Gene Spk366 (Sea Urchin)
Spk366
Sequence
Protein domains of Spk366.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk366.AA | urch | 110-314 | 37 | 2.4e-79 | 269.89 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 110-314 Range on HMM: 1-217/217 Sequence Identity: 37% (82 aa) IGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHAL--------PCLIQHEAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSR ||.|.|| |. |.|.| ||.|.| .. . ... .. .. || . .| |...||.||| .... . |.|||.|| |||.. . .. IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW ALVY-----HDLVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDR-GKLFSFPDEEKTLYMMGDDYLHIAP .. . . |.||..|..|||...|....||||||.||..|...... || |.|||||...|... |...|||||.. ||.|..| |||| CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHG-RWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAP EIVLGGAPTSKATDVFSLG |.||.|.|.|.|.||.|.| ECVLDGQPCSIASDVYSVG |
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| Kinase | Spk366.AA | urch-unclassified | 167-314 | 44 | 3.3e-79 | 269.46 | In-house | 65-215 (215) | Show / Hide |
Range on Protein: 167-314 Range on HMM: 65-215/215 Sequence Identity: 44% (69 aa) FPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSRALVYHD-----LVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIID ||| || . . ..||| || .|... . .... | . . ||||..|.||||...|....|||||||.||.|..|....||.|.||| FPRCYGMVKHE-DCPCIVMEFLGDKQTYTVYPLCQWIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIID FGMISTFDR-GKLFSFPDEEKTLYMMGDDYLHIAPEIVLGGAPTSKATDVFSLG ||||||... .|...|.|.|...||||..|.|.||||||.|.|||...|..||| FGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk366.AA | urchA | 110-311 | 29 | 4.3e-44 | 140.18 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 110-311 Range on HMM: 1-208/208 Sequence Identity: 29% (61 aa) IGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRT----CSVSRALVY | | || | | |.| .|.|.| . . . . . ..| |. . . ....|| ||| ... .||||.|| ||. ..|. LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM HDLVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDRGK---LFSFPDEEKTLYMMGDDYLHIAPEIVLGGA . . | |. .|. | .|.. | |||| ||. . . || ||||||| . .. . | ..| | . . ||||| .| . RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFG-RWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQ PTSKATDVF | | . ||. PCSTSSDVY |
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| Kinase | Spk366.AA | urchC | 154-317 | 31 | 1.8e-25 | 79.3 | In-house | 57-223 (223) | Show / Hide |
Range on Protein: 154-317 Range on HMM: 57-223/223 Sequence Identity: 31% (55 aa) EAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSRALV---YHDLVEGEETW--INITIDVCHGMNELHSRKRLHNDLKSDNIMLFR || . | .. .|||.|| . . .|. . ||.|| ..|.. |. | . | . | |. | .|.. |||| | ||. | EARVGQMMSTCPYFPRMYGTVMIDENMC-IVTEFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEH CPRRLRWAAKIIDFGMIST--FD---RGKLFSFPDEEKTLYMMGDDYLHIAPEIVL-GGAPTSKATDVFSLGYLM | || . ||| ||.|| . ||. . || | . . |||||.. | .|.|.|..| | .. --RKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQK-----LYGFIHIAPEVLDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk366.AA | urchB | 216-314 | 45 | 9.3e-21 | 71.35 | In-house | 115-212 (212) | Show / Hide |
Range on Protein: 216-314 Range on HMM: 115-212/212 Sequence Identity: 45% (45 aa) INITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDR-GKLFSFPDEEKTLYMMGDDYLHIAPEIVLGGAPTSKATDVFSLG . | |. || |.| |||||| ||..| . | |. | ||||||.|| |. | | | | |. ||||..| | .|| . |||| | VDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEK--RGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG |
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| Kinase | Spk366.AA | Ciliate-E2 | 222-314 | 21 | 2.8e-12 | 38.44 | In-house | 169-283 (365) | Show / Hide |
Range on Protein: 222-314 Range on HMM: 169-283/365 Sequence Identity: 21% (28 aa) VCHGMNELHSRK-RLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFD------------RGKLFSFPDEEKTLYMMGDDYL---------------HI .......|||.. .| |.| .||.. ||||||. .| ..| . |...| |. . IILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD---QIIQQNMFNTICGTPGYM APEIVLG--------GAPTSKATDVFSLG ||||. | . . ... |..||| APEILNGKKYDNQQKQKGYDYKCDIWSLG |
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| Kinase | Spk366.AA | TKL | 205-314 | 20 | 4.4e-10 | 32.51 | In-house | 126-276 (364) | Show / Hide |
Range on Protein: 205-314 Range on HMM: 126-276/364 Sequence Identity: 20% (32 aa) YHDLVEGEETWINITIDVCHGMNELHSRK--------RLHNDLKSDNIMLFRC---------PRRLRWAAKIIDFGMISTFDRGKLFSFP---------- .|.| . ... .|.. ||| |||.. .| ||||.||.... .. | .|| ||| .... . . LHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEH -DEEKTLYMMGDDYLHIAPEIVLGGAPTSKAT---------------DVFSLG . .||... . . . |||. | ..... ||.| | QNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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| Kinase | Spk366.AA | S_TKc | 104-354 | 17 | 6.2e-10 | -31.21 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 104-354
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)
KIESLFIGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAHELAAMVGSDFFPRFYGLIRLSRNHFKLAMEFVGDQKTGRTCSVSRAL
|| |..|.| | .|| . |.| . |. | | . .. ..|. .. .|. . ||... | . .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCD----GDLGDLFDYI
VYHDLV-----EGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGMISTFDRGKLFSFPDEEKTLYMMGDDYLH----IA
. . | . .. .| ... .||.. .| ||| .||.| . ||.|||. . . . .|
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------------TTFCGTPWYMA
PEIVLGGAPTSK-ATDVFSLG----------------YLMRDIAQRKAVVSLDFISRLCLNVEAMHRPAMDVVKK---------YV
||.. . .| . |. |.| ..| .. .|||.. ||... .|| . . ..
PEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRK-CLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Spk366.AA | STE | 218-263 | 31 | 1.3e-09 | 30.27 | In-house | 156-192 (359) | Show / Hide |
Range on Protein: 218-263 Range on HMM: 156-192/359 Sequence Identity: 31% (15 aa) ITIDVCHG-MNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFG |. ....| .. ||| .. | |.|..||.| .|..||| ICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFG |
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| Kinase | Spk366.AA | urchB | 105-194 | 33 | 4e-07 | 21.93 | In-house | 1-98 (212) | Show / Hide |
Range on Protein: 105-194 Range on HMM: 1-98/212 Sequence Identity: 33% (34 aa) IESLF-IGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAH-------ELAAMV-----GSDFFPRFYGLIRLSRNHFKLAMEFVGDQ | | || |.|| | . | | | | |.| . | ..| |.| ||. .| .||.|.| . | .| |||| . INDLQEIGRGTYGRVVIARHRQTKVPLAIKQ----PCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDID-NDLCQAQEFVGCK KTG ||| KTG |
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| Kinase | Spk366.AA | RAF | 216-246 | 51 | 7e-07 | 18.02 | In-house | 106-136 (282) | Show / Hide |
Range on Protein: 216-246 Range on HMM: 106-136/282 Sequence Identity: 51% (16 aa) INITIDVCHGMNELHSRKRLHNDLKSDNIML |.| || ||. ||... .| |||| ||.| IDISRQVCQGMDYLHAKNIIHRDLKSNNIFL |
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| Kinase | Spk366.AA | CAMK | 222-314 | 20 | 7.5e-07 | 17.34 | In-house | 188-321 (425) | Show / Hide |
Range on Protein: 222-314 Range on HMM: 188-321/425 Sequence Identity: 20% (28 aa) VCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLR------------WAAKIIDFGMISTFDRGKL---------------FSFPDEEKTLYMMGDDYLHIA .| ... .||.. | ||| .||.| . . ||||||. ||.|. .. |.| . .. . .| ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA -PEIVLG-------------GAPTSKATDVFSLG ||...| . ....|. |.| APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG |
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| Kinase | Spk366.AA | urch-unclassified | 110-133 | 37 | 4e-06 | 18.25 | In-house | 1-24 (215) | Show / Hide |
Range on Protein: 110-133 Range on HMM: 1-24/215 Sequence Identity: 37% (9 aa) IGNGSYGQVNVLRYRKTLQPIAVK || |..| |. |. ...| .|| IGKGTFGKVFMMRHQREAVPVKVK |
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| Kinase | Spk366.AA | TyrKc | 104-354 | 15 | 5.4e-05 | -141.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 104-354
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)
KIESLFIGNGSYGQVNVLRYRKTLQPIAVKNFVFGSGISSSHALPCLIQHEAHELAAM-------VGSDFFPRFYGLIRLSR------NHFKLAMEFVGD
.|.| .|.| ... .. ||| .. . .|| . | |.|| .. . . ||..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIV------RLYGVCTQQGRNFMYIEPLMIVMEYMPH
-------QKTGRTCSVSRALVYHDLVEGEETWINITIDVCHGMNELHSRKRLHNDLKSDNIMLFRCPRRLRWAAKIIDFGM-ISTFDR---GKLFSFPDE
.|.... .. ... .... ||. |||.. | || |... . .|| |||. | | |
GDLKDYLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-------E
EKTLYMM----GDDY-LHI---APEIVLGGAPTSKATDVFS----------------LG-----YLMRDIAQRKAVV-SLDFISR---------------
.| |.. | .. | | ||| | . ..||.| | ... .. ..
SKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ
---LCLNVEAMHRPAMDVVKKYV
| . .. || . ....
IMKQCWHEDPEDRPTFSEIHECF
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| Kinase | Spk366.AA | urchC | 104-118 | 46 | 0.011952 | 4.15 | In-house | 1-15 (223) | Show / Hide |
Range on Protein: 104-118 Range on HMM: 1-15/223 Sequence Identity: 46% (7 aa) KIESLFIGNGSYGQV . . .||.||||.| QTILEMIGKGSYGEV |
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| Kinase | Spk366.AA | TKL | 110-133 | 31 | 0.033537 | 3.74 | In-house | 1-32 (364) | Show / Hide |
Range on Protein: 110-133 Range on HMM: 1-32/364 Sequence Identity: 31% (10 aa) IGNGSYGQVNVLRYRK--------TLQPIAVK || |..|.| ..| | ...||| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVK |
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| Kinase | Spk366.AA | CAMK | 109-133 | 24 | 0.03929 | 1.86 | In-house | 1-37 (425) | Show / Hide |
Range on Protein: 109-133 Range on HMM: 1-37/425 Sequence Identity: 24% (9 aa) FIGNGSYGQVNVLRYRKTL------------QPIAVK .| ||.|.| . ..| | |.| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK |
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| Kinase | Spk366.AA | STE | 105-133 | 22 | 0.082156 | 2.33 | In-house | 1-45 (359) | Show / Hide |
Range on Protein: 105-133 Range on HMM: 1-45/359 Sequence Identity: 22% (10 aa) IES-LFIGNGSYGQVNVLRYRK---------------TLQPIAVK | .||.|..|.| ...| | . .|.| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIK |
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