Gene Spk380 (Sea Urchin)

Spk380

Species: Sea Urchin
Alias: SPU_016864, Spk380
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchC

Sequence

Name Sequence Type Origin Length Description Download
Spk380.AA Protein None 487 None Fasta, JSON
Spk380.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of Spk380.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk380.AA urchC 217-434 52 1.5e-168 550.16 In-house 1-223 (223) Show / Hide 
Range on Protein: 217-434
Range on HMM: 1-223/223
Sequence Identity: 52% (117 aa)

DFKFKEIGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERRANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDENMCIVQEFIGDKKTGKVFP
    ..||.|..|.|.|.||....|.||||.|..|..|.|.|.|.|...|.|...|||.|.|..|....||..|||...|||||||.||||||..|||..
QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM

LLNIME----SNPSPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNERWYGCIIDLGLVSTIAFPPHVTIKRSVMEDHKKLSGNVYVAP
|...|.    ..|.|.........||.|...|.||||..||||||||.||||||.|.|||.|||||.|.|||.|.|||......||.||.||.|....||
LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP

EVVD-DGTTLSKASDIYSVGVLL
||.| ||...|.|||||||||.|
EVLDIDGCQVSVASDIYSVGVIL
Kinase Spk380.AA urch 223-431 43 4e-122 412.03 In-house 1-217 (217) Show / Hide 
Range on Protein: 223-431
Range on HMM: 1-217/217
Sequence Identity: 43% (95 aa)

IGRGAFGRVLLARLTASSDTVAIKEPLIPPYFS--PPKIEAERRANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDENMCIVQEFIGDKKTGKVFPLLNI
||||..|||.|.|.......||||.|..|....  ......|..||...|||||.|.|..|....|||.||.. .|...|.|.||||||||||..||...
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC

ME----SNPSPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNE-RWYGCIIDLGLVSTIAFPPHVTIK-RSVMEDHKKLSGNVYVAPEV
..    ..|.|.||....|.||.|...|...||..|.||||.|.|||||| |.. ||...|||.|.|.|...|.... . ...|.......|....|||.
IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC

VDDGTTLSKASDIYSVG
|.||...|.|||.||||
VLDGQPCSIASDVYSVG
Kinase Spk380.AA urch-unclassified 223-431 33 4.2e-53 182.73 In-house 1-215 (215) Show / Hide 
Range on Protein: 223-431
Range on HMM: 1-215/215
Sequence Identity: 33% (75 aa)

IGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERR---ANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDENMCIVQEFIGDKKTGKVFPLLN
|| |.||.| . |. .    |..|   |.   .    | ..    ..    .|||.| . .. .  ||..||   .  . ||| ||.|||.|..| ||  
IGKGTFGKVFMMRHQREAVPVKVK--MIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ

IMESNP--SPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNE--RWYGCIIDLGLVSTIAFPPHVTIKRSVMEDHKK---LSGNVY--V
         | ||    ..|. |...|.| ||. .|||||.|..|.||. . .  ||   |||.|..||.. |     |     || .    .| .|   
WIHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMP----HKQRNFSDHEMREYMMGKIYHHM

APEVVDDGTTLSKASDIYSVG
|||.| .|   |..||||| |
APEIVLYGQPTSVYSDIYSLG
Kinase Spk380.AA urchB 218-392 43 2.8e-45 156.74 In-house 2-172 (212) Show / Hide 
Range on Protein: 218-392
Range on HMM: 2-172/212
Sequence Identity: 43% (77 aa)

FKFKEIGRGAFGRVLLARLTASSDTVAIKEPLI-PPYFSPPKIEAERR-ANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDENMCIVQEFIGDKKTGKVF
   .||||| .|||..||        |||.|     | ||     | . |     |||| . | .| |  ||| .||| .| ..|  |||.| ||||  .
NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY

PLLNIMESNPSPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNERWYGCIIDLGLVSTIAFPPHVT
||.        | ||    .|||.|.  |.  .|  |||||| | |||||| |  |.   ||| |.||||  |.  .
PLHE------PPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMV
Kinase Spk380.AA urchA 223-428 27 2.2e-32 101.8 In-house 1-208 (208) Show / Hide 
Range on Protein: 223-428
Range on HMM: 1-208/208
Sequence Identity: 27% (58 aa)

IGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERRANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDE-NMCIVQEFIGDKKTGKVFPLLNIM
 |||. | | | |  ..   ||.|       .  ||   ..|.    | .|. . | |...  ||..|| . ..|    .  ||.||  ||. . ... .
LGRGVYGTVHLYRHRQTDHPVALK------VIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCL

ES---NPSPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLEL-RNERWYGCIIDLGLVSTIAFPP---HVTIKRSVMEDHKKLSGNVYVAPEV
.       | |.    .... |. ||   ||..| | || | ||.|.      || . |||.|. . .. |             .. .   .  ..||| 
DKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPEC

VDDGTTLSKASDIY
. |.   | .||.|
ALDAQPCSTSSDVY
Kinase Spk380.AA TKL 223-434 16 1.2e-14 49.21 In-house 1-279 (364) Show / Hide 
Range on Protein: 223-434
Range on HMM: 1-279/364
Sequence Identity: 16% (48 aa)

IGRGAFGRVLLARLTASS--------DTVAIKEPLIPPYFSPPKIE--------------AERRANFGQFTKEAVVSQFLS-RSNHFPKLYGTLVLDEN-
||.|.|| |  ...   .         .||.|   .    .  |..               .. | . .|..| .. . .. |  .  ...|     .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MCIVQEFI--GD-KKTGKVFPLLNIMESNPSPFLSPPSLLDIADDVLEGIHFMHSNG--------LLHNDIKADNVLLE---------
            .||| |..  |.   .                   .. ....| |.  |....||..        ..| |.| .|.|.          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

--LRNERWYGCIIDLGLVSTIAFPPHVTIKRSVME-------DHKKLSGNV----YVAPEVVDDGT---------------TLSKASDIYSVGVLL
   .|. |  .| |.||  ..    . .   . |         .|...  .    . |||| .. .               . |...|.|| |..|
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase Spk380.AA Ciliate-E2 341-434 18 2.3e-13 42.21 In-house 169-286 (365) Show / Hide 
Range on Protein: 341-434
Range on HMM: 169-286/365
Sequence Identity: 18% (24 aa)

VLEGIHFMHSNG-LLHNDIKADNVLLELRNERWYGCIIDLGLVSTIAFPPHVTIKRSVMEDHKKLSGN-------------------------VYVAPEV
........||..  .| ||| .|.|.         .|||.||   .  .   ...  ..   ..  .|                          |.|||.
IILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

VD--------DGTTLSKASDIYSVGVLL
.         ...  ....||.|.||.|
LNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase Spk380.AA S_TKc 217-484 17 1.4e-12 7.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 217-484
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

DFKFKEIGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERRANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDENMCIVQEFIGD--KKTGKV
  . ..||.||||.| ..| . .   ||||.                     .. .|  . .   .  .  |||.. .  .....| |...         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG-----

FPLLNIMESNPSPF----LSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNERWYGCIIDLGLVSTIAFPPHVTIKRSVMEDHKKLSGNVYV
  |. ........     ...     ..  ..... ..||.| .| |.| .|.||          |.| ||   .               .       |.
-DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------------TTFCGTPWYM

APEVVDDGTTLSK-ASDIYSVGVLLV--FIGRAARLQGLIAIGESCSQKAPMLRPRSLKDVIPKVRALQ-------EQLA-------HESN
||||.      .| ..|..|.|..|   . |.      . .. . .        ....|| | |            | |.       |.  
APEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Spk380.AA Pkinase 219-365 20 1.6e-12 45.35 Pfam 3-141 (293) Show / Hide 
Range on Protein: 219-365
Range on HMM: 3-141/293
Sequence Identity: 20% (30 aa)

KFKEIGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERRANFGQFTKEAVVSQFLSRSNHFPKLYGTLVLDENMCIVQEFIGDKKTGKVFPLL
. . ||.|.||.| ...   ....||.|.   .   |  .... |.        |. . . | .. .  .||..   . ....|.|. .   .  |. | 
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLF

NIMESNPSPFL--SPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLL
 ...   .  .  |.  . ...  .|.|. ..||.| .| |.| .|.|.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase Spk380.AA Ciliate-E2-Unclassified 335-434 22 1.9e-12 39.48 In-house 146-260 (352) Show / Hide 
Range on Protein: 335-434
Range on HMM: 146-260/352
Sequence Identity: 22% (26 aa)

LDIADDVLEGIHFMHSNG-LLHNDIKADNVLLELRNERWYGCIIDLGLVSTIAFPPHVTIKRS--------VMEDHKKLSGNVYV----APEVVDD-GTT
....  .|.|. ..|...  .| ||| .|.|.   ... | .|||.|. . .  ..  . ...         .. . .   . |     |||| .  .  
KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYD

LS--KASDIYSVGVLL
 |  ...||.|.||.|
HSKAYKCDIWSLGVIL
Kinase Spk380.AA AGC 218-246 33 3.7e-09 18.28 In-house 1-36 (395) Show / Hide 
Range on Protein: 218-246
Range on HMM: 1-36/395
Sequence Identity: 33% (12 aa)

FKFK-EIGRGAFGRVLLARLT------ASSDTVAIK
|.|.  ||.|.||.| |.|        .. .  |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMK
Kinase Spk380.AA TyrKc 217-479 16 6.1e-08 -94.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 217-479
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

DFKFKEIGRGAFGRVLLARLTASSDTVAIKEPLIPPYFSPPKIEAERRANFGQFTKEAVVSQFL-SRSNHFPKLYGTLVLD-------ENMCIVQEFIGD
  . |..|.||||.| .....    .||.|                       | .|| .   |  .  .  .|||  . .       | ..|| |.   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM--

KKTGKVFPLLNIMESNPSPFLSPPSLLDIADDVLEGIHFMHSNGLLHNDIKADNVLLELRNERWYGCIIDLGLVSTIAFPPHVTI-----KRSVMED---
    .   |..   ..    |... ||... .. .|  . ||... | |. | |.|.  ..                    .| |      | . .|   
----PHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------------TVKISDFGLSRDIYDDDQQ

-----HKKL----SGN--V---YVAPEVVDDGTTLSKASDIYSVGVLL---------VFIG------RAARLQGLIAIGESCSQKAPML------RPRSL
      ..     .|.  .     |||. ..|.  . .||..| ||..            |       ....  ..  |.   | .  .       |  .
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEM

KDVI-----------PKVRALQEQL
 ...           |  ... |..
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase Spk380.AA urchB 409-431 52 4.3e-07 21.83 In-house 190-212 (212) Show / Hide 
Range on Protein: 409-431
Range on HMM: 190-212/212
Sequence Identity: 52% (12 aa)

YVAPEVVDDGTTLSKASDIYSVG
|.||||. .|   | .||..|||
YIAPEVILHGQSTSISSDVFSVG
Kinase Spk380.AA AGC 409-434 35 6.1e-07 12.42 In-house 273-295 (395) Show / Hide 
Range on Protein: 409-434
Range on HMM: 273-295/395
Sequence Identity: 35% (10 aa)

YVAPEVVDDGTTLSKASDIYS--VGVLL
|.|||..      .|| |..|  .|.|.
YMAPEIL-----YGKACDWWSFGLGCLM
Kinase Spk380.AA CAMK 222-246 29 9e-06 13.85 In-house 1-37 (425) Show / Hide 
Range on Protein: 222-246
Range on HMM: 1-37/425
Sequence Identity: 29% (11 aa)

EIGRGAFGRVLLARLTASS------------DTVAIK
..|||.|| | |.. . .               ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK
Kinase Spk380.AA CAMK 341-365 36 2.3e-05 12.44 In-house 188-212 (425) Show / Hide 
Range on Protein: 341-365
Range on HMM: 188-212/425
Sequence Identity: 36% (9 aa)

VLEGIHFMHSNGLLHNDIKADNVLL
.....|..||..  | |.| .|.||
ICSAVHYCHSHNIVHRDLKPENILL
Kinase Spk380.AA AGC 341-365 33 0.000175 5.93 In-house 162-188 (395) Show / Hide 
Range on Protein: 341-365
Range on HMM: 162-188/395
Sequence Identity: 33% (9 aa)

VLEGIHFMHS-NGLLHND-IKADNVLL
.. .....|| .|  | | .| .|.||
IVLALEYLHSHMGIIHRDYLKPENILL
Kinase Spk380.AA CAMK 409-434 25 0.000399 8.4 In-house 285-324 (425) Show / Hide 
Range on Protein: 409-434
Range on HMM: 285-324/425
Sequence Identity: 25% (10 aa)

YVA-PEVVDD-------------GTTLSKASDIYSVGVLL
|.| |||.                .  ....|. |.||.|
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase Spk380.AA Pkinase 409-434 38 0.005221 11.72 Pfam 177-202 (293) Show / Hide 
Range on Protein: 409-434
Range on HMM: 177-202/293
Sequence Identity: 38% (10 aa)

YVAPEVVDDGTTLSKASDIYSVGVLL
|.||||. .|.  ....|..|.|..|
YMAPEVIRGGQYYGPKVDMWSCGCIL