Gene Ack2 (Sea Urchin)
Ack2
Sequence
Protein domains of Ack2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Ack2.AA | Ack | 65-235 | 61 | 1.3e-118 | 400.37 | In-house | 1-177 (266) | Show / Hide |
Range on Protein: 65-235 Range on HMM: 1-177/266 Sequence Identity: 61% (108 aa) LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPL-KMVTELAPLGALVDRLREDPS-- .||.||||.|.||||.||.|..|.||...||||||||....||....||..||..|| ||||||||||||||..|. .|||||||.|.|.|.||.... ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA KFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASM-QKVKIGDFGLMRALPSATNYYIMTEHN--QVPYAW .|||.||..|..|||.||..||.||.||||||||||||.|. .||||.||||||||. . .|| | .| ||.|| FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAW |
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| Kinase | Ack2.AA | Pkinase_Tyr | 65-235 | 39 | 1.3e-68 | 233.01 | Pfam | 1-180 (270) | Show / Hide |
Range on Protein: 65-235 Range on HMM: 1-180/270 Sequence Identity: 39% (71 aa) LTLHEKLGNGSFGVVRRGDWK-TPRGKRVEVAVKCLRSEMVNQ-PGFFEDFVKEVNTMHLL-DHPHLVRLYGVVL--SSP--LKMVTELAPLGALVDRLR .|. .||| |.||.|..| || | .....||||.|. . . ||| .|...|. | .||..||||||.. . | . .|.|..|.| | | || ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR ED---PSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYY-IMTEHNQVPYAW . . .. ...| ...|||.||..|| |..|||||||||.|... .|||.||||.|.. . || .... .| | KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKW |
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| Kinase | Ack2.AA | TK | 65-235 | 19 | 3.2e-58 | 193.45 | In-house | 1-351 (486) | Show / Hide |
Range on Protein: 65-235
Range on HMM: 1-351/486
Sequence Identity: 19% (70 aa)
LTLHEKLGNGSFG---VVRRGDWKT----------------------PRGKRVEVAVKCLRSEMVNQPG-FFE-------------DFVKEVNTMH--LL
.|| .||| | || .|..| |.. ..|....||||.|... ... ||. .. | |. |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
DHPHLVRLYGVVLSS-------------PLKMVTELAPLGA----LVDRLREDPSK--------------------------------------------
.||..||||||.. . |. .|.|..|.| | | ||. . |
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------FLISTLSAFALQIASGMSFLEYK------RFIHRDLAARNILLASMQK-----------VKIGDFG---
. .| ...|||.||..|. | .|.||||||||.|... . .||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----LMRALPSATNYYIMTEHN-----------------------QVPYAW
| |...| ..|| .... ..| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW
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| Kinase | Ack2.AA | Src | 65-235 | 35 | 6.3e-47 | 157.45 | In-house | 1-166 (255) | Show / Hide |
Range on Protein: 65-235 Range on HMM: 1-166/255 Sequence Identity: 35% (61 aa) LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSS-PLKMVTELAPLGALVDRLR--EDPS ..| .|||.| || | | |. ....|||| |.. . |.| .| ..| |.|..||.|| |. | |||. | | | |. .. . IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGTMSP----EAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR KFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYYIMTEHNQVPYAW . . .| .| |.|.||..|| ...|||||||||.| .|..|||| | . . | . . . .|. | HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKW |
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| Kinase | Ack2.AA | UTK | 65-235 | 27 | 2.6e-43 | 146.04 | In-house | 1-205 (296) | Show / Hide |
Range on Protein: 65-235 Range on HMM: 1-205/296 Sequence Identity: 27% (56 aa) LTLHEKLGNGSFGVVRRGDWKTPR--GKRVEVAVKCLRSEMVNQPGFFED----FVKEVN---TMHLLD-HPHLVRLYGVVLSS-PLKMVTELAPLGALV . | ..|| | ||.|......... .. . |||| .... . | .... | .| . | .. ||...||.||.... |. .|||... | |. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQ--QEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR DRLR-------EDPSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASM-------QKVKIGDFG---LMRALPS--------ATNYYIMTEH . || ..| . .. .|..||.||..|. ..|.||||||||.|... ...||.||| . |.... ..|| ... SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ NQVPYAW ...| .| DRWPIRW |
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| Kinase | Ack2.AA | EGFR | 65-223 | 41 | 8.1e-43 | 139.89 | In-house | 1-158 (258) | Show / Hide |
Range on Protein: 65-223
Range on HMM: 1-158/258
Sequence Identity: 41% (67 aa)
LTLHEKLGNGSFGVVRRGDWKTPRGKRVE--VAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPLKMVTELAPLGALVDRLREDPSK
| . .|| | || | .| | | |. | ||.| || . | .|... | | .|||||||| || ..| ...|| . |.|.| | .|. .
LKKVKVLGSGAFGTVYKGIW-IPEGENVKIPVAIKVLREQT--GPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQHKDN
FLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYY
| ...|||.||..|| .| .||||||||.|. | ..||| |||| . |.. . |
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEY
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| Kinase | Ack2.AA | Syk | 65-228 | 36 | 8.2e-43 | 145.2 | In-house | 1-168 (257) | Show / Hide |
Range on Protein: 65-228
Range on HMM: 1-168/257
Sequence Identity: 36% (61 aa)
LTLHEKLGNGSFGVVRRGDWKTP----RGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPLKMVTELAPLGALVDRLREDP
| . . .| | || |. | . .....||.| |. . |||. . |. | . |. ||||. ||. |. . .. || |.|.||.. . | ..
LVQDNEIGCGNFGSVHKGWYMMKSGAGEKQWIKVAIKMLKADH-NQPADKQEFMREAQVMCQLDHPCIVRMIGICHAEMMMMVMEMAELGPMHKYLQQHR
SKFLI-STLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYYIMTEH
. | . |.|.|| || | |.||||||||.|| || |||. .|| .|| | |
HEITANNVLELWHTQVAMGMCYLEEKHFVHRDLAARNVLLVNRHYAKISDFGMSKALGADSQYYQATTH
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| Kinase | Ack2.AA | Tec | 65-214 | 40 | 4.3e-37 | 127.15 | In-house | 1-145 (254) | Show / Hide |
Range on Protein: 65-214 Range on HMM: 1-145/254 Sequence Identity: 40% (63 aa) LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLR----SEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSS-PLKMVTELAPLGALVDRLRED ||. . ||.| ||||..| | |. .||.| .. || |||. | .| | || ||.|||| . |. .||| | | . ||| LTFMKELGSGQFGVVHLGKW---RH-QYDVAIKMIKEGSMSE--------EDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREH PSKFLIST--LSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMR .| .. | ... || .|| . |||||||||| | . . ||. |||. | KHHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTR |
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| Kinase | Ack2.AA | FAK | 65-235 | 29 | 6.8e-37 | 121.05 | In-house | 1-192 (285) | Show / Hide |
Range on Protein: 65-235 Range on HMM: 1-192/285 Sequence Identity: 29% (57 aa) LTLHEKLGNGSFGVVRRGDWKTPRG------------------------KRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPL || ..| | || | | . ... ..||.| . . .. | |..| .|. .||||.|.| |.. | ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCC--DDDNKEKFMQEAYIMKQFDHPHIVKLIGICEEMPI KMVTELAPLGALVDRLREDPSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSATNYYIMTEHNQVPYAW .. ||...| | |. . . || ...|.. |..|| |.|.||| ||||.| .| . || ||||| | . . || . . | | WIIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPDCVKLGDFGLSRWM-HDHSYYKASPKGKLPIKW |
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| Kinase | Ack2.AA | Abl | 65-214 | 42 | 1e-35 | 116.31 | In-house | 1-145 (252) | Show / Hide |
Range on Protein: 65-214 Range on HMM: 1-145/252 Sequence Identity: 42% (64 aa) LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGV-VLSSPLKMVTELAPLGALVDRLREDPSKF .....||| | .| | | || |||| |. . .. ..|.|| | . || ||.| || .| ..|| . | |.| ||| . IMMKHKLGGGQYGEVYEGVWKR---HDCTVAVKTLKEDTME----VHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE LIS-TLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMR | . .| | |||||||.|| . |||||||||| |.. . ||. |||| | LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLAR |
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| Kinase | Ack2.AA | Fer | 65-212 | 34 | 4.5e-35 | 116.95 | In-house | 1-160 (283) | Show / Hide |
Range on Protein: 65-212 Range on HMM: 1-160/283 Sequence Identity: 34% (56 aa) LTLHEKLGNGSFGVVRRG--DWKTPRGKRVE-----VAVKCLRSEMVNQPGFFEDFVKEVNTMHL-LDHPHLVRLYGV-VLSSPLKMVTELAPLGALVDR ||..|||.| || |..| . | .||... |.|| ...|... ..| .| . | .|||. |..||| |. |. | |... |.| .. VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQ-IKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY LREDPSK-FLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLAS-MQKVK--IGDFGL |.. ..| . .. ...|.|.|| .|. | ||||.||||.|. |.| | |||. LKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGM |
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| Kinase | Ack2.AA | TyrKc | 65-235 | 25 | 1.5e-26 | 95.41 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 65-235
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)
LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLL--DHPHLVRLYGVVLS--------SPLKMVTELAPLGALVD
.|| .|||.| ||.|..| || ..||||.|... ||| .| . |. | .||..||||||... || .|.|..|.|.| |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
RLREDPSKFLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSA------TNYYIMTE---HN----------------
.||. |. ..| |..|||.||..|. |..|||||||||.|... . |||.||||.|.. . . || ..| .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG
----------------------QVPYA----------------------------------------------------------------W
| || .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | Ack2.AA | Pkinase | 65-212 | 27 | 4.9e-20 | 71.92 | Pfam | 1-158 (293) | Show / Hide |
Range on Protein: 65-212 Range on HMM: 1-158/293 Sequence Identity: 27% (45 aa) LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVK--EVNTMHLLDHPHLVRLYGVVL-SSPLKMVTELAPLG----ALVDRLR .....|.| ||||.|... .| . .||||... . . ... . .. |. |. |.||. ||||... .. . ||.|... | | |... YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS -EDPSKF--LISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKV----KIGDFGL .. .| .. ...||..|. .. ...||||| |||. . . ||.|||| TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL |
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| Kinase | Ack2.AA | S_TKc | 65-234 | 20 | 2.6e-12 | 3.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 65-234
Range on HMM: 1-231/231
Sequence Identity: 20% (50 aa)
LTLHEKLGNGSFGVVRRGDWKTPRGKRVEVAVKCLRSEMVNQPGFFEDFVKEVNTMHLLDHPHLVRLYGVVLSSPLKMVTELAPL--GALVDRLREDPSK
....|.| |.||.|... .| .||.|... |.. .|.. .. .||..|.||.| .. | ||.|... | | |.... ...
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH
-----FLISTLSAFALQIASGMSFLEYKRFIHRDLAARNILLASMQKVKIGDFGLMRALPSAT---------------NY------------YIMTE---
| . .. ||.... .. ...||||| |||| . .||.|||| | | | .. |.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYP
--------------------------HN----------Q-------VPYA
. | |.
PFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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