM-PRQGIPAEIVAKVIKNDSRSDQ-----FQQEIRAMSYC-DHKNIVKVLGYCEDNSNR--LSLVMEYFPLGSLEKYLRE
... . ||.|.||.|..|..    ..   .   |..|... ..|     | .|.. |.   .|.|||. .| | | .    . .|||| |.|.| .|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---KDRVSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYY-RAKESSQKVPIKWYAPEWLRHQKYQKESDV
.   |.....|.|  . .||..|| ||.. . ..||||||||.||...| |||.||||||   ...||| |.....  .||||.||| ... |.  .|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WSLGIVLWEMFSYGQDPIYQDSKGR--RVEHIELLDFF-EKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSMIVRL
|| |...||.|.||. |           .   |..... |.| |.  |. ||. | ..| .||. || .|| |.  . .|
WSFGVLMWEIFTYGEQP-------TYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase JAK1.AA TyrKc 71-334 35 1.9e-95 324.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-280/280
Sequence Identity: 35% (102 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKNDSRSDQFQQEIRAMSYC--DHKNIVKVLGYCEDNS------NRLSLVMEYFPLGSLEKYLREK
..... ||.|.|| |..|..        .   |..|.|.    | .|.| |.    .|.|||. .|.| . .        | .|||| |.|.| .|||..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KDRVSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTE------KDYYRAKE-SSQK--VPIKWYAPEWLRHQKYQK
......|.|  |  ||..|| |||. .  .||||||||.||.... |||.||||.|  . .      |||||.|| .. |  .||.|.||| ... |.  
RPKLCMKDLLSFCWQIACGMEYLHSKN-CIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

ESDVWSLGIVLWEMFSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPS--------CPAAIETMMNDCWEMDPLKRPKFQSMIVRL
.||||| |...||.|.||| | . . .   .. .|.. . ..|.|.  ||.        ||... ..| .||. || .|| |.  . ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase JAK1.AA TK 71-334 21 6.6e-94 315.18 In-house 1-486 (486) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-486/486
Sequence Identity: 21% (104 aa)

LKKEERLGSGHFG---MVFRGVLMPRQ----------------------GIPAEIVAKVIK---NDSRSDQFQ----------------QEIRAMSY--C
.. .. ||.|.||   .|..| . .|                       | . .   |..|   ..|  ..|.                .|.  |..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHKNIVKVLGYCEDNSNR-----------LSLVMEYFPLGS----LEKYLREKKDR--------------------------------------------
.|.|||. .|.| .. ..           . .|||| |.|.    | .|||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VSHKTLYLFGQQICQGMKYLHEER-----MMVHRDLAARNVLVSNENE-----------VKITDFG---
                               .. ..|  . .||..|| |||. .      .|||||||||.||...|            .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARIFGTEKDYYRAKE----------------------SSQKVPIKWYAPEWLRHQK---------YQKESDVWSLGIVLWEMFSYGQDPIYQDS
     |||  . ..||||...                      |. |.||.|.||| |....         .  .|||||.|...||.|.||| | | . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

KGRRVEH----IELLDFFEKG--------------MRLTHPPSCP--------------AAIETMMNDCWEMDPLKRPKFQSMIVRL
  ..| .     |.... ..|              ||.  || ||              .... .| .||. || .|| |. .  .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase JAK1.AA EGFR 71-335 40 5.3e-80 265.3 In-house 1-258 (258) Show / Hide 
Range on Protein: 71-335
Range on HMM: 1-258/258
Sequence Identity: 40% (108 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEI-VA-KVIKNDS---RSDQFQQEIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEKYLREKKDR
|||   |||| || |..|. .|  |    | || ||... .    .. . .|  .|   ||...|..|| |  ..  . ||  | |.|.|  |.|. ||.
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHKDN

VSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLGIVLW
.  . | ... || .||.|| ||. |||||||||||||   | |||||||||..   ... |.|..   |.|||| | | ..|..|  .||||| |. .|
IGSQHLLNWCVQIAKGMQYL-EEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGG--KMPIKWMALECIHHRCYTHQSDVWSYGVTCW

EMFSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSMIVRLG
|.  .|| | |.      ..  |  |. ||| ||  || |   .  .|  || .|.  ||.|. .. .. 
ELMTFGQKP-YDG-----IPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase JAK1.AA TK-Unique 71-334 31 1.4e-70 240.8 In-house 1-294 (294) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-294/294
Sequence Identity: 31% (95 aa)

LKKEERLGSGHFGMVFRGVLMPRQ---GIPAEIVAKVIK---NDSRSDQFQQEIRAMSYCD-HKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEKYLREKK
|. ....|.| || |.|| . ..    . .  .. |  |   .| . ..| .||. |.. . |.|||. ||.| .....  ..||| | |.|..|||...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DR-------------------------VSHKTLYLFGQQICQGMKYLHE-ERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYYRAKESSQKVP
.                          .| |.|| |. ||..||.||..  .. |||||.|||||... ...||.|||.||   |    |  ..|....|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIP

IKWYAPEWLR--HQKY-QKESDVWSLGIVLWEMFSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSC-PAAIETMMNDCWEMDPLKRPKFQSMIVR
|.| ||| |.  |. |   .|||||.|...||.|..|. . | . . ..     ... ...|.|.  |..| . ..   |  ||  .| .|| | . . |
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKD-----IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHR

L
|
L
Kinase JAK1.AA Syk 71-328 37 2.4e-65 223.4 In-house 1-257 (257) Show / Hide 
Range on Protein: 71-328
Range on HMM: 1-257/257
Sequence Identity: 37% (100 aa)

LKKEERLGSGHFGMVFRGVLMPR----QGIPAEIVAKVIKNDSRSDQFQQEI----RAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEKYLREK
| . . .|.| || |  |..| .     .   ..  |. |.|      .||.      |   ||. ||. .| |.     . .|||  .||.. ||| ..
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICH--AEMMMMVMEMAELGPMHKYLQQH

KDRVSH-KTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLG
.. ..    | |   |. .||.|| ||.  |||||||||||  |.   || |||. .  |   .||.| ..  | |.||||||     |    ||||| |
RHEITANNVLELWHTQVAMGMCYL-EEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQA-TTHGKWPVKWYAPECIYYYKFSHKSDVWSFG

IVLWEMFSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQ
. .|||||||| | |   ||      |...| |.| |.  |. ||. .   ||.||  ..  || | 
VTMWEMFSYGQKP-YGEMKG-----QEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase JAK1.AA Ack 71-334 38 8.3e-65 217.54 In-house 1-266 (266) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-266/266
Sequence Identity: 38% (106 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKND---SR--SDQFQQEIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEKYLREKKDR
..  | ||.| || | ||.     |   .   |. . |   .   .| | .|  .|   || ..|.  |   |    | .|.|  |.|||   ||.   |
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPM-LMMVTELAPCGSLLDCLRK-HCR

VSHK---TLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNE-NEVKITDFGLARIFGTEKDYYRAKESS-QKVPIKWYAPEWLRHQKYQKESDVWSL
...    ||  |  ||..|| ||.  | ..||||||||.|.    . ||| |||| |  | ..|||| ..    |||. | ||| ||| .  . ||||. 
TAFFLIHTLCDFCMQIAMGMRYLEMKR-CIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMF

GIVLWEMFSYGQDPIYQDSKGRRVEHI-ELLDFFEKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSMIVRL
|  ||||||||..|     .|.. . | ...|   .| ||. |. || .| .||  ||. .| .||.| .    |
GVTLWEMFSYGEEPW----AGCNGYQILQKIDK--EGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase JAK1.AA UTK 71-334 27 1.7e-63 216.06 In-house 1-296 (296) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-296/296
Sequence Identity: 27% (84 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKNDSRSD---------QFQQEIR---AMSYCD-HKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEK
..  ..||.|.||.|... . .  ..  | . .| ......|         .|  | |    |.... | |.....|.| . .  . .|.|| . |.| .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLREKKD----RVSHKT---LYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNE-------NEVKITDFG---LARIFG-------TEKDYYRAKESS
|||  ..    .  . |   .  .  .|  || |||. .  |||||||||.||          . .|| |||   ..|  .        . .||  . . 
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG-FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

QKVPIKWYAPEWLRHQ-KYQKESDVWSLGIVLWEMFSYGQDPIYQDSKGRRVEHIELLDFFEKG--MRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSM
...||.|.||| | |. ..   |||||.|.|.||....|. | | .       . ... ....|   |.  |..||... ..|..||..|| .|| |. .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP-YPG-----MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDL

IVRL
  ..
VQQM
Kinase JAK1.AA TKL 77-334 25 8e-63 215.02 In-house 1-364 (364) Show / Hide 
Range on Protein: 77-334
Range on HMM: 1-364/364
Sequence Identity: 25% (94 aa)

LGSGHFGMVFRGVLMP----RQGIP----AEIVAKVIKNDSRS-----------------------------DQFQQEIRAMSYCDHKNIVKVLGYCEDN
.|||.|| |..|...     .   |     ... |..| .. .                             ... .||. || ..| |||. .||| ..
IGSGGFGEVYKGKWRGWGGKC---PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCP

SNR------------LSLVMEYFPLGSLEKYLREKKDRVSHKTLYLFGQQICQGMKYLHEERM-------MVHRDLAARNVLVSNENE------------
...            | .|||| | |||. ||        .  .  . ..|..|| ||| ..        ..||||  .|.|| . ..            
PCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--VKITDFGLARIFGTEKD---------------YYRAKESSQKVPIKWYAPEWLRHQ----------------KYQKESDVWSLGIVLWEMFS---YGQ
  .||.||||.| . ....                .| . ..|   . | ||| || |                .| . .||.| ||||||...     .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DPIYQDSKGRRVEHIELLDFF--EKGMRLTHP------------PSCPAAIETMMNDCWEMDPLKRPKFQSMIVRL
|. | . ....   .|.      .||.|.. |            |.||  .   | |||..|| ||| ||  . ||
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase JAK1.AA Src 71-334 34 8.5e-62 208.72 In-house 1-255 (255) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-255/255
Sequence Identity: 34% (92 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKNDS-RSDQFQQEIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEKYLR--EKKDRVS
.| ...||.|.|| |. |.   .     .   |..| ..   ..|.||. .|  ..|...|. .  | .       | ||   ||| .||.  ..  ...
IKLCRKLGQGQFGEVWMGYWNGN----TKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLH

HKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLGIVLWEM
 ..|  .. |. .||.|| |.. ..|||||||||||...| .|. ||||||..  ..| | |..   |.|||| ||| ......   ||||| || |.|.
LPQLIDMAAQVAEGMAYL-ESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH-GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

FSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIET-MMNDCWEMDPLKRPKFQSMIVRL
..||. | |   . . |     |.  |.| |.  |. ||. .    |  ||. || .|| |  .   |
VTYGRVP-YPGMTNHEV-----LQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase JAK1.AA Csk 71-334 38 9.9e-62 209.42 In-house 1-251 (251) Show / Hide 
Range on Protein: 71-334
Range on HMM: 1-251/251
Sequence Identity: 38% (102 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKND--SRSDQFQQEIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPLGSLEKYLREK-KDRVS
|.  |  | | || |  | .  |      .  |.||.|     . |  |   |    |.| |. .|   .. | |..||||   |.|  |||   .  ..
LHLGECIGHGEFGDVMQGEYQNRK-----VAVKCIKCDGNGMAQAFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVIT

HKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLGIVLWEM
 . |  |   .|.|| || |.. .|||||||||.||| ..  |. |||||.    |  .     .| | |||| ||| ||| |.   ||||| || ||| 
RRQLLKFAMDVCEGMCYL-EQKKFVHRDLAARNILVSEDCVAKVSDFGLAK----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLWEI

FSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSMIVRL
.|.|  | |      |.   .     ||| |   |  || .. ..|..||...| ||| |. . ..|
YSFGRVP-YP-----RIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase JAK1.AA S_TKc 71-337 24 1.4e-52 181.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKNDSRSDQFQQEIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPL--GSLEKYLREKKDR---
 .. . .|.| || |....         .   |.||     .....||. ..  .|.|||| .....|  ..| .|||| .   |.| .|..... .   
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQK-ESDVWSLGI
   .  .   . .|||....|.|.    .||||   |.|...  ..||.||||||..           ... .   . ||| |   .| | ..|.||.|.
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLWEMFSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSCPAAIETMMNDCWEMDPLKRPKFQSMIV------RLGIL
.|.||.. |. | .           ..   |.| .        | |.. ... |...|| |||                 .
ILYEMLC-GYPPFP-----------QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase JAK1.AA Pkinase 71-325 23 1.4e-45 162.24 Pfam 1-282 (293) Show / Hide 
Range on Protein: 71-325
Range on HMM: 1-282/293
Sequence Identity: 23% (69 aa)

LKKEERLGSGHFGMVFRGVLMPRQGIPAEIVAKVIKNDSRSDQFQQ------EIRAMSYCDHKNIVKVLGYCEDNSNRLSLVMEYFPLG----SLEKYLR
.......||| || |....    .    . . |.|| ........|      ||. |  ..|.|||. ....|| .... .|||| . |    .|  |..
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

-EKKDRV--SHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNENEV----KITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLR-HQKYQ
 ... ..  | ...  .  ||..|..|.|. .  .||||   |.|..|....    ||.|||||. |           ..  . . . |||..| .|.| 
TWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KESDVWSLGIVLWEMFSYGQDPIYQDSKGRRVEHIELLDFFEKGMRLTHPPSCP-----------------------AAIETMMNDCWEMDPLKRP
...|.||.|..|.||..    |.....     . .. .  ... |.   . ..|                        .    ...|...|| |||
PKVDMWSCGCILYEMLC--GRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP