Gene Spk400 (Sea Urchin)
Spk400
Species: Sea Urchin
Alias: Spk400
External Links:
Annotation:
Sequence
Protein domains of Spk400.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk400.AA | urchC | 218-436 | 55 | 2.4e-155 | 506.74 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 218-436 Range on HMM: 1-223/223 Sequence Identity: 55% (125 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPY ...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||.. .|.... ||||..|.||..|....| |..|.|..| QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMST-CPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY RLHDALQ---EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIA .||||.. ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.||| MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIA PELLDVVGSQVSASTDIFAVGVQL ||.||..|.|||...||..||| | PEVLDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk400.AA | urch | 224-433 | 39 | 2.4e-96 | 326.39 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 224-433 Range on HMM: 1-217/217 Sequence Identity: 39% (86 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLK--GEAAENEWKANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPYRLHD ||.|..| |.|..... ..|||||.|..| ... .|....|||||..|..||.. .||. | .||| .. |...|...|| |. .||..|.||. IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSG-HPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHW ALQ---EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPE ... ..|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..||||| CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE LLDVVGSQVSASTDIFAVG ... |...|...|...|| CVL-DGQPCSIASDVYSVG |
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| Kinase | Spk400.AA | urch-unclassified | 224-433 | 29 | 1.2e-34 | 120.74 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 224-433 Range on HMM: 1-215/215 Sequence Identity: 29% (66 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWK---ANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRPYRLH || |.|| | .. . . ||..| ... | . . | . . .. |. ||.. .|. . ||| . | ... .| | ||.. | | IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLF-ADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLC DALQEID---PILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIA ... | | | |. .. |..| . | |. .|||||.|..||||. ... ||| |||.|...||.. ||.||| . .. |.| QWIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMA PELLDVVGSQVSASTDIFAVG || | | .||. | PEIV-LYGQPTSVYSDIYSLG |
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| Kinase | Spk400.AA | urchB | 219-387 | 40 | 4.2e-33 | 116.06 | In-house | 2-164 (212) | Show / Hide |
Range on Protein: 219-387 Range on HMM: 2-164/212 Sequence Identity: 40% (69 aa) LELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPA--HLKGEAAENEWK-ANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGR .| || |..| |.. | ||| | . .| . | . | | .|| . ||. . ||| . || |...|| | || NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVD-ELHDATRTRVTKEAMIHQLMSD-SPYFPKFWGTLDIDNDLCQAQEFVGCKKTGI PYRLHDALQEIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT | || | | |. | | |||| |.|. .|| |||||| | ||.||| || |.| |||| |.| | GYPLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST |
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| Kinase | Spk400.AA | urchA | 337-384 | 34 | 4e-10 | 28.93 | In-house | 110-158 (208) | Show / Hide |
Range on Protein: 337-384 Range on HMM: 110-158/208 Sequence Identity: 34% (17 aa) MVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEH-RGERWHGVIIDMGL . ... | | .|. | | || | ||.|. . || ..|||.|. WMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGW |
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| Kinase | Spk400.AA | S_TKc | 218-475 | 16 | 8.3e-09 | -47.74 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 218-475 Range on HMM: 1-231/231 Sequence Identity: 16% (47 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHLKGEAAENEWKANQGRTRKESLCLQLLKGXCPYFAQMVGTITIGRELCXCNRVRGSGQTGRP- |. || |.|| | ... . . ||||. ..|.| .|. .|. .. ... .|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMV------MEYCDGD -YRLHDALQEIDPILYP---SIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIA |.| ... . .. . .. ..... .|. | .| |.| .|||| . | |.| || . . .. .| LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMA PELLDVVGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVTVGEHCCENEPHLRPKALDDIV-------PKLV ||.| . . . |. ..|. |..|. . | ..|. ..|.. .| || | . . PEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk400.AA | TKL | 340-434 | 18 | 1.8e-07 | 23.02 | In-house | 137-277 (364) | Show / Hide |
Range on Protein: 340-434 Range on HMM: 137-277/364 Sequence Identity: 18% (26 aa) IAEDLVRGVSTIHDFG--------LLHNDIKGDNILLEHRGE-----------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLK .| | ||.. | . ..| |.| .|||. .. |. | |.|| ..| ... . . .|. WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT FPHIAPELLDVV--------------GSQVSASTDIFAVGV . . |||.|. |.. | ..|... |. PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI |
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| Kinase | Spk400.AA | TKL-ciliate1 | 343-434 | 28 | 1e-06 | 18.77 | In-house | 111-207 (279) | Show / Hide |
Range on Protein: 343-434 Range on HMM: 111-207/279 Sequence Identity: 28% (28 aa) DLVRGVSTIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---VVGSQVSASTDIFAVGV |. .|.. .| | | |.| |||. .| | . . |.. . || |. |.||. .| ||| .| . ... ||.|.|. DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI |
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| Kinase | Spk400.AA | Dicty3 | 340-368 | 46 | 4e-06 | 16.08 | In-house | 116-145 (351) | Show / Hide |
Range on Protein: 340-368 Range on HMM: 116-145/351 Sequence Identity: 46% (14 aa) IAEDLVRGVSTIHDFG-LLHNDIKGDNILL |..||| . . ||. . ..| |||.|||.| IICDLVKTLNYIHKNCHIIHRDIKCDNIML |
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| Kinase | Spk400.AA | FNIPK | 340-368 | 41 | 5e-06 | 15.7 | In-house | 126-156 (425) | Show / Hide |
Range on Protein: 340-368 Range on HMM: 126-156/425 Sequence Identity: 41% (13 aa) IAEDLVRGVSTIHDFG--LLHNDIKGDNILL ...||| . ||. | | |||.|||.. CMCDLVKSLNCIHENGRHIIHRDIKCDNIMI |
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| Kinase | Spk400.AA | Ciliate-E1 | 317-373 | 23 | 1.1e-05 | 14.99 | In-house | 81-147 (202) | Show / Hide |
Range on Protein: 317-373 Range on HMM: 81-147/202 Sequence Identity: 23% (16 aa) YRLHDALQ---------EID-PILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE ..|.| || .. . .......|. .|. |.. .|.....| ||| .||| .. |. CSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN |
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| Kinase | Spk400.AA | TKL | 224-248 | 36 | 2.4e-05 | 15.21 | In-house | 1-33 (364) | Show / Hide |
Range on Protein: 224-248 Range on HMM: 1-33/364 Sequence Identity: 36% (12 aa) IGNGSFGIVLLGHLDGLS--------KPVAIKR || |.||.| |.. | . |.||.|. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK |
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| Kinase | Spk400.AA | Pkinase | 319-373 | 26 | 6.8e-05 | 18.39 | Pfam | 91-146 (293) | Show / Hide |
Range on Protein: 319-373 Range on HMM: 91-146/293 Sequence Identity: 26% (15 aa) LHDALQ--EIDPILYPSIWNMVAIAEDLVRGVSTIHDFGLLHNDIKGDNILLEHRGE |.| .. . ... | | .. ..||. .|. | .| |.| .|||. ..|. LFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH |
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| Kinase | Spk400.AA | urchA | 410-430 | 38 | 0.077496 | 1.79 | In-house | 189-208 (208) | Show / Hide |
Range on Protein: 410-430 Range on HMM: 189-208/208 Sequence Identity: 38% (8 aa) HIAPELLDVVGSQVSASTDIF |||||. . .. | | |.. HIAPECA-LDAQPCSTSSDVY |
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| Kinase | Spk400.AA | Pkinase | 224-248 | 52 | 0.082045 | 7.49 | Pfam | 7-31 (293) | Show / Hide |
Range on Protein: 224-248 Range on HMM: 7-31/293 Sequence Identity: 52% (13 aa) IGNGSFGIVLLGHLDGLSKPVAIKR || |||| | ..| | .| ||.|. IGSGSFGCVYKCHHKGTGKIVAVKI |
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| Kinase | Spk400.AA | urchB | 411-433 | 47 | 0.167897 | 1.56 | In-house | 191-212 (212) | Show / Hide |
Range on Protein: 411-433 Range on HMM: 191-212/212 Sequence Identity: 47% (11 aa) IAPELLDVVGSQVSASTDIFAVG |||| . | | | |.| || IAPEVI-LHGQSTSISSDVFSVG |
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| Kinase | Spk400.AA | Ciliate-E1 | 224-235 | 66 | 0.216423 | 0.87 | In-house | 1-12 (202) | Show / Hide |
Range on Protein: 224-235 Range on HMM: 1-12/202 Sequence Identity: 66% (8 aa) IGNGSFGIVLLG ||||||.||. . IGNGSFSIVFKA |
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