Gene Spk370 (Sea Urchin)
Spk370
Sequence
Protein domains of Spk370.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk370.AA | urchC | 208-425 | 57 | 9.1e-168 | 547.6 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 208-425 Range on HMM: 1-223/223 Sequence Identity: 57% (129 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYR ...|.|||.||.|.|.||.|.|...||||||||||.|...|..|.|||.|.||..||..|......||||..|.||..|....|.||||.|..|.|..|. QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM LHDALQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQRLK-FPHIAP ||||.. ..|||.|...|||||||||..|||...|||||||||||.||.|||||.|||||.|||||.|.||||. .||.|.|..|..|.|. |.|||| LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP ELLDSAGSQVSASTDIFAVGVQL |.||..|.|||...||..||| | EVLDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk370.AA | urch | 214-422 | 40 | 1.4e-112 | 380.31 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 214-422 Range on HMM: 1-217/217 Sequence Identity: 40% (89 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQK--GEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDA ||.|..| |.|..... ..|||||.|..| . . .|....|||||..|..||..|..|. |.||| .. |...|...||.|.||.|. .||..|.||.. IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC LQ---VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMGLVTTMAYT-EQRSF-SDLIPESQRLK-FPHIAPEL .. ...|....|.||...|||| |.|.. .||.|.||||.|.||.|||.||. |||.||||.|.|.||... ....| .....|..... ..|||||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC LDSAGSQVSASTDIFAVG .. .|...|...|...|| VL-DGQPCSIASDVYSVG |
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| Kinase | Spk370.AA | urch-unclassified | 214-422 | 31 | 2.5e-45 | 156.9 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 214-422 Range on HMM: 1-215/215 Sequence Identity: 31% (69 aa) IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWK---ANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHD || |.|| | .. . . ||..| ... |.. . | . . .. |. ||..| |. . ||| . | ... .|.| || | ||.. | | . IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ ALQVID---PILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE--RWHGVIIDMGLVTTMAY-TEQRSFSDLIPESQRL--KFPHIAP .. | | |. .. |..| . | |. .|||||.|..||||. ... ||| |||.|...||.. ||.||| . .. |.|| WIHERHKSNPAL--SKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP ELLDSAGSQVSASTDIFAVG | | | .||. | EIV-LYGQPTSVYSDIYSLG |
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| Kinase | Spk370.AA | urchB | 209-376 | 41 | 8.2e-39 | 135.27 | In-house | 2-164 (212) | Show / Hide |
Range on Protein: 209-376 Range on HMM: 2-164/212 Sequence Identity: 41% (71 aa) LELDMIGNGSFGIVLLGHLDGLSKPVAIKRP-YVPAHQKGEAAENEWK-ANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPY .| || |..| |.. | ||| | | .| . | | .|| .. |. . ||| . || |...|| |||| || | NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY RLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTT || | | |. | | |||| |.|. .|| |||||| | ||.||| || |.| |||| |.| | PLHEP-----PPL--SMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVST |
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| Kinase | Spk370.AA | TKL | 214-423 | 16 | 2.7e-15 | 51.56 | In-house | 1-277 (364) | Show / Hide |
Range on Protein: 214-423
Range on HMM: 1-277/364
Sequence Identity: 16% (49 aa)
IGNGSFGIVLLGHLDGLS--------KPVAIKRPYVPAHQKGEAAENE-------------WKANQGRTRKESLVLELLKG--CPYFAQMVGTITIGRE-
|| |.||.| |.. | . |.||.|. . .. . ..| .. .. .| .. ... .| |..| . ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LCVVTEFVGSGQ-TGRPYRLHDALQVIDPILYPSIWNM-VAIAEDLVRGVSIIHDFG--------LLHNDIKGDNILLEHRGE-----
|| |.|.. | . |. . .| | ||.. | . ..| |.| .|||. ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY
------RWHGVIIDMGLVTTMAYTEQRSFSDL-------------IPESQRLKFPHIAPELLDSA--------------GSQVSASTDIFAVGV
|. | |.|| ..| ... . . .|. . . |||.|. . |.. | ..|... |.
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
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| Kinase | Spk370.AA | urchA | 262-373 | 27 | 4.3e-13 | 38.65 | In-house | 43-158 (208) | Show / Hide |
Range on Protein: 262-373 Range on HMM: 43-158/208 Sequence Identity: 27% (32 aa) RKESLVLELLKGCPYFAQMVGTITIGRELCVVT-EFVGSGQTGRPYRLHDALQV----IDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNIL ..| ....| . |.| .. | | . ||.|. ||. | . . |. | | . . ... | | .|. | | || | ||.| QNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQPAL--TRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCL LEH-RGERWHGVIIDMGL . . || ..|||.|. VRKTEFGRWRAKIIDFGW |
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| Kinase | Spk370.AA | S_TKc | 208-464 | 17 | 2.2e-11 | -10.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 208-464 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGS--GQTGRP |. || |.|| | ... . . ||||. ..|.| .|. ..|. .. ... .|..|.|... | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD---- YRLHDALQVIDPILYP---SIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYTEQRSFSDLIPESQRLKFPHIAP |.| .. . .. . .. ..... .|. | .| |.| .|||| . | |.| || . . .. .|| --LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAP ELLDSAGSQVSA-STDIFAVGV-------------QLNMIGQFIDDDELVTVGEHCCENEPHLRPKALDDIV-------PKLV |.| . . . |. ..|. |..|. . | ..|. ..|.. .| || | . . EVL-----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk370.AA | Pkinase | 214-362 | 23 | 1.1e-09 | 35.28 | Pfam | 7-146 (293) | Show / Hide |
Range on Protein: 214-362
Range on HMM: 7-146/293
Sequence Identity: 23% (36 aa)
IGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELLKGCPYFAQMVGTITIGRELCVVTEFVGSGQTGRPYRLHDALQ
|| |||| | ..| | .| ||.|. .. |.| . .. ... | .. | ..|. .. .. . ......|.|... | . |.| ..
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYIS
--VIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE
... | | .. ..||. .|. | .| |.| .|||. ..|.
TWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH
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| Kinase | Spk370.AA | TKL-ciliate1 | 332-423 | 28 | 4e-07 | 20.42 | In-house | 111-207 (279) | Show / Hide |
Range on Protein: 332-423 Range on HMM: 111-207/279 Sequence Identity: 28% (28 aa) DLVRGVSIIHDFG--LLHNDIKGDNILLEHRGERWHGVIIDMGLVTT--MAYTEQRSFSDLIPESQRLKFPH-IAPELLD---SAGSQVSASTDIFAVGV |. .|.. .| | | |.| |||. .| | . . |.. . || |. |.||. .| ||| .| . ... ||.|.|. DIAQGMQYLHMRQNPLIHRDLKMQNILY---DEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGI |
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| Kinase | Spk370.AA | TyrKc | 208-463 | 16 | 9.3e-07 | -113.39 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 208-463 Range on HMM: 1-280/280 Sequence Identity: 16% (51 aa) KLELDMIGNGSFGIVLLGHLDGLSKPVAIKRPYVPAHQKGEAAENEWKANQGRTRKESLVLELL-KGCPYFAQMVGTITIG-------RELCVVTEFVGS ....|.| ||.| .|... .||.| | . ..| .. | . | ...| .| . |..|.|.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH GQTGRPYRLHDALQVIDPILYPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGERWHGVIIDMGLVTTMAYT-EQRSFSDLIPESQ--RLK | |.| |. | . .. .. . .| . .|. .. | |. |.|. ... . | | || .| .| . .. | G------DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK --FP--HIAPELLDSA---------------------GSQVSAS--------TDIFAVGVQLNMIGQFID---------DDELVTVGEHCCENEPHLRPK .| ||| .. | | ..... | .. | . ||. .. . |.. .|. || TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT ALDDIVPKL .|. .. FS-EIHECF |
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| Kinase | Spk370.AA | Ciliate-B3 | 326-372 | 31 | 7e-06 | 17.95 | In-house | 2-49 (69) | Show / Hide |
Range on Protein: 326-372 Range on HMM: 2-49/69 Sequence Identity: 31% (15 aa) MVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE-RWHGVIIDMG . . .| . |.|. . | ||| ||||... .. . .||| | ALKHFHQVVEKIKILHEKNICHCDIKVDNILVNQQDKENYKVIIIDFG |
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| Kinase | Spk370.AA | Dicty3 | 329-357 | 46 | 7e-06 | 15.27 | In-house | 116-145 (351) | Show / Hide |
Range on Protein: 329-357 Range on HMM: 116-145/351 Sequence Identity: 46% (14 aa) IAEDLVRGVSIIHDFG-LLHNDIKGDNILL |..||| . . ||. . ..| |||.|||.| IICDLVKTLNYIHKNCHIIHRDIKCDNIML |
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| Kinase | Spk370.AA | Ciliate-E1 | 320-362 | 27 | 8e-06 | 15.38 | In-house | 105-147 (202) | Show / Hide |
Range on Protein: 320-362 Range on HMM: 105-147/202 Sequence Identity: 27% (12 aa) YPSIWNMVAIAEDLVRGVSIIHDFGLLHNDIKGDNILLEHRGE . .......|. .|. |....|.....| ||| .||| .. |. QFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGN |
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| Kinase | Spk370.AA | urchA | 399-419 | 42 | 0.064097 | 2.06 | In-house | 189-208 (208) | Show / Hide |
Range on Protein: 399-419 Range on HMM: 189-208/208 Sequence Identity: 42% (9 aa) HIAPELLDSAGSQVSASTDIF |||||. .| . | | |.. HIAPECALDAQP-CSTSSDVY |
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| Kinase | Spk370.AA | Ciliate-E1 | 214-225 | 66 | 0.216423 | 0.87 | In-house | 1-12 (202) | Show / Hide |
Range on Protein: 214-225 Range on HMM: 1-12/202 Sequence Identity: 66% (8 aa) IGNGSFGIVLLG ||||||.||. . IGNGSFSIVFKA |
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| Kinase | Spk370.AA | urchB | 400-422 | 47 | 0.293643 | 0.68 | In-house | 191-212 (212) | Show / Hide |
Range on Protein: 400-422 Range on HMM: 191-212/212 Sequence Identity: 47% (11 aa) IAPELLDSAGSQVSASTDIFAVG |||| . | | | |.| || IAPEVI-LHGQSTSISSDVFSVG |
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