Gene Spk375 (Sea Urchin)
Spk375
Sequence
Protein domains of Spk375.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk375.AA | urch-unclassified | 410-621 | 54 | 9.5e-140 | 470.57 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 410-621 Range on HMM: 1-215/215 Sequence Identity: 54% (117 aa) IGKGSFGKVFLREFQGEAVAVKVPYISEAVRDEDDEMRMVRIKADHARITMEALVNLAFADHPSFPKTLGIVDVEGTPSLVLEFLGDKETGTIYSLSQAI ||||.|||||....|.|||.|||..|.|...|.|.||||......|.||..||.|...|||||.||...|.|..|..|..|.||||||.|.|.|.|.|.| IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQWI KFQI---PALSKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANNILLQWQLEDQRWHAFIIDMGKVSTQTIPLRHKQVPKEEITGYKDGILFPHLAPEYIL .... |||||.||..|.|||.||..||||..|||||||.|||||||...||||||.|||.| .|| | |. . . .| ..| | . |.|||..| HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVL DLQPMSVQTDIYSLG . || ||..|||||| YGQPTSVYSDIYSLG |
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| Kinase | Spk375.AA | urch | 410-621 | 42 | 5.4e-113 | 381.69 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 410-621 Range on HMM: 1-217/217 Sequence Identity: 42% (93 aa) IGKGSFGKVFLREFQGEAVAVKVPYISEAVRDED-DEMRMVRIKADHARITMEALVNLAFADHPSFPKTLGIVDVEGTPSLVLEFLGDKETGTIYSLSQA ||.|..|.|.|.........|........ ...| .||.|...||.|.|.|.||.|......||.|||..|.||......||.||.|||.||..|.|... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC IKF-----QIPALSKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANNILLQWQLEDQRWHAFIIDMGKVSTQTIPLRHKQVPKEEITGYKDGILFPHLAPE |.. ..|.|||..|..|..|||||..|||..|.||||||..|.||... .. ||||.|||.| |.| | |.. .|.||.. |. | ..|.||| IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHG-RWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE YILDLQPMSVQTDIYSLG ..|| || |...|.||.| CVLDGQPCSIASDVYSVG |
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| Kinase | Spk375.AA | urchC | 408-624 | 37 | 1.8e-41 | 131.95 | In-house | 5-223 (223) | Show / Hide |
Range on Protein: 408-624 Range on HMM: 5-223/223 Sequence Identity: 37% (85 aa) DLIGKGSFGKVFLREFQGE--AVAVKVPYISEAVRDEDDEMRMVRIKADHARITMEALVNLAFADHPSFPKTLGIVDVEGTPSLVLEFLGDKETGTIYSL . |||||.|.| | || ||.| ||. | | |. |.. ||.| . | ||. .| | ... .| || ||| .| | | EMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEW---KQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYML SQAIK---FQIPALSKEHWFL--IMMDIVHGLKAMHEKGLLHNDLKANNILLQWQLEDQRWHAFIIDMGKVSTQTIPLRHKQVPKEEITGYKDGILFPHL |.. | . | . | ||. | .|| |||||| |. |.|| . | |||. ||||| ||| . | | . . . . |.| HDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKE--RWHGCIIDMGMVSTMAYP-PHQRGFNDVMPDHQKLYGFIHI APEYILD--LQPMSVQTDIYSLGKIL ||| .|| .|| .|||| | || APE-VLDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk375.AA | urchA | 474-618 | 36 | 3.1e-29 | 91.5 | In-house | 58-208 (208) | Show / Hide |
Range on Protein: 474-618 Range on HMM: 58-208/208 Sequence Identity: 36% (56 aa) FPKTLGIVDV-EGTPSLVLEFLGDKETGTI----YSLSQAIKFQIPALSKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANNILLQWQLEDQRWHAFIIDM ||. .| .. |. . || || .|| |. |. |||... |...|.|| |||.||||| | |||| |.|. | || | |||. FPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVR-KTEFGRWRAKIIDF GKVSTQTIPL---RHKQVPKEEITGYKDGILFPHLAPEYILDLQPMSVQTDIY | . | | . .... |. . . | ||| .|| || | |.| GWACPCQMPFPACRMH-FDQRQKQFYRYCHRCCHIAPECALDAQPCSTSSDVY |
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| Kinase | Spk375.AA | urchB | 451-621 | 40 | 2.9e-27 | 94.9 | In-house | 48-212 (212) | Show / Hide |
Range on Protein: 451-621 Range on HMM: 48-212/212 Sequence Identity: 40% (69 aa) IK-ADHARITMEALVNLAFADHPSFPKTLGIVDVEGTPSLVLEFLGDKETGTIYSLSQAIKFQIPALSKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANN .. | .|.| ||.. | | ||| .| |.. . || | | ||. | | | || | ||| |. .| |||||||| | LHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGYPL-----HEPPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDN ILLQWQLEDQRWHAFIIDMGKVSTQTIPLRHKQVPKEEITGYKDGILFPHLAPEYILDLQPMSVQTDIYSLG .|| .|.|| ||| | ||| | ||. |||| | | ||| ||. |. |. |..| | VLLEKR--GHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG |
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| Kinase | Spk375.AA | S_TKc | 404-666 | 17 | 7.7e-10 | -32.65 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 404-666
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)
DEDDDLIGKGSFGKVFLREFQG--EAVAVKVPYISEAVRDEDDEMRMVRIKADHARITMEALVNLAFADHPSFPKTLGIVDVEGTPSLVLEFLGDKET--
| ..||||.||||.. . . ||.|. .| | . .|| | ... . . .|.|.. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYC---DGDL
GTIYSLSQAIKFQIPA--LSKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANNILLQWQLEDQRWHAFIIDMGKVSTQTIPLRHKQVPKEEITGYKDGILF
|. ... . . . . .. | .| |. .|. .|..| .| ||| |||| | |.| | ...| . .
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFG-LARQL-----------------TTFCG
PH--LAPEYILDLQPMSV-QTDIYSLG-----------------KILARIERGIRSRPLRDLAAEMTNVKPRLRPSWKHIEK----VIAKARK
.||| . . . |..|.| ... .| |....|. . .. |. ||. . . . .
TPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Spk375.AA | Ciliate-E2 | 528-624 | 21 | 2.1e-09 | 28.39 | In-house | 169-286 (365) | Show / Hide |
Range on Protein: 528-624 Range on HMM: 169-286/365 Sequence Identity: 21% (28 aa) IVHGLKAMHEKG-LLHNDLKANNILLQWQLEDQRWHAFIIDMG---KVSTQTI---------PLRHKQVPKEEITGYKDGILF--------------PHL |...|. .|.|. .| |.| .|||. .|||.| |.... . . .. .. .|| | . . . IILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD---QIIQQNMFNTICGTPGYM APEYILDLQP--------MSVQTDIYSLGKIL ||| . . . . ||.||| || APEILNGKKYDNQQKQKGYDYKCDIWSLGVIL |
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| Kinase | Spk375.AA | Pkinase | 405-552 | 22 | 2.8e-07 | 26.84 | Pfam | 2-141 (293) | Show / Hide |
Range on Protein: 405-552 Range on HMM: 2-141/293 Sequence Identity: 22% (35 aa) EDDDLIGKGSFGKVFLREFQGEA--VAVKVPYISEAVRDEDDEMRMVRIKADHARITMEALVNLAFADHPSFPKTLGIVDVEGTPSLVLEFLGDKETGTI . ||.||||.|.. .|. ||||. |. .... ... .|. .|. . . . .|| ...... .. . .|.|... .. HIGRKIGSGSFGCVYKCHHKGTGKIVAVKI--IKKRHEKSWKDQTHRRL--------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--V YSLSQAIK-FQIPAL--SKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANNILL .|. |. . .. | .. .| |. ||. .|..| .| ||| |||. MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI |
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| Kinase | Spk375.AA | TKL | 410-458 | 18 | 6e-06 | 17.55 | In-house | 1-87 (364) | Show / Hide |
Range on Protein: 410-458 Range on HMM: 1-87/364 Sequence Identity: 18% (16 aa) IGKGSFGKVFLREFQG----------EAVAVKVPYI----------------------------SEAVRDEDDEMRMVRIKADHARI ||.|.||.|. ...| . ||||. . .. |.. | |. .. .| | IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNI |
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| Kinase | Spk375.AA | ULK | 524-552 | 34 | 6e-06 | 16.73 | In-house | 135-163 (329) | Show / Hide |
Range on Protein: 524-552 Range on HMM: 135-163/329 Sequence Identity: 34% (10 aa) IMMDIVHGLKAMHEKGLLHNDLKANNILL ....|. |.|..|... | |.| |||. FFKQILNGFKELHKHNIIHRDIKPQNILI |
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| Kinase | Spk375.AA | ULK | 524-552 | 34 | 1e-05 | 16.4 | In-house | 131-159 (324) | Show / Hide |
Range on Protein: 524-552 Range on HMM: 131-159/324 Sequence Identity: 34% (10 aa) IMMDIVHGLKAMHEKGLLHNDLKANNILL ....|. |.|..|... | |.| |||. FFKQICNGFKELHKHNIIHRDIKPQNILI |
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| Kinase | Spk375.AA | TyrKc | 404-661 | 16 | 1.1e-05 | -130.54 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 404-661 Range on HMM: 1-280/280 Sequence Identity: 16% (52 aa) DEDDDLIGKGSFGKVFLREFQGEAVAVKVPYISEAVRDEDDEMRMVRIKADHARITMEALVNLAF-ADHPSFPKTLGIVDVE-------GTPSLVLEFLG . .. .| | ||.|.. . . ||||. . .. . || . . .|| . .|.. . . . .|.|. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM- DKETGTIYSLSQAIKFQIPALSKEHWFLIMMDIVHGLKAMHEKGLLHNDLKANNILLQWQLEDQRWHAFIIDMGKVS----TQTIPLR-HKQVPKEEITG . | .| . .. | |. .. .. .| | |.|.. | || | |.|. .. |.| . | .. . |. .. --PHG---DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDYYRK --YKDGI-LFP--HLAPEYILDLQPMSVQTDIYS----------------LG---------KILARIERGIRSRPLRD--------LAAEMTNV------ |.| ..| .||| | . . ..|..| | .......| | .. . .|| .. KEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH -KPRLRPSWKHIEKVI .| ||. . | . . EDPEDRPTFSEIHECF |
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| Kinase | Spk375.AA | ULK | 405-432 | 32 | 1.5e-05 | 15.76 | In-house | 2-35 (324) | Show / Hide |
Range on Protein: 405-432 Range on HMM: 2-35/324 Sequence Identity: 32% (11 aa) EDDDLIGKGSFG-KVFLR---EFQ--GEAVAVKV . .. .|||||| ||. . . ...||.|. CLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKM |
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| Kinase | Spk375.AA | ULK | 405-432 | 35 | 2.4e-05 | 14.69 | In-house | 2-35 (329) | Show / Hide |
Range on Protein: 405-432 Range on HMM: 2-35/329 Sequence Identity: 35% (12 aa) EDDDLIGKGSFGKVFLRE---FQ---GEAVAVKV . .. .||||||||. . . .|.||.|. CLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKM |
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| Kinase | Spk375.AA | LISK | 409-431 | 44 | 7.9e-05 | 11.4 | In-house | 1-25 (296) | Show / Hide |
Range on Protein: 409-431 Range on HMM: 1-25/296 Sequence Identity: 44% (11 aa) LIGKGSFGKVFLREFQ--GEAVAVK ||||.||||. . |. .|.| EIGKGFFGKVYKGTHRQTGQVMAIK |
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| Kinase | Spk375.AA | TKL | 524-621 | 18 | 0.000167 | 12.15 | In-house | 137-276 (364) | Show / Hide |
Range on Protein: 524-621 Range on HMM: 137-276/364 Sequence Identity: 18% (26 aa) IMMDIVHGLKAMHE--------KGLLHNDLKANNILLQ--WQ-------LEDQRWHAFIIDMG--KVSTQTIPLRHKQVP--------KEEITGYKDGIL ...|| |. .| ....| ||| .|||. |. . |.. | |.| .. .|. . . . . | .. . WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT FPHLAPEYILDLQ---------------PMSVQTDIYSLG . ..||| . . . . | ..|.|| | PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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| Kinase | Spk375.AA | LISK | 536-569 | 29 | 0.000194 | 10.11 | In-house | 118-150 (296) | Show / Hide |
Range on Protein: 536-569 Range on HMM: 118-150/296 Sequence Identity: 29% (10 aa) HEKGLLHNDLKANNILLQWQLEDQRWHAFIIDMG |... .| |||..|.|. . .. .| . ..|.| HSMNIIHRDLKSKNCLVR-ENDNNQWRIKVCDFG |
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| Kinase | Spk375.AA | LISK | 634-661 | 32 | 0.005513 | 5.31 | In-house | 269-296 (296) | Show / Hide |
Range on Protein: 634-661 Range on HMM: 269-296/296 Sequence Identity: 32% (9 aa) RPLRDLAAEMTNVKPRLRPSWKHIEKVI .|. ||. . ....|. ||| |.|.... PPFLDLCFDCCKYDPKNRPSFKEIVQWL |
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| Kinase | Spk375.AA | TKL | 634-661 | 25 | 0.040524 | 3.44 | In-house | 337-364 (364) | Show / Hide |
Range on Protein: 634-661 Range on HMM: 337-364/364 Sequence Identity: 25% (7 aa) RPLRDLAAEMTNVKPRLRPSWKHIEKVI .....|. . . .|. ||| . | | . PSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | Spk375.AA | Ciliate-E2 | 404-422 | 31 | 0.139336 | 1.18 | In-house | 1-19 (365) | Show / Hide |
Range on Protein: 404-422 Range on HMM: 1-19/365 Sequence Identity: 31% (6 aa) DEDDDLIGKGSFGKVFLRE . .||.|.||.|.. . YKFIKKIGQGNFGSVYKCK |
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