Gene WNK (Sea Urchin)
WNK
Sequence
Protein domains of WNK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | WNK.AA | WNK | 248-507 | 79 | 1.1e-226 | 739.46 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-261/261 Sequence Identity: 79% (207 aa) MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSGTLKTYLKRFKGV ||.|..||.||||||.|||||||.|.|||||||..|||..|||||||||||||.|.|||||.||||||.| ..|||.|||||||||||||||||||||.. MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESV-LCGKKCIVLVTELMTSGTLKTYLKRFKKM KNRVLRSWCRQILKGLHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGDLGLA-TLKKSSFAKSVIGTPEFMAPEMYEEHYDEAVDVYAFGMCLLEMAT |..||||||||||||||||||||| |||||||||||||||||.|.||||||||| |||.|||||||||||||||||||||||||.|||||||||.||||| KPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAT SEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIKEIIDGCTKTNNTERYLIQELLKHTFF |||||.||.|||||||.||.|.||.||.|......||||..|...|..||. ||.||.|.|| SEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF |
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Kinase | WNK.AA | S_TKc | 248-507 | 24 | 8.8e-62 | 212.48 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-231/231 Sequence Identity: 24% (67 aa) MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTS--GTLKTYLKRFK . .|.|.| .|... ...|| || .. .... | ..|| ||||| .||.... .|. .|.|.. |.|..|.|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG G------VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKSSFAKSVIGTPEFMAPEMYEEHYDE-AVDVYAFGM . . |....||...| ..| . ||||||| .||... .||.| |||.. ....|||..||||. .|. ..|....| RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC CLLEMATSEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIKEIIDGCTKTNNTERYLIQELLK-------HTFF .| ||.. . |. . ....... . |..|..| . . ..|. . |.|. | .| ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | WNK.AA | Pkinase | 248-507 | 26 | 2.4e-56 | 198.3 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-293/293 Sequence Identity: 26% (79 aa) MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKE--EAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSG----TLKTYL . .|.||| .|... . || || .. |. . ...|. |....| |.||||| .||..|. |.|| .|.|.. | |..|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI K--RFKGV--KNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAV----KIGDLGLAT---LKKSSFAKSVIGTPEFMAPEM--YEEHYD . | ... ........|||.|| ..| . ||||||| .||.| | . ||.| ||| . ..| .... |||..|||| ..|. STWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG EAVDVYAFGMCLLEMATSEYPYAEC-----SNAAQIYRRVTTGVKPQSFEKVND-------------------NKIKEIIDGCTKTNNTERYLIQELLKH .||....| | ||.. . |. .. . |...|. . . .... .. |..|..| . . ..|. ....|.| PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH TFF .| PWF |
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Kinase | WNK.AA | STE | 248-507 | 20 | 1.8e-54 | 187.29 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-359/359 Sequence Identity: 20% (74 aa) MKYDVAVGQGSFKTVFRGLDT------ETG-----------VAVAWCELQE--------RKLSRS-------ERQRFKEEAEMLKGLS--HPNIVSFYDY . .|.|.| ||..... .|| .|. .|.. . . . |.|....| ...| .. ||||| .|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC WEEVS--PRGKKHIVLVTELMTSGTLKTYLK-RFKGVK-------------NRVLRSWCRQILKG-LHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGD . . . .. .. |.| |.| .| ... | ... ||||||| |..|| . |||||.|..||.. ||. | YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCD LGLATLKKSS------------------FAKSVIGTPEFMAPEMYEE-------HYDEAVDVYAFGMCLLEMATSEYPYAECSNAAQIYRRVTTG----- |... .| ....||| .||||. . .||. .|.. .| ...|||| ..|... .. ... . . FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ --------VKPQSFEK-------------------VNDNKIKEIIDGCTKTNNTERYLIQELLK--HTFF .| ... . |. |. | . . .| ..||| | |. FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | WNK.AA | CAMK | 253-507 | 16 | 1.9e-47 | 150.56 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 253-507 Range on HMM: 1-425/425 Sequence Identity: 16% (71 aa) AVGQGSFKTVFRGLDTETG------------VAVAWCELQERKLS--------------------------RSERQRFKEEAEMLKGLS-------HPNI |.||| .|... ...|. . || . .||. . |.... | |..| |. |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSFYDYWEE-----------VSPRG----KKHIVLVT---ELMTSG----TLKTYLKRFKG---------------VKNRVLRSWCRQILKGLHFLHTRQ ...|...| .. .||...|. |... | | |... .. .. | | . |||. ..|..| . IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN PPIIHRDLKCDNIFITGTS----------------GAVKIGDLGLATLKKSS-------------------------FAKSVIGTPEFMA-PEMYE---- |.|||||..|| .. . . .|| | |.|. .... | . ||||.|| ||. . --IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH -----------EHYDEAVDVYAFGMCLLEMATSEYPYAECS------------NAAQIYRRVTTGVKPQSFEKVND----------------------NK . |....|. . | | | . ..|. . . | ........| ... . CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE IKEIIDGCTKTNNTERYLIQELLKHTFF | | .. ... ..|. |.. |.| .. CKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | WNK.AA | TKL | 254-505 | 20 | 9.5e-47 | 161.62 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 254-505 Range on HMM: 1-364/364 Sequence Identity: 20% (76 aa) VGQGSFKTVFRGLDTETG----------VAV--------AWCELQERK---------------LSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPR .|.|.| .|..| .| ||| ....... .. .|....||. |.. |.|||||.|. | . ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG G--------KKHIVLVTELMTSGT-LKTYLKRFKGVKNRVLRSWCRQILKGLHFLHTRQ------PPIIHRDLKCDNIFITG-------------TSGAV . .... .|.|.. |. | ... .. .|...| .|...||... ||||||||| .||.. . . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KIGDLGLATLKKSSF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDEAVDVYAFGMCLLEMATSEYPYAECS ||.|.||.. .. |. ...||| .||||. . . |.|..|||.||..| |..| . ||.. KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP NAAQI---------YRRVTTGVKPQSFEKVN--------DNK---IKEIIDGCTKTNNTERYLIQELLKHT . .| . .. | .| . . .. .|... | ... ..| ||.||. YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | WNK.AA | Ciliate-E2 | 248-507 | 17 | 4.2e-46 | 156.25 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-365/365 Sequence Identity: 17% (69 aa) MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSE---------------------RQRFKEEAEM---------------LKGLSHPNIVSFY | |||.| .|... . ... .| . .|. .. .| ..|. .| |. |.||||. .| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY DYWEEVSPRGKKHIVLVTELMTSGTLKTYLK--RFKGVKN---------RVLRSWCRQILK---------------GLHFLHTRQPPIIHRDLKCDNIFI ....| ...| ||.|. |.|. |.| . | .. . . .|||. .|..|| . . |||||.| .||.. ECFQE---KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF TGTSGAVKIGDLGLAT----------------LKKSSF------------------AKSVIGTPEFMAPEMYE----------EHYDEAVDVYAFGMCLL .|| |.||.. ... . .....|||..||||... ..||...|....|..| ------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY EMATSEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIK----------------------------EIIDG----CTKTNNTERYL-IQELLKHTFF || . ..|. ... ..||. .| . . . .|. ....|.| .| EMLFGKPPF---------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | WNK.AA | NRBP | 254-508 | 31 | 1.6e-42 | 147.3 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 254-508 Range on HMM: 2-261/261 Sequence Identity: 31% (84 aa) VGQGSFKTVFRGLDTETGVAVAWCELQ--ERKLSRSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSGTLKTYLKRFK----GV .... .|||.|| | | |.| ||| ... . .. . | | |.||| | || ... | .. .|| | || .| .||. | . RDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEE-KPRVIFITEYMSSGSMKQFLKKTKKNHKNM KNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKS-SFAKSVIGTPEFMAPEMY---EEHYDEAVDVYAFGMCLLEM . . . || ||| | .||. .||||| | || ||| | .||| ..... .. |.||| .. |||.|.|||| ||| NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM ATSEYPYAECSNAAQIYRRVTTGVKPQSFEKVNDNKIKEIIDGCTKTNNTERYLIQELLKHTFFE | | . |.|. | || . .. . ..|. ...| | . . .| .||| | AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF |
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Kinase | WNK.AA | STE11 | 248-507 | 23 | 1.1e-40 | 141.53 | In-house | 1-303 (303) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-303/303 Sequence Identity: 23% (72 aa) MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLS------RSERQR------FKEEAEMLKGLSHPNIVSFYDYWEEVSPRG-KKHIVLVTELMTS . |.|.| ||...... ||. .| . .... . . | | ..|| ...|.|.|.||| .|. . . ..|. | . WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLH---DNQNDHVNIFMEYCPG GTLKTYLK-RFKG--VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKSS------------FAKSVIGTPE--- |.|. |. .. | | .|||.||..|| . |||||.| .||.. ... .|..| | |. ... . ||. ||| GSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSM -----FMAPEMYE-EH---YDEAVDVYAFGMCLLEMATSEYPYAECSN--AAQIYRRVTT-GVKPQSFEKVND-----NKIKEIIDGCTKTNNTERYLIQ .||||.. | |. ..|. ..| . .|||| |...... .|.... ... . |. |.. . ..... | . . .|. . MGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTAN ELLKHTFF .||.| |. QLLQHPFI |
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Kinase | WNK.AA | Ciliate-E2-Unclassified | 255-507 | 18 | 5e-38 | 129.5 | In-house | 8-352 (352) | Show / Hide |
Range on Protein: 255-507 Range on HMM: 8-352/352 Sequence Identity: 18% (66 aa) GQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQR-------FKEEAEMLKG---------------LSHPNIVSFYDYWEEVSPRGKKHIVLVTELM |||.| .|.. . ... .. . . ... .| ....... | |.||... ...... . |..| .|.|.. GQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQD---KQNIYIVMEYC TSGTLKTYLKRFKG-----------------VKNRVLR-----SWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSG--AVKIGDLGLAT------- |.|. |.| .|. . . . ...|||.|| .|| . |||||.|..||... . .|| |.|.. EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNN ----------LKKSSFAKSVIGTPEFM----APEMYEE-HYD----EAVDVYAFGMCLLEMATSEYPY-AECSNA--------------AQIYRRVTTG- |. .....|||..| |||.... .|| ...|....|..| || . .||. ..... |.|. . CDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKN VKPQSFEK-----VNDNKIKEIID----GCTKTNNTERYLIQELLKHTFF .. ..|.. ... |..| . | | .|. ....|.| .| IQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | WNK.AA | ULK | 255-507 | 21 | 3.6e-37 | 127.35 | In-house | 8-329 (329) | Show / Hide |
Range on Protein: 255-507 Range on HMM: 8-329/329 Sequence Identity: 21% (72 aa) GQGSFKTVFRGLDTET----GVAVAWCELQERKLSRSERQR--------FKEEAEMLKGLS--------HPNIVSFYDYWEEVSPRGK--KHIVLVTELM |.||| .|..| . .| ...|| .. |..... .. .| | . .| | ||||| .||. |. . ..| ...|. GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFET-----SNHNNIYIIMEYC TSGTLKTYLKRFKG----------VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGT-----------SGAVKIGDLGLATLKKSS----- |.|..|.|. |. .. ..||| |. .|| .. |||||.| .|| |. .| .||.| |.| .. NGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ FAKSVI------GTPEFMAPEMYEEH-----YDEA-VDVYAFGMCLLEMATSEYPYAECSNAAQI----YRRVTTG--------VKPQSFE-----KVND ... ||| .|||. ... |... .|.. .|. . || . ..|. .. . |. .. . . .| |. .. MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS NKIKEIIDGCTKTNNTERYLIQELLKHTFF ...|..| .. . . ..| ..||..| .| PECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | WNK.AA | ULK | 255-507 | 22 | 6.7e-36 | 124.88 | In-house | 8-324 (324) | Show / Hide |
Range on Protein: 255-507 Range on HMM: 8-324/324 Sequence Identity: 22% (74 aa) GQGSFK-TVFRGLDTET---GVAVAWCELQERKLSRSERQ--------RFKEEAEMLKGLS---HPN--IVSFYDYWEEVSPRGK--KHIVLVTELMTSG |.||| .|..| . .| ...|| . |.. .. . .| | . .| | ||| || .||. |. . ..| ...|. | GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFET-----SNHNNIYIIMEYCNGG TLKTYLKRFKGVKNRV----------LRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGT-----------SGAVKIGDLGLATLKKS-SFAKSVI- .|..|.|. |. . . .. ..||. |. .|| .. |||||.| .|| |. .| .||.| |.| . .... .. DLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ ---------GTPEFMAPEMYEEH-----YDEA-VDVYAFGMCLLEMATSEYPYAECSNAAQI------------YRRVTTGVKPQSFEKV---NDNKI-- ||| .|||. ... |... .|.. .|. . || . .||. .. . |. . . .| | ... .|.|| TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ---QIYIKNQPIQFPKPPKDPKISP --KEIIDGCTKTNNTERYLIQELLKHTFF |..| .. . . ..| ..|...| .| ECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | WNK.AA | FRWNK_Wnk1 | 508-596 | 47 | 4.1e-28 | 99.32 | In-house | 2-92 (92) | Show / Hide |
Range on Protein: 508-596 Range on HMM: 2-92/92 Sequence Identity: 47% (43 aa) EDTAFRVDIVHDDN--KDQIQLQLRVEDPKKRRERHRDNEALQFEIDLNKDEPDQVAKEMVRIGFVSEEDSKAVTKVIRDRIGTVWKNREK ||| ||. .|. |. | | |..||||| . ...||||..| ||.|| |..||.||| .||. |.|.|.| | ||||. ....||. EDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER |
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Kinase | WNK.AA | Pkinase_Tyr | 285-400 | 33 | 6.3e-20 | 68.12 | Pfam | 41-158 (270) | Show / Hide |
Range on Protein: 285-400 Range on HMM: 41-158/270 Sequence Identity: 33% (41 aa) SRSE--RQRFKEEAEMLKGL-SHPNIVSFYDYWEEVSPRGKKHIVLVTELMTSGTLKTYLKR----FKGVKNRVLRSWCRQILKGLHFLHTRQPPIIHRD . .. |. | .||...| | .|||||..| . . . .| .|.|.| | |..||.. . .. | ..|.|| ||. .|. .. .|||| MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRD LKCDNIFITGTSGAVKIGDLGLA | . |. .| . |||.| ||| LAARNCLVTENN-VVKICDFGLA |
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Kinase | WNK.AA | TyrKc | 248-507 | 23 | 2.1e-16 | 42.58 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 248-507 Range on HMM: 1-280/280 Sequence Identity: 23% (68 aa) MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKLSRSERQRFKEEAEMLKGL--SHPNIVSFYDYWEEVSPRGK---KHIVLVTELMTSGTLKTYLK . . | | | .|..| . . || |.| . |. | .||.... | .||||| .| . . . . . . .|.|.| | || ||. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR RFKG-VKNRVLRSWCRQILKGLHFLHTRQPPIIHRDLKCDNIFITGTSGAVKIGDLGLATLKKSS----FAKSVIGT-----PEF------MAPEMYEEH . .. .... | |.| || .| .|| . ..||||| . |. .. |||.| ||. .. .|... . . |||| .. KHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG -YDEAVDVYAFGMCLLEMATSEYPYAEC-----SNAAQIYRRVTTGVKPQSFEKV-------NDNKIKEIIDGCTKTNNTERYLIQELLKHTFF . .. ||..|| |. |. | . . ........| .| . . . .. .|. | . . .| .|. | .| KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | WNK.AA | OSR1_C | 525-562 | 57 | 4.7e-16 | 61.92 | Pfam | 1-38 (38) | Show / Hide |
Range on Protein: 525-562 Range on HMM: 1-38/38 Sequence Identity: 57% (22 aa) IQLQLRVEDPKKRRERHRDNEALQFEIDLNKDEPDQVA |.|.||..||||| ..|..|||.||| |..||.|..|| INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA |
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Kinase | WNK.AA | FRWNK_Wnk2.hmm | 549-594 | 28 | 0.000917 | 10.13 | In-house | 18-63 (63) | Show / Hide |
Range on Protein: 549-594 Range on HMM: 18-63/63 Sequence Identity: 28% (13 aa) FEIDLNKDEPDQVAKEMVRIGFVSEEDSKAVTKVIRDRIGTVWKNR | ||. |.|...|. ||. |. |.. .. . .|| | . . FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM |
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Kinase | WNK.AA | Pkinase_Tyr | 418-466 | 29 | 0.005197 | 10.82 | Pfam | 181-232 (270) | Show / Hide |
Range on Protein: 418-466 Range on HMM: 181-232/270 Sequence Identity: 29% (16 aa) MAPE--MYEEHYDEAVDVYAFGMCLLEMAT-SEYP-YAECSNAAQIYRRV-TTG |||| .| . . .. ||..|| .. |. | | | |... ...|... | MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG |
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FRWNK_Wnk2.hmm | WNK.AA | FRWNK_Wnk2.hmm | 1214-1275 | 26 | 1.2e-09 | 29.88 | In-house | 1-63 (63) | Show / Hide |
Range on Protein: 1214-1275 Range on HMM: 1-63/63 Sequence Identity: 26% (17 aa) DQVIECSLETHRGDTIVFKFS-EDDQLDGIVSNLTVAKWVHEQHAGLFKEQLLKVMEDAKRLG |...|| |||| .. ||| . |. . | . . . .. |.. | ||. .... |. .. DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM |
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OSR1_C | WNK.AA | OSR1_C | 2045-2053 | 55 | 41.490473 | 0.54 | Pfam | 30-38 (38) | Show / Hide |
Range on Protein: 2045-2053 Range on HMM: 30-38/38 Sequence Identity: 55% (5 aa) ERDTPDSIA |.|||. .| EKDTPEEVA |