Gene Wee1b (Sea Urchin)
Wee1b
Sequence
Protein domains of Wee1b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Wee1b.AA | WEE | 296-498 | 47 | 5.4e-110 | 370.08 | In-house | 1-207 (297) | Show / Hide |
Range on Protein: 296-498 Range on HMM: 1-207/297 Sequence Identity: 47% (106 aa) FVEVGKVGSGEFGSVYKCINRLDGCFYAIKKSKRPIAGSAFEQMALNEVYAHAVLG------THIHVVRYYSAWSEAGHMIIQNEYCNGGS--LADIISS | || |.|.|.||.||||..|.|||.|||||||.|..|. ....||.|||||.||| .|.|.|||||||.|..||.||.||||||| |...|.. FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMYIQMEYCNGGSNLLQFWIQQ NKQNNHRMTEIELKQVLVQIAQGLKYIHSE-GLVHMDIKPGNIFISKK--------EPLPSTTPESEKIDEEEEEGATEDNTPLASLIYKIGDLGHVTSI ....||...|....|.||.|.|||..|||. |.|||||||.||||||| . .. .| . ..||||.||||.. CHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNN----------------DQQNNNDWW-FN-MMCKIGDFGHVTDM S----NPKVE-EGDVRFLPVEILQE . ||..| ||| |... ||||. NSNNNNPHQEQEGDSRYMAPEILQG |
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| Kinase | Wee1b.AA | Pkinase | 296-497 | 26 | 5.1e-43 | 153.18 | Pfam | 1-184 (293) | Show / Hide |
Range on Protein: 296-497 Range on HMM: 1-184/293 Sequence Identity: 26% (57 aa) FVEVGKVGSGEFGSVYKCINRLDGCFYAIKKSKRPIAGSAFEQMALN--EVYAHAVLGTHIHVVRYYSAWSEAGHMIIQNEYCNGG----SLADIIS-SN .. ..|.||| ||.||||... .|. .|.|. |.. . | ..| ... |.. .. | | ..||.| .. . .|. . |||.|| .|.|.|| .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR KQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFISKKEPLPSTTPESEKIDEEEEEGATEDNTPLASLIYKIGDLGH-----VTSISNPKV . . ..| |.| .. ||..||.|.||.| .| |.|| ||.|... ... . ||.| | . | ... HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--------------------------CVKICDFGLAKQFDY-NNS-MTT EEGDVRFLPVEILQ | .... |... FCGTPWYMAPEVIR |
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| Kinase | Wee1b.AA | STE | 296-480 | 22 | 3.6e-30 | 103.8 | In-house | 1-199 (359) | Show / Hide |
Range on Protein: 296-480
Range on HMM: 1-199/359
Sequence Identity: 22% (53 aa)
FVEVGKVGSGEFGSVYKCINRL---------------DGCFYAIKKSKRPIAGS---------------AFEQMALNEVYAHAVLGT-HIHVVRYYSAWS
. ..|.|.| ||.|||..|. |...|||. . . .| |.|. . . | ..|.|| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
EAG-------HMIIQNEYCNGGSLADIISSN----KQNN------HRMTEIELKQVLVQIAQG-LKYIHSEGLVHMDIKPGNIFISKKEPLPSTTPESEK
| . | ||..|||| ||| .. |..| ||. | ... ...|| .| |.|.|| . .| ||||.||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------
IDEEEEEGATEDNTPLASLIYKIGDLGHVTSISN
|. | |. .....
--------------------VKLCDFGVCGQLTD
|
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| Kinase | Wee1b.AA | Ciliate-E2 | 296-481 | 20 | 6.3e-28 | 92.93 | In-house | 1-209 (365) | Show / Hide |
Range on Protein: 296-481
Range on HMM: 1-209/365
Sequence Identity: 20% (49 aa)
FVEVGKVGSGEFGSVYKCINRLDGCFYAIK--------------KSKRPIAGSAFEQMALNEVYA--HAV-----------------LGTHIHVVRYYSA
. . | |.| ||||||| ...... .||| . .| ... .... | . | .....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
WS--EAGHMIIQNEYCNGGSLADIISSNKQNN-------HRMTEIELKQVLVQIAQ---------------GLKYIHSEG-LVHMDIKPGNIFISKKEPL
. .. . |||.||.| |.| .||.. ...|| | |.. ||.| .|.|.||.. .| |||| ||..
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
PSTTPESEKIDEEEEEGATEDNTPLASLIYKIGDLGHVTSISNP
|| |.| . ....
-----------------------------IKIIDFGLSKKYDDD
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| Kinase | Wee1b.AA | CAMK | 301-435 | 18 | 8.1e-26 | 79.56 | In-house | 1-216 (425) | Show / Hide |
Range on Protein: 301-435 Range on HMM: 1-216/425 Sequence Identity: 18% (40 aa) KVGSGEFGSVYKCINRLDG------------CFYAIKK-SKRPIAG------------------------SAF-EQMALNEVYAHAVLGT------HIHV . |.| || |..||..... .||| .|. . . ... ... ..|. . | | .. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VRYYSAWSEAGH-------------------MIIQN---EYCNGG----SLADIISSNKQNN-----------HRMTEIELKQVLVQIAQGLKYIHSEGL .. | .. . . |.. ||| || | | | ..... .|.|| | ... ||.....|.|| . IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VHMDIKPGNIFISKKE || |.|| || ..... VHRDLKPENILLDDNN |
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| Kinase | Wee1b.AA | Ciliate-E2-Unclassified | 296-434 | 21 | 1e-25 | 86.15 | In-house | 1-180 (352) | Show / Hide |
Range on Protein: 296-434 Range on HMM: 1-180/352 Sequence Identity: 21% (39 aa) FVEVGKVGSGEFGSVYKCINRLDGCFY--------AIKKSKRPI-AGSAFEQMALNEVYAH---------AVLGT------HIHVVRYYSAWSEAGHMII . . . |.| ||.||||... .. .| ....... | . . ..|. . . |...|... . ...| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI QNEYCNGGSLADIISS-------------NKQNNHRMTEIELK-----QVLVQIAQGLKYIHSEG-LVHMDIKPGNIFISKK |||.||.| ..|.. |...... || . | . . || |||.|.|... .| |||| ||..... VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNN |
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| Kinase | Wee1b.AA | NEK | 296-473 | 27 | 3.9e-24 | 82.17 | In-house | 1-168 (286) | Show / Hide |
Range on Protein: 296-473 Range on HMM: 1-168/286 Sequence Identity: 27% (54 aa) FVEVGKVGSGEFGSVYKCINRLDGCF-----YAIKKSKRPIAGSAFEQMAL-NEVYAHAVLG--THIHVVRYYSAWSEAG--HMIIQNEYCN-GGSLADI . .. |.|.| ||.|||. . || |..|| . . |.|. ||| .| | ..|.|| .. | . ...| |||. || |.. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEV---RILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQK ---ISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSE-----GLVHMDIKPGNIFISKK--EPLPSTTPESEKIDEEEEEGATEDNTPLASLIYKIGDLG | .|| .. . | . ...|.. .|||.|.. .| |||| |||..|. . . ||||.| IKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY----------------------------HNVKIGDFG |
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| Kinase | Wee1b.AA | ULK | 296-436 | 28 | 1.4e-21 | 73.38 | In-house | 1-164 (324) | Show / Hide |
Range on Protein: 296-436 Range on HMM: 1-164/324 Sequence Identity: 28% (47 aa) FVEVGKVGSGEFG-SVYKCI-NRLD--GCFYAIKKSKRP-IAGSAFE-------QMALNEVYAHAVLG--THIH--VVRYYSA-WSEAG--HMIIQNEYC .. . |.| || ||| . .. . . ..|.|. . . . | |. ||. | | . .|..| .. . ||. ||| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM-EYC NGGSLADIISSNKQ-----NNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFISKKEP ||| | ..| || .. | .| | .|.. ||..|.|..|... .| |||| || |... | NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQP |
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| Kinase | Wee1b.AA | ULK | 374-436 | 40 | 4.4e-20 | 66.87 | In-house | 100-168 (329) | Show / Hide |
Range on Protein: 374-436 Range on HMM: 100-168/329 Sequence Identity: 40% (28 aa) EYCNGGSLADIISSNKQ------NNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFISKKEP |||||| | ..|. || .. | .| | .|.. ||..|.|..|... .| |||| || |... | EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQP |
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| Kinase | Wee1b.AA | PEK | 296-365 | 36 | 4.7e-18 | 58.79 | In-house | 1-85 (655) | Show / Hide |
Range on Protein: 296-365 Range on HMM: 1-85/655 Sequence Identity: 36% (31 aa) FVEVGKVGSGEF-GSVYKCINRLDGCFYAIKKSKRPIAG---------------SAFEQMALNEVYAHAVLGTHIHVVRYYSAWSE | |. ..|.|.| |.|||..|.||||.||||. | .... . .. .| || . | | |...|||..|| | FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARL-NHPNIVRYHNAWIE |
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| Kinase | Wee1b.AA | PEK | 371-473 | 21 | 9.2e-17 | 54.22 | In-house | 360-477 (655) | Show / Hide |
Range on Protein: 371-473 Range on HMM: 360-477/655 Sequence Identity: 21% (31 aa) IQNEYCNGGSLADIISSNK--------------------QNN--------------------HRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIF || |||....| |.|..|. ..| . . .... . ||. ||.|||| |..| |.||.||| IQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIF ISKKE---PLPSTTPESEKIDEEEEEGATEDNTPLASLIYKIGDLG .. .. . .. |||| | LDCDGQHHQ----------------------------MQVKIGDFG |
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| Kinase | Wee1b.AA | GCN2 | 371-431 | 42 | 2.7e-15 | 49.65 | In-house | 284-341 (511) | Show / Hide |
Range on Protein: 371-431 Range on HMM: 284-341/511 Sequence Identity: 42% (26 aa) IQNEYCNGGSLADIISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFI || ||| |..|...|.... .. . ||.... || ||.|||| | .| |.|| |||. IQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFL |
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| Kinase | Wee1b.AA | S_TKc | 296-505 | 19 | 1.1e-13 | 23.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 296-505
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)
FVEVGKVGSGEFGSVYKCINRLDGCFYAIKKSKRPIAGSAFEQMALNEVYAHAVLGTHIHVVRYYSAWSEAGHMIIQNEYCNG--GSLADIISSNKQNNH
. . |.|.| ||.||||... .| .|||. | .....|. . | ..|..| .. . .|. . |||.| |.| |.| ... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
R--MTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFI--------------------------------SK------------------KEPLPSTT
| ..| . . .. ||...|.|.|| | .| |.|| ||.. .| . | |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP---
PESEKIDEEEEEGATEDNTPLASLIYKIGDLGHVTSISNPKVE---------EGDVRFLPVEILQ---EVRSKDAF
.. .. ||| | . . . | |.|| .... |
-------------------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Wee1b.AA | GCN2 | 296-365 | 39 | 1.1e-12 | 40.38 | In-house | 1-72 (511) | Show / Hide |
Range on Protein: 296-365 Range on HMM: 1-72/511 Sequence Identity: 39% (29 aa) FVEVGKVGSGEFGSVYK-CINRLDGCFYAIKKSKRPIAGSAFEQM--ALNEVYAHAVLGTHIHVVRYYSAWSE |.|. .| |.||.|.| .|..||..||||| . .... . . || . | |.|||||| || | FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRL-HHQHVVRYYQAWIE |
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| Kinase | Wee1b.AA | Pkinase_Tyr | 296-421 | 25 | 6.3e-10 | 34.24 | Pfam | 1-134 (270) | Show / Hide |
Range on Protein: 296-421 Range on HMM: 1-134/270 Sequence Identity: 25% (35 aa) FVEVGKVGSGEFGSVYKCINR----LDGCFYAIKKSKRPIAGSA---FEQMALNEVYAHAVLGTHIHVVRYYSAWS-EAGH---MIIQNEYCNGGSLADI . | |.|.||.|||.. . ... |.|. .. | . | . |. || | ..||.| . . . .. .|. ||. .|.| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVM-EYMPHGDLLDY ISSNKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVH ... .... | .| | .|||.|. | .| ...| LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH |
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| Kinase | Wee1b.AA | TyrKc | 296-518 | 14 | 1.5e-09 | -68.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 296-518
Range on HMM: 1-280/280
Sequence Identity: 14% (45 aa)
FVEVGKVGSGEFGSVYKCINRLDGCFYAIKKSKRPIAGSAFEQMALNEVYAHAVLG-THIHVVRYYSAWSEA-------GHMIIQNEYCNGGSLADIISS
. | |.|.|| |||.. . |.|. | ... ..| || | ..|| | . .. . . | ||. .|.| | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK
NKQNNHRMTEIELKQVLVQIAQGLKYIHSEGLVHMDIKPGNIFISKKEPLPSTTPESEKIDEEEEEGATEDNTPLASLIYKIGDLG---HVTSI------
.. . . .| . .|||.| |.|| ...| |. |. .... . ||.| | ...
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------------------TVKISDFGLSRDIYDDDQQGES
-SNPKVEE-GDVR-------------------------------------------------FLPVEILQEVRSK---DAFHS-----------------
. .. | .. . . |... |.. . ..
KDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM
----HI------TMVIILGIM
| |. | ..
KQCWHEDPEDRPTFSEIHECF
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| Kinase | Wee1b.AA | ULK | 296-312 | 41 | 0.041777 | 3.25 | In-house | 1-17 (329) | Show / Hide |
Range on Protein: 296-312 Range on HMM: 1-17/329 Sequence Identity: 41% (7 aa) FVEVGKVGSGEFGSVYK .. . |.| || ||| YCLNHCLGKGSFGKVYK |
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