Gene CCK4 (Sea Urchin)

CCK4

Species: Sea Urchin
Alias: Spk257, SPU_010698, CCK4
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: CCK4

Sequence

Name Sequence Type Origin Length Description Download
CCK4.AA Protein None 769 None Fasta, JSON
CCK4.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of CCK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 CCK4.AA IGc2 28-91 42 6.9e-20 73.31 SMART 1-56 (56) Show / Hide 
Range on Protein: 28-91
Range on HMM: 1-56/56
Sequence Identity: 42% (27 aa)

EEGGKVTLICRASGNPVPMVTWYHDQTPVVAGSNVDISGTRLKIKSATPLDSGIYSCMATNVAG
.||. ||| |.|.|||.| ..||.  .|.        .. .|.||..|| |||.|.| |.| .|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set CCK4.AA I-set 27-92 31 4.7e-14 50.22 Pfam 12-83 (92) Show / Hide 
Range on Protein: 27-92
Range on HMM: 12-83/92
Sequence Identity: 31% (23 aa)

VEEGGKVTLICRASGNPVPMVTWYHDQTPVVA---GSNVDISG---TRLKIKSATPLDSGIYSCMATNVAGS
| ||  ... |...|.| | |.|..|  |.       ... .|   ..| |. ..| |.|.|.| ||| .|.
VQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGE
IG CCK4.AA IG 22-104 22 1.1e-11 46.06 SMART 1-58 (58) Show / Hide 
Range on Protein: 22-104
Range on HMM: 1-58/58
Sequence Identity: 22% (20 aa)

NLPEDVEEGGKVTLICRASGNPVPMVTWYHDQTPVVAGSNVDISGTRLKIKSATPLDS---GIYSCMATNVAGSMPSTE--NVQFNIV
     | ||. ||| | .|      ..||                  | | ...| ||   |.| |.||    ..  .   ...  . 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
V-set CCK4.AA V-set 15-103 17 4.6e-05 19.29 Pfam 1-128 (128) Show / Hide 
Range on Protein: 15-103
Range on HMM: 1-128/128
Sequence Identity: 17% (22 aa)

RVQLNR-PNL----PEDVEEGGKVTLICRAS-GN----PVPMVTWYH-DQT-----------------PVVAGSNVDISGTR------------LKIKSA
 .|.   |      .  |.||..||| |  | .     .. ...||   ..                     ..    .|..            |.|...
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TPLDSGIYSCMATNVAGSMPSTENVQFNI
.| |||.| | ..|  . .   . ..  .
QPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IG CCK4.AA IG 115-205 15 2.1e-10 41.78 SMART 1-58 (58) Show / Hide 
Range on Protein: 115-205
Range on HMM: 1-58/58
Sequence Identity: 15% (15 aa)

PTDAIRVLGDSIMFHCQFSGDPTPPVEWYTTSKAGGEIPPQLMNDTETGTYIIGNGSLSLANLTAGDE---GEFQCVCDSPHGRPFA--SARLTIA
|     ..|... ..| .|      . ||                            | . |... |.   |...|.    ||  ..  ...||. 
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 CCK4.AA IGc2 121-194 25 9.1e-10 39.69 SMART 1-56 (56) Show / Hide 
Range on Protein: 121-194
Range on HMM: 1-56/56
Sequence Identity: 25% (19 aa)

VLGDSIMFHCQFSGDPTPPVEWYTTSKAGGEIPPQLMNDTETGTYIIGNGSLSLANLTAGDEGEFQCVCDSPHG
  |.|. . |  .|.|.| . ||     | ..|              .|..|.. | | .|.|. .|.  .|.|
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set CCK4.AA I-set 109-204 28 1.2e-08 31.88 Pfam 1-92 (92) Show / Hide 
Range on Protein: 109-204
Range on HMM: 1-92/92
Sequence Identity: 28% (29 aa)

PVVEVAPTDAIRVLGDSIMFHCQFSGDPTPPVEWYTTSKAGGEIPP-----QLMNDTETGTYIIGNGSLSLANLTAGDEGEFQCVCDSPHGRPFASARLT
|...  |.|.    |... | || .|||.| |.|.     | ...|     |  .|        |. .|   | ...|||.  ||   . |   ..|.||
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKD---GQPLRPDSDRHQMTYDG------DGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELT

I
.
V
V-set CCK4.AA V-set 108-204 18 1.5e-05 21.0 Pfam 1-128 (128) Show / Hide 
Range on Protein: 108-204
Range on HMM: 1-128/128
Sequence Identity: 18% (24 aa)

TPVVEV-APT----DAIRVLGDSIMFHCQFSGDP----TP-PVEWYTTSKAGGEIPPQLM-----NDTE----------TGTY-IIGNGS-----LSLAN
  .|..  |.        ..|.|. ..|..| |.    ..  . || .    |. | ...     ....           |.. . ||.|     |.. |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

LTAGDEGEFQCVCDSP-HGRPFASARLTI
|.  |.|   |.  .. ..   .. |||.
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG CCK4.AA IG 213-305 14 2.2e-11 45.08 SMART 1-58 (58) Show / Hide 
Range on Protein: 213-305
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

FEAQLIPEGDTKTINCSYPAGDVGGIPTPSIHWLKPSLREVPLDGTKTKRVRVEEQKNLLVFDPIKKSDE---GNYTCVSSNMAGETTQ--ILKVVVA
 . ..  ||.| |..| ..          .|.|.                         |.. .....|.   |.|.|. .  .|....    .. | 
PP-VTVKEGETVTLTC-VS----------QIWWY-------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set CCK4.AA I-set 211-304 26 3.2e-11 40.61 Pfam 1-92 (92) Show / Hide 
Range on Protein: 211-304
Range on HMM: 1-92/92
Sequence Identity: 26% (26 aa)

PEFEAQLIP----EGDTKTINCSYPAGDVGGIPTPSIHWLKPSLREVPLDG-TKTKRVRVEE-QKNLLVFDPIKKSDEGNYTCVSSNMAGETTQILKVVV
|.|. .. .    ||.| . .|     .| | |.|.. |.|    . ||   ..  ... .. .   | .. ....||| |||| .| .|| .   .. |
PKFTQKPKDVEVQEGETARFEC-----QVTGDPPPQVSWFKD---GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 CCK4.AA IGc2 219-294 27 1e-07 32.86 SMART 1-56 (56) Show / Hide 
Range on Protein: 219-294
Range on HMM: 1-56/56
Sequence Identity: 27% (21 aa)

PEGDTKTINCSYPAGDVGGIPTPSIHWLKPSLREVPLDGTKTKRVRVEEQKNLLVFDPIKKSDEGNYTCVSSNMAG
 ||.. |..|     .. | |.|.|||.|    . ||.            .. | . .....|.|.|||. .| .|
HEGQSVTLTC-----PATGNPDPNIHWYK----GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set CCK4.AA V-set 219-304 15 0.000166 17.37 Pfam 19-128 (128) Show / Hide 
Range on Protein: 219-304
Range on HMM: 19-128/128
Sequence Identity: 15% (18 aa)

PEGDTKTINCSYPAGDVGGI----PTPSIHWLK-PSLREVPLDGT------------------KTKRVRVEEQKN-----LLVFDPIKKSDEGNYTCVSS
.||.. |..|.|      .     .. .|.| .  .. . |                      . .||..  . .     |   . .. ||.| |.|...
QEGQSVTLPCHYS----DDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN-LQPSDSGTYYCAVW

NM-AGETTQILKVVV
|.  .   .  ...|
NCNEDYFGHGTRLTV
Kinase CCK4.AA CCK4 493-760 63 7.50000000001e-220 736.67 In-house 2-273 (273) Show / Hide 
Range on Protein: 493-760
Range on HMM: 2-273/273
Sequence Identity: 63% (174 aa)

EHFTHLPNGHGAYGEVTLSRAAGIKDGEEATTVMVKALE-TKEESLQLDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRGE
   . .  |||..|||.|..|.|||||...|.||||||. ||.|....||||||||.|||||.|.|.|||.||..||..|..||.||||||||||||||.
QPIIQI--GHGEFGEVFLAKAQGIKDGATETLVMVKALQKTKDEQQCQDFRREIEMFGKLNHKNVVRLLGLCREKEPHYMVLEYVDWGDLKQFLQATRGK

NGTKNV----PPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRPEYHEYHQKLIPVRWMPAEAIFEDELSAKSD
|.|||.    |||||.||||.|..|||||||.|..|||||.||||||||.||.|.||.|.|....|.|..|||...||.||.||||.|.|||||.|.|||
NNTKNKGSSSPPPLTTSQKIAICYQVALGMEHLYNNRFIHRDLAARNCLISPQMQVKVCYMGLCKDVYNREYHHHRQKWIPIRWMPPECIFEDEYSTKSD

VWAYGIFVWEVFSQG-TLPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHL
|||||.|.||||.|| ..|..|.|||.||..|..|.||...|.|.|.....||||||||.|||||.||||||||
VWAYGVFMWEVFNQGTKMPHEQQDNDQVMQDMQAGKLMWPQPEDCPDKLYRMMHRCWADNPKDRHSFSEITHHL
Kinase CCK4.AA TK 501-760 18 2.7e-83 278.99 In-house 8-486 (486) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-486/486
Sequence Identity: 18% (91 aa)

GHGAYG---EVTLSRAAGIKD--------------------GEEATTVMVKALE---TKEESLQLD--------------FRREIEMLG--KLNHENIVK
|.|..|   || . .. |...                    ... |.| || |    . ..  ..|              . .|..|.   ...|.|||.
GEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVR

LLGVCRDT------------EPQLMITEYLDWGD----LKQFLQATRGENGTKNVPPP------------------------------------------
|.||| .             || ....|| . ||    |...|.. |..  .    |.                                          
LYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKD

------------------------LTLSQKIDIVNQVALGMETLSAN------RFIHGDLAARNCLLSPSME-----------VKICTMS--------VS
                        ||. |.. .  |.| ||| |...      .|.|.||||||||.. ..            .||.            .
HPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA

QDLYR-PEYHEYH------------------------QKLIPVRWMPAEAIFEDE---------LSAKSDVWAYGIFVWEVFSQG-TLPYTQLDN-----
 |.|.  .|.  .                        .  .|.|||. |.... .          . |||||..|...||.|. | . .| ...|     
RDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWK

----DAVMRAMIDG-------------ELMLETPPDTP--------------EEIELMMHRCWADSPKDRHTFSEITHHL
    . ||.   .|              . .. ||. |              ||....| .||.  |.|| |||.. . |
DGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CCK4.AA Pkinase_Tyr 501-760 36 1.6e-80 273.29 Pfam 8-270 (270) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-270/270
Sequence Identity: 36% (98 aa)

GHGAYGEVTLSRAAGIKDGEEATTVMVKAL-ETKEESL--QLDFRREIEMLGKL-NHENIVKLLGVCR-DTEP--QLMITEYLDWGDLKQFLQATRGENG
|.||.||| . .. | ..... ..| || | |.  ..   . || ||.... .| .|.|||.|.|||  . ||   ....||   |||. .|.. |    
GEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR----

TKNVPPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRPEYHEYHQKL---IPVRWMPAEAIFEDELSAKSDVWA
  . ..|||.......  |.| ||| |.....|| ||||||||.. .. ||||    . |.|  .|  |...    .|..||. |.|.. . . |||||.
--EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIFVWEVFSQGTLP-YTQLDNDAVMRAM-IDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHL
.|.  ||.|. |  | |  ..|  |...   ||.  .. |...|.||  .| .||.  |.|| ||||| ..|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR-MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CCK4.AA TyrKc 501-760 33 3.7e-73 250.29 SMART 8-280 (280) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-280/280
Sequence Identity: 33% (98 aa)

GHGAYGEVTLSRAAGIKDGEEATTVMVKALETKEESLQLDFRREIEMLGKL--NHENIVKLLGVCRDT-------EPQLMITEYLDWGDLKQFLQATRGE
|.||.||| . ..         ..| || |  ||.. . ||.||.... ||  .|.|||.|.|||..        || ....|| ..||||..|...|..
GEGAFGEVYKGTWK--------IQVAVKML--KEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

NGTKNVPPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRP-------EYHEY----HQK-LIPVRWMPAEAIFE
         |........  |.| ||| |. ...|| ||||||||..    |||.    | |.|         .|       . | ..|.|||. |.|..
---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

DELSAKSDVWAYGIFVWEVFSQGTLPYTQ-----LDNDAVMRAMIDGELMLETPPD--------TPEEIELMMHRCWADSPKDRHTFSEITHHL
 . . |||||..|.  ||.|. |  ||       ..|. |..   .|. | . ||.         |.|.  .| .||.  |.|| ||||| . .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM-PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CCK4.AA Musk 501-760 36 1.4e-65 215.59 In-house 8-282 (282) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-282/282
Sequence Identity: 36% (102 aa)

GHGAYGEVTLSRAAGIKDGEEATTVMVKAL-ETKEESLQLDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQAT---RGENGTKN
| ||.| |   || |   .|| | | || | .. .. .| || ||  |. .  | |||||||||    |  .  ||.  |||  ||..    |    | .
GEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQ

VP-----------PPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRPEYHEYHQK-LIPVRWMPAEAIFEDELSA
 .           |.|    .  .  |.| ||  ||  .|.| ||| ||||    | |||     |.  |  .|   |.   ||.|||| |.|.    . 
DRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTY

KSDVWAYGIFVWEVFSQGTLPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHL
 |||||||.  ||.|| .  ||  .    |.  . .|  .|  |  .| ..  .| |||   | ||  | .| | .
ESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGN-ILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase CCK4.AA Trk 501-760 35 4.5e-64 216.09 In-house 8-275 (275) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-275/275
Sequence Identity: 35% (95 aa)

GHGAYGEVTLSRAAGIKDGEEATTVMVKALETKEESLQLDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRG--ENGTKNVP
| ||.| | |     .   .. . | ||.|    |.   ||.|| |.| .| |..|||. |||.| .| ||. ||.  |||...|.. .|   .   . .
GEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQ-HGPDAMCYAQYQ

P-----PLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYR-PEYHEY-HQKLIPVRWMPAEAIFEDELSAKSDVWAY
|     |||..|   |. |.| ||  .    |.| |.|.||||      |||     | |.|   .|    |.   |.|||| |.|     .  |||| .
PRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYESDVWSF

GIFVWEVFSQGTLPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHL
|.  ||.|. |  |. || |  |      | . || |   |.|.  .|  ||   |. |..  .| . .
GVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase CCK4.AA TK-Unique 501-760 29 2.3e-61 210.16 In-house 8-294 (294) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-294/294
Sequence Identity: 29% (86 aa)

GHGAYGEVTLSRAAGIKDGEEAT-TVMVKALE-TKEESLQLDFRREIEMLGKLN-HENIVKLLGVCRDT-EPQLMITEYLDWGDLKQFLQATRGE-----
| ||.|.|    . ||. .....  | ||.|.    .  . || .||.|. .|  |.|||..||.| .. ||...| ||.  |.|  .|. .|..     
GEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQ

-----------NGTKNVPPPLTLSQKIDIVNQVALGMETLSA--NRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRPEYHEYHQK--LIPVRWMPAEA
           .  |. . |... . . .  |.| ||| |.    ...|.||.|||.||.   ..||| .  . |.| .. ..  ..   ||.|||. |.
TYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPES

IF--EDEL-SAKSDVWAYGIFVWEVFSQGTLPYTQLDNDAVMRAMIDGELMLETPPDT-PEEIELMMHRCWADSPKDRHTFSEITHHL
.   .    . |||||..|.. ||.|. |  ||...... .|... ||   .. |.   ..|.   | .|| ..|..| .|..|.| |
LKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDG-YRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CCK4.AA UTK 496-760 30 3.1e-59 201.31 In-house 1-296 (296) Show / Hide 
Range on Protein: 496-760
Range on HMM: 1-296/296
Sequence Identity: 30% (90 aa)

THLPN--GHGAYGEVTLSRAAGIKDGEEATTVMVKALETKEESLQL-----DFRREIE---MLGKLN-HENIVKLLGVCRDTEPQLMITEYLDWGDLKQF
..|..  |.||.||| . |.  ... ..   | ||.. ... . |      ||..|     |..... |.|...|.||| . || ...|||   ||| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQATRGENGTKNVPPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPS-------MEVKICTMS---VSQDLYR----------PEYHEYHQ
|.  | . .    |  ||| |... ....| ||. |.  .|.|.||||||||.  .       | .||.       | ....          ..|   ||
LRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

KLIPVRWMPAEAIFED-ELSAKSDVWAYGIFVWEVFSQGTLPYTQLDNDAVMRAMIDGE-LMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHL
. .|.|||  ||. .    . |||||..|...||... | |||  . |..|  .  .|  . .. |.| |...  .|||||. .| .| .| ...  .
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase CCK4.AA ALK 501-762 34 1e-50 173.32 In-house 8-273 (273) Show / Hide 
Range on Protein: 501-762
Range on HMM: 8-273/273
Sequence Identity: 34% (92 aa)

GHGAYGEVTLSRAAGIKDGEEATTVMVKAL-ETKEESLQLDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRGENGTKNVPP
||||.|||      ..        | .| | |   .  ..||  |   .|| ||.|.|...|.| .  | . . ||.  ||.|.||  .| . .  . | 
GHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHPESLQ-PS

PLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLS---PSMEVKICTMSVSQDL-YRPEYHEYHQK-LIPVRWMPAEAIFEDELSAKSDVWAYGIF
.|| .  . .   || |   |  |.||| | |||||||.   |.  .||     . |  || .|     . ..|| ||| ||  .     |.|||..|. 
QLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDVWSFGVL

VWEVFSQGTLPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHLGR
 ||.|| |  ||    |  ||     |. | . | . |  .  .|  ||   | || .|  |  |.  
CWEIFSLGYMPYPGRHNQEVMEFVTEGGRM-DPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase CCK4.AA DDR 501-760 33 1.7e-49 170.76 In-house 8-306 (306) Show / Hide 
Range on Protein: 501-760
Range on HMM: 8-306/306
Sequence Identity: 33% (99 aa)

GHGAYGEVTLSRAAGIKD-----------GEEATTVMVKALET-KEESLQLDFRREIEMLGKLN-HENIVKLLGVCRDTEPQLMITEYLDW-GDLKQFLQ
| |  ||| |  . |..|             ..| | || |     . .  ||..||  ....  | |||.|.|||   || .||.||    |||.||..
GEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLGDLNQFWM

ATRGE-NGTKNVP--------PPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMS--VSQDLYRPEYHEYHQ------KLIPV
.  .|  |..|..        | .  .. . |  |.| ||  |.  .|.|.|||.||||  ..  .|||     .|  ||  .|              |.
EHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGRQRHHMPI

RWMPAEAIFEDELSAKSDVWAYGIFVWEVFSQG-TLPYTQLDNDAV---MRAMIDGELM---LETPPDTPEEIE-LMMHRCWADSPKDRHTFSEITHHL
|||  |.|   . . |||||| |. .||.|..    || || .. |   . .. . . |   |  ||  |.||    | |||   .. | .|.||  .|
RWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFEEIHKFL
Kinase CCK4.AA TKL 501-760 17 1.8e-46 160.68 In-house 2-364 (364) Show / Hide 
Range on Protein: 501-760
Range on HMM: 2-364/364
Sequence Identity: 17% (68 aa)

GHGAYGEVTLSRAAGIKDGEE----ATTVMVKALETKEES---------------------------LQLDFRREIEMLGKLNHENIVKLLGVCRDTEP-
| |..|||   .  |.    .    ...| || . .....                           ..  ...|| |. .|.|.|||...|.| . .. 
GSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------QLMITEYLDWGD-LKQFLQATRGENGTKNVPPPLTLSQKIDIVNQVALGMETLSANR--------FIHGDLAARNCLLSPSME-----
              ...|| . |. | ...                 ..|..... ..|.||. | ...         || ||  .|.|.   ..     
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

---------VKICTMSVSQDLYRPEYHEYH---------------QKLIPV---RWMPAEAIFED----------------ELSAKSDVWAYGIFVWEVF
         .||| .  |... . .  .                 ..  ..   |||. |.. ..                | | |.||...||  ||..
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL

SQGTLPYTQLDND---------AVMRAMIDGELMLETP------------PDTPEEIELMMHRCWADSPKDRHTFSEITHHL
.  . || .....         . .   .|  | .. |            ||.|...   | .||.  |..| .|.||...|
TRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CCK4.AA InsR 501-762 31 2.6e-46 153.51 In-house 8-278 (278) Show / Hide 
Range on Protein: 501-762
Range on HMM: 8-278/278
Sequence Identity: 31% (86 aa)

GHGAYGEVTLSRAAGIKDGEEAT--TVMVKALE---TKEESLQLDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRGENG-T
| |. | | .  | || ..|| .   . .| .    . .|   ..|  | .   . |. ..|.|||||   .| . . |  . |||| .| . | |..  
GQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRE--RIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRPEEEFN

KNVPP----PLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRPEYHEYHQK-LIPVRWMPAEAIFEDELSAKSDVW
  . .    . .|.| .  . ... ||  | |. |.| |||.|||. . .  |||       |.|   |     | . |||||. | . .   ...||||
NPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGVFTTHSDVW

AYGIFVWEVFSQGTLPYTQLDNDAVMRAM-IDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHLGR
 .|.  ||. . | .||  | |. | .   .||  .|. |   ||    .| .||. .||.| || .| | |  
SFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGN-VLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase CCK4.AA S_TKc 494-760 21 4.1e-16 59.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 494-760
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

HFTHLPNGHGAYGEVTLSRAAGIKDGEEATTVMVKALETKEESLQLDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDW--GDLKQFLQATRGE
   . . |.||.|.| . |  .         | .| .         ..||||..| | .|.|||||..|..| .   |..||.|   |||.....  ...
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

NGTKNVPPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTMSVSQDLYRPEYHEYHQKLIPVRWMPAEAIFEDELSA-KSDVWA
 . .    |..  .   .. |.....| .  ...|| ||   | ||.   ..|||   ..  |        .       .|. | .     .  |.|.|.
GLRF----PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWS

YGIFVWEVFSQGTLPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITH-------H--L
 |. ..| .. |  |.   . ..... .            .|| .. .. .|.   |..| |  |. .       |  .
CGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CCK4.AA Pkinase 501-646 25 8e-15 53.5 Pfam 8-154 (293) Show / Hide 
Range on Protein: 501-646
Range on HMM: 8-154/293
Sequence Identity: 25% (40 aa)

GHGAYGEVTLSRAAGIKDGEEATTVMVKALETKEESLQLD--FRR--EIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWG----DLKQFLQATRGEN
| |..|.|   ..  ...|.   .| || .. ..|. . |   ||  ||... .|||.|||.|.....|     |..||.. |    ||. ....     
GSGSFGCV--YKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----

GTKNVPPPL--TLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEV----KIC
       ..  .  . .... |.. |.| . ....|| ||   |.|..  ...    |||
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
IG CCK4.AA IG 314-449 12 6e-11 43.61 SMART 1-58 (58) Show / Hide 
Range on Protein: 314-449
Range on HMM: 1-58/58
Sequence Identity: 12% (17 aa)

PVDVHIREREEATLRCNATGTPTPTISWTFGTRDITNVRNHVLTILKFNPRPIAVTSLDRGEMNRLVCHATASIQPFIAWHKQGIIGTWPDHISEPNSGV
|  |  .| | .||.| ..     .|.|.                                                                       
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------------------------------------

LQFNPAEASDA---GTYICIASTGLERINTTV--RIDVVVK
|.. .....|.   ||| | |.      ...    . . |.
LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
I-set CCK4.AA I-set 308-344 43 3.2e-10 37.19 Pfam 1-37 (92) Show / Hide 
Range on Protein: 308-344
Range on HMM: 1-37/92
Sequence Identity: 43% (16 aa)

PKITTRPVDVHIREREEATLRCNATGTPTPTISWTFG
||.|..| || ..| | |.. |..||.|.|..||. .
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKD
Kinase CCK4.AA Pkinase 670-760 18 1.5e-09 34.9 Pfam 176-293 (293) Show / Hide 
Range on Protein: 670-760
Range on HMM: 176-293/293
Sequence Identity: 18% (22 aa)

RWMPAEAIF-EDELSAKSDVWAYGIFVWEVFSQGTLPYTQL------DNDAVMRAMIDGELMLETPPDTP-------------------EEIELMMHRCW
..|. | |    . . |.|.|..|. ..|... | .|. .       | .....   ...|. . | . .                   ||    . .|.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

ADSPKDRHTFSEITHH--L
.  ||.| |. .| .|  .
CKDPKKRPTAEQILQHPWF
I-set CCK4.AA I-set 450-483 35 4.1e-07 26.64 Pfam 1-34 (92) Show / Hide 
Range on Protein: 450-483
Range on HMM: 1-34/92
Sequence Identity: 35% (12 aa)

PKFVIIPNNTIGFEGYSLKIDCTAHGDPEPTITW
|||.. | .    || ... .|.. |||.|...|
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSW
IGc2 CCK4.AA IGc2 320-436 14 5e-06 27.34 SMART 1-56 (56) Show / Hide 
Range on Protein: 320-436
Range on HMM: 1-56/56
Sequence Identity: 14% (17 aa)

REREEATLRCNATGTPTPTISWTFGTRDITNVRNHVLTILKFNPRPIAVTSLDRGEMNRLVCHATASIQPFIAWHKQGIIGTWPDHISEPNSGVLQFNPA
.| . .||.| ||| |.|.|.|..    .                                                             ... |.. ..
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------------------------------------WNWTLTIKNV

EASDAGTYICIASTGLE
. .|.|.| |.|.    
TPEDSGYYTCYARNPWG
IG CCK4.AA IG 456-528 14 0.106725 5.7 SMART 1-58 (58) Show / Hide 
Range on Protein: 456-528
Range on HMM: 1-58/58
Sequence Identity: 14% (11 aa)

PNNTIGFEGYSLKIDCTAHGDPEPTITWISKPIMNYPEHFTHLPNGHGAY---GEVTLSRAAGIKDGEE--ATTVMVK
|  . . || .... | ..     .|.|           .|  .         |. .       ....    ||. |.
PP-VTVKEGETVTLTC-VS-----QIWWY----------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set CCK4.AA V-set 401-448 22 1.475486 3.75 Pfam 83-128 (128) Show / Hide 
Range on Protein: 401-448
Range on HMM: 83-128/128
Sequence Identity: 22% (11 aa)

TWPDHISEPNSGVLQFNPAEASDAGTYICIASTGLERINTTVRIDVVV
|.  ..|  |.  |. . .. || ||| | ....   ..    . ..|
TFSGNPS-KNDFSLTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
I-set CCK4.AA I-set 416-432 29 2.669432 3.53 Pfam 62-78 (92) Show / Hide 
Range on Protein: 416-432
Range on HMM: 62-78/92
Sequence Identity: 29% (5 aa)

FNPAEASDAGTYICIAS
.  ....|.|.| |.|.
ISNVQPDDEGKYTCVAT