Gene Spk389 (Sea Urchin)
Spk389
Sequence
Protein domains of Spk389.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk389.AA | urchA | 434-638 | 60 | 2.4e-162 | 527.41 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 434-638 Range on HMM: 1-208/208 Sequence Identity: 60% (126 aa) LGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKSAIEKLQNEMKILQRLGCTEWFPEFYGCCKVCKDVVGIAMEFCGDVEKGESYSILNCIDG-- ||.|..|||.||||..|..|||||||.||........ .||..||||.|.|.|||..|||.|||||..|.|.||.|||||||...||||.|..|.|. LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRR--KIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAM --KGPKLDKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVK-SGGEWRAKIIDFGWSSDMNMLFPACRMPFTARQKRDYKYRHAYNYIAPECALKG ..|.|..|.|||||||||.||.|||.||||||||||||.|..| ..|.||||||||||.....|.||||||.|..|||..|.|.|....|||||||.. EMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDA KSFSQSSDVY ...|.||||| QPCSTSSDVY |
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| Kinase | Spk389.AA | urch | 434-641 | 42 | 2.7e-117 | 395.99 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 434-641 Range on HMM: 1-217/217 Sequence Identity: 42% (93 aa) LGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKS------AIEKLQNEMKILQRLGCTEWFPEFYGCCKVCKDVVGIAMEFCGDVEKGESYSILN .|.||.|.|.||||..|..|||.|.. .|... |.|... ..|. ..|....|.......||.||||.... | ....|||.|| ..|.||.... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW CIDG-----KGPKLDKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVKSGG-EWRAKIIDFGWSSDMNMLFPACRMPFTARQKRDYKYRHAYNYIA ||.. ..|.|.|. |.|...||..|...||..|||.||||||||||.|.| .|.|.||||||...|.| | ..|.|.....|.|...|.|..|| CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPF--KMMHFPDEEMREYMHGHGYCHIA PECALKGKSFSQSSDVYSLG |||.|.|...|..|||||.| PECVLDGQPCSIASDVYSVG |
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| Kinase | Spk389.AA | urch-unclassified | 493-641 | 38 | 9.3e-35 | 121.14 | In-house | 65-215 (215) | Show / Hide |
Range on Protein: 493-641 Range on HMM: 65-215/215 Sequence Identity: 38% (59 aa) FPEFYGCCKVCKDVVGIAMEFCGDVEKGESYSILNCIDGKG---PKLDKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVKSGG--EWRAKIIDFG || || |. | .|.||| || . . |. | . |.| | | |...|| |. || .. | |||| .|.|| ... |.|.||||| FPRCYGMVKH-EDCPCIVMEFLGDKQTYTVYPLCQWIHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFG WSSDMNMLFPACRMPFTARQKRDYKYRHAYNYIAPECALKGKSFSQSSDVYSLG | | | |. |. .| | | ..||| | |. | ||.|||| MISTMTM--PHKQRNFSDHEMREYMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk389.AA | TKL | 434-641 | 18 | 1.7e-15 | 52.23 | In-house | 1-276 (364) | Show / Hide |
Range on Protein: 434-641
Range on HMM: 1-276/364
Sequence Identity: 18% (54 aa)
LGSGTAGTVYLYRHAKTN--------EPVALKVIALPPSGVDG------------------NKKSAIEKLQNEMKILQRLGC-TEWFPEFYGCCKVCKDV
.|||. |.|| .. .. ..|| |.. . . .... .. . | |.. . . . |.|.|. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------VGIAMEFCGDVEKGES-YSILNCIDGKGPKLDKDAWM---NVMLDIADGLTVMHK--------KGFLCNDLKEDNVLLVKSG------
.| ||.| .| | ...|. | . .|||| |. .| .. . ||| .|.|. . .
CVCMHPVGPWGQLCIVMEYC----PGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY
-----GEWRAKIIDFGWSSDMNMLFPACRMPFT--------ARQKRDYKYRHAYNYIAPECAL---------------KGKSFSQSSDVYSLG
.|..|| ||| | .|.. . .. | . |. .. . ... |||. ||...|...|||| |
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG
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| S_TKc | Spk389.AA | S_TKc | 428-685 | 20 | 2.9e-13 | 17.7 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 428-685
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)
PNSSIELGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKSAIEKLQNEMKILQRLGCTEWFPEFYGCCKVCKDVVGIAMEFCGDVEK--GESYSI
..|.|. |.||. || ||.. ||.|.| |....|..||.. .. .|... | . . ||.| . |. ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYC---DGDLGDLFDY
LNCIDGKGPK--LDKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVKSGGEWRAKIIDFGWSSDMNMLFPACRMPFTARQKRDYKYRHAYNYIAPE
. ..|.. .. .| |...| .|..|.. ||| .|.|| . . ||.||| . . . . .|.|||
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------------TTFCGTPWYMAPE
CALKGKSFSQ-SSDVYSLG--------RLAAFVGQEVPGLKELGDYGFNIYSSPRGK-------------RPSLQKFSQ-E-----INYL
... ..|..|.| . | |. .| .| || .| ||. . | | ..
VL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Spk389.AA | urchC | 492-587 | 33 | 1.1e-11 | 33.9 | In-house | 69-168 (223) | Show / Hide |
Range on Protein: 492-587 Range on HMM: 69-168/223 Sequence Identity: 33% (35 aa) WFPEFYGCCKVCKDVVGIAMEFCGDVEKGESYSILNCID---GKGPKLDKDAWMNVMLDIAD----GLTVMHKKGFLCNDLKEDNVLLVKSGGEWRAKII .|| .|| . .. | || || | .| .. . | | .. | |..||. | .|| | | || | ||||| . | . || YFPRMYGTVMIDENMC-IVTEFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWN--MVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCII DFG | | DMG |
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| Kinase | Spk389.AA | urchB | 547-590 | 54 | 1.6e-09 | 30.58 | In-house | 120-163 (212) | Show / Hide |
Range on Protein: 547-590 Range on HMM: 120-163/212 Sequence Identity: 54% (24 aa) DIADGLTVMHKKGFLCNDLKEDNVLLVKSGGEWRAKIIDFGWSS || |. .| | | |||| ||||| | | . | ||||| | DIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVS |
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| Kinase | Spk389.AA | CAMK | 433-487 | 18 | 4.1e-09 | 24.75 | In-house | 1-88 (425) | Show / Hide |
Range on Protein: 433-487 Range on HMM: 1-88/425 Sequence Identity: 18% (16 aa) ELGSGTAGTVYLYRHAKTN------------EPVALKVIALPPSGVDGN---------------------KKSAIEKLQNEMKILQRL .||.|. |.|.| .| .|. . || |.| . | . . .....|..|...| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKL |
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| Kinase | Spk389.AA | STE | 429-515 | 18 | 2.7e-08 | 25.52 | In-house | 1-120 (359) | Show / Hide |
Range on Protein: 429-515
Range on HMM: 1-120/359
Sequence Identity: 18% (22 aa)
NSS-IELGSGTAGTVYLYRHA------KTNEP---------VALKVIALPPSGVDGNK-----------KSAIEKLQNEMKILQRLGC-TEWFPEFYGCC
..|.|. ||||. .. ||.| .| |.. | .. . .. ......|.||.... . . ..|||.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY
KVC------KDVVGIAMEFCG
. .| . |.||...
FKEGHNHKNDDELWICMEYMD
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| Kinase | Spk389.AA | Pkinase | 434-641 | 23 | 1.4e-07 | 27.9 | Pfam | 7-199 (293) | Show / Hide |
Range on Protein: 434-641 Range on HMM: 7-199/293 Sequence Identity: 23% (51 aa) LGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKSAIEKLQNEMKILQRLGCTEWFPEFYGCCKVCKDVVGIAMEFCGDVEKG----ESYSILNCI .|||. |.||. .| .|.. ||.|.| .. . . .|. . .| .| .|..|| . . ..|... || . . ||.| |.| . .... IGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYC---EGGLYVMDLFDYIST- DGKGPKL--DKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVKSGGEWRA----KIIDFGWSSDMNMLFPACRMPFTARQKRDYKYRHAYNYIAPE .. .. . . ..|. |. || .|..|.. ||| .|.|... | ||.||| . .. . .. . . ..|.||| -WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG---HIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPE CALKGKSFSQSSDVYSLG ..|. ....|..|.| VIRGGQYYGPKVDMWSCG |
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| Kinase | Spk389.AA | urchB | 619-641 | 65 | 6.6e-07 | 21.15 | In-house | 190-212 (212) | Show / Hide |
Range on Protein: 619-641 Range on HMM: 190-212/212 Sequence Identity: 65% (15 aa) YIAPECALKGKSFSQSSDVYSLG ||||| | | | | ||||.| | YIAPEVILHGQSTSISSDVFSVG |
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| Kinase | Spk389.AA | LISK | 433-487 | 29 | 1e-06 | 17.24 | In-house | 1-53 (296) | Show / Hide |
Range on Protein: 433-487 Range on HMM: 1-53/296 Sequence Identity: 29% (16 aa) ELGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKSAIEKLQNEMKILQRL |.|.| | || .| |....|.| | | | |..... ... |......| EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQP--NDPNDPEYQKFMLREVQMMKNL |
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| Kinase | Spk389.AA | urch-unclassified | 434-461 | 39 | 2.5e-05 | 15.25 | In-house | 1-28 (215) | Show / Hide |
Range on Protein: 434-461 Range on HMM: 1-28/215 Sequence Identity: 39% (11 aa) LGSGTAGTVYLYRHAKTNEPVALKVIAL .| || | |...|| .. ||. | | . IGKGTFGKVFMMRHQREAVPVKVKMIHE |
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| TyrKc | Spk389.AA | TyrKc | 428-682 | 18 | 2.6e-05 | -136.74 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 428-682
Range on HMM: 1-280/280
Sequence Identity: 18% (58 aa)
PNSSIELGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKSAIEKLQNEMKILQRLG-CTEWFPEFYGCCKVCK------DVVGIAMEFCGDVEKG
.||.| |.||. . ..|| |.. .| . .|..|. .|| . .||.| . . . | ||.. ..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM---PHG
ESYSILNCIDGKGPKLDKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVKSGGEWRAKIIDFGWSSDMNML-FPACRMPFTARQKRDYK------Y
. .. . ..||| . . ...||.| |.|.. || |.|. . . ..|| ||| | | | |.
---DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGG
R--HAYNYIAPECALKGKSFSQSSDV----------YSLGRLAA-------FVGQEVPGLKELGDYGFNIYS--------SP--------------RGKR
. . |||| . . |. ||| ...| ||| . . |.. . | .|
KTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR
PSLQKFSQEI
|. . ...
PTFSEIHECF
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| Kinase | Spk389.AA | urchC | 619-644 | 42 | 0.000246 | 9.7 | In-house | 197-223 (223) | Show / Hide |
Range on Protein: 619-644 Range on HMM: 197-223/223 Sequence Identity: 42% (12 aa) YIAPECALK--GKSFSQSSDVYSLGRLA .|||| |. | | .||.|| | . HIAPEV-LDIDGCQVSVASDIYSVGVIL |
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| Kinase | Spk389.AA | TKL-Unique | 430-487 | 20 | 0.000782 | 9.61 | In-house | 1-52 (290) | Show / Hide |
Range on Protein: 430-487 Range on HMM: 1-52/290 Sequence Identity: 20% (12 aa) SSIELGSGTAGTVYLYRHAKTNEPVALKVIALPPSGVDGNKKSAIEKLQNEMKILQRL .. .|.|..|.|| . .... |||.|.... ... .. .... || ... .| FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHP-NEDS---SNEMMQEFENEVNWMKKL |
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| Kinase | Spk389.AA | TKL-Unique | 617-641 | 40 | 0.001371 | 8.74 | In-house | 190-215 (290) | Show / Hide |
Range on Protein: 617-641 Range on HMM: 190-215/290 Sequence Identity: 40% (11 aa) YNYIAPECALKG--KSFSQSSDVYSLG ....||| |.. . .|..||||| | FRWMAPEV-LRMNFCQYSEKSDVYSFG |
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| Kinase | Spk389.AA | LISK | 546-587 | 39 | 0.0032 | 6.09 | In-house | 108-150 (296) | Show / Hide |
Range on Protein: 546-587 Range on HMM: 108-150/296 Sequence Identity: 39% (17 aa) LDIADGLTVMHKKGFLCNDLKEDNVLLVKS-GGEWRAKIIDFG |||| |.. | .. . ||| |.|. .. . ||.|..||| LDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFG |
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| Kinase | Spk389.AA | CAMK | 564-587 | 31 | 0.003369 | 5.36 | In-house | 204-241 (425) | Show / Hide |
Range on Protein: 564-587 Range on HMM: 204-241/425 Sequence Identity: 31% (12 aa) DLKEDNVLLVKSGGE--------------WRAKIIDFG ||| .|.||...... . |||||| DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG |
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| Kinase | Spk389.AA | TKL-Unique | 542-587 | 34 | 0.003797 | 7.16 | In-house | 113-162 (290) | Show / Hide |
Range on Protein: 542-587 Range on HMM: 113-162/290 Sequence Identity: 34% (17 aa) MNVMLDIADGLTVMHKKG--FLCNDLKEDNVLLVKS--GGEWRAKIIDFG .. .|||.|. | .. . ||| |.|.. ||..||.||| VKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG |
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| Kinase | Spk389.AA | urchB | 429-457 | 44 | 0.011497 | 5.78 | In-house | 2-30 (212) | Show / Hide |
Range on Protein: 429-457 Range on HMM: 2-30/212 Sequence Identity: 44% (13 aa) NSSIELGSGTAGTVYLYRHAKTNEPVALK | | | || | | . || | | | | NDLQEIGRGTYGRVVIARHRQTKVPLAIK |
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| Kinase | Spk389.AA | STE | 564-587 | 37 | 0.126445 | 1.66 | In-house | 177-192 (359) | Show / Hide |
Range on Protein: 564-587 Range on HMM: 177-192/359 Sequence Identity: 37% (9 aa) DLKEDNVLLVKSGGEWRAKIIDFG |.| .|.|| .|..||| DIKPANILL--------VKLCDFG |
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