Gene Spk017 (Sea Urchin)
Spk017
Sequence
Protein domains of Spk017.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk017.AA | urchB | 179-390 | 78 | 2.1e-195 | 655.47 | In-house | 1-212 (212) | Show / Hide |
Range on Protein: 179-390 Range on HMM: 1-212/212 Sequence Identity: 78% (166 aa) INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIA |||||||||||||||..|||.|||.||||||.|.|.|||..||||||.|||||.||.|||..|||.||||.||.|.||||||.|||.||||||..|.||. INDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIG FPLLEPPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEGDYVAPEVILHGQ .||.||||||..|..|||||.|.|.||.|||||||||||.|||||||||||||||||||||||||..||.|.|.|..||.||.||||.||.||||||||| YPLHEPPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQ STSISSDVFSVG |||||||||||| STSISSDVFSVG |
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| Kinase | Spk017.AA | urch | 185-390 | 53 | 4.1e-127 | 428.59 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 185-390 Range on HMM: 1-217/217 Sequence Identity: 53% (117 aa) IGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIAFPLLEP |||||||||.|.|| |||.|.|||. | ..||. .|||..|...|...|..|||.||||.|..|.||.|.|..|||.||||..||.|..| |. .||... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC PP----------LSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGH-RYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEGDYVAPEV . || | |.||||.|.|.|..||||.|||||| |||||||||| |.||||||||.|.|. |..|...|. .. .|.||.. ...|||. IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPEC ILHGQSTSISSDVFSVG .|.||..||.|||.||| VLDGQPCSIASDVYSVG |
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| Kinase | Spk017.AA | urchC | 180-393 | 38 | 7e-72 | 232.02 | In-house | 2-223 (223) | Show / Hide |
Range on Protein: 180-393
Range on HMM: 2-223/223
Sequence Identity: 38% (88 aa)
NDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIAF
. | .||.| ||.|.|.| | | ||| . . | . |..|||.| |..| .|.|||..||. ||...|. .||.| . | .
TILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQH--FTPEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY
PL---LE-------PPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSP----LRMTELPEALKVA-YIHGE
.| .. | .. | ..||||..|| . .|| |||||| | |||||| |. | |..||| |||||. | .|. | .||
MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIH--
EGDYVAPEVIL-HGQSTSISSDVFSVGKIL
.||||. | .| .||..||| ||
----IAPEVLDIDGCQVSVASDIYSVGVIL
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| Kinase | Spk017.AA | urch-unclassified | 185-390 | 35 | 1.1e-65 | 224.52 | In-house | 1-215 (215) | Show / Hide |
Range on Protein: 185-390
Range on HMM: 1-215/215
Sequence Identity: 35% (76 aa)
IGRGTYGRVLLARHVQTKTPLAIK-QSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIAFPLL-
|| ||.|.| . || . | ..| .. . | || . .| |||.||.|..|.| ||| .| .. ..|.. || |. . .. ||
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYD--YEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQ
----EP---PPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGH--RYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEGDYVAPEV
. | || . ..|..|.. |... |. .||||||| .|.||....| | || ||||||.||. |. .. . | | . |||.
WIHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEI
ILHGQSTSISSDVFSVG
.| || ||. ||..| |
VLYGQPTSVYSDIYSLG
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| Kinase | Spk017.AA | urchA | 185-387 | 32 | 5e-47 | 149.76 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 185-387 Range on HMM: 1-208/208 Sequence Identity: 32% (71 aa) IGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKD-LCLAQEFVGNRKSGIA----F |||.|| | | || ||. | |.| | .|... . ..|. .||.|. .|.|| |.| ..|..| .| ||.| | LGRGVYGTVHLYRHRQTDHPVALKV------IELPKEYKKMRR--KIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITW PLLE-----PPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEK-RGHRYHAVIIDFGMVSTISSPL---RMTELPEALKVAYIHGEEGDYVA |. | |. .... |. || .|. | | |||| ||.|. | . | |.||||| . . | || . . | | . ..| CLDKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRM-HFDQRQKQFYRYCHRCCHIA PEVILHGQSTSISSDVF || .| .|. |.||||. PECALDAQPCSTSSDVY |
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| Kinase | Spk017.AA | S_TKc | 179-437 | 16 | 2.4e-15 | 48.13 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 179-437 Range on HMM: 1-231/231 Sequence Identity: 16% (48 aa) INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKSGIA |..||.|..|.| ..||. |. |||. ....| ... . |. ..... . ..|.. |.... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLF FPLLEPPP------LSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEG--DYVA . . .. .. .. ....| .|.|| .| ||| .|.|| . | |.|||. . . | .|.| DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------------TTFCGTPWYMA PEVILHGQSTSI-SSDVFSVG---------KI----LEDITQVVEEGSPLLKALTALANKCMKRNPESRPDLPSLLR-------ASST |||. . . ..|. |.| . .. . ... . . . .||....|| || .|. PEVL----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk017.AA | Pkinase | 179-393 | 20 | 2.4e-14 | 51.8 | Pfam | 1-202 (293) | Show / Hide |
Range on Protein: 179-393 Range on HMM: 1-202/293 Sequence Identity: 20% (47 aa) INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEM---VDEAHDATRARVKKEALVHQLLSDSPFFPRFLGTLDIDKDLCLAQEFVGNRKS . .. ||.|..|.| ...|. | |.|. ..... .. |. ... | ..|. |.... ...... .|.... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------------SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY GIAFPLL------EPPPL--SVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHR-YHAVIIDFGMVSTISSPLRMTELPEALKVAYIHGEEG . | . .. | ... ..||| .|..| .| ||| .|.|. ..|| . |.||| .. . .. | --VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCG --DYVAPEVILHGQSTSISSDVFSVGKIL .|.|||||..|| . ..|..|.| || TPWYMAPEVIRGGQYYGPKVDMWSCGCIL |
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| Kinase | Spk017.AA | STE | 295-390 | 21 | 1e-09 | 30.62 | In-house | 156-255 (359) | Show / Hide |
Range on Protein: 295-390 Range on HMM: 156-255/359 Sequence Identity: 21% (24 aa) IAEDVVRG-LMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSPLRMTELPE----------ALKVAYIHGEEGDYVAPEVILHG-----Q |. ....| | .|.|. | |.| .|.|| . ..||| . ... .. . . . | . | . |||||. . . ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQNGQGRDK STSISSDVFSVG ....|. |.| GYDTKCDIWSLG |
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| Kinase | Spk017.AA | Ciliate-C7 | 287-339 | 37 | 6.5e-09 | 25.22 | In-house | 99-148 (164) | Show / Hide |
Range on Protein: 287-339 Range on HMM: 99-148/164 Sequence Identity: 37% (20 aa) LSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGM |. . . .|.|. || .||. ... |||| || | | ||..|||. LNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGN---AVVCDFGL |
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| Kinase | Spk017.AA | NKF1 | 180-209 | 36 | 1.1e-08 | 26.1 | In-house | 2-31 (269) | Show / Hide |
Range on Protein: 180-209 Range on HMM: 2-31/269 Sequence Identity: 36% (11 aa) NDLQEIGRGTYGRVLLARHVQTKTPLAIKQ . .. | |.||..||..| |..|..|.|. EIIRQLGEGCYGKILLCEHRQSGTRMALKF |
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| Kinase | Spk017.AA | TyrKc | 179-435 | 17 | 2.1e-08 | -86.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 179-435 Range on HMM: 1-280/280 Sequence Identity: 17% (55 aa) INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENYQLLNEMVDEAHDATRARVKKEALVHQLL-SDSPFFPRFLGTLDID-------KDLCLAQEFV | ....|.| .|.| ... .. |.| . |. .|| . | . | |..| . . |.. |.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM GN-------RKSGIAFPLLEPPPLSVANGLDIAEDVVRGLMEIHDHGLLHNDLKTDNVLLEKRGHRYHAVIIDFGMVSTISSP-LRMTELPEALKVAYIH . ||.. |... |... .. .| .|.... | || . |.|. ... .. | |||. | . . . | | . PHGDLKDYLRKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-----ESKDYYRK GE--EGD------YVAPEVILHGQSTSISSDVFS----------------VG-----KILEDITQVVEEG----SPLL----------KALTALANKCMK | |. |||.| .| |. |||.| | . ... . |..| | ... . .| . KEHKGGKTMLPIRWMAPECINYGKFTT-KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH RNPESRPDLPSLLRAS ..||.|| . . EDPEDRPTFSEIHECF |
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| Kinase | Spk017.AA | TKL | 293-390 | 19 | 6.6e-08 | 24.58 | In-house | 135-276 (364) | Show / Hide |
Range on Protein: 293-390
Range on HMM: 135-276/364
Sequence Identity: 19% (27 aa)
LDIAEDVVRGLMEIHDHG--------LLHNDLKTDNVLLEKRGH-----------RYHAVIIDFGMVSTISSPLRMTELPEALK-------VAYIHGEEG
...| |. ||. | .. ..| |||..|.|. . .. ... | ||| ..| |. . . . .. ..
CRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQC
---DYVAPEVIL---------------HGQSTSISSDVFSVG
. ||||. .| . | ..||.| |
GTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG
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| Kinase | Spk017.AA | Ciliate-E2-Unclassified | 293-393 | 21 | 7.7e-07 | 19.78 | In-house | 146-260 (352) | Show / Hide |
Range on Protein: 293-393 Range on HMM: 146-260/352 Sequence Identity: 21% (28 aa) LDIAEDVVRGLMEIHDHG-LLHNDLKTDNVLLEKRGHRYHAVIIDFGMVS---------------------TISSPLRMTEL--PEALKVAYIHGEEGDY .... .. || .| . .| |.| .|.|. . | .|. ||||| . ... | | | KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------------Y VAPEVILH-GQSTS--ISSDVFSVGKIL ||||. ....| ...|..|.| || TAPEVLQGQNYDHSKAYKCDIWSLGVIL |
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| Kinase | Spk017.AA | STE | 179-209 | 23 | 1.4e-05 | 15.76 | In-house | 1-46 (359) | Show / Hide |
Range on Protein: 179-209 Range on HMM: 1-46/359 Sequence Identity: 23% (11 aa) INDLQEIGRGTYGRVLLARHV------QTKTP---------LAIKQ ....||.|..| | .|... .|. |||| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQ |
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| Kinase | Spk017.AA | Ciliate-E2-Unclassified | 179-216 | 26 | 4.8e-05 | 13.48 | In-house | 1-38 (352) | Show / Hide |
Range on Protein: 179-216 Range on HMM: 1-38/352 Sequence Identity: 26% (10 aa) INDLQEIGRGTYGRVLLARHVQTKTPLAIKQSCRSENY . .. ||.| .| | ...| ..| |.|. . . .| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIY |
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| Kinase | Spk017.AA | TKL | 185-209 | 21 | 0.000556 | 10.24 | In-house | 1-33 (364) | Show / Hide |
Range on Protein: 185-209 Range on HMM: 1-33/364 Sequence Identity: 21% (7 aa) IGRGTYGRVLLARHVQTK--------TPLAIKQ ||.|..| | ... .. .. |.|. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKK |
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| Kinase | Spk017.AA | NKF1 | 306-323 | 44 | 0.00414 | 6.82 | In-house | 117-134 (269) | Show / Hide |
Range on Protein: 306-323 Range on HMM: 117-134/269 Sequence Identity: 44% (8 aa) IHDHGLLHNDLKTDNVLL .|...| | |.| .|||. MHSRNLVHRDIKPENVLV |
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| Kinase | Spk017.AA | Ciliate-C7 | 182-208 | 40 | 0.005131 | 6.05 | In-house | 1-27 (164) | Show / Hide |
Range on Protein: 182-208 Range on HMM: 1-27/164 Sequence Identity: 40% (11 aa) LQEIGRGTYGRVLLARHVQTKTPLAIK . .|.| .| ||||. .|. ||| FRFLGQGQQGLVLLAKDQKTNMRYAIK |
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| Kinase | Spk017.AA | STE | 396-433 | 17 | 0.06601 | 2.67 | In-house | 293-353 (359) | Show / Hide |
Range on Protein: 396-433 Range on HMM: 293-353/359 Sequence Identity: 17% (11 aa) ITQVVEEGSPLL------------------------KALTALANKCMKRNPESRPDLPSLLR . ..|....| | . . ||| ...|. ||. ||. L-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK |
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