Gene Spk376 (Sea Urchin)
Spk376
Sequence
Protein domains of Spk376.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk376.AA | urchC | 40-258 | 70 | 1e-183 | 600.09 | In-house | 1-223 (223) | Show / Hide |
Range on Protein: 40-258 Range on HMM: 1-223/223 Sequence Identity: 70% (158 aa) QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYM |||||..||||||||||||||||||||.|||..|.|..|.|.|||..||.|.|||||||.|.||||.|||||..||||.|...|.||||||||.|||.|| QTILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVYM LMDAICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYP-HLSGSNGSMSTHAKGY-FIHTAP |.||.||||||||.|.|||||.|||.|||||||...|...||||||||||||||.||.||...|||.|||||..|| |..|.|..|..|.|.| |||.|| LHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAP EVLK--GCATSVASDVYSVGIIL |||. ||..|||||.||||.|| EVLDIDGCQVSVASDIYSVGVIL |
|||||||||
| Kinase | Spk376.AA | urch | 46-255 | 46 | 1.9e-123 | 416.4 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 46-255 Range on HMM: 1-217/217 Sequence Identity: 46% (100 aa) VGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLT--AELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYMLMDA .|.|.||.|.|.|....|.|| ||.....||.| .|.|....|... |..|||. ...||..||||.|.|.|. |.|.|||.||||||..||.|.|... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC ICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKN-RWVAVIIDLGMVSTVTYP-HLSGS-NGSMSTHAKGY-FIHTAPEV |.....|.| |...|||...|.|||..|. |.|. ..||||.|.||||||.|.. ||.|||||.|.|.|.|.| ..... ...|.....|. ..|.|||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC LK-GCATSVASDVYSVG .. |...|.|||||||| VLDGQPCSIASDVYSVG |
|||||||||
| Kinase | Spk376.AA | urch-unclassified | 46-216 | 36 | 7e-46 | 158.74 | In-house | 1-172 (215) | Show / Hide |
Range on Protein: 46-216 Range on HMM: 1-172/215 Sequence Identity: 36% (64 aa) VGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRK---QCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYMLMD |||..| | ..|. .| || .| ...| .. .| .. . | |||. . .. .||||| .| | .. |.| ||.||| ...| | . IGKGTFGKVFMMRHQREAVPVKVKMIHEHHN--DYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ AICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKN--RWVAVIIDLGMVSTVTYPH .| | | . | . | .||. | |.| |||||.| .|.||. . || | |||.||.||.|.|| WIHERHKSN--PALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPH |
|||||||||
| Kinase | Spk376.AA | urchB | 41-215 | 41 | 2.5e-33 | 116.89 | In-house | 2-168 (212) | Show / Hide |
Range on Protein: 41-215 Range on HMM: 2-168/212 Sequence Identity: 41% (73 aa) TILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQ--CNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTY | .| |.|| |.. | | | || | | | . | ||| .|| |||||.|.|| | | |. ||.| | | | NDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIGY MLMDAICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYP | | | | | |||..|. .| ||||| | |||||| | |. ||||| |||||.| | PLHEP----------PPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAP |
|||||||||
| Kinase | Spk376.AA | TKL | 46-258 | 16 | 3.2e-20 | 69.52 | In-house | 1-279 (364) | Show / Hide |
Range on Protein: 46-258
Range on HMM: 1-279/364
Sequence Identity: 16% (51 aa)
VGKGSYGEVMLGRLNGEK--------DPVVIKRALVKQNLTAELEESD-------------RKQCNIRCEKEARAGLMMST--SPYFPRFLGTVMTDGD-
.|.|..||| |...|. .|..|. .... .. . . . ...| . .||| | .|.| .. ..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------HCLVTEFI-----GDKIQGKTYMLMDAICPRKGCDPVPDVQKWNL-VAIGEDIIRGVIALHGLS--------LLHNDIKDDNVLLE--
.|.|.|.. . .. |.. . . || ||. || ..| |.| .|.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN
---------FRKNRWVAVIIDLGMVSTVTYPH--------------LSGSNGSMSTHAKGYFIHTAPEVLKGC----------------ATSVASDVYSV
... |.. | |.| ... .. .|.... . | . . |||||.| | ..||||
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSF
GIIL
||.|
GIVL
|
|||||||||
| Kinase | Spk376.AA | urchA | 95-252 | 25 | 1.5e-17 | 53.29 | In-house | 44-208 (208) | Show / Hide |
Range on Protein: 95-252 Range on HMM: 44-208/208 Sequence Identity: 25% (44 aa) KEARAGLMMSTSPYFPRFLGTVMTDGDHC-LVTEFIGDKIQGKTYMLMDAICP----RKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDN .|.. . . .|.|| |.| ..| . ||.|| .|. | ... . |. |. . .. || | ..| | || |.|| NEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEMRQ-----PALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDN VLLEF-RKNRWVAVIIDLGMVSTVTYPH------LSGSNGSMSTHAKGYFIHTAPE-VLKGCATSVASDVY .|. || |.|||.| . . | .. ... | ||| .|.. | .|||| CLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRC-CHIAPECALDAQPCSTSSDVY |
|||||||||
| Kinase | Spk376.AA | S_TKc | 40-297 | 18 | 1e-12 | 9.56 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-297 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEFIGDKIQGKTYM .||...|||..|.|...| .. . | ||. .. ..| . . |. ..... . .. ..|.|... | . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCD----GDLGD LMDAICPRKG---CDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPHLSGSNGSMSTHAKGYFIHT- |.| |. |.. . | | . . ... |.... .| . .| |.| .|.|| . |.| |. . |. | LFDYIKKRGRHGLRFPFPE-HARFYMY---QICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TTFCGTP ---APEVLKGCATSV-ASDVYSVGIIL-------------DCIGDFIKDDDLCTLVEVCCKEDPKERPGDMEEML-------PGVV ||||| . ..|..|.|.|| . . . |...... ... |.. ||..||. | . . WYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | Spk376.AA | C8 | 168-258 | 26 | 1.5e-10 | 32.9 | In-house | 132-226 (226) | Show / Hide |
Range on Protein: 168-258 Range on HMM: 132-226/226 Sequence Identity: 26% (26 aa) IIRGVIALHGLSLLHNDIKDDNVLLEFRKNRW-VAVIIDLGMVSTVTYPHLSGSNGSMSTHAK---GYFIHTAPEVLKG-----CATSVASDVYSVGIIL .| || .| .| ||| .| |. . .| . |.|. |.|. . .. .. | . |||..|. . ||..|||..| MIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSK-----NKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
|||||||||
| Kinase | Spk376.AA | Ciliate-E3 | 161-261 | 31 | 6.2e-10 | 27.46 | In-house | 105-202 (202) | Show / Hide |
Range on Protein: 161-261 Range on HMM: 105-202/202 Sequence Identity: 31% (32 aa) LVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPHLSGSNGSMSTHAKG-YFIHTAPEVLKGCATSVASDVYSVG-IIL . | ||.|.||.| . | ||| || |. ..|. .. | |.| |. .| .| . | . . |||... . | || |||| ... IYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESK-----QLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFC DCI . . QLC |
|||||||||
| Kinase | Spk376.AA | Ciliate-C8 | 168-258 | 26 | 4.4e-09 | 29.02 | In-house | 128-238 (238) | Show / Hide |
Range on Protein: 168-258 Range on HMM: 128-238/238 Sequence Identity: 26% (29 aa) IIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVII-------DLGMVSTVTYPHL----SGSNGSMST--HA-KGYFIHTAPEVLKG------CATSV .| .| || .| ||| .| |. | .. . . |.| | ... . .|. . .. | . .||||.|. | MIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSK ASDVYSVGIIL ||.||||..| KSDSYSVGLVL |
|||||||||
| Kinase | Spk376.AA | Ciliate-E2-Unclassified | 168-258 | 23 | 1e-07 | 22.9 | In-house | 152-260 (352) | Show / Hide |
Range on Protein: 168-258
Range on HMM: 152-260/352
Sequence Identity: 23% (27 aa)
IIRGV-IALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVS--------------------TVTYPHLSGSNGSMSTHAKGYFIHTAPEVLKGCATS
|. | | . .| ||| .|.|. ... |||.| . . . .|... |. ||||||.|. .
ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYD
----VASDVYSVGIIL
..|..|.|.||
HSKAYKCDIWSLGVIL
|
|||||||||
| Kinase | Spk376.AA | urch-unclassified | 234-255 | 65 | 1e-06 | 20.06 | In-house | 193-215 (215) | Show / Hide |
Range on Protein: 234-255 Range on HMM: 193-215/215 Sequence Identity: 65% (15 aa) HTAPE-VLKGCATSVASDVYSVG | ||| || | |||.||.|| | HMAPEIVLYGQPTSVYSDIYSLG |
|||||||||
| Kinase | Spk376.AA | TyrKc | 40-314 | 14 | 2e-06 | -117.95 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 40-314
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)
QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTS-PYFP---RFLGTVMTD-------GDHCLVTE-
| ... | | .|||..|... .| .| .||| .|. . | |..| .... . ...|.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREAR---IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY
--------FIGDKIQGKTYMLMDAICPRKGCDPVPDVQKWNLVAIGEDIIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVAVIIDLGMVSTVTYPH---
.. .. .. |. . .| .| || . | |. |.|. .. .. | | |. | | .
MPHGDLKDYLRKHRPK--------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGL-SRDIYDDDQQ
-LSGSNGSMST--HAK--GYFIHTAPEVLKGCATSVASDVYSVGIIL-----DCIGDF-------IKDDDLCTLVEVCCKEDPKER---------PGDME
|.. .... ..| .|||... . . .|||.| |. . .. ...... .|. .. . | .|
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY
EMLPGVVDIKEKHRTVARLAGESL
.. . . . | . | .
QIMKQCWHEDPEDRPTFSEIHECF
|
|||||||||
| Kinase | Spk376.AA | urchB | 236-255 | 66 | 3e-06 | 18.97 | In-house | 192-212 (212) | Show / Hide |
Range on Protein: 236-255 Range on HMM: 192-212/212 Sequence Identity: 66% (14 aa) APEV-LKGCATSVASDVYSVG |||| | | .||..|||.||| APEVILHGQSTSISSDVFSVG |
|||||||||
| Kinase | Spk376.AA | Pkinase | 168-258 | 27 | 6e-06 | 22.21 | Pfam | 117-202 (293) | Show / Hide |
Range on Protein: 168-258 Range on HMM: 117-202/293 Sequence Identity: 27% (26 aa) IIRGVIALHGLSLLHNDIKDDNVLLEFRKNRWVA----VIIDLGMVSTVTYPHLSGSNGSMSTHAKGYFIHTAPEVLK-GCATSVASDVYSVGIIL |.||. .| . .| |.| .|.|. ... . |.| | . |.| |. | ||||.. | . ..|..|.|.|| ILRGLEYCHSMGIIHRDLKPENILID-NNG--HIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL |
|||||||||
| Kinase | Spk376.AA | Pkinase | 40-128 | 16 | 0.000125 | 17.45 | Pfam | 1-81 (293) | Show / Hide |
Range on Protein: 40-128 Range on HMM: 1-81/293 Sequence Identity: 16% (15 aa) QTILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQNLTAELEESDRKQCNIRCEKEARAGLMMSTSPYFPRFLGTVMTDGDHCLVTEF .|....|.||.|.| ... |. . |..|. .. . .... | |.. ... .|. |.......... ..|.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEY |
|||||||||
| Kinase | Spk376.AA | Ciliate-E2-Unclassified | 41-76 | 22 | 0.001697 | 8.02 | In-house | 2-37 (352) | Show / Hide |
Range on Protein: 41-76 Range on HMM: 2-37/352 Sequence Identity: 22% (8 aa) TILETVGKGSYGEVMLGRLNGEKDPVVIKRALVKQN .|... |.|..|.| . . . .| ..| . ..|. KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI |
|||||||||
| Kinase | Spk376.AA | Pkinase_Tyr | 41-69 | 33 | 0.004209 | 11.13 | Pfam | 2-34 (270) | Show / Hide |
Range on Protein: 41-69 Range on HMM: 2-34/270 Sequence Identity: 33% (11 aa) TILETVGKGSYGEVMLGRLN----GEKDPVVIK |.... |.|..|||..|... ..| || .| TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK |
|||||||||
| Kinase | Spk376.AA | Pkinase_Tyr | 235-253 | 36 | 0.174699 | 5.65 | Pfam | 181-199 (270) | Show / Hide |
Range on Protein: 235-253 Range on HMM: 181-199/270 Sequence Identity: 36% (7 aa) TAPEVLKGCATSVASDVYS .|||... . ...|||.| MAPECINYGKFTTKSDVWS |
|||||||||
| Kinase | Spk376.AA | TKL | 267-286 | 30 | 0.204975 | 0.87 | In-house | 336-355 (364) | Show / Hide |
Range on Protein: 267-286 Range on HMM: 336-355/364 Sequence Identity: 30% (6 aa) DDDLCTLVEVCCKEDPKERP ..... | . |...||..|| PPSMKKLMQDCWDHDPEKRP |
|||||||||