Gene DDR (Sea Urchin)

DDR

Species: Sea Urchin
Alias: SPU_026731, DDR, Spk259
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: DDR

Sequence

Name Sequence Type Origin Length Description Download
DDR.AA Protein None 913 None Fasta, JSON
DDR.kin_dom Protein Kinase Domain None 296 None Fasta, JSON

Protein domain

Protein domains of DDR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
F5_F8_type_C DDR.AA F5_F8_type_C 41-183 24 2e-24 86.03 Pfam 1-140 (140) Show / Hide 
Range on Protein: 41-183
Range on HMM: 1-140/140
Sequence Identity: 24% (37 aa)

QLSASSVYENNTLSFGPQNARLHLN--QGAGAWCP-VNAQPESSGHYEYLQVDLLNLTVILALSTQGRWDTNFGNEYTSRFRLELSRDG-GK-TWIRYVQ
|..||| . ... .  |  .... |   . ..|..  .    .... ...||||   . | .. .|.|   ..||.... .... | || .. .|. |..
QITASSQWSGYWGNGWPPDNAIDGNGYPN-TFWHSQKWS---NNDDPQWIQVDLGKPYKITGVVYQWR--QDGGNGWVKKYKIQYSNDGGDESNWTTYKD

MTGEEVFVGNRDTNSQITVHISPPIVAQVLRIIPV-VLIQTPVCMRIEL
 .|  || || | . . ...  |||.|. .||.|.        .|| |.
HDG-KVFYGN-DND-PVKNMFFPPIKARYVRIHPTSWNNHNWWAMRWEF
FA58C DDR.AA FA58C 25-186 26 7.6e-21 76.49 SMART 1-199 (199) Show / Hide 
Range on Protein: 25-186
Range on HMM: 1-199/199
Sequence Identity: 26% (53 aa)

TCRYPLGMNDKAIKDEQLSASSVYENNT----LSFGPQNARLHLNQG-----AGAWCPVNAQPESSGH----YEYLQVDLLN-LTVILALSTQGRWDTN-
 |..|||| . .| |.|. ||| .. |     .  .|  |||. | .     ..|||| .. .|  .     .. ..|||.  .. . .. |...  .. 
ECNEPLGMEGGHIPDWQITASSSHYWNRDMPWWYWWPHIARLNGNGSNHDYWDNAWCPWKNDYEDWIFDYHCPHWWLVDLGRKTHRVTGV-TITGRRRRG

--FGNEYTSRFRLELSRDGGK---------TWIRYV-----QMT-GEEVFVGNRDTNSQITVHISPPIVAQVLRIIPV------VLIQTPVCMRIELYGC
  .|...   ....  .|...         ||. |.      .| ...|| || | | . ...  ||.||.  ||.|.       . .  .|||.|||||
HGWGHDDWWTYYWMMYKDDRRDNNERQNGHTWTTYKDFWIEHGTGNSMVFYGNWDNNHPWHNMFHPPMVARYIRIWPTWWNTNATGWHHNYCMRWELYGC
Kinase DDR.AA DDR 604-900 63 3.3e-227 761.12 In-house 1-306 (306) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-306/306
Sequence Identity: 63% (195 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKNARADFMKEMKIMSQLR-DPNIVRLLAACTEDEPYCMIVEYMEN-
|.|.|..|||.||||||||.|..||||...|... ..||..|||||||||.||.|.||.||.||.|.|||.. .||||||...||.|||||||.||||| 
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCD-VHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENL

GDLNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFG--MSRNLYSSNYYRIEG---
||||||..|.|....||.||.|...||.|..||....||..||||||||||..|||||||||.|||||||.|.|.|.|||  |||||||..|||.||   
GDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTG

--RAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIH-NLMKRCWTSEPGQRPTF
  |...||||||||||||||||.|.||||||||.||..|.||||||..|||||||||...||...|..|||..||.||..|. .||.|||.....|||.|
RQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSF

DFLHTFL
...|.||
EEIHKFL
Kinase DDR.AA TyrKc 604-900 35 3.8e-122 413.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-280/280
Sequence Identity: 35% (116 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKNARADFMKEMKIMSQL--RDPNIVRLLAACTED-------EPYCM
. ... |||| ||||.....                     . ||||||..||    |.|||.|..||..|  . ||||||...||..       ||...
ITLGKKLGEGAFGEVYKGTWK--------------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI

IVEYMENGDLNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSS-----
..|||..|||...| ....                   ...  |.. ..|||.|| ||. .|..||||| ||||||. .|..|.|||.||..|.      
VMEYMPHGDLKDYLRKHRPK------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGE

--NYYRI----EGRAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCREQPYSR-----LTDEQVIENTGQFFEKDGTPVYLAKPPQ--------
   |||      |...|||||||.|.|  ||||.|.|||.|||..||.. .. .|||.      .....|||.  | .       .. .||         
SKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYG-QQPYPGMIQQMMSNQEVIEYVKQGY-------RMPQPPNDYPMSFVC

CPKDIHNLMKRCWTSEPGQRPTFDFLHTFL
||......||.||  .| .||||  .| ..
CPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDR.AA Pkinase_Tyr 604-900 38 1.2e-114 388.91 Pfam 1-270 (270) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-270/270
Sequence Identity: 38% (118 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKNA--RADFMKEMKIMSQL-RDPNIVRLLAACT-EDEP--YCMIVE
. |.. |||| ||||..... .             . ..... ||||||. .|.. .  |.|||.|.|||.|| . ||||||...|| ..||  .....|
ITFGKKLGEGAFGEVYKGTWKG-------------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME

YMENGDLNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSSNYY-RIEG
||..|||  .| ..                 .| ....  |.  ..|||.|| ||...|..||||| |||||... ...|.|||..| .|.  || |  |
YMPHGDLLDYLRKHR---------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRG

RAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCREQP-YSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDF
 . |||.||| |.|  ||||.|.|||.|||..||.. ... || |  ...|.|.|    .. .||    ...|. ||..|..|||.||  .| .||||  
GGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGE-QPTYPGMSNEEVYE----YIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSE

LHTFL
.| .|
IHEQL
Kinase DDR.AA TK 604-900 25 1.8e-113 381.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-486/486
Sequence Identity: 25% (122 aa)

LNFLELLGEGMFG---EVHLCEAEDIQDYIRNGFPFENK--------NKGERTLVAVKMLRKD--ASKNARAD--------------FMKEMKIMSQ--L
. ... |||| ||   ||...|.... ..  ..|| ...         .|..| ||||||...  .|.... |              .. |||.|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RDPNIVRLLAACTED------------EPYCMIVEYMENGD----LNQFLYEREGFEVGLNNCNANLSNCNKSS--------------------------
. ||||||...||..            ||.....|||..||    | ..| .. . .    .|..|..|.. .|                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ISVGALVYKSTQIASGMKYLSNM------NFVHRDLANRNCLVGKSYT-----------IRIADFGMS-
                               ...  |.  . |||.|| ||. .      |||||||| ||||||....           ..|||||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RNLYS------------------------SNYYRIEGRAVLPIRWMAWESIL---------LGKFTSKTDVWAFGVTLWEVMMLCREQPYSRL
       | .||                        ..||| . .. |||||||.|...          ||||.|.|||.|||..||......|..|  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TD---------EQVIENTGQFFE-------KDGTPVYLAKPPQCP--------------KDIHNLMKRCWTSEPGQRPTFDFLHTFL
..         ..|.|.  .          . |    ...||.||              .... ||..||  .| .||||. || .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDR.AA Trk 604-900 36 1.7e-88 300.16 In-house 1-275 (275) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-275/275
Sequence Identity: 36% (109 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMENGD
. .   |||| || | | | ...             .. ....|||| | ||||.||| || .| ... .|  ..||..   ||...|  |. |||..||
IVLKWELGEGAFGKVFLAECYNLC------------PEQDKMMVAVKTL-KDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGD

LNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYS-SNYYRIEGRAVLPI
||..|  .    . . . ..  .   .    .. . .   |||||| |.    |||||.| ||||||.   ..|.|||||| .|| ..|||....  |||
LNKYLRQHGPDAMCYAQYQPRQA---PGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPI

RWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDFLHTFL
|||  |||.  |||   ||| |||..||..   . ||.  |    ||| . |  ..      | .| .||... ..|  ||  || || .   .|. .
RWMPPESIMYRKFTYESDVWSFGVVMWECFTYGK-QPWYQLSNHEVIECIHQGRHR------LERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase DDR.AA Musk 643-900 40 1.8e-82 272.34 In-house 28-282 (282) Show / Hide 
Range on Protein: 643-900
Range on HMM: 28-282/282
Sequence Identity: 40% (106 aa)

ERTLVAVKMLRKDASKNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMENGDLNQFLYEREGFEVGLNNCNAN-----LSNCNKSSISVGA
| |.||||||. ||||   .||  |  .| .   ||||.||  |    | |.  |||  |||| ||  .  . .     .       .|    .  .   
EETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKCYH

LVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSSNYYRIEGRAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCRE
.     ||| || ||| | ||||||| ||||..    ..|||||.||. |. .||. ..    |||||. |||.  .||   ||||.|| |||.     .
QLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYA-L

QPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDFLHTFL
|||  .| | ||      . ..|    |. |  || ....||.|||  .|  || |  .|  .
QPYYGMTHEEVI-----YYIRQG--NILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase DDR.AA TK-Unique 604-900 33 1e-80 274.47 In-house 1-294 (294) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-294/294
Sequence Identity: 33% (105 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKNARADFMKEMKIMSQLR-DPNIVRLLAACTED-EPYCMIVEYMEN
|......||| ||.|. .|.. |            |. .... ||||||...|..  ..||.|| ..|..|   ||||..| .||.. || ..| ||...
LEVGDVIGEGAFGQVWRGEVWGIW-----------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPC

GDLNQFLYEREGFEVGLNNCNANLS--------NCNKSSISVGALVYKSTQIASGMKYLSN--MNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSSNY
|.|  .| .. .  .. .   .||           ....|| . |.    |||.||.||.   ...|||||. ||.|..  ... |.||||.| .|  . 
GNLQHYLRTCRPAMRQHQ-TYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGV

YRIE-GRAVLPIRWMAWESIL--LGKF-TSKTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQC-PKDIHNLMKRCWTSE
|  . ..  .|||||| ||..   | . |.|.|||.|||..||.. |   .||... .....|.      .||  . . .|..| .....||||.||..|
YSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKDIMECI-----RDG--YRMPQPEHCCSHEMYNLMKSCWQWE

PGQRPTFDFLHTFL
| .||.|. .   |
PEERPSFRQIKHRL
Kinase DDR.AA UTK 604-900 31 3e-80 272.91 In-house 1-296 (296) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-296/296
Sequence Identity: 31% (102 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLR--KDASKNAR--ADFMKEMK---IMSQLR-DPNIVRLLAACTEDEPYCMI
. ....||.|.|||||.......            .. ..  .|||| ..  .|| .. .  .|||.| .   .|.|..  ||..||.. || .|| ...
VQLGRQLGQGAFGEVHKARFTQC------------SEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIV

VEYMENGDLNQFLY-EREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKS-------YTIRIADFG---MSR
.|||||||| ..|   |. ..             .  . .   ... . .||.|| ||....||||||| |||||...       ....|||||   |||
TEYMENGDLRSYLRRHRPTPP------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSR

NLY---------SSNYYRIEGRAVLPIRWMAWESILLG-KFTSKTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQF-FEKDGTPVYLAKPPQCPK
...         .|.||.  ..  .|||||| |..  . .||.|.|||.|||..||...    .||  ....||... .            ...|..|| 
RVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGR------YRMPCPWDCPH

DIHNLMKRCWTSEPGQRPTFDFLHTFL
.. .||.|||...|  ||.|. |  ..
PVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase DDR.AA Ror 645-831 46 7.5e-75 254.99 In-house 30-214 (308) Show / Hide 
Range on Protein: 645-831
Range on HMM: 30-214/308
Sequence Identity: 46% (88 aa)

TLVAVKMLRKDASKNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMENGDLNQFLYEREG-FEVGLNNCNANLSNCNKSSISVGALVYKST
..||.| ...|||   ..|| .| ..|..|  |||| || .|| |.||||. ||| .|||  ||  |     .|   |        ||| . .  ..  .
MAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHSDHG---CSSDDDRMVKSSLDHPDFLHIAI

QIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSSNYYRIEGRAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEV
|||.|| ||| . ||||||| ||||||   ...|.||| .|  ||| |||. .....|||||. |.|. |||..  |.| |||.|||.
QIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEI
Kinase DDR.AA Src 644-900 33 1.1e-73 249.69 In-house 23-255 (255) Show / Hide 
Range on Protein: 644-900
Range on HMM: 23-255/255
Sequence Identity: 33% (88 aa)

RTLVAVKMLRKDASKNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMENGDLNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKST
.| |||| |...    . ..| .| .|| .|| ...|.|.| |...||.  . |||..| | ..| .                .   .....  |.. ..
NTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----------------DGEGRHLHLPQLIDMAA

QIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYS--SNYYRIEGRAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCREQPYS
|.|.||.||. ||..||||| || |||..    .||||  | |     . |  .  | .||.|.| | |. |.|| |.||| ||. |.|..   |  || 
QVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR-VPYP

RLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHN-LMKRCWTSEPGQRPTFDFLHTFL
  | ..|...  . .        . .|..||. ... .|..|| ..| |||||..|. ||
GMTNHEVLQQVERGYR-------MPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase DDR.AA InsR 604-902 34 3.1e-73 245.33 In-house 1-278 (278) Show / Hide 
Range on Protein: 604-902
Range on HMM: 1-278/278
Sequence Identity: 34% (106 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERT-LVAVKMLRKDASKNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMENG
.  .  .|.| || | .  |..|            .. ..|   .|.| .  .||   | .| .|  .| .    ..||||  |.  .|   . | |. |
IVLIRECGQGSFGMVYEGIAKGIV-----------PDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYG

DLNQFLY-EREGFEVGLNNCNANLSNCN--KSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSSNYYRIEGRAV
||  .|   |.  |        |   ||  .. .. . ..    .|..|| ||   .||||||| |||.| ...|. |.|||| | .| . ||| .|.  
DLKSYLRSRRPEEEF-------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGM

LPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDFLHTF
||.|||| ||.  |.||.. ||| ||| |||.  |  ||||  |  |||    ...  .||   .| .|  ||.  . ||..||   |  ||||  .   
LPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLG-EQPYQGLSNEQV----LKYIGMDGN--VLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHY

LQA
|. 
LCD
Kinase DDR.AA CTKA 739-900 44 1.5e-53 178.23 In-house 134-290 (290) Show / Hide 
Range on Protein: 739-900
Range on HMM: 134-290/290
Sequence Identity: 44% (73 aa)

VYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSS-NYYRIEGRAVLPIRWMAWESILLGKFTSKTDVWAFGVTLWEVMMLCRE
||   ||| || ||. | ||||||| ||||.|.  .| ||||| .| | .   || .  . |.|.|||| | .  |||..  ||||||| |||.|    |
VYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMG-E

QPYSRLTDEQVIENTGQF-FEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDFLHTFL
 |. ...|  | .       .       |  |. ||  .  .|. ||  || |||||  |   |
KPWRHMSDQEVCQAYTSHGMRR------LPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase DDR.AA S_TKc 604-900 19 1.8e-36 128.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 604-900
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKNARADFMKEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYMEN--
  .|...|.| ||.|..|   .                    .||.|...         ....|..|... . ||||.|. .. . . ..|. ||...  
YEILRKIGKGAFGKVYKCRHKK-----------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDL

GDLNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTIRIADFGMSRNLYSSNYYRIEGRAVLP
||| ... .| .             . ... ..     .   ||.....|. .....||||   | |. .  .| |.|||..| |            .  
GDLFDYIKKRGR-------------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGT

IRWMAWESILLGKFTS-KTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQFFEKDGTPVYLAKPPQCPKDIHNLMKRCWTSEPGQRPTFDFL----
  .|| | .   ...  | |.|..|..|.|  |||.. |..  ........ |                  ...  .....|.. .| .||| . |    
PWYMAPEVL---GYGKCKCDWWSCGCILYE--MLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEW

----HTFL
    | ..
DIKCHPWF
Kinase DDR.AA Pkinase 604-899 21 2.6e-29 104.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 604-899
Range on HMM: 1-293/293
Sequence Identity: 21% (72 aa)

LNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGERTLVAVKMLRKDASKN--ARADFM-KEMKIMSQLRDPNIVRLLAACTEDEPYCMIVEYME
. ... .|.| ||.| .|   . ..                 .|||| ..|.  |    ....   | .||  |. ||||||. .....  ..|. ||.|
YHIGRKIGSGSFGCVYKCHHKGTGK-----------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCE

NG----DLNQFLYEREGFEVGLNNCNANLSNCNKSSI--SVGALVYKSTQIASGMKYLSNMNFVHRDLANRNCLVGKSYTI----RIADFGMSRNLYSSN
.|    ||  ..                    .. ..  |   .    .||..|..|. .|...||||   |.|. . ..|    .|.||| .. ..   
GGLYVMDLFDYIST-----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---

YYRIEGRAVLP--IRWMAWESIL-LGKFTSKTDVWAFGVTLWEVMMLCREQPYSRL------TDEQVIENTGQ----FFEKDGTPVYLA----------K
| . .   ..   ...|| | |.   . ..| |.|..|..|.|  |||.. |..        .. |.|.....    | .    ....           .
Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYE--MLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF

PPQCPKDIHNLMKRCWTSEPGQRPT-FDFLHT--F
 .  ...   ..|.|..  | .|||  . |.   |
-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDR.AA CTKA 645-704 41 3.1e-18 57.75 In-house 35-96 (290) Show / Hide 
Range on Protein: 645-704
Range on HMM: 35-96/290
Sequence Identity: 41% (26 aa)

TLVAVKMLRKDASKNARADFMKEMKIMS--QLRDPNIVRLLAACTEDEPYCMIVEYMENGDL
..||||||...|   .|  |  |  . |  ..  ||..|||  || ..|  || |.|  |||
KDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDL
Kinase DDR.AA Ror 604-619 50 0.001623 10.35 In-house 1-16 (308) Show / Hide 
Range on Protein: 604-619
Range on HMM: 1-16/308
Sequence Identity: 50% (8 aa)

LNFLELLGEGMFGEVH
. |.| |||. || |.
VRFMEELGECQFGKVY
Kinase DDR.AA Ror 868-902 40 0.00877 7.43 In-house 243-277 (308) Show / Hide 
Range on Protein: 868-902
Range on HMM: 243-277/308
Sequence Identity: 40% (14 aa)

PPQCPKDIHNLMKRCWTSEPGQRPTFDFLHTFLQA
|  ||  |  ||  ||   |  ||.|   |. |..
PHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLRS
Kinase DDR.AA Src 604-618 46 0.0099 5.05 In-house 1-15 (255) Show / Hide 
Range on Protein: 604-618
Range on HMM: 1-15/255
Sequence Identity: 46% (7 aa)

LNFLELLGEGMFGEV
. ... ||.| ||||
IKLCRKLGQGQFGEV