Gene Spk401 (Sea Urchin)

Spk401

Species: Sea Urchin
Alias: Spk401
External Links:
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchC

Sequence

Name Sequence Type Origin Length Description Download
Spk401.AA Protein None 339 None Fasta, JSON
Spk401.kin_dom Protein Kinase Domain None 216 None Fasta, JSON

Protein domain

Protein domains of Spk401.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk401.AA urchC 50-267 56 5e-167 545.16 In-house 1-223 (223) Show / Hide 
Range on Protein: 50-267
Range on HMM: 1-223/223
Sequence Identity: 56% (127 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYR
...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||..|......||||..|..........|.||||.|..|.|..|.
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM

LHDALQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIAP
||||..   ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.||||
LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP

ELLDIAGSQVSASTDIFAVGVQL
|.|||.|.|||...||..||| |
EVLDIDGCQVSVASDIYSVGVIL
Kinase Spk401.AA urch 56-264 39 1.6e-109 370.17 In-house 1-217 (217) Show / Hide 
Range on Protein: 56-264
Range on HMM: 1-217/217
Sequence Identity: 39% (87 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLK--GEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHDA
||.|..| |.|..... ..|||||.|..| ...  .|....|||||..|..||..|..|. |.||| ..   ......||.|.||.|. .||..|.||..
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

LQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPEL
..   ...|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..|||||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

LDIAGSQVSASTDIFAVG
.. .|...|...|...||
VL-DGQPCSIASDVYSVG
Kinase Spk401.AA urch-unclassified 56-264 30 1.5e-41 144.35 In-house 1-215 (215) Show / Hide 
Range on Protein: 56-264
Range on HMM: 1-215/215
Sequence Identity: 30% (68 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWK---ANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHD
|| |.|| | .. . .   ||..|  ... | . .  | . .   ..  |. ||..|  |. . |||  .    . .  .|.| || |  ||.. | | .
IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ

ALQVID---PILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIAP
..       | |  |. ..  |..| . |    |. .|||||.|..||||. ...  |||  |||.|...||..   ||.|||   .  ..     |.||
WIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP

ELLDIAGSQVSASTDIFAVG
|     |   |  .||.  |
EIV-LYGQPTSVYSDIYSLG
Kinase Spk401.AA urchB 51-218 39 7.8e-36 125.37 In-house 2-164 (212) Show / Hide 
Range on Protein: 51-218
Range on HMM: 2-164/212
Sequence Identity: 39% (68 aa)

LELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPA--HLKGEAAENEWK-ANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRP
 .|  || |..| |..        | ||| |       . .|  . | . |   | .|| ..  |. . ||| .      ....||   ||||   ||  
NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVD-ELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIG

YRLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT
| ||       | |  |. | | |||| |.|.  .|| |||||| | ||.||| || |.| |||| |.| |
YPLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST
Kinase Spk401.AA urchA 137-215 30 1.1e-12 37.26 In-house 77-158 (208) Show / Hide 
Range on Protein: 137-215
Range on HMM: 77-158/208
Sequence Identity: 30% (26 aa)

EFVGSGQTGRPYRLHDALQV----IDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEH-RGERWHGVIIDMGL
||.|.  ||. | . . |.       | |  .   . ... |   |   .|. | | || | ||.|.    . || ..|||.|.
EFCGDEMTGESYTITWCLDKAMEMRQPAL--TRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGW
Kinase Spk401.AA TKL 56-265 16 8.6e-12 38.74 In-house 1-277 (364) Show / Hide 
Range on Protein: 56-265
Range on HMM: 1-277/364
Sequence Identity: 16% (48 aa)

IGNGSFGIVLLGHLDGLS--------KPVAIKRPYVPAHLKGEAAENE-------------WKANQGRTRKESLVLELLKG--CPYFAQMVSAITMGRE-
|| |.||.|  |.. | .        |.||.|.  .    . .  ..|             .. ..    .|  .. ...   .|   |.. . . ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCVVTEFVGSGQ-TGRPYRLHDALQVIDPILYPSIWNM-VAIAEDLVRGVSIIHDFG--------LLHNDIKGDNILLEHRGE-----
            || |.|..  |    .                   |.  . .| |  ||..  |  .        ..| |.| .|||.   ..     
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLKFPHIAPELLD--------------IAGSQVSASTDIFAVGV
       |.  | |.|| ..|  ... . .                  .|.  . . |||.|.              . |.. | ..|... |.
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
Kinase Spk401.AA S_TKc 50-306 17 2.3e-11 -10.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-306
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGS--GQTGRP
   |. || |.|| | ...  .  . ||||.                     ..|.|  .|.   ..|.  ..  ..    .|..|.|...   |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD----

YRLHDALQVIDPILYP---SIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIAP
  |.| ..   .  ..   .      ..  .....  .|. | .| |.| .|||| .     |  |.| || . .              ..      .||
--LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAP

ELLDIAGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVMVGEHCCENEPHLRPKALDDIV-------PKLV
|.|     . .  . |. ..|.             |..|. . | ..|.    ..|.. .|  || | .             .
EVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Spk401.AA Pkinase 56-204 23 4.1e-09 33.32 Pfam 7-146 (293) Show / Hide 
Range on Protein: 56-204
Range on HMM: 7-146/293
Sequence Identity: 23% (36 aa)

IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVSAITMGRELCVVTEFVGSGQTGRPYRLHDALQ
|| |||| | ..|  | .| ||.|.  .. | | .  .. ...       |  ..  | ..|.  ..  . . ......|.|... | .     |.| ..
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYIS

--VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
     ...  | |    ..  ..||.  .|. | .| |.| .|||. ..|.
TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH
Kinase Spk401.AA TKL-ciliate1 174-265 28 3.1e-07 20.8 In-house 111-207 (279) Show / Hide 
Range on Protein: 174-265
Range on HMM: 111-207/279
Sequence Identity: 28% (28 aa)

DLVRGVSIIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---IAGSQVSASTDIFAVGV
|. .|.. .|     | | |.|  |||.   .|     | . . |..     .   || |.  |.||.  .|  ||| .|     . ...   ||.|.|.
DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI
Kinase Spk401.AA TyrKc 50-305 16 2e-06 -117.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-305
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLVLELL-KGCPYFAQMVSAITMG-------RELCVVTEFVGS
   ....|.| ||.| .|...    .||.|     |              .   ..|  ..  | .  |   ... ..| .         |..|.|..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GQTGRPYRLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQ--RLK
|       |.| |.   |    .   .. .. .  .| . .|. .. | |.   |.|. ...   .  | | ||        .|   .| .  ..    |
G------DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--FP--HIAPELLDIA---------------------GSQVSAS--------TDIFAVGVQLNMIGQFID---------DDELVMVGEHCCENEPHLRPK
  .|    ||| ..                       | |            .....   | ..  |  .          ||. .. . |.. .|. || 
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

ALDDIVPKL
   .|. ..
FS-EIHECF
Kinase Spk401.AA Ciliate-B3 168-214 31 7e-06 17.95 In-house 2-49 (69) Show / Hide 
Range on Protein: 168-214
Range on HMM: 2-49/69
Sequence Identity: 31% (15 aa)

MVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMG
 .   . .|  . |.|.  . | ||| ||||... ..  .  .||| |
ALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFG
Kinase Spk401.AA Dicty3 171-199 46 7e-06 15.27 In-house 116-145 (351) Show / Hide 
Range on Protein: 171-199
Range on HMM: 116-145/351
Sequence Identity: 46% (14 aa)

IAEDLVRGVSIIHDFG-LLHNDIKGDNILL
|..||| . . ||. . ..| |||.|||.|
IICDLVKTLNYIHKNCHIIHRDIKCDNIML
Kinase Spk401.AA Ciliate-E1 162-204 27 8e-06 15.38 In-house 105-147 (202) Show / Hide 
Range on Protein: 162-204
Range on HMM: 105-147/202
Sequence Identity: 27% (12 aa)

YPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
. .......|. .|. |....|.....| ||| .||| .. |.
QFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN
Kinase Spk401.AA urchA 241-261 38 0.008342 4.96 In-house 189-208 (208) Show / Hide 
Range on Protein: 241-261
Range on HMM: 189-208/208
Sequence Identity: 38% (8 aa)

HIAPELLDIAGSQVSASTDIF
|||||.  . ..  | | |..
HIAPECA-LDAQPCSTSSDVY
Kinase Spk401.AA urchB 242-264 47 0.05021 3.46 In-house 191-212 (212) Show / Hide 
Range on Protein: 242-264
Range on HMM: 191-212/212
Sequence Identity: 47% (11 aa)

IAPELLDIAGSQVSASTDIFAVG
|||| . . |   | | |.| ||
IAPEVI-LHGQSTSISSDVFSVG
Kinase Spk401.AA Ciliate-E1 56-67 66 0.216423 0.87 In-house 1-12 (202) Show / Hide 
Range on Protein: 56-67
Range on HMM: 1-12/202
Sequence Identity: 66% (8 aa)

IGNGSFGIVLLG
||||||.||. .
IGNGSFSIVFKA