Gene MEKK15 (Sea Urchin)

MEKK15

Species: Sea Urchin
Alias: SpMAP3K8, MEKK15, SPU_002246, Spk224
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK15

Sequence

Name Sequence Type Origin Length Description Download
MEKK15.AA Protein None 338 None Fasta, JSON
MEKK15.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of MEKK15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MEKK15.AA MEKK15 26-286 81 8.60000000001e-214 716.54 In-house 1-264 (264) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-264/264
Sequence Identity: 81% (215 aa)

WKKGNLLGKGAFGTVYCGLTNTGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDNVVNIFMQFIPGGSIASLLARFGSLDE
|||||.|||||.|||||||||||||.|||||||.|||||||||||.||||||.|||||.|||||..|||.||||||||||||.|||||.|...|||.|||
WKKGNILGKGAYGTVYCGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLDE

TVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQ-ISRSQ-NVLKSMRGTPYWMAPEVIMETGHGKKSDIWSIGCTVFEM
.|||.||||||.|.||||||.|.||||||.|.|||.||.|||||||||||||.| |.|.. ..||||||||||||||||||||.|.||||||||||||||
MVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVFEM

ATRKPPWADMPPMAAIFAIGSG-DPVPQLPVKFSEDARMFVNACLTRDQDERATASELLKHPFI
||||||||||..|||.|.||.. ||.|||||||||||||||..||||||.||.|||.|||||||
ATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK15.AA STE11 26-286 47 1.8e-166 559.36 In-house 1-303 (303) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-303/303
Sequence Identity: 47% (145 aa)

WKKGNLLGKGAFGTVY-CGLTNTGQLLAVKQVELSEIDK--EKAKQQYLK------LQEEVQLLKTLRHKNIVGFLGVSL---EDNVVNIFMQFIPGGSI
|.||...||||||||| |  ..||.|.||||.|.  ...  |.....| .      .|||..|.|.|.||||| ..|..|   ... |||||...||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

ASLLA-RFGS--LDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGV-IKLIDFGCAKRLCIQISRSQN------VLKSMRGTPY--------
.|.|  ..|   .||.|...||||||||.||||....||||||||||.|.|.|. .||.||||||||. ......|       .|||.||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVIMETG---HGKKSDIWSIGCTVFEMATRKPPWADMP--PMAAIFAIGSG-DPVPQLPVKFS------EDARMFVNACLTRDQDERATASELLKH
|||||||...|   .|.|.||||.||||.|||| ||||...   .|||.| ||.| .| |..| ..|      |..|.|.. |...|. .|.||..||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFI
|||
PFI
Kinase MEKK15.AA STE11-Unclassified 26-286 43 7.6e-128 431.03 In-house 1-308 (308) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-308/308
Sequence Identity: 43% (133 aa)

WKKGNLLGKGAFGTVYCGL-TNTGQLLAVKQVELSEID--KEKAKQQ-YLKLQEEVQLLKTLRHKNIVGFLGVS--LEDNVVNIFMQFIPGGSIASLLAR
|.||...|||.||.|| .. .|||...||||.|   ..   |....  .  .|.|...||.|.|||||  .|..   . . .||||  .|||||.|.| .
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGSLDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAK---------------------RLCIQISRSQNVLKSMRGTPY---
.| .||.|   |||||||| .|||....|||||||||| . . |..|| ||||||                      .| .|   || .|||.||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMAPEVIM---ETGHGKKSDIWSIGCTVFEMATRKPPWADMPP---MAAIFAIGSGDPVPQLPVKFS-----------EDARMFVNACLTRDQDERATAS
|||||||    .|||. ||||||.|||| |||| |.||..  .   |.||. |.. .  ||.| . |           .... | ..|...|  .|.||.
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLKHPFI
.||.||||
QLLQHPFI
Kinase MEKK15.AA STE 26-286 30 1.5e-118 400.11 In-house 1-359 (359) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

WKKGNLLGKGAFGTVYCGLTN----------------TGQLLAVKQVELSEIDKEKAK------------QQYLKLQEEVQLLKTLR--HKNIVGFLGVS
|..   .|||||||||... .                ||.. |.||..|.. .... .            ..  ....|....| ..  |.||| ..|  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LED-------NVVNIFMQFIPGGSIASLLA-RFGSLD-------------ETVFCRYTKQILEG-TQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCA
. .       . ..|.| ...|||. ...  ..| ..             |.. .....|||.|  .|||....||||||.|||.|     .||.|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KRLCIQIS------------RSQNVLKSMRGTPYWMAPEVIME------TGHGKKSDIWSIGCTVFEMATRKPPWADMPPMAAIFAIGSG----------
..|   ..             .|   ... ||| |||||||.        |.. |.||||.|||. |||| ||||.||.|| |.|.|  .          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----DPVPQLPV-------------------KFSEDARMFVNACLTRDQDERATASELLK--HPFI
    .| |.||                    |.|.. . |.| ||..| ..|.|||.|||  ||||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK15.AA MEKK2 26-286 48 3.1e-99 335.98 In-house 1-262 (262) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-262/262
Sequence Identity: 48% (128 aa)

WKKGNLLGKGAFGTVY-CGLTNTGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDN--VVNIFMQFIPGGSIASLLARFGS
|..| |||.|||| || |    ||  ||||||.  . |   ...    |. |.|||| |.|. || . |   . .  .. ||| ..||||.   |  .|.
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQF-DPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGA

LDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRSQNVLKSMRGTPYWMAPEVIMETGHGKKSDIWSIGCTVFE
| |||  .||.|||||..|||.. ..|||||||||.  |.| .|| ||| .|||   |  .   .||. ||||||.||||   | |.| |.||||||| |
LTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQT-ICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVE

MATRKPPWADMPPMAAIFAIGSGDPVPQLPVKFSEDARMFVNACLTRDQDERATASELLKHPFI
| | |||||.   ||||| |   .  |||| . |..|| |.  |  . . .|  | |||.| |.
MLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKK15.AA S_TKc 26-286 29 1.1e-91 311.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

WKKGNLLGKGAFGTVYCGLTNT-GQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDNVVNIFMQFIPG--GSIASLLARFGS
.......||||||.||..  .  |.. |.|..               ... |.|.||  .|.||| ...|  . . . ..| ...|  |.  ... . |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------LDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRSQNVLKSMRGTPYWMAPEVIMETGHGK-KSDIWS
      ..| . ..|..||... .|.|....||||.| .||.| .  .||..||| |..|           ... |||..|||||.   |.|| |.|.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWS

IGCTVFEMATRKPPWADMPPMAAIFAIGSGDPVPQLPVKFSEDARMFVNACLTRDQDERATASELLK-------HPFI
.||...||....||.     |...| .             |..|. |.. ||..| ..| || |.|.       ||..
CGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK15.AA STE20 26-286 35 6.8e-84 285.02 In-house 1-288 (288) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-288/288
Sequence Identity: 35% (103 aa)

WKKGNLLGKGAFGTVYCGLT-NTGQL----LAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLED----NVVNIFMQFIPGGSIASL
...   .|.|..|.|| .    ||..     |.|...|.. | |.  ..   .| |.. .| ..|.||| ..|  | |    .   | | .  |||.  .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ--DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDI

LARFG---------SLDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISR----SQN-VLKSMRGTPYWMAPEVI
. ..          ...|      ....|.| .|||.|..||||||..||.| . | .||.|||    .| |...    ...   ... |||||||||||
MKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFG----VCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVI

ME-----TGHGKKSDIWSIGCTVFEMATRKPPWADMPPMAAIFAIG-SGDPVPQLPV----KFSEDARMFVNACLTRDQDERATASELLKHPFI
..      |.. |.|||| | |  |||...|| .||.|| |.| |  .. | | |      |.| . . ||. ||..| ..|.|||.|||||||
QCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEKK15.AA Pkinase 26-286 28 3.7e-81 280.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

WKKGNLLGKGAFGTVY-CGLTNTGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDNVVNIFMQFIPGG----SIASLLA--
...|  .|.|.||.|| |   .||.. |||..........| ..  .    |.|..| |.|.||| ....  ... . . | . .||    . ....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RFGSL--DETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVI----KLIDFGCAKRLCIQISRSQNVLKSMRGTPYWMAPEVIM-ETGHGKKS
| |..  .| . ..| .|||.| .|.|....||||.| .||.. ..|.|    |..|||.|| .      ..  ...  |||..||||||.  ...|.|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSIGCTVFEMATRKPPWADM------PPMAAIFAIGSGDPVPQLPVKFS-------------------EDARMFVNACLTRDQDERATASELLKHPFI
|.||.||...||....||. .        .|. |. |.....  . | . |                   |... |.. ||..|  .| || ..|.||..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MEKK15.AA Dicty2 26-286 39 2.9e-78 266.31 In-house 1-264 (264) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-264/264
Sequence Identity: 39% (108 aa)

WKKG-NLLGKGAFGTVYCGL-TNTGQLLAVKQVE----LSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDNVVNIFMQFIPGGSIASLLAR
 . |   .||||||||| || . ||.  | ||..    .. |..|    |   .  |. |||.|.| ||| ....    |  .|.. .| .|| .  . .
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEE----QHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKK

FGSLDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGV---IKLIDFGCAKRLCIQISRSQNVLKSMRGTPYWMAPEVIMETG--HGKKSDIW
|| . |.  |.| .|.|.|  |||.. |||||||.|||     |.   ||| ||| |  .    | ..  . .  |||||||||||   |  .  ..|||
FGCFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHID--YSDDDSRY-TVVGTPYWMAPEVIQMSGNHCCTACDIW

SIGCTVFEMATRKPPWADMPPMAAIFAIGSGDPVPQLPVKFSEDARMFVNACLTRDQDERATASELLKHPFI
| |||. |. |  ||  |  ||.| |.. . |. | ||   | .   |  .|  .|  .|.||..||.|| |
SLGCTIIELLTGNPPYWDLNPMHAMFRMVQ-DDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MEKK15.AA ASK 31-286 41 9.3e-75 248.04 In-house 1-254 (254) Show / Hide 
Range on Protein: 31-286
Range on HMM: 1-254/254
Sequence Identity: 41% (109 aa)

LLGKGAFGTVYCGLTNTGQL-LAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDNVVNIFMQFIPGGSIASLL-ARFGSLD--ET
 ||||..|.|| |     |  .|.| ..      |. ...   |.||..| |.|||.||| .||   |.. . |||  .||||...|| ...| .   | 
VLGKGTYGIVYAGRDMHTQVRIAIKEIP------ERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNEN

VFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMS-TGVIKLIDFGCAKRLCIQISRSQNVLKSMRGTPYWMAPEVIMET--GHGKKSDIWSIGCTVFEM
    |||||||| .|||||...|||||| |...    ||.|. ||| .|||     . . . .. .||  .|||||| .   |.||  ||||.|||. ||
TMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLA----GINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEM

ATRKPPWADM-PPMAAIFAIGSGDPVPQLPVKFSEDARMFVNACLTRDQDERATASELLKHPFI
|| |||. ..  | ||.| .|     |..| ..|.... |.  |   | ..||.|..||. ||.
ATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK15.AA YSK 26-286 38 9.5e-75 224.39 In-house 1-257 (257) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-257/257
Sequence Identity: 38% (103 aa)

WKKGNLLGKGAFGTVYCGLTN-TGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTLRHKNIVGFLGVSLEDNVVNIFMQFIPGGSIASLLAR--FGS
..|    |.| || || |  | |..  |.| ..|     |.|      .| |.| |  .   .|  ..|  |.|    | | .  |||...|. .   |.
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDL-----EHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQ

LDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRSQNVLKSMRGTPYWMAPEVIME--TGHGKKSDIWSIGCTV
.||.      . || |  |||....|||||| ||. |   | .|| ||| |     ||  .|  .  . |||||||||||..  ..   | ||||.| | 
FDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVA----GQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITA

FEMATRKPPWADMPPMAAIFAIGSGDPVPQLPV-KFSEDARMFVNACLTRDQDERATASELLKHPFI
 |||.  || .|. || . | | .  | |.|   ..|  .  ||..||  |  .| .|.||||| ||
YEMAKGEPPYCDYHPMRVMFLIPKNNP-PKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase MEKK15.AA ULK 26-286 26 4e-63 216.01 In-house 1-324 (324) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-324/324
Sequence Identity: 26% (88 aa)

WKKGNLLGKGAFG-TVYCGL---TNT-GQLLAVKQVELSEIDKEKAKQQ----YLKLQEEVQLLKTLR---HKN--IVGFLGVSLED--NVVNIFMQFIP
. . . ||||.|| .|| |    ||| .|. |.|....... | | .|.      .|. |.|..|.|    |.|  || .. .. ..  | . |.| . .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGSIASLLARFGS---------LDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMST------------GVIKLIDFGCAKRLCIQI-SRSQNVL
||   ... . .          | |     . |||..| ..||..|.|||||| .||..               ||.|. ||| || .  .  . .|...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHV--DNNNMEQQMC

KSMR------GTPYWMAPEVIMETG----HG-KKSDIWSIGCTVFEMATRKPPWADMPPMAAI----FAIGSG--------DPVPQLP-----VKFSEDA
...       |||. |||..... |    .. .|.||||.||  .|| . |.|.  . ..  .      |  |        .   | |     .|.|.. 
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

RMFVNACLTRDQDERATASELLKHPFI
. .   .|..|...| .  |...||..
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase MEKK15.AA Pkinase_Tyr 26-250 27 5.3e-25 85.29 Pfam 1-237 (270) Show / Hide 
Range on Protein: 26-250
Range on HMM: 1-237/270
Sequence Identity: 27% (68 aa)

WKKGNLLGKGAFGTVYCGLTN-----TGQLLAVKQVELSEIDKEKAKQQY---LKLQEEVQLLKTL-RHKNIVGFLGVSL-EDNV--VNIFMQFIPGGSI
 ..|  ||.||||.|| |  .     |..  ||| .       |.| ..     .. .|....|.| .|.||| ..|| . ..    . | | . |.|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

ASLLAR----FGSLDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRSQN-VLKSMRGTPY-WMAPEVIMETGH
 . | .     ..|.    . .  || .| .||...| ||||.   |... ...|.|  ||| |. .    . ..  . ..    |  |||||.|..   
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKF

GKKSDIWSIGCTVFEMAT-RKPP-WADMPPMAAIFAI-GSGDPVPQ
  |||.|| | . .|. |  . | ...|..   . .|  .|   |.
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase MEKK15.AA TyrKc 26-286 25 8.1e-20 73.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-286
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

WKKGNLLGKGAFGTVYCGLTNTGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLKTL--RHKNIVGFLGVSLED-------NVVNIFMQFIPGGSIASL
 ..|  || ||||.|| |  .  .  ||| .  .             . .| .... |  .|.||| ..|| ...         . | | . |.|.  . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LARFGS-LDETVFCRYTKQILEGTQYLHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRS-------QNVLK----SMR--GTPYWMAPEVI
| . .  |    .. .  || .| .|||..|.||||.   |... . ...|  |||    |.  |          .   |    . .      |||||.|
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

METGHGKKSDIWSIGCTVFEMATR-KPPWAD-----MPPMAAIFAIGSGDPVPQLPV--------KFSEDARMFVNACLTRDQDERATASELLKHPFI
..     |||.|| | . .|. |. ..|. .     |..  .|  . .|.  || |           .|  .     |  .| ..| | ||.  | ..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF