Gene Npr2 (Sea Urchin)

Npr2

Species: Sea Urchin
Alias: Npr2, SPU_005954, Spk215
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
Npr2.AA Protein None 1128 None Fasta, JSON
Npr2.kin_dom Protein Kinase Domain None 241 None Fasta, JSON

Protein domain

Protein domains of Npr2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor Npr2.AA ANF_receptor 49-400 22 2e-44 157.92 Pfam 1-364 (364) Show / Hide 
Range on Protein: 49-400
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

YNDPAIDIAVEEIRRRVT-EGEYVNISLTLEDVTIRCFGGERQAGAIFAETYFKRPLAAIMGPPCSNQMHSVAELAAAWDIPVLSGLSSSRDLEN--EAI
   ||...|.|.| .. .  .   .|.|...|  . .     ||.|  .. .  .. .|| || || ... || .|..|.||..|  ...  | .     
QCAPAMRMAIEDINADPGILL--PGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNR

YSTLTRTTQIIASGYAYAIVEVLRH-FGWGVASVIWDGGIN-YW------SLIEEAATRELDRIEFDYH-DFSMRAISD----NFLALLNA--SKVGRII
| ...||.   .. |..|.|. ..| |||   .|| | .   ||        . . . ||  ... .|.  .||   .|    ..|  ..   .. .|.|
YPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYYYWRGGCYFMEAFQDELREH-GGNCVYYAYVSMVIPWDDDFMDYLKKIKDIIKMKARVI

FMAVDGDTL----REIMLHAYDLDLINGDYAFINIIPFRDEQLFGDDSWERGDNRDEEAKVAYQALMTIRVFEPTSEAYREFEENVRERQKRDFNITDSG
.|   .|..    |.||. |..| . .|.|..| . .. . .. . . |...|  ..... |... .....  | |  ..|| .....           .
VMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-W-WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK-----------T

AGSNIFLASAFYDVMILYSLAINETIAEGGDVYDGH---------AVTKKMWN-RTFDGLYGKVKINENGDRDSEYSLWDMTDT
  .  . |  .||   ||  |....  .......|          .... ||| ..|.|. | |....||.|   |..|.|...
DTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKWHGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase Npr2.AA RGC 544-787 37 3.3e-128 432.25 In-house 1-300 (300) Show / Hide 
Range on Protein: 544-787
Range on HMM: 1-300/300
Sequence Identity: 37% (113 aa)

KGRLVVIRRIEKT----KLDLTREVLKELNYMRQVEHNNLVRFVGACVDAP------NISIISEYCPKGSLQDIVENDALKLDNMFKNSLITDVMRGLHY
.|..|.|......    ..|.||....||. |||..| ||..|.|.|.| |      |..|..|||..|||||| ||| .|.|.||| |.|.|...|..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSVIMLHSRLSSSNCVVDSRFVLKLTDYGL-----TKFRDT------------DSNERQTSKNEQKMLWQAPETLR----SANQQP-------TQKGD
||.| |  | .|.|.|||||||.|.|.||.||     ..|.              .. ... .....||||.||| ||    .. ..|       |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSVGIIMQEIVTRAR-----PFEE-----ERSSMEIDEIVKKLTETSS-PPFRPEIDPQ------LCTDEIRSIIQACWEEMPENRPA-TTDLLSSMKK
.||.||||.||.|| .     ||..     |.| ||| |.||.. .. . .||||.|...       | ... .....||.| ||.||     . . .|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Npr2.AA RGC 544-787 37 3.3e-128 432.25 In-house 1-300 (300) Show / Hide 
Range on Protein: 544-787
Range on HMM: 1-300/300
Sequence Identity: 37% (113 aa)

KGRLVVIRRIEKT----KLDLTREVLKELNYMRQVEHNNLVRFVGACVDAP------NISIISEYCPKGSLQDIVENDALKLDNMFKNSLITDVMRGLHY
.|..|.|......    ..|.||....||. |||..| ||..|.|.|.| |      |..|..|||..|||||| ||| .|.|.||| |.|.|...|..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSVIMLHSRLSSSNCVVDSRFVLKLTDYGL-----TKFRDT------------DSNERQTSKNEQKMLWQAPETLR----SANQQP-------TQKGD
||.| |  | .|.|.|||||||.|.|.||.||     ..|.              .. ... .....||||.||| ||    .. ..|       |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSVGIIMQEIVTRAR-----PFEE-----ERSSMEIDEIVKKLTETSS-PPFRPEIDPQ------LCTDEIRSIIQACWEEMPENRPA-TTDLLSSMKK
.||.||||.||.|| .     ||..     |.| ||| |.||.. .. . .||||.|...       | ... .....||.| ||.||     . . .|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase Npr2.AA TKL 541-785 19 9.2e-48 165.0 In-house 12-364 (364) Show / Hide 
Range on Protein: 541-785
Range on HMM: 12-364/364
Sequence Identity: 19% (71 aa)

ANYKG----------RLVVIRRIEKTKLDLT---------------------------REVLKELNYMRQVEHNNLVRFVGACVDAPN------------
....|          . |.. .. ..  |..                            .  .|.. |..  | |.|.|.|.| . |.            
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-ISIISEYCPKGSLQDIVENDALKLDNMFKNSLITDVMRGLHYLHSSVI-------MLHSRLSSSNCVVDSRFV--------------LKLTDYGLTKFR
 . |. ||||.||| ...           . ... |. ||..||||.         ..|  | |.|. ||. .               .|..|.|| .| 
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

DTDSNERQTSKNEQ-----------------KMLWQAPETLRSANQ--------------QPTQKGDIYSVGIIMQEIVTRARPFEEERSSMEI-----D
....|   |.....                    | ||| || ...              . ..| |.|| ||.. ||.|| ||.... ....|     .
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFE

EIVKKLTETSSPPFRPE--------IDPQLCTDEIRSIIQACWEEMPENRPATTDLLSSM
|. ..  . . .| .|.         ..  | .......| ||.. ||.||  ...|. .
EMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Npr2.AA TKL-Unique 522-785 27 1.5e-46 160.98 In-house 1-290 (290) Show / Hide 
Range on Protein: 522-785
Range on HMM: 1-290/290
Sequence Identity: 27% (83 aa)

FVTSIGHGTSHHRQMFATVANYKG--RLVVIRRIEK---TKLDLTREVLKELNYMRQVE-HNNLVRFVGACV----DAPNISIISEYCPKGSLQDIVE--
|. .|| |.      ...|  .|.    | | ....     .....|  .|.| |   . | |.|...|.|.    ..|| .|..|||| ||| |     
FWNKIGEGG------YGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQN

-------NDALKLDNMFKNSLITDVMRGLHYLHSSVI-MLHSRLSSSNCVVDSR-----FVLKLTDYGLTKFRDTDSNERQTSK----NEQKM---LWQA
       |. .||..  ..... |. .|..|||..   ..|  | |||  ||..     .  |. | || ||.......  . .    |. ..   .| |
NNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PETLRSANQQPTQKGDIYSVGIIMQEIVTRAR------PFEEERSSMEIDEIVKKLTETSSPPFRPEIDPQLCTDEIRSIIQACWEEMPENRPATTDLLS
|| ||. . | ..| |.|| ||.. ||.|| .      |...    |. ... ......    .||.| |. |  |.| .||.||   |..||  .. ..
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG----MDQEQWCEMVHYM-EENYRPPI-PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIH

SM
. 
RL
Kinase Npr2.AA TK 565-785 16 1.5e-34 112.7 In-house 86-486 (486) Show / Hide 
Range on Protein: 565-785
Range on HMM: 86-486/486
Sequence Identity: 16% (67 aa)

LKELNYMRQVE-----HNNLVRFVGACVDA------------PNISIISEYCPKGS----LQDIVENDALK-----------------------------
|.|.. | .       | |.||..|.|..             . . |. ||.|.|.    |.|   .   |                             
LEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDIT

----------------------------------------------LDNMFKNSLITDVMRGLHYLHSSVI-----MLHSRLSSSNCVVDSRFV------
                                              |.   .     .. .|. ||||  .     . |  |   || |... |      
YSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFD

-----LKLTDYGLT------KFRDTDSNERQTSKNEQKML--------------------------WQAPETLRSA-------NQQPTQKGDIYSVGIIM
      |..|.||.        || .|..  ..|.....                           | |||.|..        .   | | |..| |. |
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

QEIVTRA-RPFEEERSS---------MEIDEIVKK--------LTETSSPPFRPEIDP-QLCT--------------DEIRSIIQACWEEMPENRPATTD
 ||.|..  |. .. |.          |. | ...        | .  .   | .  . ..|.              .|.  ..| ||.. || ||  ..
WEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGL-N--EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQ

LLSSM
|.. .
LHEQL
Kinase Npr2.AA TKL-ciliate2 562-786 28 1.2e-27 88.93 In-house 41-273 (273) Show / Hide 
Range on Protein: 562-786
Range on HMM: 41-273/273
Sequence Identity: 28% (71 aa)

REVLKELNYMRQVEHNNLVRFVGACVDAPNISIISEYCPKGSLQDIVENDALKLDNMFKNSLITDVMRGLHYLHSSV-IMLHSRLS--------------
|. . | . |  . | |.| |.||| . || .|| ||| .|||  .. |.  .|    .  .  |. || ||||||   ..|  |               
RDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINII

------SSNCVVDSRFVLKLTDYGLTKFRDTDSNERQTSKNEQKMLWQAPETLRSANQQPTQKGDIYSVGIIMQEIVTRARPFEEERSSMEIDEIVKKLT
      | | .||  |  ||||.| |. .  |     | |      | ||| ...     | | |..| .||. ||  |  |. . .      .....  
TLIKINSLNVLVDDNFRCKLTDFGWTRVKPQD--NYMTNKIGT-YQWMAPEVIKAFYY--TEKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNN-

ETSSPPFRPEIDPQLCTDEIRSIIQACWEEMPENRPATTDLLSSMK
       || | |. |  ..  ..| ||..  . ||.  ...  ..
------LRPTI-PKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase Npr2.AA TK-Unique 562-785 23 9.2e-26 85.89 In-house 48-294 (294) Show / Hide 
Range on Protein: 562-785
Range on HMM: 48-294/294
Sequence Identity: 23% (60 aa)

REVLKELNYMRQVE-HNNLVRFVGACVDAP-NISIISEYCPKGSLQDIVENDALK---------LD------NMFKN-SLIT---------DVMRGLHYL
.. |||.. |...  | |.|...|.|..   .  || ||||.|.||.   . . .         |.      ..... . |.         .. .|. ||
QDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYL

HS--SVIMLHSRLSSSNCVVDSRFVLKLTDYGLTK-FRDTDSNERQTSKNEQKMLWQAPETLRSANQQP-TQKGDIYSVGIIMQEIVTR-ARPFEEERSS
.|    |  | .|...|. . ...|.|..|.|...  ...  .....|...    | ||| |. . ..  | |.|..| |..| ||.|  |.|. . ...
ASQRKKI-VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWK

MEIDEIVKKLTETSSPPFRPEIDPQLC-TDEIRSIIQACWEEMPENRPATTDLLSSM
     |...... . .|     .|. | ..|...... || . || ||  .....  
D----IMECIRDGYRMP-----QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Npr2.AA MLK 541-785 20 1.9e-22 74.77 In-house 18-291 (291) Show / Hide 
Range on Protein: 541-785
Range on HMM: 18-291/291
Sequence Identity: 20% (59 aa)

ANYKGRL-----VVIRRIEKTKLDLTRE------VLKELNYMRQVEHNN----LVRFVGACVDAPN-ISIISEYCPKGSLQDIV--ENDALK--------
.......     | ..|.. .. |  ..      . .| .  | . |.|     ..|.|.| . |.   |..|||..||| ..   ...           
GRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKN

---LDNMFKNSLITDVMRGLHYLHS-SV-IMLHSRLSSSNCVVDS------RFVLKLTDYGLTK-FRDTDSNERQTSKNEQKMLWQAPETL-RSANQQPT
    |  ....  ... ||.|||||  .    |  | |.| ..|         .|| .| |. . . ....|     .|     | ||| . .. ... .
DRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN---MMSNAGTYAWMAPEVIQQFRCEKYS

QKGDIYSVGIIMQEIVTRARPFEEERSSMEIDEIVKKLTETSSPPFRPEIDPQLCTDEIRSIIQACWEEMPENRPATTDLLSSM
 | |..| |... |..||  |.... ..|.|  . .   .   || ...     | . . . .. ||.. |..||     ..  
EKCDVWSWGVVLWEMLTREVPYKQHYDPMAI--AWWVAYNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Npr2.AA Dicty4-Unclassified 563-785 27 2.7e-22 73.13 In-house 44-263 (263) Show / Hide 
Range on Protein: 563-785
Range on HMM: 44-263/263
Sequence Identity: 27% (66 aa)

EVLKELNYMRQVEHNNLVRFVGACVDAP-----NISIISEYCPKGSLQDIVE------NDALKLDN--MFKNSLITDVMRGLHYLHSSVIMLHSRLSSSN
. .||   .  . | |||.  |.|. .|      . |. |  .|| |  ..       .  .|||     |  .  |. .|. .|| .. . |  . |||
DFKKEVEILGSIQHPNLVKCYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAF--DIAQGMQHLH-TRNFIHRDIKSSN

CVVDSRFVLKLTDYGLTKFRDTDSNERQTSKN-EQKMLWQAPETLRSANQQPTQKGDIYSVGIIMQEIVTRARPFEEERSSMEIDEIV--KKLTETSSPP
  .|  |  |  | |.   | .| |   |      |  | .|| |.      .|| |.|| .... | .|   |. |  | |..   |  |||       
ILMDKHFNIKIADFGIS--RVIDFNFNMTTIAGTPK--WESPECLMHESY--NQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKL-------

FRPEIDPQLCTDEIRSIIQACWEEMPENRPATTDLLSSM
 ||.| |  |   ... |  || . |  ||   .    .
-RPKI-PDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Npr2.AA DRK 558-665 33 3.8e-19 61.51 In-house 38-146 (258) Show / Hide 
Range on Protein: 558-665
Range on HMM: 38-146/258
Sequence Identity: 33% (37 aa)

LDLTREVLKELNYMRQVEHNNLVRFVGACVDAPNISIISEYCPKGSLQDIVENDALKLDNMFKNSLITDVMRGLHYLHSSV-IMLHSRLSSSNCVVDSRF
...  |  .| | | |  | | . | |.|   | | |. || |.|||  |  ......|     ..  |. .|. |||..  | .|  | | |  ||  .
ENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHW

VLKLTDYGL
  |  |.||
QVKVADFGL
Kinase Npr2.AA Pkinase 545-785 19 1.5e-17 63.11 Pfam 24-293 (293) Show / Hide 
Range on Protein: 545-785
Range on HMM: 24-293/293
Sequence Identity: 19% (55 aa)

GRLVVIRRIEKTKLDLTREVLK----ELNYMRQVEHNNLVRFVGACVDAPNISIISEYCPKG----SLQDIVE---NDAL--KLDNMFKNSLITDVMRGL
|..|.. .|.| . .   .. .    |. .|. . | | ||. ... | ..| .. |||..|    .| |...   . ..    .   .   .. . |||
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF--YMYQILRGL

HYLHSSVIMLHSRLSSSNCVVDSRFVL----KLTDYGLTKFRDTDSNERQTSKNEQK--MLWQAPETLRSANQQPTQKGDIYSVGIIMQEIVTRARPFEE
 |.||    .|  | ..|. .|.. ..    |..| || |. |   . ...  .       . ||| .|  .|  ..| |..|.|.|. | ...  || .
EYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPG

E---RSSMEIDEIVKKLTETSSPPFRPEIDPQL---------------CTDEIRSIIQACWEEMPENRPATTDLLSS--M
.    . .. ......  ..  .  .|. ..                  ..| ...|  |..  |. ||  ...| .  .
HCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc Npr2.AA S_TKc 520-786 18 1.2e-16 62.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 520-786
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)

GSFVTSIGHGTS------HHRQMFATVANYKGRLVVIRRIEKTKLDLTREVLKELNYMRQVEHNNLVRFVGACVDAPNISIISEYCPK--GSLQDIVEND
  ..  ||.|.       .|.          ||.| | .|        . ...|.. ...  | |.|.. ....|  .. .. |||.   |.| |. .. 
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

ALK-----LDNMFKNSLITDVMRGLHYLHSSVIMLHSRLSSSNCVVDSRFVLKLTDYGLTKFRDTDSNERQTSKNEQKML----WQAPETLRSANQQPTQ
  .     ..     ...  . ..| |.||    .|  |  .|  .|.  ..|..| || ..                .     . ||| |     . . 
GRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-----GYGK

-KGDIYSVGIIMQEIVTRARPFEEERSSMEIDEIVKKLTETSSPPFRPEIDPQLCTDEIRSIIQACWEEMPENRPATTDLLS--------SMK
 | |..|.|.|. | ...  ||.      ..... ||.                 ..| ...|. |..  ||.||   ..|            
CKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc Npr2.AA TyrKc 520-785 23 3.1e-16 39.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 520-785
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

GSFVTSIGHGTSHHRQMFATV--ANYKGRLVVIRRIEKTKLDLTREVLKELNYMRQV--EHNNLVRFVGACVDA-------PNISIISEYCPKGSLQDIV
 ..   .|.|       | .|  . .| . | .  . . .    .. ..|.. |...  .| |.||..|.|..        . . |. ||.|.|.|.|  
ITLGKKLGEGA------FGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

ENDALKLDNMFKNSLITDVMRGLHYLHSSVIMLHSRLSSSNCVVDSRFVLKLTDYGLTKFRDTD----SNERQTSKNE--QKM--L---WQAPETLRSAN
 .   || .  . |  ... .|  ||||     |  |   || |..... | .| ||... . |     ..   .| |  ..   |   | |||..    
RKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY

QQPTQKGDIYSVGIIMQEIVTRARPFEEE---RSSMEIDEIVKKLTETSSPPFRPE-IDPQL----CTDEIRSIIQACWEEMPENRPATTDLLSSM
   | | |..| |. | || |.  .  ..   .  |. .|..... .   .|  |.   | .    |.||. .|.. ||.| ||.||  ... . .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Npr2.AA Pkinase_Tyr 554-606 30 5.2e-10 34.53 Pfam 38-96 (270) Show / Hide 
Range on Protein: 554-606
Range on HMM: 38-96/270
Sequence Identity: 30% (18 aa)

EKTKLDL--TREVLKELNYMRQV-EHNNLVRFVGACV-DAPN--ISIISEYCPKGSLQD
|..  .    .. ..|.. |.|   | |.||..|.|. .     | |. ||.|.|.| |
EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase Npr2.AA Pkinase_Tyr 753-785 33 5.9e-07 24.17 Pfam 238-270 (270) Show / Hide 
Range on Protein: 753-785
Range on HMM: 238-270/270
Sequence Identity: 33% (11 aa)

PQLCTDEIRSIIQACWEEMPENRPATTDLLSSM
|..|.||| .... ||.. ||.||  ..... .
PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Npr2.AA DRK 687-723 51 2e-06 18.06 In-house 168-202 (258) Show / Hide 
Range on Protein: 687-723
Range on HMM: 168-202/258
Sequence Identity: 51% (19 aa)

WQAPETLRSANQQPTQKGDIYSVGIIMQEIVTRARPF
| ||| ||  ||  | | |.|| .|.  |.|||  |.
WTAPEVLR--NQRYTEKADVYSFAIVLWECVTRQDPY
Kinase Npr2.AA DRK 764-787 29 0.229038 0.43 In-house 235-258 (258) Show / Hide 
Range on Protein: 764-787
Range on HMM: 235-258/258
Sequence Identity: 29% (7 aa)

IQACWEEMPENRPATTDLLSSMKK
.. ||.| |  ||   . |  .  
MNDCWNEDPQHRPSMQECLERLEA
CYCc Npr2.AA CYCc 825-1019 45 9.3e-104 351.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 825-1019
Range on HMM: 1-231/231
Sequence Identity: 45% (106 aa)

EEKKRSETLLYEVLPRSVAEQLKQGS-SVSPKSYESVTIYFSDIVGFTSISADSTPLQVVTLLNDLYTCFDGTIGNFD-----VYKVETIGDAYMVVSGL
.||.. ..||...|||.||.|||||  .| |..|..|||.|.||||||.... .||.|||..|||.||.||  |....     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIRNG-------------------IHHVKEIASMALSLVREAYKFRIRHK----PEEKLLLRVGVHSGACVAGVVGLRMPRYCLFGDTVNTASRMESTGQ
| ||.                     | ..||..||  | ..  | ..|.    |...| .|.|.|.| .|.||||.||||||.||||||.|||||||| 
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

AMKVHISESTKKLL-------DTFKNFETEP
....|.||.|...|         .  ||.||
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc Npr2.AA Guanylate_cyc 852-1026 43 8.5e-86 296.14 Pfam 1-199 (214) Show / Hide 
Range on Protein: 852-1026
Range on HMM: 1-199/214
Sequence Identity: 43% (86 aa)

VSPKSYESVTIYFSDIVGFTSISADST----PLQVVTLLNDLYTCFDGTIGNF--DVYKVETIGDAYMVVSGLPIR-----NGIHHVKEIASMALSLVRE
| ...|..|||.|.||||||.... ..    |.|.|..|||.|||||  ....  ..|||.||||.||.||||| .     ...||   .| ||| ..  
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

AYKFRIRHKPEEK-----LLLRVGVHSGACVAGVVG--LRMPRYCLFGDTVNTASRMESTGQAM--KVHISESTKKLLDTFKNFETE----PRGEVVLK
. .... |.. |      . .|.|.|.| .||||.|  .||||||..|||||.||||||||..   |.|.||.|...| .  ||. |    .|||. .|
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVK
HNOBA Npr2.AA HNOBA 825-846 54 1.2e-08 32.86 Pfam 213-234 (234) Show / Hide 
Range on Protein: 825-846
Range on HMM: 213-234/234
Sequence Identity: 54% (12 aa)

EEKKRSETLLYEVLPRSVAEQL
||||....|||...|.|||..|
EEKKKTDDLLYSMFPKSVANRL
Guanylate_cyc Npr2.AA Guanylate_cyc 1101-1112 40 5.915221 1.61 Pfam 200-214 (214) Show / Hide 
Range on Protein: 1101-1112
Range on HMM: 200-214/214
Sequence Identity: 40% (6 aa)

GKGSQ---QTYWLTA
||| .   .||.|..
GKGKMGEMETYFLHG