Gene MEK (Sea Urchin)

MEK

Species: Sea Urchin
Alias: Spk246, MEK, SPU_021504
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
MEK.AA Protein None 412 None Fasta, JSON
MEK.kin_dom Protein Kinase Domain None 291 None Fasta, JSON

Protein domain

Protein domains of MEK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MEK.AA MEK1 87-377 76 2.2e-209 701.87 In-house 1-297 (297) Show / Hide 
Range on Protein: 87-377
Range on HMM: 1-297/297
Sequence Identity: 76% (229 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHECNSPYIVGFFGAYYSDGEICICMENMDGGSLDQVMKSAPKGRIPENI
||...|||.||||||.|..|...||.||||||.|||||||||||||||.|||||||||||||.||.||||||.||||.|||||||||.|.|  |||||.|
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA--GRIPEKI

LGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSLGLSLVEMAIGRYPIPA
||||.|||||||.|||| |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.
LGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPP

PDETALANLFG---YELQAGETKNIR-KTRVGG-VFS---DSPRPMAIFELLNYIVEEHPPRLPSRAFSEEFVDFVDVCLIKNPNERADLKKLKVHTFA
||.......||   |. |.||..||. ..|... ..|   ||||.|||||.|.|||.|.||.||.|.|||||.||||.||||||.||||||.|.||||.
PDQKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPISHGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MEK.AA STE7 87-377 50 2.2e-179 602.25 In-house 1-288 (288) Show / Hide 
Range on Protein: 87-377
Range on HMM: 1-288/288
Sequence Identity: 50% (159 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIK-PAIRNQIIRELKVLHECN-SPYIVGFFGAYYSDGE--ICICMENMDGGSLDQVMKSAPK---
.|...|||.||.|||.|. || ||..||.|.|.|... |....||..||.|||.|| .||||.|.||.|..|.  |.|||| ||||.||...| . |   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQG--THYTVQSDIWSLG
    |||||.||||..|||..|| ||.. | |.|||||||||||||||..||||||..|||.|||  |..|||...||.|||..|  .||.|.||.||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LSL-VEMAIGRYPIP-----APDETALANLFGYELQAGETKNIRKTRVGGVFSDSPRPMAIFELLNYIVEE-HPPRLPSRAFSEEFVDFVDVCLIKNPNE
... .|||.||||.|     .||.. ..| |.                       |. |||||.|..||.| .|||||   ||.||.|||. ||.|.|||
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ-----------------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNE

RADLKKLKV-HTFA
|.....|.. | | 
RPKYHQLMKEHPFI
Kinase MEK.AA STE7-Unclassified 87-377 38 1.7e-131 443.12 In-house 1-301 (301) Show / Hide 
Range on Protein: 87-377
Range on HMM: 1-301/301
Sequence Identity: 38% (130 aa)

FEVLKELGAGNGGVVTKVKHKM------SGMVMARKLIKLEIK-PAIRNQIIRELKVLHECN-SPYIVGFFGAYYSDGE---ICICMENMDGGSLD---Q
.|.||.||.|..|.| |..||       .| .|| | |....  .....||.||||.||.|. .||||...||||...    | |||| ||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VMKSA------PKGRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGT-----
..| .      ..|.||| .|||.. .|..|| || . | | |||.||.||||||.|..|.|||||.|||....  |...||. .||||||.||      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

HYTVQSDIWSLGLSLVEMAIGRYPIP------------APDETALANLFGYELQAGETKNIRKTRVGGVFSDSPRPMAIFELLNYIVEEHPPRLPS-R--
 |.|.||||||||.. |.|.|.||..            .|                                    | ..|||..||..  ||||. .  
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP----------------------------------ENMSFWELLSCIVNFPVPRLPDDPED

-AFSEEFVDFVDVCLIKNPNERADLKKLKV-HTFA
  .|.|| ||.. |..|.|.||.|   | . | . 
IIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase MEK.AA STE 87-377 29 1.6e-110 373.48 In-house 1-359 (359) Show / Hide 
Range on Protein: 87-377
Range on HMM: 1-359/359
Sequence Identity: 29% (114 aa)

FEVLKELGAGNGG-VVTKVKHKMS--------------GMVMARKLIKLEIK----------------PAIRNQIIRELKVLHECN--SPYIVGFFGAYY
.| ....| |..| |.....|| .              | .|| | ..|| .                . ...||..|.|....||  .|.|| ..|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDG-------EICICMENMDGGSLDQVMK---SAPK---------GRIPENILGKVTVAVLRG-LIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVS
 .|       |..|||| |||||||...|   . .|         .|.||..........|.| | || . | |.|||.||.|||.     .|||||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GQLIDS------------------MANSFVGTRSYMSPERLQG------THYTVQSDIWSLGLSLVEMAIGRYPI---PAPDETALANLFGYELQAGETK
|||.||                  . |.||||  .|.||..|.       .|....||||||. ..||| |..|    . .    ...  ..  |  .  
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ--Q--

NIRKTRVGGVFSDSPRPMAIFELLNYIVEEHPPRLPS------------------RAFSEEFVDFVDVCLIKNPNERADLKKLKV--HTFA
                    ||.| .||...||.||.                  . .|.|| ||.. ||.|.||.|.. ..|    | | 
--------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEK.AA MEK5 88-286 51 1.3e-81 277.49 In-house 2-193 (254) Show / Hide 
Range on Protein: 88-286
Range on HMM: 2-193/254
Sequence Identity: 51% (102 aa)

EVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHECNSPYIVGFFGAYYSDGEICICMENMDGGSLDQVMKSAPKGRIPENIL
     || |||| | |  |  || ..| |.| |.|   .. ||. ||..|. | ||||.||.||.. .  | || | |||||||   .      ||| ||
RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC------IPEHIL

GKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSLGLSLVEMAIGRYPIPA
|..|||. .|| || ..  ||||||||||.||| .|.||||||||| ||..|..  ..||  || |||. | .| . ||.||||....|||.||.| |.
GRMTVAIVKGLNYLWNLK-IMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQ
Kinase MEK.AA S_TKc 87-377 25 1.6e-76 261.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 87-377
Range on HMM: 1-231/231
Sequence Identity: 25% (79 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHECNSPYIVGFFGAYYSDGEICICMENMDG--GSLDQVMKSAPKGR---
.|.|...| |  |.| |..|| .| ..| | ||        ..|.||...|.. . |.|| ....... ......|| .||  |.| ...|. ....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTV-QSDIWSLGLSLVEMAI
 .||    ...  ....| |. .   |.|||.||.|||...  .||.||||.. ||     ..|.||. ||.|| |   .|.   .|.||.|  | ||. 
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRYPIPAPDETALANLFGYELQAGETKNIRKTRVGGVFSDSPRPMAIFELLNYIVEEHPPRLPSRAFSEEFVDFVDVCLIKNPNERADLKKLKV------
|. | |  .. .. .. |                                                 |.|. ||.. || |.|..|    ..        
GYPPFP--QMQMMFKKIG-------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HTFA
 | . 
CHPWF
Kinase MEK.AA MEK4 87-283 42 1.9e-67 219.18 In-house 1-211 (275) Show / Hide 
Range on Protein: 87-283
Range on HMM: 1-211/275
Sequence Identity: 42% (91 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIK-LEIK-----PAIRNQIIRELKVLHEC-NSPYIVGFFGAYYSDGEICICMENMDGGSLDQVMK---S
 . | |.|.|. |.| |  || || .|| | |.   .           .  .|. |     | |||| |.|| .. |   |||| ||  |.|   |   .
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

APKGRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYTVQSDIWSLG
  | ||||||.|..||.. . | ||   | | ||||||||||.. .| .||||||..||| ||.| .  .| | || |||..       | . ||.||||
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

LSLVEMAIGRYP
  ..| | |..|
ITMYEVATGKFP
Kinase MEK.AA Pkinase 87-377 25 4.6e-66 230.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 87-377
Range on HMM: 1-293/293
Sequence Identity: 25% (81 aa)

FEVLKELGAGNGGVVTKVKHKMSGM-VMARKLIKLEIKPAIRNQIIR--ELKVLHECNSPYIVGFFGAYYSDGEICICMENMDGG----SLDQVMKSAPK
..... .|.|. |.| | .|| .|  |   .. | ..|.  . . .|  |.......|.|.|| ..........|...|| ..||    .|  ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRI--PENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEI----KLCDFGVSG---QLIDSMANSFVGTRSYMSPERLQ-GTHYTVQSDIWS
|..  .|. . ..   .|||| |. . . |.|||.||.|||....|.|    |.||||..       .| ...|.||. ||.|| .. |..|.  .|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGLSLVEMAIGRYPIPAPDETALANLFGYE----LQAGETKNIRKTRVGGVFSDSP--RPMAIFELLNYIVEEHPPRLPSRAFSEEFVDFVDVCLIKNPN
.|. | ||. ||             .|  .      . . . |.... . . .|.|  ...  |. ...   .  ...   . |||. ||.. || |.|.
CGCILYEMLCGR------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPK

ERADLKKLKVHTFA
.|   . .. | . 
KRPTAEQILQHPWF
Kinase MEK.AA MEK3 87-283 41 3.5e-62 210.25 In-house 1-205 (264) Show / Hide 
Range on Protein: 87-283
Range on HMM: 1-205/264
Sequence Identity: 41% (85 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHECNS-PYIVGFFGAYYSDGEICICMENMDGGSLDQVMKSAPK---GRI
 .|. ||| |  |.| |..|. || .|| | |.  .      ... .. .       || | |.|| .  | . |||| ||  .||   . . |    .|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHI

PENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYTVQSDIWSLGLSLVEM
||.||||. . . ..| |..    . ||||||||.|.|  | .|.||||.||.|.||||     | . || |||  .      | | ||.||||  ..||
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

AIGRYP
||||||
AIGRYP
Kinase MEK.AA MEK7 87-283 42 2e-61 207.18 In-house 1-206 (269) Show / Hide 
Range on Protein: 87-283
Range on HMM: 1-206/269
Sequence Identity: 42% (87 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHECN-SPYIVGFFGAYYSDGEICICMENMDGGSLDQVMKSAPKG---RI
 . . ..| |  | |.|..|| || .|| |  .          | . | |   |. .||||  ||..  | .. |||| | .  .|  .|   .     |
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERLQG-----THYTVQSDIWSLGLSLVE
|| |.||..||.   | || . | ||||||||||||   || |||||||.|| ..||.|..   |   || |||.         | . .|.|||| .|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

MAIGRYP
.| |.||
LATGQYP
Kinase MEK.AA STE20 87-278 36 1.5e-53 184.21 In-house 1-221 (288) Show / Hide 
Range on Protein: 87-278
Range on HMM: 1-221/288
Sequence Identity: 36% (80 aa)

FEVLKELGAGNGGVVTKVKHKMSGMV----MARKLIKLEIKP---AIRNQIIRELKVLHECNSPYIVGFFGAYYSD----GEICICMENMDGGSLDQVMK
.| |...| |. |.| |. || .| .     | | ..|| .      .. |. |  .. .|..|.|| ..|.|. |     |. |.|| ..|||| ..||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---SAPKG----RIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID----SMA---NSFVGTRSYMSPERLQG---
   .  |     .. |     ..  ||.|| ||   | |.|||.|  |||....||.||.||||..||..    .|.   |.||||  .|.|| .|.   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH-IIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--THYTVQSDIWSLGLSLVEMA
    |.  .||||||  . |||
PDKGYDYKCDIWSLGITAIEMA
Kinase MEK.AA MST 87-278 38 8.7e-47 146.7 In-house 1-191 (254) Show / Hide 
Range on Protein: 87-278
Range on HMM: 1-191/254
Sequence Identity: 38% (75 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHECNSPYIVGFFGAYY--SDGEICICMENMDGGSLDQVMKSAPKGRIPE
|...  || |. |.| |  || .| . | |... .      ..|| |   . .|.|.|||...| |.   . .. |.||  ..||.  .||   .    |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNED---LQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQR-TLNE

NILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYTVQSDIWSLGLSLVEMA
     .   .|.|| || |.. ..||| |. |||.| .|| || ||||||||.| |  .|...||  .|.|| .|   |.   |||||| . .|||
QQIACILYDTLQGLQYLHDNK-KIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMA
Kinase MEK.AA MEK3 327-377 42 5.5e-16 50.86 In-house 213-264 (264) Show / Hide 
Range on Protein: 327-377
Range on HMM: 213-264/264
Sequence Identity: 42% (22 aa)

FELLNYIVEEHPPRLPSRA-FSEEFVDFVDVCLIKNPNERADLKKLKVHTFA
|. |  .||| ||.||    ||....||. .|| ||..||   ..|  | | 
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MEK.AA MEK5 328-377 48 9.8e-15 50.33 In-house 205-254 (254) Show / Hide 
Range on Protein: 328-377
Range on HMM: 205-254/254
Sequence Identity: 48% (24 aa)

ELLNYIVEEHPPRLPSRAFSEEFVDFVDVCLIKNPNERADLKKLKVHTFA
.||  ||.|||||||.  ||| ||.|.  |. | | .|   . |  | | 
QLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MEK.AA TyrKc 87-376 17 1.4e-12 -19.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-376
Range on HMM: 1-280/280
Sequence Identity: 17% (58 aa)

FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKLEIKPAIRNQIIRELKVLHEC--NSPYIVGFFGAYYSD-------GEICICMENMDGGSLDQVMKSA
 . .|.|| |. |.| | . |   .  | | .| .     |  ..||......   . | || ..|.  ..       . ..| || |..|.|..  .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PKGRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM------ANSFV-----GTRS-----YMSPERLQGTHY
 .  ..   | .  . . .|  || .   . |||    |.||.... .| .||| |   |..           .     |...      |.|| ..   .
RPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TVQSDIWSLGLSLVEMA--IGRYPIP-----APDETALANL-FGYELQAGET----KNIRKTRVGGVFSDSPRPMAIFELLNYIVEEHPPRLPSRAFSEE
| .||.|| |  . |.    .  .        ... .....  || .   .                                          .   ..|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------FVCCPDE

FVDFVDVCLIKNPNERADLKKLKVHTF
  .    |   .|..|   . . .. |
MYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MEK.AA MEK4 324-377 25 9.7e-12 34.42 In-house 216-275 (275) Show / Hide 
Range on Protein: 324-377
Range on HMM: 216-275/275
Sequence Identity: 25% (15 aa)

M--AIFELLNYIVEEHPPRLPSRAF----SEEFVDFVDVCLIKNPNERADLKKLKVHTFA
.   .|. .  .|.  ||.| .  .    |.....|.  ||.|. |.|.  ..|| . | 
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MEK.AA MEK7 327-377 35 1.2e-11 35.75 In-house 214-269 (269) Show / Hide 
Range on Protein: 327-377
Range on HMM: 214-269/269
Sequence Identity: 35% (20 aa)

FELLNYIVEE--HPPRLPSRA---FSEEFVDFVDVCLIKNPNERADLKKLKVHTFA
|| .  | ..   ||.||      || .| .||| || |.. .| . ..|  | | 
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MEK.AA STE20 332-377 37 1e-09 31.96 In-house 238-288 (288) Show / Hide 
Range on Protein: 332-377
Range on HMM: 238-288/288
Sequence Identity: 37% (19 aa)

YIV--EEHPPRLP---SRAFSEEFVDFVDVCLIKNPNERADLKKLKVHTFA
.|    . ||.|    .. .| || ||||.|| |.|..|.  ..|  | | 
MIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEK.AA MST 346-377 46 1.5e-08 23.19 In-house 223-254 (254) Show / Hide 
Range on Protein: 346-377
Range on HMM: 223-254/254
Sequence Identity: 46% (15 aa)

FSEEFVDFVDVCLIKNPNERADLKKLKVHTFA
.| || |||  ||.|||..|.  . |  |.| 
WSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase MEK.AA Pkinase_Tyr 126-271 25 4e-06 21.47 Pfam 46-201 (270) Show / Hide 
Range on Protein: 126-271
Range on HMM: 46-201/270
Sequence Identity: 25% (41 aa)

IRNQIIRELKVLHEC-NSPYIVGFFGAYY-SDGE--ICICMENMDGGSLDQVMKSA--PKGRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILV
.|   .||.|....  . | || . |. .  ..   |.| || | .|.|.   ..   .|....   | .  . . .|. || . . . |||.   |.||
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLV

NSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQGTHYTVQSDIWSLG
.. . .| |||| .  .  .  .  . .|.        |.|| ..   .|..||.|| |
TENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG