Gene Wee1a (Sea Urchin)
Wee1a
Sequence
Protein domains of Wee1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Wee1a.AA | WEE | 48-249 | 43 | 6.9e-115 | 386.73 | In-house | 37-297 (297) | Show / Hide |
Range on Protein: 48-249 Range on HMM: 37-297/297 Sequence Identity: 43% (113 aa) QDTPFRQMALNEVYAHAVLG------THIHVVRYYSAWSEAGHMIIQNEYCNGGS--LADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSE-GLVHM ... .|..||.|||||.||| .|.|.|||||||.|..||.||.||||||| |...|......||...|....|.||.|.|||..|||. |.||| RGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHM DIKPG---------------------------------DLGHVTSIS----NPKVE-EGDVRFLPVEILQE--EHTHLTKADIFALALTAYLAAGGESLP ||||. |.||||... ||..| ||| |... ||||. ..|||.|||||.|..| | .|....|| DIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLP KNGDDWHRIRQG-------HFP-P--LLHISTDLVDLLQTMIDPDPSQRPSASALVQHPLL ||||.||.|||| ..| | . ||..| .|.. |..|||.|||....|.|||.| KNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | Wee1a.AA | Pkinase | 52-142 | 32 | 1.2e-20 | 74.04 | Pfam | 41-136 (293) | Show / Hide |
Range on Protein: 52-142 Range on HMM: 41-136/293 Sequence Identity: 32% (32 aa) FRQMALN--EVYAHAVLGTHIHVVRYYSAWSEAGHMIIQNEYCNGG----SLADIIS-SNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP ..| ... |.. .. | | ..||.| .. . .|. . |||.|| .|.|.|| ... . ..| |.| .. ||..||.|.||.| .| |.|| KDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKP |
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| Kinase | Wee1a.AA | STE | 69-143 | 34 | 3.6e-17 | 57.27 | In-house | 89-181 (359) | Show / Hide |
Range on Protein: 69-143 Range on HMM: 89-181/359 Sequence Identity: 34% (32 aa) HIHVVRYYSAWSEAG-------HMIIQNEYCNGGSLADIISSN----KQNN------HRMTEIELKQVLVQIAQG-LKYIHSEGLVHMDIKPG | ..|.|| . | . | ||..|||| ||| .. |..| ||. | ... ...|| .| |.|.|| . .| ||||. HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA |
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| Kinase | Wee1a.AA | Ciliate-E2 | 69-142 | 28 | 5.3e-17 | 54.89 | In-house | 91-189 (365) | Show / Hide |
Range on Protein: 69-142 Range on HMM: 91-189/365 Sequence Identity: 28% (28 aa) HIHVVRYYSAWS--EAGHMIIQNEYCNGGSLADIISSNKQNN-------HRMTEIELKQVLVQIAQ---------------GLKYIHSEG-LVHMDIKP | .....| .. .. . |||.||.| |.| .||.. ...|| | |.. ||.| .|.|.||.. .| |||| HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP |
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| Kinase | Wee1a.AA | ULK | 90-142 | 40 | 7.5e-17 | 55.44 | In-house | 100-158 (329) | Show / Hide |
Range on Protein: 90-142 Range on HMM: 100-158/329 Sequence Identity: 40% (24 aa) EYCNGGSLADIISSNKQ------NNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP |||||| | ..|. || .. | .| | .|.. ||..|.|..|... .| |||| EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKP |
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| Kinase | Wee1a.AA | ULK | 90-142 | 41 | 1.8e-16 | 55.03 | In-house | 97-154 (324) | Show / Hide |
Range on Protein: 90-142 Range on HMM: 97-154/324 Sequence Identity: 41% (24 aa) EYCNGGSLADIISSNKQ-----NNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP |||||| | ..| || .. | .| | .|.. ||..|.|..|... .| |||| EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKP |
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| Kinase | Wee1a.AA | Ciliate-E2-Unclassified | 69-142 | 27 | 7.2e-16 | 51.55 | In-house | 80-172 (352) | Show / Hide |
Range on Protein: 69-142 Range on HMM: 80-172/352 Sequence Identity: 27% (26 aa) HIHVVRYYSAWSEAGHMIIQNEYCNGGSLADIISS-------------NKQNNHRMTEIELK-----QVLVQIAQGLKYIHSEG-LVHMDIKP |...|... . ...| |||.||.| ..|.. |...... || . | . . || |||.|.|... .| |||| HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKP |
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| Kinase | Wee1a.AA | CAMK | 53-142 | 21 | 4.6e-14 | 41.01 | In-house | 75-207 (425) | Show / Hide |
Range on Protein: 53-142 Range on HMM: 75-207/425 Sequence Identity: 21% (28 aa) RQMALNEVYAHAVLGT------HIHVVRYYSAWSEAGH-------------------MIIQN---EYCNGG----SLADIISSNKQNN-----------H |.. ..|. . | | .... | .. . . |.. ||| || | | | ..... . RKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERG RMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP |.|| | ... ||.....|.|| . || |.|| RFTEREARRYFRQICSAVHYCHSHNIVHRDLKP |
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| S_TKc | Wee1a.AA | S_TKc | 35-249 | 19 | 1.7e-13 | 20.84 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 35-249 Range on HMM: 1-231/231 Sequence Identity: 19% (49 aa) YGFKPQCSTGVPG-----QDTP----------FRQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQNEYCNG--GSLADIISSNKQNNHR--MTEIE | . . | | ... .....|. . | ..|..| .. . .|. . |||.| |.| |.| ... . | ..| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H LKQVLVQIAQGLKYIHSEGLVHMDIKP-----------GDLGHVTSISNPKVEEGDVRFLPVEILQEEHTHLT-KADIFALALTAYLAAGGES-LPKNGD . .. ||...|.|.|| | .| |.|| .| | . . . | ... |.| . . |.|. .. . | . |. | . . ARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQ DWHRIRQGHFPPLLHISTDLVDLLQTMIDPDPSQRPSASALVQ-------HPLL .. | .. |... . . ||..||.| . | || . MMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Wee1a.AA | GCN2 | 87-142 | 41 | 1.3e-12 | 40.13 | In-house | 284-336 (511) | Show / Hide |
Range on Protein: 87-142 Range on HMM: 284-336/511 Sequence Identity: 41% (23 aa) IQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKP || ||| |..|...|.... .. . ||.... || ||.|||| | .| |.|| IQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKP |
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| Kinase | Wee1a.AA | PEK | 87-143 | 23 | 2e-12 | 38.82 | In-house | 360-456 (655) | Show / Hide |
Range on Protein: 87-143 Range on HMM: 360-456/655 Sequence Identity: 23% (23 aa) IQNEYCNGGSLADIISSNK--------------------QNN--------------------HRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPG || |||....| |.|..|. ..| . . .... . ||. ||.|||| |..| |.||. IQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPS |
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| Kinase | Wee1a.AA | NEK | 69-142 | 30 | 2e-11 | 36.9 | In-house | 63-147 (286) | Show / Hide |
Range on Protein: 69-142 Range on HMM: 63-147/286 Sequence Identity: 30% (26 aa) HIHVVRYYSAWSEAG--HMIIQNEYCN-GGSLADI---ISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSE-----GLVHMDIKP | ..|.|| .. | . ...| |||. || |.. | .|| .. . | . ...|.. .|||.|.. .| |||| HPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKP |
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| Kinase | Wee1a.AA | NEK | 206-249 | 35 | 9e-11 | 34.56 | In-house | 239-286 (286) | Show / Hide |
Range on Protein: 206-249 Range on HMM: 239-286/286 Sequence Identity: 35% (17 aa) RIRQG-HFPPLL-H--ISTDLVDLLQTMIDPDPSQRPSASALVQHPLL .|..| ..||. | |.|| .|.. |. .||.||||.. . ..|.. KIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | Wee1a.AA | PEK | 207-249 | 31 | 3.1e-09 | 27.52 | In-house | 605-655 (655) | Show / Hide |
Range on Protein: 207-249 Range on HMM: 605-655/655 Sequence Identity: 31% (16 aa) IRQ------GHFP-PLLHI-STDLVDLLQTMIDPDPSQRPSASALVQHPLL .|. | || ... ... |..| |...||.|||||. . ||... LRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF |
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| Kinase | Wee1a.AA | Pkinase | 143-249 | 16 | 4e-09 | 33.35 | Pfam | 154-293 (293) | Show / Hide |
Range on Protein: 143-249
Range on HMM: 154-293/293
Sequence Identity: 16% (23 aa)
GDLGH-----VTSISNPKVEEGDVRFLPVEILQEEHTHLTKADIFALALTAYLAAGGESLPKNG------DDWHRIRQGHFPPLLHIS------------
.| | . | ... | .... |.... . .|.|.... .. | . |. . .. |. ..|.. ||| .
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFR
------------TDLVDLLQTMIDPDPSQRPSASALVQHPLL
.. |.. ....||..||.| ..||| .
HWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | Wee1a.AA | STE | 167-249 | 19 | 1.1e-08 | 26.92 | In-house | 232-359 (359) | Show / Hide |
Range on Protein: 167-249 Range on HMM: 232-359/359 Sequence Identity: 19% (25 aa) EILQE-----EHTHLTKADIFALALTAYLAAGGESL----PKNGDDWHRIRQ--------------GHFPPLL--------------------HISTDLV |..| .. . ||.|| | .|. | |. . .. .. |. ||| . | .. EVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFK DLLQTMIDPDPSQRPSASALVQ--HPLL | .. . ||..||.|| | . || . DFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | Wee1a.AA | GCN2 | 219-249 | 38 | 1.4e-08 | 25.68 | In-house | 481-511 (511) | Show / Hide |
Range on Protein: 219-249 Range on HMM: 481-511/511 Sequence Identity: 38% (12 aa) STDLVDLLQTMIDPDPSQRPSASALVQHPLL ..| |... ....||..||||. | ||..| HKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL |
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| Kinase | Wee1a.AA | CAMK | 204-249 | 17 | 1.7e-08 | 22.75 | In-house | 356-425 (425) | Show / Hide |
Range on Protein: 204-249 Range on HMM: 356-425/425 Sequence Identity: 17% (12 aa) WHRIRQGHFP-PLLHIST-----------------------DLVDLLQTMIDPDPSQRPSASALVQHPLL ...|..| . | ..|. . ||.. | .||..|.... .|| . FEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | Wee1a.AA | Ciliate-E2 | 216-249 | 23 | 2.5e-08 | 24.68 | In-house | 327-365 (365) | Show / Hide |
Range on Protein: 216-249 Range on HMM: 327-365/365 Sequence Identity: 23% (9 aa) LHISTDLVDLLQT----MIDPDPSQRPS-ASALVQHPLL ...| . ||.. |.. ||..|.. .. . .|| . KKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| TyrKc | Wee1a.AA | TyrKc | 35-249 | 14 | 2.8e-08 | -88.74 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 35-249 Range on HMM: 1-280/280 Sequence Identity: 14% (43 aa) YGFKPQCSTG-----------------VPGQDTPFRQMALNEVYAHAVLG-THIHVVRYYSAWSEA-------GHMIIQNEYCNGGSLADIISSNKQNNH .. . | . |. |.. ..| || | ..|| | . .. . . | ||. .|.| | . ... . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-- RMTEIELKQVLVQIAQGLKYIHSEGLVHMDI--------KPG-----------DLGHV------TSISNPK---VEE--GDVRFLPVEILQEEHTHLTKA . .| . .|||.| |.|| ...| |. ... |... .. .| . .| .. | . ... || -LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKS DIFALALTAY-LAAGGESLP-------KNGDD-WHRIRQGHFPPLLHI---------STDLVDLLQTMIDPDPSQRPSASALVQHPLL |... . . . |.. . .. .. ....||. .| . .... .. .. . ||..||. |.. | .. DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | Wee1a.AA | Pkinase_Tyr | 66-137 | 28 | 2.9e-07 | 25.25 | Pfam | 60-134 (270) | Show / Hide |
Range on Protein: 66-137 Range on HMM: 60-134/270 Sequence Identity: 28% (22 aa) LGTHIHVVRYYSAWS-EAGH---MIIQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVH || | ..||.| . . . .. .|. ||. .|.| | ... .... | .| | .|||.|. | .| ...| LGHHPNIVRLYGVCTDQGEPNQIYIVM-EYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH |
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| Kinase | Wee1a.AA | Ciliate-E2-Unclassified | 224-249 | 34 | 2e-06 | 18.12 | In-house | 327-352 (352) | Show / Hide |
Range on Protein: 224-249 Range on HMM: 327-352/352 Sequence Identity: 34% (9 aa) DLLQTMIDPDPSQRPSASALVQHPLL |||| |.. .|..|.... . .||.. DLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | Wee1a.AA | ULK | 212-249 | 31 | 0.000361 | 10.55 | In-house | 289-329 (329) | Show / Hide |
Range on Protein: 212-249 Range on HMM: 289-329/329 Sequence Identity: 31% (13 aa) FP---PLLHISTDLVDLLQTMIDPDPSQRPSASALVQHPLL || . .|| .. ||.. |. |...| | | .||.. FPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | Wee1a.AA | ULK | 212-249 | 29 | 0.000842 | 9.44 | In-house | 284-324 (324) | Show / Hide |
Range on Protein: 212-249 Range on HMM: 284-324/324 Sequence Identity: 29% (12 aa) FP---PLLHISTDLVDLLQTMIDPDPSQRPSASALVQHPLL || . .|| .. ||.. |. |...| | . .||.. FPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | Wee1a.AA | PEK | 69-81 | 53 | 0.025491 | 3.01 | In-house | 73-85 (655) | Show / Hide |
Range on Protein: 69-81 Range on HMM: 73-85/655 Sequence Identity: 53% (7 aa) HIHVVRYYSAWSE |...|||..|| | HPNIVRYHNAWIE |
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| Kinase | Wee1a.AA | GCN2 | 69-81 | 76 | 0.066367 | 1.95 | In-house | 60-72 (511) | Show / Hide |
Range on Protein: 69-81 Range on HMM: 60-72/511 Sequence Identity: 76% (10 aa) HIHVVRYYSAWSE |.|||||| || | HQHVVRYYQAWIE |
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