Gene Spk372 (Sea Urchin)
Spk372
Sequence
Protein domains of Spk372.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Spk372.AA | urch-unclassified | 275-481 | 53 | 1.2e-149 | 503.5 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 275-481 Range on HMM: 1-215/215 Sequence Identity: 53% (114 aa) IGKGAFGKVNLMRYLPTNIPVAVK-VQEKKNRGISEDEMKNKLVS--RSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIHPLCDVL ||||.||||..||......||.|| ..|..|....|..|.|||.. |.||||..|....|.|.||...|.|..||....|.||.||||.....|||... IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQWI LERR---PGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGE--RWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHLAPEIVR .||. |.||...||.|..||..|....|...|||||||.||||||.... ||.|||||||..||.|||.|...||..|.||||.|..|||.|||||. HERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIVL DQQPTSVYSDIYSLG ..||||||||||||| YGQPTSVYSDIYSLG |
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Kinase | Spk372.AA | urch | 275-481 | 44 | 5.4e-121 | 408.26 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 275-481 Range on HMM: 1-217/217 Sequence Identity: 44% (96 aa) IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGI--SEDEMKNKLVS--RSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIHPLCDV ||.|..|.|.|.|. .|..|||.|... .... .|.||...... | .|||..|..||..|.|| ..|.|.|.|.|..|.||||||.. ...||... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC LLE-----RRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGE-RWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHLAPEI .. . | ||. .|..||.||..|. .||...||||||..|.||...|. ||.|.|||||. .|.|||.|...|. ||.||||.| |.|.|||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC VRDQQPTSVYSDIYSLG |.|.||.|..||.||.| VLDGQPCSIASDVYSVG |
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Kinase | Spk372.AA | urchA | 275-478 | 34 | 1.3e-45 | 145.18 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 275-478 Range on HMM: 1-208/208 Sequence Identity: 34% (73 aa) IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEI-EDNLGVVLEFIGDKQ----FVIIHPLCD | |. | | | | |..|||.|| | . . . .. .|. | | . | || ..| || || | ||.|| . |. | LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRR----KIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDK VLLERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQR-SGERWRAYIIDFGHGSTVTMPL---KFPTFSLEEEREYMEGLLYHHLAPEIV .. | | |.| .| ... || .|| .|.| | |||| |.|. .. |||| ||||| . . || .. |. .. ..| . . | ||| . AMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMH-FDQRQKQFYRYCHRCCHIAPECA RDQQPTSVYSDIY | || | ||.| LDAQPCSTSSDVY |
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Kinase | Spk372.AA | urchC | 271-485 | 37 | 2.7e-39 | 124.79 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 271-485 Range on HMM: 1-223/223 Sequence Identity: 37% (86 aa) EEIL--IGKGAFGKVNLMRYLPTNIPVAVK---VQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIH || ||||..|.| | | |||.| | | | | . . | |||. .|| | || ..| | |. |. .| ||||||| QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNG-RCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY PLCDVLL-----ERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTF-SLEEEREYMEGLLYHH .| |.. . | .. ..|| ||| | .|| ||||| | |.|| .||| . ||| | ||.. | . | .. .. |. | MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFI--H LAPEIVR-DQQPTSVYSDIYSLGKVLL |||.. | .|| ||||| | |.| IAPEVLDIDGCQVSVASDIYSVG-VIL |
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Kinase | Spk372.AA | urchB | 275-481 | 39 | 9.1e-38 | 131.79 | In-house | 7-212 (212) | Show / Hide |
Range on Protein: 275-481 Range on HMM: 7-212/212 Sequence Identity: 39% (84 aa) IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLV----SRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIHPLCDV || | .| | . | | .| |.| . . | || . | | ||| | ||| | || .| |. .| ||.| | | | IGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGYP---- LLERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHLAPEIVRDQQP |.| | || .||| ||..|. .|| ||||||| |.|| . | |. | ||||| ||.| ||| | | | |||.. . |. LHE-PPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQS TSVYSDIYSLG ||. ||..| | TSISSDVFSVG |
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Kinase | Spk372.AA | TKL | 275-481 | 16 | 3.9e-15 | 50.94 | In-house | 1-276 (364) | Show / Hide |
Range on Protein: 275-481 Range on HMM: 1-276/364 Sequence Identity: 16% (47 aa) IGKGAFGKVNLMRYLPTN--------IPVAVKVQEKKNRGISED-----------------EMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDN- ||.|.||.| .. .. .||||. ..| ... ..... .| .|.. . . | ..|.. ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------LGVVLEFI--GDKQFVIIHPLCDVLLERRPGLSRLEWIDIAFDIIQGLASLHDKR--------LLHNDLKKNNILLQRSGE------- |. | |.. |. ... ...| || .|.. || .. ..| ||| .|||. . .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY ----RWRAYIIDFGHGSTVTMPLKFPTFS-----------LEEEREYMEGLLYHHLAPEIVRDQQPTSVYS---------------DIYSLG |.. | ||| |.. . . . . . ... .... . ..|||. |.|.... .. |.|| | NPNADWCCKICDFGL-SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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S_TKc | Spk372.AA | S_TKc | 269-522 | 18 | 1.6e-12 | 6.61 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 269-522 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) AAEEILIGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDKQFVIIH--- .||||||||| . | |. ||.|. . ..| ... . | |..| . |.| .|.|... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCD-------GDLG PLCDVLLERRPG-----LSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLLYHHL | |.. .|... .. . .. |...|. .|... .| ||| |||| . . |.||| . . . . | . DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWY--M APEIVRDQQPTSV-YSDIYSLG----------------KVLLDIGRVSGDRDLRLVAEMCTRVKPYRRPTMSNVEL--------SVM |||.. . . .|..|.| ...... . ..... . | .. | .||| . . APEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | Spk372.AA | Pkinase | 275-481 | 24 | 1.4e-11 | 42.08 | Pfam | 7-199 (293) | Show / Hide |
Range on Protein: 275-481 Range on HMM: 7-199/293 Sequence Identity: 24% (52 aa) IGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVMSDNPSFPGLLGVVEIEDNLGVVLEFIGDK-QFVIIHPLCDVLL- ||.|.||.| . . |.. ||||. .|... ..|. . .| . ..|... ..| |....| .|.. .|.|. . |. |.|.. IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPN--IVRLYDWFEDKDHIYMVMEYCEGGLY-VM--DLFDYIST ERRPGL--SRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGER-WRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGLL--YHHLAPEIVRD .|. .. | | .... |..||. .|... .| ||| |||. . |. . |.||| . . . | .. .. .|||..|. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRG QQPTSVYSDIYSLG .|. . .|..|.| GQYYGPKVDMWSCG |
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Kinase | Spk372.AA | Ciliate-E2 | 390-485 | 24 | 1.7e-11 | 35.74 | In-house | 169-286 (365) | Show / Hide |
Range on Protein: 390-485 Range on HMM: 169-286/365 Sequence Identity: 24% (32 aa) IIQGLASLHDKR-LLHNDLKKNNILLQRSGERWRAYIIDFGHGSTVTMPLKFPTFSLEEEREYMEGL------------------------LYHHLAPEI ||..| .|| | .| |.| .|||. ||||| .. . . | . . .||. .. .|||| IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI VR--------DQQPTSVYSDIYSLGKVLL .. .|.. . .||.||| |.| LNGKKYDNQQKQKGYDYKCDIWSLG-VIL |
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Kinase | Spk372.AA | Ciliate-E2-Unclassified | 390-481 | 24 | 1.6e-09 | 29.24 | In-house | 152-257 (352) | Show / Hide |
Range on Protein: 390-481 Range on HMM: 152-257/352 Sequence Identity: 24% (31 aa) IIQGLASLHDK-RLLHNDLKKNNILLQRSGERWRAYIIDFGH------------------------------GSTVTMPLKFPTFSLEEEREYMEGLLYH |.||| .|| | .| |.| .|||.. .|.. . ||||| |. .|| . ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------------------- HLAPEIVRDQQPTS---VYSDIYSLG .|||. . |.. .||.||| YTAPEVLQGQNYDHSKAYKCDIWSLG |
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Kinase | Spk372.AA | LISK | 384-429 | 38 | 3.6e-08 | 22.44 | In-house | 104-150 (296) | Show / Hide |
Range on Protein: 384-429 Range on HMM: 104-150/296 Sequence Identity: 38% (18 aa) IDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRS-GERWRAYIIDFG ..|| || .|.. ||.. .| ||| .|.|. .. ..||. ..||| VKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFG |
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TyrKc | Spk372.AA | TyrKc | 269-521 | 18 | 6.9e-07 | -111.33 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 269-521 Range on HMM: 1-280/280 Sequence Identity: 18% (58 aa) AAEEILIGKGAFGKVNLMRYLPTNIPVAVKVQEKKNRGISEDEMKNKLVSRSMKEAVMHHVM-SDNPSFPGLLGVVEIE-------DNLGVVLEFI--GD . .| ||||.| . .. |.||||. . . |.|| . . ..| |.||. . . | .|.|. || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD KQFVIIHPLCDVLLERRPGLSRLEWIDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFG----HGST--------VTMP-----LK-- | | | ..|| |. . ......| .| . ||.|.. | || |.|. . . .. | ||| ... . .. | --------LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM FP-----------------------------TFSLEEEREY------MEGLLYHHLAPEIVRDQQPTSVYSDIYSLGKVLLDIGRVSGDRDLRLVAEMCT .| |.. .. . |. ... . | || ..| . . | .. . ..| LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSF----------VCCPDEMYQIMKQCW RVKPYRRPTMSNVELSV . .| |||.|.. HEDPEDRPTFSEIHECF |
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Kinase | Spk372.AA | Ciliate-E3 | 384-429 | 39 | 3e-06 | 15.91 | In-house | 106-151 (202) | Show / Hide |
Range on Protein: 384-429 Range on HMM: 106-151/202 Sequence Identity: 39% (18 aa) IDIAFDIIQGLASLHDKRLLHNDLKKNNILLQRSGERWRAYIIDFG .||. ||||. .| | . | |.| |||. . . . | ||| YDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFG |
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Kinase | Spk372.AA | Ciliate-E3 | 461-488 | 42 | 4e-06 | 15.6 | In-house | 176-202 (202) | Show / Hide |
Range on Protein: 461-488 Range on HMM: 176-202/202 Sequence Identity: 42% (12 aa) APEIVRDQQPTSVYSDIYSLGKVLLDIG |||.. ||. | ||.||.| |.... APEQNDQQQI-SKESDYYSVGAVFCQLC |
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Kinase | Spk372.AA | LISK | 274-298 | 44 | 5e-06 | 15.5 | In-house | 1-25 (296) | Show / Hide |
Range on Protein: 274-298 Range on HMM: 1-25/296 Sequence Identity: 44% (11 aa) LIGKGAFGKVNLMRYLPTNIPVAVK ||||.|||| ... |. ..|.| EIGKGFFGKVYKGTHRQTGQVMAIK |
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Kinase | Spk372.AA | Ciliate-E2-Unclassified | 275-315 | 27 | 0.06334 | 2.49 | In-house | 7-59 (352) | Show / Hide |
Range on Protein: 275-315 Range on HMM: 7-59/352 Sequence Identity: 27% (15 aa) IGKGAFGKVNLMRYLPTNIPV-----AVKVQEKKNRGISE--------DEMKNK ||.|.|||| ... .. . . |.|..| . | . .||.|| IGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNK |