Gene VPS15 (Sea Urchin)
VPS15
Sequence
Protein domains of VPS15.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | VPS15.AA | VPS15 | 208-318 | 46 | 1.2e-68 | 234.38 | In-house | 162-296 (296) | Show / Hide |
Range on Protein: 208-318 Range on HMM: 162-296/296 Sequence Identity: 46% (63 aa) FVEGSSSRPVDNATSETVEGLQVRQDVKG--------------------GELTPAMDIFSVGCVIAELFTEG-NAPFDLSQLLAYCSGAYSP--DAVLEQ |...|..|....|....|......||... |||||||||||.||||||||.|| ..|||.|||..|.||.|.| ....|. FFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEK IEDEHIKDLCKHMLQKD-PSKRMSAEQYLVKGRGT |.||||..||.||.||| |.||||.|.||.|.||. IQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRGF |
|||||||||
| Kinase | VPS15.AA | VPS15 | 26-138 | 56 | 7.2e-65 | 221.83 | In-house | 1-115 (296) | Show / Hide |
Range on Protein: 26-138 Range on HMM: 1-115/296 Sequence Identity: 56% (65 aa) YEFDHSLGSTRFFKVARAKYKEGLAVVKVFVIHDPSLPLRSFKEKIEDIKTRLSNGS--NCLPFLRSTLSDKAALLFRQYVRNNLYDRISTRPFLISIEK ... .||||||.||..|| .||. ||||||.||. ..|...|..||.|| |. . ||.|. . ..|||| ..||||..|||||||||||| .||| CHYVKNLGSTRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIEK KWIAFQLLCALNQAH ||||||.||||.|.| KWIAFQTLCALEQCH |
|||||||||
| Kinase | VPS15.AA | VPS15 | 142-169 | 89 | 9e-18 | 58.14 | In-house | 154-181 (296) | Show / Hide |
Range on Protein: 142-169 Range on HMM: 154-181/296 Sequence Identity: 89% (25 aa) DNPADFSFFFDTSRRRTCYIAPERFVEG ||||||.|||||||||||||||||||.. DNPADFTFFFDTSRRRTCYIAPERFVSN |
|||||||||
| Kinase | VPS15.AA | VPS15 | 170-207 | 31 | 2.3e-12 | 39.19 | In-house | 166-223 (296) | Show / Hide |
Range on Protein: 170-207 Range on HMM: 166-223/296 Sequence Identity: 31% (18 aa) SSSRPVDSATSETVEGLQVRQDVKG--------------------GELTPAMDIFSVG |..|... |....|......||... |||||||||||.| SRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDSIDRQQNPWLFGELTPAMDIFSAG |
|||||||||
| Kinase | VPS15.AA | S_TKc | 26-324 | 14 | 2.5e-09 | -40.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-324
Range on HMM: 1-231/231
Sequence Identity: 14% (47 aa)
YEFDHSLGSTRFFKVARAKYKE--GLAVVKVFVIHDPSLPLRSFKEKIEDIKTRLSNGSNCLPFLRSTLSDKAALLFRQYVRN---NLYDRISTRPF---
||. .|. | || ... |. . .|. .... |. | . | .. . . . .. |. . .|.|.| |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
---LISIEKKWIAFQLLCALNQAH--------------LVGDNPA-----DFSFFFDTSRRRTC----YIAPERFVEGSSSRPVDSATSETVEGLQVRQD
. . . .. |..|||. | |. . .. .. . | |.||| .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL-------------------------
VKGGELTPAMDIFSVGFVEGSSSRPVDNATSETVEGLQVRQDVKGGELTP-AMDIFSVGCVIAELFTEGNAPFDLSQLLAYCSGAYSPDAVLEQIEDEHI
.. . |. |.||...|... | ||. . . . ..
----------------------------------------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG-----------SPEA
KDLCKHMLQKDPSKRMSAEQYLVKGRGTAFPEFF
||. ...|||||.||..| . | .. . ..|
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | VPS15.AA | Ciliate-E2 | 240-310 | 23 | 3.9e-08 | 23.99 | In-house | 274-358 (365) | Show / Hide |
Range on Protein: 240-310 Range on HMM: 274-358/365 Sequence Identity: 23% (24 aa) TPAMDIFSVGCVIAELFTEGNAPFDLSQLLAYCSGAYSPDAVLEQIEDEHIK----------------------------DLCKH----MLQKDPSKRMS . . ||.|.|... |. . |. || ..||.. |. ||.| ||||||.||.. DYKCDIWSLGVILYEMLF-GKPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT -AEQ .|| GWEQ |
|||||||||
| Kinase | VPS15.AA | KIS | 289-324 | 36 | 7.5e-07 | 16.24 | In-house | 445-473 (473) | Show / Hide |
Range on Protein: 289-324 Range on HMM: 445-473/473 Sequence Identity: 36% (13 aa) HIKDLCKHMLQKDPSKRMSAEQYLVKGRGTAFPEFF | .|| | ||. |...| .|| | || HLRDLIKSMLHCDIARRIPAEMILCHP-------FF |
|||||||||
| Kinase | VPS15.AA | IRE | 239-310 | 30 | 9e-07 | 19.05 | In-house | 209-285 (292) | Show / Hide |
Range on Protein: 239-310 Range on HMM: 209-285/292 Sequence Identity: 30% (25 aa) LTPAMDIFSVGCVIAELFTEGNAPFD---LSQLLAYCSGAYSPDAVLEQIE-DEHIK-----DLCKHMLQKDPSKRMSAEQ .| . |||| |||. ..|.|. || |. .|.|. |.|.. . |.. || . |...||.|| .... KTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYN----LDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKE |
|||||||||
| Kinase | VPS15.AA | Pkinase | 240-310 | 25 | 2e-06 | 23.75 | Pfam | 190-286 (293) | Show / Hide |
Range on Protein: 240-310 Range on HMM: 190-286/293 Sequence Identity: 25% (25 aa) TPAMDIFSVGCVIAELFTEGNAPFD-L------SQLLAYCSGAYSPDAVLEQIED--------------------EHIKDLCKHMLQKDPSKRMSAEQ .|. |..|.||...|... |. ||. .|. .| . | .. .. | ||..| .|.|||.|| .||| GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ |
|||||||||
| Kinase | VPS15.AA | CAMK1 | 291-312 | 59 | 3e-06 | 14.21 | In-house | 250-271 (276) | Show / Hide |
Range on Protein: 291-312 Range on HMM: 250-271/276 Sequence Identity: 59% (13 aa) KDLCKHMLQKDPSKRMSAEQYL ||. |||| .||.|| ..|| | KDFIKHMLEVDPKKRYTCEQCL |
|||||||||
| Kinase | VPS15.AA | CDPK | 291-310 | 65 | 7e-06 | 14.31 | In-house | 245-264 (271) | Show / Hide |
Range on Protein: 291-310 Range on HMM: 245-264/271 Sequence Identity: 65% (13 aa) KDLCKHMLQKDPSKRMSAEQ ||| . ||..|| |||||.| KDLIRKMLCYDPKKRMSAQQ |
|||||||||
| Kinase | VPS15.AA | Ciliate-E2a | 291-310 | 65 | 1.2e-05 | 12.6 | In-house | 249-268 (275) | Show / Hide |
Range on Protein: 291-310 Range on HMM: 249-268/275 Sequence Identity: 65% (13 aa) KDLCKHMLQKDPSKRMSAEQ ||| | ||.|||.|| .|.| KDLMKKMLEKDPKKRITAQQ |
|||||||||
| Kinase | VPS15.AA | CMGC | 240-257 | 50 | 2.4e-05 | 12.54 | In-house | 313-330 (513) | Show / Hide |
Range on Protein: 240-257 Range on HMM: 313-330/513 Sequence Identity: 50% (9 aa) TPAMDIFSVGCVIAELFT |...|. ||||..||..| TTPIDMWSVGCIFAEMYT |
|||||||||
| Kinase | VPS15.AA | CDK8 | 240-257 | 55 | 0.000192 | 9.26 | In-house | 203-220 (329) | Show / Hide |
Range on Protein: 240-257 Range on HMM: 203-220/329 Sequence Identity: 55% (10 aa) TPAMDIFSVGCVIAELFT |.| || ..||. ||| | TKAIDIWAIGCIFAELIT |
|||||||||
| Kinase | VPS15.AA | RCK | 243-255 | 61 | 0.00033 | 8.93 | In-house | 195-207 (298) | Show / Hide |
Range on Protein: 243-255 Range on HMM: 195-207/298 Sequence Identity: 61% (8 aa) MDIFSVGCVIAEL |||..|||...|| MDIWAVGCIMYEL |
|||||||||
| Kinase | VPS15.AA | CMGC | 283-310 | 50 | 0.000362 | 8.57 | In-house | 479-506 (513) | Show / Hide |
Range on Protein: 283-310 Range on HMM: 479-506/513 Sequence Identity: 50% (14 aa) EQIEDEHIKDLCKHMLQKDPSKRMSAEQ . .|. || | ||| ||.||..||| RKCCDPQAIDLLKKMLQYDPDKRITAEQ |
|||||||||
| Kinase | VPS15.AA | RCK | 292-312 | 52 | 0.000794 | 7.7 | In-house | 273-293 (298) | Show / Hide |
Range on Protein: 292-312 Range on HMM: 273-293/298 Sequence Identity: 52% (11 aa) DLCKHMLQKDPSKRMSAEQYL .|.. ||| ||.|| .|.| | ELMEKMLQWDPQKRITAQQAL |
|||||||||
| Kinase | VPS15.AA | CDK8 | 286-310 | 44 | 0.001367 | 6.54 | In-house | 298-322 (329) | Show / Hide |
Range on Protein: 286-310 Range on HMM: 298-322/329 Sequence Identity: 44% (11 aa) EDEHIKDLCKHMLQKDPSKRMSAEQ .| | .| .|| ||.||...|| RDSHAYHLLYKMLTMDPTKRITCEQ |
|||||||||
| Kinase | VPS15.AA | KIS | 238-257 | 50 | 0.011938 | 2.79 | In-house | 370-389 (473) | Show / Hide |
Range on Protein: 238-257 Range on HMM: 370-389/473 Sequence Identity: 50% (10 aa) ELTPAMDIFSVGCVIAELFT | | | || | ||.| . .| ECTHAVDIWSLGCIIVRMYT |
|||||||||
| HEAT | VPS15.AA | HEAT | 422-452 | 29 | 0.000291 | 18.62 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 422-452 Range on HMM: 1-31/31 Sequence Identity: 29% (9 aa) IIPCILHFVHDPFPRVRAEAIRTITQTLMLV |.|..|. .|| ..||. |.....| . . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | VPS15.AA | HEAT | 467-497 | 32 | 0.006416 | 13.97 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 467-497 Range on HMM: 1-31/31 Sequence Identity: 32% (10 aa) ILPNLSNIAQDPIDMVRMVYAENIAVLAETA ||| | . .|| . ||. .. ...|.| . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | VPS15.AA | HEAT | 580-611 | 25 | 0.770039 | 6.77 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 580-611 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) LLSHMITFLNDKEDWHLRGSFFDSIVGVAAYV .|.|... |||. ||. | . . ... .. .. ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | VPS15.AA | HEAT | 619-649 | 22 | 0.102681 | 9.8 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 619-649 Range on HMM: 1-31/31 Sequence Identity: 22% (7 aa) LKPLLQQGLTDHEEQVICKALKSVTGLVQLG . |.| ..|.| ...| . |..... |.. ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| HEAT | VPS15.AA | HEAT | 659-689 | 12 | 1.979582 | 5.35 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 659-689 Range on HMM: 1-31/31 Sequence Identity: 12% (4 aa) MAYELVPYVCHPNLWIRQATVGFIAAIARSL . |. ..|. .|.|.. ...... . ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
|||||||||
| WD40 | VPS15.AA | WD40 | 1080-1118 | 22 | 1.8e-11 | 35.6 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1080-1118 Range on HMM: 1-39/39 Sequence Identity: 22% (9 aa) GLLIAHLHEHKGAVNRLQVSYD-HTLFSTCSDDGTVKVWD . ... . .|...|. . .. | ... ..|.|||...|| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1079-1118 | 20 | 2.7e-10 | 41.44 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1079-1118 Range on HMM: 1-46/46 Sequence Identity: 20% (10 aa) RGLLIAHLHEHKG--AVNRLQVSYDH------TLFSTCSDDGTVKVWD ... .. |.| .|. .... |. ... ..| |||...|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1128-1167 | 22 | 0.000217 | 21.83 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1128-1167 Range on HMM: 1-46/46 Sequence Identity: 22% (11 aa) TNKSRQTYNRQPG--KIKTLTFCQSS------HSIASGSDDGSIHVNR | | .|.. | . ........ . .|||| ||.|.. T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1129-1167 | 25 | 0.000436 | 14.38 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1129-1167 Range on HMM: 1-39/39 Sequence Identity: 25% (10 aa) NKSRQTYNRQPGKIKTLTFCQS-SHSIASGSDDGSIHVNR | .|. ... . .... .| .||||.||.|.. WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1224-1265 | 16 | 0.108865 | 6.44 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1224-1265 Range on HMM: 1-46/46 Sequence Identity: 16% (8 aa) EAFRLRNQQRHGA--LVRRVRLHPSQ-----QSLVISAVQGNNEVSMWD . .. . | . |. |. ||. ....|. .. . .|| T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS--DGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1225-1265 | 17 | 6.350908 | 2.4 | Pfam | 1-39 (39) | Show / Hide |
Range on Protein: 1225-1265 Range on HMM: 1-39/39 Sequence Identity: 17% (7 aa) AFRLRNQQRHGALVRRVRLHPSQQSLVISAVQGNNEVSMWD .. | . |. .. ||.......|. . . .|| WKCKHTF-GHTHWVTCCAWHPDMGHYLASGS-RDGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1280-1318 | 12 | 0.084639 | 7.13 | SMART | 1-46 (46) | Show / Hide |
Range on Protein: 1280-1318 Range on HMM: 1-46/46 Sequence Identity: 12% (6 aa) HPPLSQTQH------AIHALYCIPSM---EQTPCFLTAGSDQRIRYWN . .| . ..... |. .. ...... | || |. T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD |
|||||||||
| WD40 | VPS15.AA | WD40 | 1287-1318 | 18 | 0.192451 | 6.77 | Pfam | 10-39 (39) | Show / Hide |
Range on Protein: 1287-1318 Range on HMM: 10-39/39 Sequence Identity: 18% (6 aa) QHAIHALYCIPSMEQTPCFLTAGSDQRIRYWN .|.. .. . |. . ....... | || |. THWVTCCAWHPD--MGHYLASGSRDGTIRIWD |
|||||||||