Gene Spk378 (Sea Urchin)
Spk378
Sequence
Protein domains of Spk378.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk378.AA | urch-unclassified | 513-720 | 54 | 4.5e-154 | 518.14 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 513-720 Range on HMM: 1-215/215 Sequence Identity: 54% (118 aa) IGKGTFGVVFMKRLGAEAVAVKVQGIHEDQKANEEDVKRV-ISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLGDKGTRTVYPLSKAI |||||||.|||.|...|||.|||..|||............ ..|.|.|..||..||||...||.||||.|..||..||..|.||||||.|.|||||...| IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQWI KTKN---PALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRR---DDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPEYIL .... ||||...|.||..||..|.|||||.||||||.|.||.||.. |.||.|||||.|...|.|||||.||..||||..|..|..|.|.|||..| HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVL YGEYSSIQSDIFSLG ||...|..|||.||| YGQPTSVYSDIYSLG |
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| Kinase | Spk378.AA | urch | 513-720 | 40 | 1.5e-117 | 396.83 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 513-720 Range on HMM: 1-217/217 Sequence Identity: 40% (89 aa) IGKGTFGVVFMKRLGAEAVAVKVQGIHEDQKAN--EEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLGDKGTRTVYPLSKA ||.||.| |...|.......|... ....|... .|.. ...||.|. ||. ||.|...|| ||...|.... ....||.||.||| |...|||... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC IKT-----KNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRR---DDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPE |.. .||.||...||||..||..|..|||....||||.|..||||.. . ||.|.|||.|.|.|.|||.|.....|.||. |. | .|.|.||| IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHG-RWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE YILYGEYSSIQSDIFSLG ..|.|...||.||..|.| CVLDGQPCSIASDVYSVG |
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| Kinase | Spk378.AA | urchC | 507-723 | 35 | 1e-36 | 116.28 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 507-723
Range on HMM: 1-223/223
Sequence Identity: 35% (81 aa)
TVDTKPIGKGTFGVVFMKRLGAE--AVAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHG--YTKHASCPGLVVEFLGDKGTR
. |||| .| | . || .| ||.| . ... | . | |. || | .. | ||| | . | .| || ||| .
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQ--NNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMC--IVTEFIGDKQQG
TVYPLSKAIK---TKNPALSDQEW--LNIVVDITEGIHAMHERDLLHNDIKPNNVLLR-RDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVY
||.| |.. .| . | | . | || .|.|.|| . ||||||| |||| | .|| . ||||| |.|.. | | | |. . . .
KVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDV-MPDHQKLYGF
QHLAPEYIL-YGEYSSIQSDIFSLGRII
| ||| . | | |||.| | |
IHIAPEVLDIDGCQVSVASDIYSVGVIL
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| Kinase | Spk378.AA | urchA | 562-717 | 33 | 9.3e-28 | 86.67 | In-house | 44-208 (208) | Show / Hide |
Range on Protein: 562-717
Range on HMM: 44-208/208
Sequence Identity: 33% (55 aa)
KEVAVHRLLGEHPAFPRCHGYTK-HASCPGLVVEFLGDKGTRTV----YPLSKAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRR
.|. .| .|| | || | . |. || || | |.||. ..|||. ..|.|. .|| || .|||. | || | |.|.|
NEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRK
--DDRWKAYIIDMGNVTTVTMPH--KNRNLTDHEMEGYRLGVVYQHLAPEYILYGEYSSIQSDIF
||.| |||.| . || .. . . || . . | ||| .| . |. ||..
TEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQPCSTSSDVY
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| Kinase | Spk378.AA | urchB | 559-720 | 38 | 5.9e-20 | 68.43 | In-house | 55-212 (212) | Show / Hide |
Range on Protein: 559-720 Range on HMM: 55-212/212 Sequence Identity: 38% (62 aa) RTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLGDKGTRTVYPLSKAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLL-RRD | || .| |. . | ||. | . .|| | | | . ||| | || . | || |. .| ||||| | |||| .| RVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGYPLHEP-----PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRG DRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPEYILYGEYSSIQSDIFSLG |. | ||| | | |.| | | .. | | ||| || | || ||.|| | HRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG |
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| Kinase | Spk378.AA | TKL | 513-720 | 14 | 3.8e-14 | 47.34 | In-house | 1-276 (364) | Show / Hide |
Range on Protein: 513-720
Range on HMM: 1-276/364
Sequence Identity: 14% (42 aa)
IGKGTFGVVFMKRLGA----------EAVAVKVQGIHEDQKANEEDVKRVI--------------SLNHSRTVKEVAVHRLLGE-HPAFPRCHGYTKHAS
||.|.||.|. .. . ||||. ..... .... . . . . | .|. . .. || .. || . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK--FKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP
C-------------PGLVVEFLGDKGT-RTVYPLSKAIKTKNPALSDQEW-LNIVVDITEGIHAMHERD--------LLHNDIKPNNVLLRRDDR-----
| ...| |. ..|. . .. . .... || |.. .| .. ..| |.|..|.|. .. .
CGCVCMHPVGPWGQLCIVMEYC-PGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY
-------WKAYIIDMGNVTTVTMPHKNRNLTDHEMEGY---------RLGVV--YQHLAPEYILYGEY---------------SSIQSDIFSLG
|.. | |.| ..... .. ..|| . .. ....||| . .. | ..|..| |
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME-SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG
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| Kinase | Spk378.AA | Ciliate-E2 | 612-725 | 17 | 9.7e-13 | 40.04 | In-house | 138-288 (365) | Show / Hide |
Range on Protein: 612-725
Range on HMM: 138-288/365
Sequence Identity: 17% (29 aa)
KTKNPALSDQEWLNIVVDITE---------------GIHAMHERD-LLHNDIKPNNVLLRRDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGV-
| . ....| ..| |.. ... .|.. .| ||||.|.|. |||.|. . .. ...|| ... |
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KN
-----------------------VYQHLAPEYILYGEY--------SSIQSDIFSLGRIIHY
. .||| . ...| . ..||.||| |...
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE
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| Kinase | Spk378.AA | S_TKc | 507-762 | 14 | 8.1e-12 | -3.58 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 507-762
Range on HMM: 1-231/231
Sequence Identity: 14% (43 aa)
TVDTKPIGKGTFGVVFMKRLGA--EAVAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTKHASCPGLVVEFLG-DKGTRT
..||||.||.|. | . ||.|. .. .|..... || ..... . .. .| |... |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGD-----
VYPLSKAIKTKNPA-----LSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQH
. | . || ... .. . .. | ... .|.. .| |.|| |.|| . |.| | . . . . .
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----------------TTFCGTPWY
LAPEYILYGEYSSIQSDIFSLG-----------------RIIHYVSRVIHNSDLFNLATLMIDSHPHLRPSWKEINR-------VKQA
.||| . |. .|. |.| .... . ... .. . . | ||. |. .
MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Spk378.AA | Ciliate-A1 | 618-668 | 39 | 1.6e-11 | 35.4 | In-house | 98-146 (301) | Show / Hide |
Range on Protein: 618-668 Range on HMM: 98-146/301 Sequence Identity: 39% (20 aa) LSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWKAYIIDMG .. | | . |.||. ..|.. || |.|| |.|. ||.|| |.|.| MKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWK--ICDLG |
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| Kinase | Spk378.AA | WEE | 614-720 | 29 | 1.1e-10 | 32.11 | In-house | 104-223 (297) | Show / Hide |
Range on Protein: 614-720
Range on HMM: 104-223/297
Sequence Identity: 29% (39 aa)
KNPALSDQEWLNIVVDITEGIHAMHER-DLLHNDIKPNNVLLRRDD--------------------RWKAYIIDMGNVTTVTMPHKNRNLTDHEMEGYRL
.|..|.... .| ||| .|.| .|.. ...|.|||| |... ... . | | | | ||... |.| . .| || .
WNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCK--IGDFGHVTDMNS---NNNNPHQEQEGDS-
GVVYQHLAPEYILYG--EYSSI-QSDIFSLG
.||| || | .|. .||||||
----RYMAPE-ILQGYYHYTHLYKADIFSLG
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| Kinase | Spk378.AA | C8 | 609-723 | 22 | 8.6e-09 | 26.76 | In-house | 111-226 (226) | Show / Hide |
Range on Protein: 609-723 Range on HMM: 111-226/226 Sequence Identity: 22% (28 aa) KAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWK--AYIIDMGNVTTVTMPHKNRNLTDHEMEGYRLGVVYQHLAPEYILY . ..|. .|... ..| . . .|. .| .| ||||.| |.. | . |.| ..|. . .. .| . .||| |.. DERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----CGTW-AYFAPE-IEK G-----EYSSIQSDIFSLGRII . ..||||.||.| . KQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | Spk378.AA | Pkinase | 507-654 | 22 | 2e-06 | 23.83 | Pfam | 1-141 (293) | Show / Hide |
Range on Protein: 507-654 Range on HMM: 1-141/293 Sequence Identity: 22% (34 aa) TVDTKPIGKGTFGVVFMKRLGAEA--VAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLGEHPAFPRCHGYTK-HASCPGLVVEFLGDKGTRT . ..||.|.||.|. . . ||||. ...| ... .| . |..... | || |.... . .. .| |.. ..| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI-IKKRHEKSWKDQTHRRL--------SEIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYC-EGGLY- VYPLSKAIK-TKNPAL--SDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLL | |. |. .. .. |..| ... | .|. .|.. .| |.|| |.|. VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI |
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| Kinase | Spk378.AA | TyrKc | 507-762 | 17 | 2e-06 | -120.17 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 507-762 Range on HMM: 1-280/280 Sequence Identity: 17% (56 aa) TVDTKPIGKGTFGVVFMKRLGAEAVAVKVQGIHEDQKANEEDVKRVISLNHSRTVKEVAVHRLLG-EHPAFPRCHGYTKHA-------SCPGLVVEFLGD . | .| | ||.|. .. . ||||. ..|| . .| . . || .|| |..|. . . .|.|. ITLGKKLGEGAFGEVYKGTWK-IQVAVKM--LKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH KGTRTVYPLSKAIKTKNPALSDQEWLNIVVDITEGIHAMHERDLLHNDIKPNNVLLRRDDRWKAYIIDMGNVTTVTMPHKNRNLTDHEMEG--------- | | . .. . | |. .. |.. ..| .| |.. . | |. |.|. .. . | | | |. .. -G-----DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFG-------------LSRDIYDDDQQGESKDY YR-----LG---VVYQHLAPEYILYGEYSSIQSD----------IFSLGRIIHYV---------------------SRVIH---------NSDLFNLATL || | . . .||| | ||.... .|| ||..| .. . . ...... . YRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ MIDSHPHLRPSWKEINRVKQA . |. ||. .|| ... CWHEDPEDRPTFSEI--HECF |
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| Kinase | Spk378.AA | WEE | 733-756 | 25 | 0.103008 | 1.61 | In-house | 268-291 (297) | Show / Hide |
Range on Protein: 733-756 Range on HMM: 268-291/297 Sequence Identity: 25% (6 aa) SDLFNLATLMIDSHPHLRPSWKEI ..| .| .|.. | .||.. .. QELKQLIKWMMHPDPEQRPTCQQL |
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| Kinase | Spk378.AA | Ciliate-A1 | 713-723 | 72 | 0.249791 | 0.2 | In-house | 208-218 (301) | Show / Hide |
Range on Protein: 713-723 Range on HMM: 208-218/301 Sequence Identity: 72% (8 aa) QSDIFSLGRII |||..||| || QSDMYSLGCII |
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| Kinase | Spk378.AA | Pkinase | 699-726 | 35 | 3.977286 | 1.53 | Pfam | 178-205 (293) | Show / Hide |
Range on Protein: 699-726 Range on HMM: 178-205/293 Sequence Identity: 35% (10 aa) LAPEYILYGEYSSIQSDIFSLGRIIHYV .||| |. |.| . .|..|.| |.... MAPEVIRGGQYYGPKVDMWSCGCILYEM |
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