Gene MEKK2 (Sea Urchin)

MEKK2

Species: Sea Urchin
Alias: MEKK2, Spk227, SPU_010629
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: MEKK2

Sequence

Name Sequence Type Origin Length Description Download
MEKK2.AA Protein None 681 None Fasta, JSON
MEKK2.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of MEKK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 MEKK2.AA PB1 71-154 18 6e-06 24.03 Pfam 1-86 (86) Show / Hide 
Range on Protein: 71-154
Range on HMM: 1-86/86
Sequence Identity: 18% (16 aa)

EIRVKFEFNGEKRI--LQIPRPLKYDDILLKARTTFGQPVDMFLTNHNTTFS-LLIPIRDQTDLNHAVEITDNNPNAKSLRLHLELA
 .|.|... |..|.  ....|.....| . | .  .... . |.     .    ...| .. || ...|. .. .  ..||||.  .
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCD-HTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSMTLRLHVFPS
PB1 MEKK2.AA PB1 71-154 21 5.4e-05 23.85 SMART 1-95 (95) Show / Hide 
Range on Protein: 71-154
Range on HMM: 1-95/95
Sequence Identity: 21% (21 aa)

EIRVKFEF-NGEKRILQIPRPLKYDDILLKARTTFGQPV--DMFLTNH--NTTFSLLIPIRDQTDLNHAVEITD---NNP----NAKSLRLHLELA
 ..||. . .|. |....||....|| . | .  .|..   .. |     .     ...|  . || ...|. |   . .    . |.||||.  .
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLES-QNKSSCWKTLRLHVFPF
Kinase MEKK2.AA MEKK2 417-675 77 1.9e-210 705.42 In-house 1-262 (262) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-262/262
Sequence Identity: 77% (203 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSNTDARKEVQSLKQEIELLRNLQHPRIVQYFGCLEENG--TLSIFMEFMSGGSVKDELRLYGPL
|.|||||||||||.||||||.|||||||||||.....|...|||||.|..||.||.||||.|||||.|||..|.  |||||||.|.||||||.|..||.|
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

TDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLR-SSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIINGEGYGRRADVWSIGCTVVEML
|.|||||||||||||..|||||.||||||||||.|| |||||||.|||||.|||||..||||||.|||||||||||.||||||||.||||||||||||||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVEML

TTKPPWADYEAMAAIFKIATKETEPVLPQSVSQDARNFLTLCFKKILADRPSAAELLRHNFV
|.|||||.||||||||||||..|.|.|||.|||.||.||..||..|..|||||.|||||.||
TEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKK2.AA STE11 417-675 45 3e-164 551.94 In-house 1-303 (303) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-303/303
Sequence Identity: 45% (137 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSNT---DARKEVQS------LKQEIELLRNLQHPRIVQYFG-CLE--ENGTLSIFMEFMSGGSV
||.|...|.||||.|| |.. |||...||||....|.|.   |..||.||      ...||.|...|.|..||.|.| ||.  .|....||||...|||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

KDELR-LYGP--LTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLRSS-GN-VKLADFGASTRLQTIHSHITG-------MKTVTGTPY--------
.. ||  .||  .. .|.||||.|||||..|||.|.|.||||||||.|. | || .||||||...||..|... ..       .|..|||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMSPEIINGEG---YGRRADVWSIGCTVVEMLTTKPPWADYEA--MAAIFKIATK-ETEPVLPQSVS------QDARNFLTLCFKKILADRPSAAELLRH
||.||.|..||   |||.||.||.||||.||.|.||||..|..  |||.|||...  . | .|...|      ...|.|| .||..   .||.|..||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

NFV
.|.
PFI
Kinase MEKK2.AA STE 417-675 30 1.5e-114 386.82 In-house 1-359 (359) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-359/359
Sequence Identity: 30% (111 aa)

WQRGKLLGQGAFGVVYVCYDAD---------------TGRELAVKQVPTENSNTDARK-------------EVQSLKQEIELLRNLQ--HPRIVQYFGCL
|.. . .|.||||.|| ... .               ||.  |.||.. ||.|.   .             |.|....||.......  || ||.|.|| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EENG-------TLSIFMEFMSGGSVKDELR-LYGPLT-------------DTVTRKYTRQILEG-TAYLHDHHIVHRDIKGANVLRSSGNVKLADFGAST
. .|       .| |.||.|.|||. | ..  ||..               .. ....||||.|  .|||.|||.|||||.||.|     |||.||| ..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

RLQTIHSHI----------TGM-K--TVTGTPYWMSPEIING------EGYGRRADVWSIGCTVVEMLTTKPPWADYEAMAAIFKIATK-----------
.|. ....|          |.  |  |..||| ||.||.|..       ||....|.||.|||..||.| ||||.|.  | |.| |...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---ETEPVLPQ-------------------SVSQDARNFLTLCFKKILADRPSAAELLR--HNFV
   .. | ||.                   ..|.. ..|. .|..|   .||.| .||.  | |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKK2.AA STE11-Unclassified 417-675 39 3e-110 372.57 In-house 1-308 (308) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-308/308
Sequence Identity: 39% (121 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSN---TDARKE-VQSLKQEIELLRNLQHPRIVQYFGCL--EENGTLSIFMEFMSGGSVKDELRL
|| |...|.|.|| || | ...||  .||||. ....|    |. || .||...|...|..| |. |||| ||   .... ..|||| |.|||.   |. 
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

YGPLTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLR-SSGNVKLADFGASTRLQ------------------TIHSHI----TGMKTVTGTPY---
||..  .|..|||.||||| |||| |.|.||||||||.|  . |..||.|||..                      .|..||       |.  ||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMSPEIIN---GEGYGRRADVWSIGCTVVEMLTTKPPWADYEA---MAAIFKIATKETEPVLPQSVS-----------QDARNFLTLCFKKILADRPSAA
||.||.|.    .|..|..|.||.||||.|| | |.||.....   |.||.||.   . | .|.  |           |....|| .||.    .||.| 
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLRHNFV
.|| | | 
QLLQHPFI
Kinase MEKK2.AA MEKK15 417-675 46 3.2e-101 342.59 In-house 1-264 (264) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-264/264
Sequence Identity: 46% (124 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSN-TDARKEVQSLKQEIELLRNLQHPRIVQYFG-CLEENGTLSIFMEFMSGGSVKDELRLYGPL
|..|..||.||.| || |   .||  .|||||  ....   |... . |. |..||. |.|  || | | |||.| ...|||.|. |||.   .  .|||
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDN-VVNIFMQFVPGGSISSIINRFGPL

TDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANV-LRSSGNVKLADFGASTRLQTI---HSHITGMKTVTGTPYWMSPEIINGEGYGRRADVWSIGCTVV
 ..|  |||.|||.|..|||.  .|||||||.|| | . | .|| |||   ||       .|   .| . |||||| ||.|.  ||||..|.||||||| 
DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVF

EMLTTKPPWADYEAMAAIFKIATK-ETEPVLPQSVSQDARNFLTLCFKKILADRPSAAELLRHNFV
|| | |||||| . |||.| | .. .  | ||.  | |||.|  .|  .   .||.| .||.| |.
EMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKK2.AA S_TKc 417-675 29 1.6e-95 324.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSNTDARKEVQSLKQEIELLRNLQHPRIVQYFGCLEENGTLSIFMEFMSG--GSVKDELRLYGP-
.. ....|.||||.|| |.. .|||. |.|...            .....||..|.. .|| ||..... .. . | ..||...|  |...| .. .|. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLRSSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIINGEGYGR-RADVWSIGC
     ..  ..|.|..||... .|.|.|.|.|||.| .|.| .. ..|..||| ...|          .|. |||..|.||..   |||. ..|.||.||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

TVVEMLTTKPPWADYEAMAAIFKIATKETEPVLPQSVSQDARNFLTLCFKKILADRPSAAELLR-------HNFV
.. |||. .||.     |...||.             |..|..|.  |..|  ..||.| |.|.       | ..
ILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKK2.AA Pkinase 417-675 27 7e-86 296.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSNTDARKEVQSLKQEIELLRNLQHPRIVQYFGCLEENGTLSIFMEFMSGG----SVKDELR--L
...|. .|.|.||.|| |.. .||.. |||... .. . . ...   | .||.....|.|| ||..... |... . . ||.. ||    . .| ..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

YGPL--TDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLRS-SGNV----KLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIIN-GEGYGRRADV
.|..  .. . ..| .|||.| .|.|.. |.|||.| .|.| .  |..    |..||| .  ..  . . . |.|..|||..|.||.|. |..||...|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSIGCTVVEMLTTKPPWADY------EAMAAIFKIATKETEPVLPQSVS-------------------QDARNFLTLCFKKILADRPSAAELLRHNFV
||.||.. |||. .||. .       . |. |..|  ....   |.. |                   .... |.. |..|  ..||.|...| | ..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MEKK2.AA ASK 422-675 43 4e-81 269.56 In-house 1-254 (254) Show / Hide 
Range on Protein: 422-675
Range on HMM: 1-254/254
Sequence Identity: 43% (114 aa)

LLGQGAFGVVYVCYDADTGRELAVKQVPTENSNTDARKEVQSLKQEIELLRNLQHPRIVQYFGCLEENGTLSIFMEFMSGGSVKDELR-LYGPLT--DTV
 ||.|..|.||   | .| . .|.| .|  .|.     .|| |. ||.| ..|.|  |||| ||  ||| . |||| . |||. . ||  .||.   .  
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR-----YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENT

TRKYTRQILEGTAYLHDHHIVHRDIKGANVL--RSSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIIN--GEGYGRRADVWSIGCTVVEMLT
 . ||.|||||  |||...|||||||| |||    || ||..||| . ||  |       .| |||  .| ||.|     |||. ||.||.|||.||| |
MNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPC---TETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMAT

TKPPWADY-EAMAAIFKIATKETEPVLPQSVSQDARNFLTLCFKKILADRPSAAELLRHNFV
 |||. .  |. ||.||.    . | .|...|....||.  ||.    .|.||..||. .|.
GKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKK2.AA STE20 417-675 31 1.1e-79 271.03 In-house 1-288 (288) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-288/288
Sequence Identity: 31% (93 aa)

WQRGKLLGQGAFGVVYVCYDADTGRE----LAVKQVPTENSNTDARKEVQSLKQEIELLRNLQHPRIVQYFGCLEEN----GTLSIFMEFMSGGSVKDEL
..  . .|||..|.||..|. .||..     |.|... |. .    .|......||  .....|| ||.|.|.   .      | | ||...|||. | .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

R---LYG------PLTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVL-RSSGNVKLADFGASTRLQT--IHSHITG--MKTVTGTPYWMSPEIING-
.     |      |..       .|..|.| .||| .||.|||||..|.|  ..|.||||||| .  |..        .   .|. ||||||.||.|.. 
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPEVIQCM

----EGYGRRADVWSIGCTVVEMLTTKPPWADYEAMAAIFKIA--TKETEPVL---PQSVSQDARNFLTLCFKKILADRPSAAELLRHNFV
     ||. ..|.|| | |  ||.. .|| .|. .| |.|.|.  .... .     | . |.. ..|. .|  |  ..||.| .||.| |.
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEKK2.AA Dicty2 417-675 36 6.2e-70 238.65 In-house 1-264 (264) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-264/264
Sequence Identity: 36% (97 aa)

WQRG-KLLGQGAFGVVYVCYDADTGRELAVKQVP-TENSNTDARKEVQSLKQEIELLRNLQHPRIVQYFGCLEENGTLSIFMEFMSGGSVKDELRLYGPL
 | |   .|.||||.||   .. ||   | ||.     ..    .  ||..|||.||..|.|. || | .  |    | |..|.. .||  . .  .|..
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFGCF

TDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLRSSGNV----KLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIINGEG--YGRRADVWSIGCT
  .    | .|.|.| .|||   ..|||||.|| | .  ..    ||||||  | .    | ..   || |||||| ||.|   |       |.|| |||
PESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHID--YSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCT

VVEMLTTKPPWADYEAMAAIFKIATKETEPVLPQSVSQDARNFLTLCFKKILADRPSAAELLRHNFV
. |.||  ||  |   |.| |..   .  | ||  .| .  .||  ||.|    |..| .|| |  .
IIELLTGNPPYWDLNPMHAMFRMV-QDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MEKK2.AA MEKK4 417-675 35 3.2e-68 232.96 In-house 1-271 (271) Show / Hide 
Range on Protein: 417-675
Range on HMM: 1-271/271
Sequence Identity: 35% (99 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSNTDARKEVQSLKQ---EIELLRNLQHPRIVQYFGCLEENGTLSIFMEFMSGGSVKDELRLYGP
||||   |.| || || | . ||.. .|.| .         | . . .|    ||  .. . ||  | |.|   .   . ||||. | |  .   .| | 
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQ------RNDHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLGGN

LTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANV-LRSSGNVKLADFGASTRLQTIHS-HITG-MKTVTGTPYWMSPEIIN---GE-------GYGRRA
.   ..|.|| |.| .  ||| | |||||||.||. | ... .|| ||| | .||  ||  . | . .  ||. .| ||...   ..       |.|| |
MQEHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQN-HSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAA

DVWSIGCTVVEMLTTKPPWA---DYEAMAAIFKIATKETEPVLPQSVSQDARNFLTLCFKKILADRPSAAELLRHNFV
|.||.||.|||| | | ||.   .|.   .|     . . |  | . |.. . |.  |..    ||. |.||| |.|.
DIWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase MEKK2.AA CAMK 422-675 19 1.3e-67 216.67 In-house 1-425 (425) Show / Hide 
Range on Protein: 422-675
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

LLGQGAFGVVYVCYDADTG------------RELAVKQVP-----------------TENSNTD------ARKEVQSLKQEIELLRNLQ-------HPRI
 ||.|.||.|. |..  |.            .. |.| ..                  ..|...        |  .....|||....||       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYFGCLE------------ENGT--------LSIFM---EFMSGG----SVKDELRLYGP---------------LTDTVTRKYTRQILEGTAYLHDHH
.. .   |               .        . ..|   |..|||     . | ..  |.               .|   .|.| |||... .|.|.|.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDIKGANVLRSS------------------GNVKLADFGASTRLQTIHSHITG--------------------MKTVTGTPYWMS-PEIING-----
|||||.|  |.| ..                  .|.|..||| .....  ..  .                     |||. |||. |. ||..||     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EGYGRRADVWSIGCTVVEMLTTKPPWAD----------------YEAMAAIFKIATK-ETEPVLPQS------------------VSQDAR
         ..||. .|.||.|.    ||. .||. .                || .  | |     . ... | |                  |||...
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NFLTLCFKKILADRPSAAELLRHNFV
...  . ..   .|..... |.| ..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MEKK2.AA Pkinase_Tyr 417-561 31 1.3e-22 77.25 Pfam 1-156 (270) Show / Hide 
Range on Protein: 417-561
Range on HMM: 1-156/270
Sequence Identity: 31% (50 aa)

WQRGKLLGQGAFGVVYVCYDA----DTGRELAVKQVPTENSNTDARKE---VQSLKQEIELLRNL-QHPRIVQYFGCLE-ENGT--LSIFMEFMSGGSVK
 . || ||.||||.|| ..      .|. . ||| .  |    .| .|    ... .|......| .|| ||.. |.   . .   . | ||.| .|. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

DELRLY----GPLTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLRS-SGNVKLADFG
| ||      .|||     .. .|| .| .||......|||.   |.| . .. || .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MEKK2.AA TyrKc 417-674 24 1.2e-18 69.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 417-674
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

WQRGKLLGQGAFGVVYVCYDADTGRELAVKQVPTENSNTDARKEVQSLKQEIELLRNL--QHPRIVQYFGCLEEN-------GTLSIFMEFMSGGSVKDE
 . || || ||||.|| .      .. ||| .  .         .. . .|......|  .|| ||. .|.  .        . | | ||.|..|. || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRLYGP-LTDTVTRKYTRQILEGTAYLHDHHIVHRDIKGANVLRSSGN-VKLADFGASTRLQTI------HSHITGMK--TVT--GTPYWMSPEIINGEG
|| ..| |.     ..  || .| .|||.....|||.   |.| .... || .||| |  .         .. .. ..           ||.|| ||   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YGRRADVWSIGCTVVEMLTT-KPPWAD-----YEAMAAIFKIATKETEPVLPQS--------VSQDARNFLTLCFKKILADRPSAAELLRHNF
.    |||| | .  |..|  ..|. .      ..  .| .. . .  |  |..         ...  .  . | .   .|||. .|. .. |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMP-QPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase MEKK2.AA Pkinase_Tyr 585-614 43 0.137705 6.0 Pfam 180-209 (270) Show / Hide 
Range on Protein: 585-614
Range on HMM: 180-209/270
Sequence Identity: 43% (13 aa)

WMSPEIINGEGYGRRADVWSIGCTVVEMLT
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WMAPECINYGKFTTKSDVWSFGVLMWEIFT