Gene EGFR (Sea Urchin)

EGFR

Species: Sea Urchin
Alias: SPU_008595, EGFR, Spk260
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: EGFR

Sequence

Name Sequence Type Origin Length Description Download
EGFR.AA Protein None 1247 None Fasta, JSON
EGFR.kin_dom Protein Kinase Domain None 229 None Fasta, JSON

Protein domain

Protein domains of EGFR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain EGFR.AA Recep_L_domain 54-168 38 6.4e-36 122.5 Pfam 1-121 (121) Show / Hide 
Range on Protein: 54-168
Range on HMM: 1-121/121
Sequence Identity: 38% (49 aa)

NCTYVDGNLEISFLHEQ---EYDLGFLSSIREVTGYILILLT--YSRVIPLTNLRVIRGTKLYDD-KYALYVALTFHTGDPTIATE--EMWLTSLHEILK
||| ..|||||.   |.   |.|| |...|||.|||.||  |   .  ... |||.|||..|..| .||||.    .        .  | |. .|..|. 
NCTVIYGNLEITWRDEHNELEEDLSFFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNM-------GLQELWMWNLKNITR

--GDVYFHQNN--QLCYVET-IAWDDMQ
  |.||.|.|.  .|||..| | |..  
KNGGVYIHNNPHPKLCYTHTEIMWWMIY
Furin-like EGFR.AA Furin-like 183-333 35 2.4e-47 155.86 Pfam 1-182 (182) Show / Hide 
Range on Protein: 183-333
Range on HMM: 1-182/182
Sequence Identity: 35% (65 aa)

QRNCS------EHRCHESC-------NGH-CWGPGEEHCQILTLKDCSSTCDY-RCRGPTQADCCHRSCAGGCTNSS-NAGCLACRQFSLDNTCVETCPR
 |.|          ||..|       .|. ||||...|||.|| | | . |   ||.|| . .||| .|.||||    .  |.||| |. ..|||..||.
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQTLTKKVCPEQCKHRRCTGPKPGECCHEQCLGGCTGPNNDTDCVACRHFYHNGTCVDQCPP

RYEYDRNTFTNVENPNFRYSY-GSRCL--KDCP-------NNVLV-DGDNCVKVCGPGKK----EQDNQCIPCEGVCPSTCD
.  |. .||  . ||. .|.. |.||.  | ||       .| .| ... |. .| .|..     . ..| |||| || .| 
MMIYNPTTFQMEPNPDGTYQFEGWRCVTFKECPKLSHNPDCNYYVIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU EGFR.AA FU 228-271 30 3.8e-08 34.31 SMART 1-48 (48) Show / Hide 
Range on Protein: 228-271
Range on HMM: 1-48/48
Sequence Identity: 30% (15 aa)

QADC--CHRSCAGGCTNSSNAGCLACRQFSLD---NTCVETCPRRYEYD
.  |  || .||.||. . .  |..|. . .    .|||..||   .| 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCP-PGYYP
FU EGFR.AA FU 183-225 28 0.062386 5.32 SMART 1-48 (48) Show / Hide 
Range on Protein: 183-225
Range on HMM: 1-48/48
Sequence Identity: 28% (14 aa)

QRNCSEHRCHESCNGHCWGPGEEHCQI----LTLKD---CSSTCDYRCRG
.. |  ..||..| ..|||||...|.     . |..   | |.|     .
DGVC--KPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Recep_L_domain EGFR.AA Recep_L_domain 353-477 32 1e-31 108.33 Pfam 1-121 (121) Show / Hide 
Range on Protein: 353-477
Range on HMM: 1-121/121
Sequence Identity: 32% (42 aa)

NCTQINGNLIITSHTFTGDAFAGTTPIDPSALEIFRTVKQITGYLSVQGLHQHFTNLSMFSNLERIDGRNLYGEPPFASLAILDNQH--LEALSLISLNE
|||.|.|||.||. .. ..        ... |. |.... ||||| ...    ..|||.|.||. | ||.|.    ...|.|.||..  |. | . .| .
NCTVIYGNLEITWRDEHNE--------LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQLFHD-DNYALYIYDNPNMGLQELWMWNLKN

LKL--GGAYVQNNR--LLCYSEETAFDAVIN
.    || |..||    |||....    .|.
ITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU EGFR.AA FU 490-541 38 2.9e-09 38.0 SMART 1-48 (48) Show / Hide 
Range on Protein: 490-541
Range on HMM: 1-48/48
Sequence Identity: 38% (21 aa)

RATCIAENKTCDPQCADIGCWGPGPRQCAKCKNAIIG---DTCIEACDLDNGQYV
. .|    | |.|.||. ||||||| || .|..   .   .||.. |    | | 
DGVC----KPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCP--PGYYP
Furin-like EGFR.AA Furin-like 500-533 34 4.980748 0.71 Pfam 65-98 (182) Show / Hide 
Range on Protein: 500-533
Range on HMM: 65-98/182
Sequence Identity: 34% (12 aa)

CDPQCADIGCWGPG-PRQCAKCKNAIIGDTCIEAC
|..||.  || ||. .. |  |..  . .|| ..|
CHEQCL-GGCTGPNNDTDCVACRHFYHNGTCVDQC
FU EGFR.AA FU 609-665 26 7e-08 33.43 SMART 1-48 (48) Show / Hide 
Range on Protein: 609-665
Range on HMM: 1-48/48
Sequence Identity: 26% (15 aa)

QKNCTDCHSNCLKGCNGPENNLGEDGCLECPQVMLDYNRKVMECMLINTPCSDDYFY
.. |  ||..|. ||.||     .| |..||   .  ..   .|.     |.. |..
DGVCKPCHPECATGCWGPG----PDQCTSCPHGYYLHHN--GTCVS---QCPPGYYP
FU EGFR.AA FU 550-606 27 0.063718 5.21 SMART 1-48 (48) Show / Hide 
Range on Protein: 550-606
Range on HMM: 1-48/48
Sequence Identity: 27% (16 aa)

AAVCEHCDTQCSAGCSGPEPDQCD-CQSDSTGTNCRRMCRNVQDGPFCRAECPEPKFA
. ||. |. .|. ||.|| ||||  | .   . .  . |           .||.  ..
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-GTCVS---------QCPPGYYP
Furin-like EGFR.AA Furin-like 590-624 28 0.310987 4.66 Pfam 145-182 (182) Show / Hide 
Range on Protein: 590-624
Range on HMM: 145-182/182
Sequence Identity: 28% (11 aa)

VQDGPFCRAECPEPKFA---NAQKNCTDCHSNCLKGCN
| ..  |. |||  .     | .. |. |   | | |.
VIHNGECMRECPSGYTENEENNTMMCEPCEGPCPKVCY
FU EGFR.AA FU 680-723 33 1e-08 36.17 SMART 1-48 (48) Show / Hide 
Range on Protein: 680-723
Range on HMM: 1-48/48
Sequence Identity: 33% (16 aa)

SVICQQCDPMCIG-CDGAGPRRCKQC--KLFRQD-DECVDECRSGFYP
.  |. |.| | . | |.||  |. |   .. .. ..||..| .|.||
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU EGFR.AA FU 726-774 28 5.6e-05 23.79 SMART 1-48 (48) Show / Hide 
Range on Protein: 726-774
Range on HMM: 1-48/48
Sequence Identity: 28% (14 aa)

DDMCQPCHPQCRQ-CFNGTVHDCLDCESYTVQTGENTFFCALSCPAEYPN
|..|.||||.|   |   .  .|. |... .. ..    |  .||. |  
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN--GTCVSQCPPGYYP
Furin-like EGFR.AA Furin-like 726-747 29 2.399779 1.75 Pfam 1-31 (182) Show / Hide 
Range on Protein: 726-747
Range on HMM: 1-31/182
Sequence Identity: 29% (9 aa)

DDMCQ--------PCHPQCRQCFNGTVHD-C
.  |.        |||| |.  .||...  |
NRECPDVCPGTCEPCHPCCKTTINGHYGYRC
FU EGFR.AA FU 794-838 27 0.000135 22.51 SMART 1-48 (48) Show / Hide 
Range on Protein: 794-838
Range on HMM: 1-48/48
Sequence Identity: 27% (13 aa)

MSKCEGCHTECKDGCHNGTRSGCYACKNVVVNLE---CRAECPAAYKN
 ..|. || ||..||   .   | .|..  . ..   | ..||. |  
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Kinase EGFR.AA EGFR 938-1097 70 6.7e-113 376.25 In-house 1-161 (258) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-161/258
Sequence Identity: 70% (113 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVS-PHAAEELLEEAKVMASVDHPCLLRLLCVCIAQNMTLITQLMPLGAILDYVRQHKEQIGS
||...|||||||||||||.|||.||...||||||.||| . |.|.||.|.||.||||||||.|.|||.||....|.|.||.||.|..||||||||..|||
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDNIGS

HHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNEYKAQ
.|||||..||||||.||||....|||||||||||.||..||||||||||.||.|..||.||
QHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQ
Kinase EGFR.AA TyrKc 938-1165 32 6.2e-89 302.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 938-1165
Range on HMM: 1-280/280
Sequence Identity: 32% (95 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEELLEEAKVMASV--DHPCLLRLLCVCIA--------QNMTLITQLMPLGAILDYV
..|| .||.||||.|||| |.       |.||.| |.| .    |....||..| ..  .||...||. ||.         . . ... .||.|. .|| 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RQHKEQIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVD------SNEYK------AQ------------------
| |....   .||....|||.|| ||..|..|||||||||.|| .. .|||.||||..... |      .  |.      .                   
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

---------GVTLWELMTFGGKPYEG-----VKAREVPELLERGERLPQPPI--------CTIDIYMLMVKCWLIDEDSRPTFKQMQEEL
         ||..||..|.|..||.|     ....|| |....|.|.||||         |. ..|..| .||  | ..||||..  |..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EGFR.AA Pkinase_Tyr 938-1097 43 7e-68 230.53 Pfam 141-312 (270) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 141-312/270
Sequence Identity: 43% (74 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAA---EELLEEAKVMASV-DHPCLLRLLCVCI--AQN--MTLITQLMPLGAILDYVRQ
...| .||.||||.|||| | .|... .||||.| |.| . | .   |....|||.| .  .|| ..||. ||.   .   . ... .||.|  ||| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---KEQIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNE-YKAQ
|   |...  ..||....|||||| |||.|..|||||||||.|| .. .|||.|||||. .. |..  .|..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRG
Kinase EGFR.AA TK 938-1097 21 4.9e-57 189.39 In-house 1-319 (486) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-319/486
Sequence Identity: 21% (68 aa)

LKLGPVLGSGAFG---TVYKGLWIPD---------------------GEKIRIPVAIKALREVSPHAAEE-----------------LLEEAKVMAS--V
..|| .||.|.||   .||||.|...                     .|. ..|||.| |.| .....||                 ..||.|.| .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPCLLRLLCVCIAQN-------------MTLITQLMPLGA----ILDYVRQHKE---------------------------------------------
.|| ..||. ||  .              . ... .||.|      .|| |....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QIGSHHLLNWSFQIAKGMVYLEEK------HLIHRDLAARNVLVQSPAQ-----------VKITDFG---
                              |.  |.|| ...|||.|| ||..|      ...||||||||.|| .  .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKFLEVDSNEYKAQ
     ||. .. |.. |...
QGSGVLARDIYSDDDYYRKS
Kinase EGFR.AA Syk 938-1097 41 4.3e-52 177.6 In-house 1-166 (257) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-166/257
Sequence Identity: 41% (69 aa)

LKLGPVLGSGAFGTVYKGLWIPD---GEKIRIPVAIKALR-EVSPHA-AEELLEEAKVMASVDHPCLLRLLCVCIAQNMTLITQLMPLGAILDYVRQHKE
| ..  .|.| ||.| ||        ||| .|.|||| |. . .  |  .|.. ||.||.  ||||  |.. .| |  | ..  . .||. ..|  ||..
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADHNQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHRH

QIGSHHLLNWSF-QIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNEYKAQ
 |     |     |.| || |||||| .||||||||||     . || |||. | |  ||..|.|.
EITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQAT
Kinase EGFR.AA EGFR 1098-1166 75 7.5e-51 166.99 In-house 190-258 (258) Show / Hide 
Range on Protein: 1098-1166
Range on HMM: 190-258/258
Sequence Identity: 75% (52 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEELE
|||.|||||||.|||.|..|||.|.|||.|||||||||||||.||.|||||.||||.|||||...||..
GVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase EGFR.AA Src 938-1097 36 8.4e-49 163.91 In-house 1-157 (255) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-157/255
Sequence Identity: 36% (60 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQ-NMTLITQLMPLGAILDYVR-QHKEQ-I
.||   ||.| || |..|.|     . ...||.| |.. .  . | .|.||..| ...|. |..|. ||        .| .|  |  ||| . . ... .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

GSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNEYKAQ
   .|.  . |.|.|| |||.. .||||||||||||     .|. |||||. ...| .|| |.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCAR
Kinase EGFR.AA Ack 938-1097 40 9.3e-48 159.17 In-house 1-166 (266) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-166/266
Sequence Identity: 40% (68 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREV---SPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQNM-TLITQLMPLGAILDYVRQHKE-
..|.  ||.| || | .|.|       .|.||.| ||     .| . ...| |. .| | ||| |.||  |  .| |  ..| | |.|. ||  |.|.  
ITLCEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRT

-QIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSP-AQVKITDFGLAKFLEVDSNEYKAQ
     | |.... |||.|| ||| |..|||||||||.|. |.   ||| ||||   | .  . |. .
AFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRME
Kinase EGFR.AA UTK 938-1097 29 1.4e-43 146.95 In-house 1-196 (296) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-196/296
Sequence Identity: 29% (57 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRI-PVAIKALR--EVSPHAAE---ELLEEAK---VMASVD-HPCLLRLL-CVCIAQNMTLITQLMPLGAILDY
..||  ||.||||.|.|. . .. |      ||.|...  ...... |   ...|||.   .|. .. || .|||.  ..  . . ..| .|. |  ..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

VRQHKEQIG-------SHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSP-------AQVKITDFG---LAKFLEV--------DSNEYKAQ
.| |... .       .|..| .. .|| || ||......||||||||.|| .         ..|| |||   ... .          .|..|.||
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ
Kinase EGFR.AA Abl 938-1090 41 2.2e-38 125.29 In-house 1-150 (252) Show / Hide 
Range on Protein: 938-1090
Range on HMM: 1-150/252
Sequence Identity: 41% (64 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQN-MTLITQLMPLGAILDYVRQ-HKEQIG
. .   || | .| ||.|.|     .    ||.|.|.| .  . .| |.|| .|  . || | .|| ||       .||  |. | .|||.|.  .|.. 
IMMKHKLGGGQYGEVYEGVW----KRHDCTVAVKTLKEDT-MEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELP

SHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVD
.  ||    ||| || |||..| ||||||||| ||     ||. |||||.... |
AVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDD
Kinase EGFR.AA TK-Unique 938-1085 28 2.7e-38 129.68 In-house 1-181 (294) Show / Hide 
Range on Protein: 938-1085
Range on HMM: 1-181/294
Sequence Identity: 28% (51 aa)

LKLGPVLGSGAFGTVYKGLWIPDG--EKIRIPVAIKALR-EVSPHAAEELLEEAKVMASVD-HPCLLRLLCVCI--AQNMTLITQLMPLGAILDYVR---
|..| |.|.||||.|..|   ..   .  .. ||.|.|. .....   ..| |...| ... || ....| .|.   ... .|   .| |  ..| |   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-QHKEQ---------------------IGSHHLLNWSFQIAKGMVYLEE--KHLIHRDLAARNVLVQSPAQVKITDFGLAK
 .....                     | .. |... .|||.|| ||..  |. .||||.|||||...  ..||.|||.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMAR
Kinase EGFR.AA Frk 938-1097 38 6.3e-37 125.33 In-house 1-159 (260) Show / Hide 
Range on Protein: 938-1097
Range on HMM: 1-159/260
Sequence Identity: 38% (63 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQN-MTLITQLMPLGAILDYVR---QHKEQ
..|   |||| || |. |||        .|||.| |.  .    ...| ||..| .. || |..|  ||  .. . .|| ||  |....|..   .. .|
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLKPGT-MDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

IGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSN-EYKAQ
.  . |.. . |.| || |||..  ||||||||||||     .|| |||||. | .|    | ..
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESR
Kinase EGFR.AA FAK 938-1096 30 4.1e-35 114.99 In-house 1-182 (285) Show / Hide 
Range on Protein: 938-1096
Range on HMM: 1-182/285
Sequence Identity: 30% (56 aa)

LKLGPVLGSGAFGTVYKGLWIPDGE-----------------------KIRIPVAIKALR-EVSPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQNMTL
 .|. ..| | || ||.| ..                              | ||||  . . ..   |. ..|| .|   ||| . .|. .|  . . .
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPIWI

ITQLMPLGAILDYVRQHKEQIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNEYKA
|  |...| .  | . .|..     |. ...|... | ||| |  .||| ||||||| ||  ||  ||||  ... |.  |||
IMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWMH-DHSYYKA
Kinase EGFR.AA Pkinase_Tyr 1098-1165 44 7.3e-32 108.53 Pfam 201-270 (270) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 201-270/270
Sequence Identity: 44% (31 aa)

GVTLWELMTFGGKP-YEGVKAREVPELL-ERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEEL
||..||..|.|..| |.|..  || |.. |.|.|.|.|. |. .||.|| .||  | . ||||.. .|.|
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EGFR.AA Pkinase 938-1088 24 1.4e-26 95.02 Pfam 1-163 (293) Show / Hide 
Range on Protein: 938-1088
Range on HMM: 1-163/293
Sequence Identity: 24% (41 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEE--LLE--EAKVMASVDHPCLLRLLCVCI-AQNMTLITQLMPLG----AILDYVR
...| ..|||.||.|||. .. .|.     ||.| .. .. .  ..  ..   |...|....||. .||....   ... ... ... |       ||..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-QHKEQI--GSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQV----KITDFGLAKFLE
 . .  .    ... ..  ||..|. |. ..  |||||   |.|. .  ..    ||.||||||...
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD
Kinase EGFR.AA UTK 1098-1165 34 3e-25 83.31 In-house 227-296 (296) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 227-296/296
Sequence Identity: 34% (24 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERG--ERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEEL
||..||..|.| .||.|  ...| . ...|   |.|.|. |  ..|.||..||  | . ||.|... ...
GVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EGFR.AA TK 1098-1165 32 6.1e-25 79.89 In-house 381-486 (486) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 381-486/486
Sequence Identity: 32% (34 aa)

GVTLWELMTFGGKPYEGVKA----------REVPELLERG--------------ERLPQPPICT--------------IDIYMLMVKCWLIDEDSRPTFK
||..||..|.| .|| |             .|| |.|.||               |.|||| |.               ..| || .||  | . ||||.
GVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFS

QMQEEL
|..|.|
QLHEQL
Kinase EGFR.AA TK-Unique 1098-1165 37 1.2e-24 82.0 In-house 226-294 (294) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 226-294/294
Sequence Identity: 37% (26 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPIC-TIDIYMLMVKCWLIDEDSRPTFKQMQEEL
||..||..|.|. || |...... |....| |.|||. | . ..| ||  ||  ....||.| |   .|
GVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EGFR.AA Syk 1098-1159 43 4.6e-23 76.21 In-house 196-257 (257) Show / Hide 
Range on Protein: 1098-1159
Range on HMM: 196-257/257
Sequence Identity: 43% (27 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFK
|||.||    | ||| . |  || ...| |.|...|. |  ..| || |||. .   |||| 
GVTMWEMFSYGQKPYGEMKGQEVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase EGFR.AA S_TKc 938-1168 19 6.3e-23 83.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 938-1168
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

LKLGPVLGSGAFGTVYKGLWIPDGEKIRIPVAIKALREVSPHAAEELLEEAKVMASVDHPCLLRLLCVCIAQNMTLITQLMPL--GAILDYVRQHKEQ--
 ... ..|.||||.|||. ..         |||| ..       | .. | ... . .|| . .|. |.  ... ... ...   |  .|| .... .  
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARNVLVQSPAQVKITDFGLAKFLEVDSNEYKA-------------Q--------GVTLWELMTFGG
   .   |   .  ||.... |. ... |||||   |.|. .  ..||.|||||..|    . .                        |..|.|... | 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLC-GY

KPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQE-E-----LERM
 |..     .. .....          . .   .. ||.  | . |||  .  . |      . .
PPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EGFR.AA Ack 1098-1165 39 1.1e-22 73.39 In-house 198-266 (266) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 198-266/266
Sequence Identity: 39% (27 aa)

GVTLWELMTFGGKPYEGVKAREVPELLE-RGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEEL
||||||  ..| .|. |. . .. ....  |||||.|. |  ||| .|..||  .   |||| . .. |
GVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase EGFR.AA Src 1098-1165 40 2.9e-22 72.42 In-house 187-255 (255) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 187-255/255
Sequence Identity: 40% (28 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYM-LMVKCWLIDEDSRPTFKQMQEEL
|. |.|..|.|  ||.| . .|| . .||| |.|.|. |   .|. .| .||  | . ||||. .|. |
GILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EGFR.AA FAK 1098-1170 41 4.9e-22 70.49 In-house 213-285 (285) Show / Hide 
Range on Protein: 1098-1170
Range on HMM: 213-285/285
Sequence Identity: 41% (30 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEELERMTK
|| .|| . .| ||. .||  .|   .|.||||| || |    | || .||  |   || ||.. ..|. . .
GVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCPPTLYSLMTRCWAYDPSKRPRFKELKCQLKDIYQ
Kinase EGFR.AA Abl 1096-1165 38 7.1e-20 62.54 In-house 183-252 (252) Show / Hide 
Range on Protein: 1096-1165
Range on HMM: 183-252/252
Sequence Identity: 38% (27 aa)

AQGVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEEL
| || |||. |.|  || |.   .| ..||.| |. .|. |  ..| || .||  ..  ||.||.. ...
AFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase EGFR.AA Frk 1098-1169 40 7.9e-19 61.59 In-house 189-260 (260) Show / Hide 
Range on Protein: 1098-1169
Range on HMM: 189-260/260
Sequence Identity: 40% (29 aa)

GVTLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFKQMQEELERMT
|. | |..|.|  || |.  .|| . ...| |.|||| |   .| .| .||  | . ||||  .|  ||   
GILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EGFR.AA Pkinase 1098-1165 15 0.634009 4.35 Pfam 199-293 (293) Show / Hide 
Range on Protein: 1098-1165
Range on HMM: 199-293/293
Sequence Identity: 15% (15 aa)

GVTLWELMTFGGKPYEGV----KAREVPELLERGER----LPQPPICT-------------------IDIYMLMVKCWLIDEDSRPTFKQMQEE--L
|..|.|... |  |. |     . ..  ....|  .     . |  |.                    .   .. .|.  |  .|||..|  .   .
GCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF