Gene Spk363 (Sea Urchin)
Spk363
Sequence
Protein domains of Spk363.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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| Kinase | Spk363.AA | urchA | 528-722 | 56 | 7.1e-152 | 493.12 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 528-722 Range on HMM: 1-208/208 Sequence Identity: 56% (117 aa) LGRGVAGTVSLFRHAVSKIPVAAKLVEYPG---------ECFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITDCLEKSMLK |||||.||| |.||.....|||.|..|.|. |||.||..|||.....||||||||...|..|....||||.|.|....|||||.||.|.|.. LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM TGPDLTRDEWFGVLNDVAEGLKALHSNGFLCNDLKEDNVLVVE-ESGRWRAKIIDLGWASEIATPF---VMPLDEEQIDFYRSGQGCGHIAPECVLDASP ..|.||||.|. |..|.|||||..|..|||||||||||.||.. |.|||||||||.|||.....|| .|..|..|..|||....|.||||||.|||.| RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQP CSTSSDVY |||||||| CSTSSDVY |
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| Kinase | Spk363.AA | urch | 528-725 | 43 | 2.7e-114 | 386.03 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 528-725 Range on HMM: 1-217/217 Sequence Identity: 43% (95 aa) LGRGVAGTVSLFRHAVSKIPVAAKLVEYPG-----------------ECFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITD .|||..|.| |.||. .|.||| | ...| |.|..|...||..|| |.||.||| .||. |. .|.|||||......||.... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW CLEKS-MLKTGPDLTRDEWFGVLNDVAEGLKALHSNGFLCNDLKEDNVLVVE-ESGRWRAKIIDLGWASEIATPF-VMPLDEEQIDFYRSGQGCGHIAPE |..|| |....|.|....|. ...|...|..|.|..|||.|||||||||... ..|||.|.|||.||......|| .|....|....|..|.|..||||| CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE CVLDASPCSTSSDVYSLG ||||..|||..|||||.| CVLDGQPCSIASDVYSVG |
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| Kinase | Spk363.AA | urch-unclassified | 563-725 | 32 | 1.3e-41 | 144.53 | In-house | 52-215 (215) | Show / Hide |
Range on Protein: 563-725 Range on HMM: 52-215/215 Sequence Identity: 32% (54 aa) EVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITDCLEKSMLKTGPDLTRDEWFGVLNDVAEGLKALHSNGFLCNDLKEDNVLVVEE |...|.. .. | || || ..|.. . ..|||.| . . |. . . | | | . .|. .. |. .|..|.|. . | |||| .|.|. EAMVHRLFADHPYFPRCYGMVKHEDCPC-IVMEFLGDKQTYTVYPLCQWIHERH-KSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWC SG--RWRAKIIDLGWASEIATP---FVMPLDEEQIDFYRSGQGCGHIAPECVLDASPCSTSSDVYSLG . ||.|.|||.| .| .. | . .. |.. |..| |.||| ||. | | ||.|||| DHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMRE--YMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk363.AA | urchC | 560-728 | 31 | 2.8e-25 | 78.61 | In-house | 54-223 (223) | Show / Hide |
Range on Protein: 560-728
Range on HMM: 54-223/223
Sequence Identity: 31% (54 aa)
FRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITDCLE-KSMLKTGPDLTRDEWFGVLNDVAEGLKALHSNGFLCNDLKEDNVL
.. | |. | .|. |.|| .|| |... . ||||. ..| | .. . |.. . |. .| ..|..| | || | ||||
CEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVT-EFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVL
VVEESGRWRAKIIDLGWASEIATPFVMPLDEEQIDFYRSGQGCGHIAPECVLD--ASPCSTSSDVYSLGRFL
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LEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAPE-VLDIDGCQVSVASDIYSVGVIL
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| Kinase | Spk363.AA | urchB | 634-725 | 40 | 2.2e-16 | 55.46 | In-house | 120-212 (212) | Show / Hide |
Range on Protein: 634-725 Range on HMM: 120-212/212 Sequence Identity: 40% (38 aa) DVAEGLKALHSNGFLCNDLKEDNVLVVEESGRWRAKIIDLGWASEIATPFVM-PLDEEQIDFYRSGQGCGHIAPECVLDASPCSTSSDVYSLG |. |. .| | | |||| |||| |. | ||| | .| | | | . .| | | |||| .|. . | ||||.| | DIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG |
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| S_TKc | Spk363.AA | S_TKc | 522-766 | 18 | 1.7e-10 | -22.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 522-766 Range on HMM: 1-231/231 Sequence Identity: 18% (50 aa) TRCSIELGRGVAGTVSLFRHAVSKIPVAAKLVEYPGECFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGS--ESEDRSYTITDCLEKSMLKT . ..|.| |.| . || .. || | . | .|.|..|.. . |. ..|..|. | . ||... . | . . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD----------LFDYIKKR GPD-----LTRDEWFGVLNDVAEGLKALHSNGFLCNDLKEDNVLVVEESGRWRAKIIDLGWASEIATPFVMPLDEEQIDFYRSGQGCGH-IAPECVLDAS |. .. . .. ....|. .||.|.. ||| .|.|. | . ||.| | | .. .. | . .||| . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---- PCST-SSDVYSLG--------------RFLAIVGHAMRYDDFECFGTQIYLTDEGQRPTVQEIID--------QLY . .. ..|..|.| .. . . ... | .. | .|||. |. . GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk363.AA | TKL | 634-725 | 20 | 5e-07 | 21.36 | In-house | 140-276 (364) | Show / Hide |
Range on Protein: 634-725 Range on HMM: 140-276/364 Sequence Identity: 20% (28 aa) DVAEGLKALHSNG--------FLCNDLKEDNVLVVEES-----------GRWRAKIIDLGWASEIATPFVMPLDEEQID-----------FYRSGQGCGH |.| |. |||.. . ||| .|.|| | |..|| |.| . .. . . | . . .. . .. DIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW IAPECVLDA---------------SPCSTSSDVYSLG |||. .. .. |...|||| | MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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| Kinase | Spk363.AA | Trio | 632-689 | 25 | 9.8e-07 | 12.6 | In-house | 101-159 (258) | Show / Hide |
Range on Protein: 632-689 Range on HMM: 101-159/258 Sequence Identity: 25% (15 aa) LNDVAEGLKALHSNGFLCNDLKEDNVLVVEESG-RWRAKIIDLGWASEIATPFVMPLDE . .. |.. ||... | |.| .|..... . | . ||.|.| | .. . | |... MWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHH |
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| Kinase | Spk363.AA | LISK-DD1 | 634-676 | 40 | 1e-06 | 20.07 | In-house | 131-174 (290) | Show / Hide |
Range on Protein: 634-676 Range on HMM: 131-174/290 Sequence Identity: 40% (18 aa) DVAEGLKALHSNGFLCNDLKEDNVLVVEE-SGRWRAKIIDLGWA |.|.. |||.. . ||| | || | ...||.|..|.| | DIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFA |
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| Kinase | Spk363.AA | Ciliate-C7 | 633-658 | 50 | 2e-06 | 17.18 | In-house | 109-134 (164) | Show / Hide |
Range on Protein: 633-658 Range on HMM: 109-134/164 Sequence Identity: 50% (13 aa) NDVAEGLKALHSNGFLCNDLKEDNVL .|.|.|| ||.... |||| || | KDIAQGLYYIHSKNCVVNDLKMDNIL |
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| Kinase | Spk363.AA | Dicty5 | 634-674 | 41 | 5e-06 | 16.8 | In-house | 112-149 (260) | Show / Hide |
Range on Protein: 634-674 Range on HMM: 112-149/260 Sequence Identity: 41% (17 aa) DVAEGLKALHSNGFLCNDLKEDNVLVVEESGRWRAKIIDLG |.| ... ||| . ||| |.|. | .| .|||| | DIAQSMRHLHSMNIIHRDLKSMNFLITE---NWKIKIIDFG |
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| Kinase | Spk363.AA | urchB | 566-598 | 45 | 3.6e-05 | 14.86 | In-house | 62-93 (212) | Show / Hide |
Range on Protein: 566-598 Range on HMM: 62-93/212 Sequence Identity: 45% (15 aa) IHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIG ||| .|. |.|| |.| || . .| ||.| IHQLMSDSPYFPKFWGTLDI-DNDLCQAQEFVG |
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| Kinase | Spk363.AA | TKL | 754-765 | 50 | 0.049276 | 3.13 | In-house | 353-364 (364) | Show / Hide |
Range on Protein: 754-765 Range on HMM: 353-364/364 Sequence Identity: 50% (6 aa) QRPTVQEIIDQL .||. |||...| KRPSFQEILKRL |
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| Kinase | Spk363.AA | urchB | 527-551 | 48 | 0.076854 | 2.79 | In-house | 6-30 (212) | Show / Hide |
Range on Protein: 527-551 Range on HMM: 6-30/212 Sequence Identity: 48% (12 aa) ELGRGVAGTVSLFRHAVSKIPVAAK | ||| | | . || |.| | | EIGRGTYGRVVIARHRQTKVPLAIK |
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