Gene Spk399 (Sea Urchin)

Spk399

Species: Sea Urchin
Alias: Spk399
External Links:
Annotation:

Classification

Group: Other
Family: urch
Subfamily: urchA

Sequence

Name Sequence Type Origin Length Description Download
Spk399.AA Protein None 537 None Fasta, JSON
Spk399.kin_dom Protein Kinase Domain None 163 None Fasta, JSON

Protein domain

Protein domains of Spk399.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk399.AA urchA 292-490 54 1.2e-144 469.48 In-house 1-208 (208) Show / Hide 
Range on Protein: 292-490
Range on HMM: 1-208/208
Sequence Identity: 54% (113 aa)

LGSGANGTVHLYRHRATDHPIALKTFELPNDIKSMTRKATAIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGES----WTLSR--GM
||.|..|||||||||.||||.|||..|||...|.|.||....|.|..|..|||.|..||||.||.||...|.|.||.|.||.|||||    |.|..  .|
LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM

RNLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLACPCDAPY---FYRFSNENKEKYRRREVHVHIAPECALDDRL
|..||... |....||||..|...||||||.|||||||||.|||..|||.|.|.|||.||||..|.   ...|. . |. || .    ||||||||| . 
RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQP

TSVASDVF
 | .|||.
CSTSSDVY
Kinase Spk399.AA urch 292-493 38 1.9e-110 373.26 In-house 1-217 (217) Show / Hide 
Range on Protein: 292-493
Range on HMM: 1-217/217
Sequence Identity: 38% (84 aa)

LGSGANGTVHLYRHRATDHPIALKTFELPNDIKSMTR--------KATAIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGES----W
.|.|..|.|||||||.|..|.|.|....|.....|..        . .....||...........||.|.||..|. ....|.|.|.||..||.|    |
IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW

TLS---RGMRNLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLACPCDAPY-FYRFSNENKEKYRRREVHVHIAPE
...   ..|.|..||.. ||. |.||.... ..|..|||.|||||||.||.|...|||.|||.|||..|....|. ...|..| .. |..... .|||||
CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE

CALDDRLTSVASDVFQLG
|.|| . .|.||||. .|
CVLDGQPCSIASDVYSVG
Kinase Spk399.AA urch-unclassified 292-493 28 2e-40 140.63 In-house 1-215 (215) Show / Hide 
Range on Protein: 292-493
Range on HMM: 1-215/215
Sequence Identity: 28% (61 aa)

LGSGANGTVHLYRHRATDHPIALK-TFELPND-IKSMTRK---AT--AIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGESWTLSRG
.| |. | | ..|| ..  | . |   |. || .  | ..   .    |  || .  ...    ||  .|  ..  .  ...|.| ||  |.   .|.. 
IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQNKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHE-DCPCIVMEFLGDKQTYTVYPLCQW

MRNLA-----LSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPT-GRWQAVIVDFGLACPCDA-PYFYRFSNENKEKYRRREVHVHIAPECA
          || . |.  ..|| . .   ||.. | |||| .| ||.. .   || | | |||.. . .    . .|| . .. |.   .  |.|||  
IHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAPEIV

LDDRLTSVASDVFQLG
|.   |||.||.. ||
LYGQPTSVYSDIYSLG
Kinase Spk399.AA urchB 293-493 35 8.1e-17 57.06 In-house 8-212 (212) Show / Hide 
Range on Protein: 293-493
Range on HMM: 8-212/212
Sequence Identity: 35% (74 aa)

GSGANGTVHLYRHRATDHPIALKT------FELPNDIKSMTRKAT--AIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGESWTLSRG
| |  | | . ||| |  | | |       . .||      . ||   .. || |   .     || |.| | |      .|  |||   ||  . |   
GRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDID-NDLCQAQEFVGCKKTGIGYPL---

MRNLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLACPCDAPY-FYRFSNENKEKYRRREVHVHIAPECALDDRLT
     ||    .  | || | .  .|  | | |||| || || |    |. |||.|||..    ||        | |  |   |    ||||  |..  |
HEPPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGH-RYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQST

SVASDVFQLG
|..||||  |
SISSDVFSVG
Kinase Spk399.AA urchC 336-496 29 6.5e-16 47.8 In-house 57-223 (223) Show / Hide 
Range on Protein: 336-496
Range on HMM: 57-223/223
Sequence Identity: 29% (50 aa)

EAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGESWTLSRGMR-------NLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLL--
|| .. .. .   || ..| . |  . . .   |.||  .| .. |   |         . ..    .| | || .    .|  | | || | || ||  
EARVGQMMSTCPYFPRMYGTVMID-ENMCIVTEFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEH

RKTPTGRWQAVIVDFGLACPCDAPYFYRFSNENKEKYRRREVHVHIAPECALD--DRLTSVASDVFQLGRLL
||    || ..|.| |.      |   | .|   .  ..    .|||||  ||     .|||||..  | .|
RKE---RWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAPEV-LDIDGCQVSVASDIYSVGVIL
Kinase Spk399.AA TESK 387-450 39 6.9e-13 36.58 In-house 88-155 (292) Show / Hide 
Range on Protein: 387-450
Range on HMM: 88-155/292
Sequence Identity: 39% (27 aa)

NLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLA----CPCDAP
.|.|| .  . ||.|||. .  .|.||    ||   ||| |. .   ..||. |||||    |  | |
ELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPP
Kinase Spk399.AA LISK 398-444 38 2.1e-08 23.2 In-house 106-152 (296) Show / Hide 
Range on Protein: 398-444
Range on HMM: 106-152/296
Sequence Identity: 38% (18 aa)

LALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLA
.|||||...   |... .  |||  |||.|. . ..|.... |||.|
IALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA
S_TKc Spk399.AA S_TKc 283-537 13 5.6e-08 -59.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 283-537
Range on HMM: 1-231/231
Sequence Identity: 13% (40 aa)

FHKGGGDVFLGSGANGTVHLYRHRATDHPIALKTFELPNDIKSMTRKATAIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMT--GESWT
....     .|.|| |.|.. ||. |..  |.|                 |..|  ||    . .   ..... .   ... . |...    .  |.  .
YEILR---KIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYC---DGDLGDLFD

LSRGMRN----LALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLACPCDAPYFYRFSNENKEKYRRREVHVH--IAP
. . ..       ..      ..  |.. |  .|..|..  ||| .| || .      .  | |||||.                   .  .     .||
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------TTFCGTPWYMAP

ECALDDRLTSVASDV-------FQLGRLLTLMGGATTNADLTAIGNICRQSSQLC-------------RPSIEEVVA-----ELERMM
|       .  ..|.       . .    ..        .. .. .... |....             ||.. |. .      .   .
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Spk399.AA Ciliate-C7 386-444 40 2e-06 17.18 In-house 95-149 (164) Show / Hide 
Range on Protein: 386-444
Range on HMM: 95-149/164
Sequence Identity: 40% (24 aa)

RNLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLA
.|  |..   .  | |||  |  ||.|....|||| || |          ||. |||||
QNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDY----NGNAVVCDFGLA
Kinase Spk399.AA IKK 289-334 23 1.1e-05 15.62 In-house 4-49 (297) Show / Hide 
Range on Protein: 289-334
Range on HMM: 4-49/297
Sequence Identity: 23% (11 aa)

DVFLGSGANGTVHLYRHRATDHPIALKTFELPNDIKSMTRKATAIQ
.  ||.|| | | ..||..|.  .| |...  .  . ...    ..
CDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFE
Kinase Spk399.AA TKL 398-444 27 0.000469 10.51 In-house 137-201 (364) Show / Hide 
Range on Protein: 398-444
Range on HMM: 137-201/364
Sequence Identity: 27% (18 aa)

LALDIAKSLGRIHE--------KGFLMNDLKEDNCLLRKTPT----------GRWQAVIVDFGLA
.|||||. .   |         .. .  ||| .|.|. .  |            | . | ||||.
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLS
Kinase Spk399.AA TyrKc 292-533 16 0.000638 -159.22 SMART 7-280 (280) Show / Hide 
Range on Protein: 292-533
Range on HMM: 7-280/280
Sequence Identity: 16% (50 aa)

LGSGANGTVHLYRHRATDHPIALKTFELPNDIKSMTRKATAIQSEAFILDVLG-REDCFPTFLGCLEI--------SPGKIGLAM-------DFVGDTMT
||.|| |.|.. . .    . | |.               .. .|| |.  || . ..   ..|.            |  | .         |.  ..  
LGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

GESWTLSRGMRNLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQAVIVDFGLACPCDAP-YFYRFSNENKEKYRRRE-VHVH--
              |. .  |  ...||.    .|.|..   ||   |||. .      .. | ||||.   .          |.|. || .|  . .  
K-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTM

-----IAPECALDDRLTSVASDVF--------------------------------QLGRLLTLMGGAT--------TNADLTAIGNICRQSSQLCRPSI
      ||||  ...  . .|||.                                .. .   ..  .           ...  |   | .    .||. 
LPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

EEVVAEL
.|.. ..
SEIHECF
Kinase Spk399.AA TKL 292-326 25 0.001098 9.16 In-house 1-43 (364) Show / Hide 
Range on Protein: 292-326
Range on HMM: 1-43/364
Sequence Identity: 25% (11 aa)

LGSGANGTVHLYRHRATD--------HPIALKTFELPNDIKSM
.|||. |.|.  ..| ..         ..| |.|   || ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFT
Kinase Spk399.AA LISK 291-315 36 0.212995 0.07 In-house 1-25 (296) Show / Hide 
Range on Protein: 291-315
Range on HMM: 1-25/296
Sequence Identity: 36% (9 aa)

FLGSGANGTVHLYRHRATDHPIALK
 .|.|. | |   .||.|  ..|.|
EIGKGFFGKVYKGTHRQTGQVMAIK