Gene TLK (Sea Urchin)

TLK

Species: Sea Urchin
Alias: TLK, Spk194, SPU_022809
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: TLK

Sequence

Name Sequence Type Origin Length Description Download
TLK.AA Protein None 504 None Fasta, JSON
TLK.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of TLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TLK.AA TLK 189-469 74 1.9e-244 818.38 In-house 1-285 (285) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-285/285
Sequence Identity: 74% (212 aa)

YLLLRLLGKGGFSEVYKGYDLKDHRDVACKIHQLSKEWKEDKKANYIKHALREYEIHKSLDHARVVKLYDVFEIDANSFCTVLEFCPGNDLDFHLKQHKL
|.||.||||||||||||..||...|.||||||||.|.|||.|||||||||.|||.|||.|||.|.|||||.||||.||||||||.|.||||||.|||||.
YQLLHLLGKGGFSEVYKAFDLHEFRYVACKIHQLNKNWKEEKKANYIKHACREYKIHKELDHCRIVKLYDYFEIDNNSFCTVLEYCEGNDLDFYLKQHKT

MVEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHGSTCGAIKLTDFGLSKVMDDEHFNSQEGGMDLTSQGAGTYWYLPPECFVVGK-----EP
|.|.||||||||.|..||||||.|||||||||||.||....|.|||.||.|||||||.||||......| |.|||||||||||||||||||||     .|
MPEKEARCIIMQIVCCLKYLNEIKPPIIHYDLKPQNIIFHKGNTCGEIKITDFGLSKIMDDEQYRHDHG-MELTSQGAGTYWYLPPECFVVGKCEEFENP

PKISSKVDVWSTGIIFYQCLYGKKPFGHNLSQASILEQNTILRATQVQFSPKPTVSQEAKDFIRRCLMYRKEDRADVLALAKDPYL
||||.||||||.|.||||||||.||||||.||..||||||||.||.|||..||.||.|.||||||||.||.|||.|| .|...||.
PKISCKVDVWSVGVIFYQCLYGQKPFGHNMSQQQILEQNTILKATEVQFPSKPQVSNECKDFIRRCLQYRQEDRWDVQQLWNHPYM
Kinase TLK.AA S_TKc 189-469 30 3.1e-78 267.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YLLLRLLGKGGFSEVYKGYDLKDHRDVACKIHQLSKEWKEDKKANYIKHALREYEIHKSLDHARVVKLYDVFEIDANSFCTVLEFCPG--NDLDFHLKQH
| .||..|||.|..|||... |..| ||.||                .|..|| .|.|. .|  .|||||||.   .... |.|.|.|   ||  ..|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

KL------MVEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHGSTCGAIKLTDFGLSKVMDDEHFNSQEGGMDLTSQGAGTYWYLPPECFVVG
.       . | .||... |...||.|. ..   ||| |||| ||||..      ||..||||....               .   || ||..|| .   
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-----HIKICDFGLARQL---------------TTFCGTPWYMAPEVL---

KEPPKISS-KVDVWSTGIIFYQCLYGKKPFGHNLSQASILEQNTILRATQVQFSPKPTVSQEAKDFIRRCLMYRKEDRADVLALAK-------DPYL
    . .  |.|.|| |.|.| .|.|. ||          .......            |.|||||||.|| .  |.|  .  . .       .|..
----GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TLK.AA ULK 189-469 28 4.1e-58 199.37 In-house 1-324 (324) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-324/324
Sequence Identity: 28% (96 aa)

YLLLRLLGKGGFS-EVYKGYDLKDH---RDVACKIHQLSKEWKEDKKA--NYIKHALR-EYEIHKSLD------HARVVKLYDVFEIDA-NSFCTVLEFC
| | . |||| |   ||||.. |..    .||||. ...|  |  ...  .|..  |. | .| | |.      |  .|||||.|| .  | .. ..|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

PGNDLDFHLKQHKLMVERE----------ARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHG----------STCGAIKLTDFGLSKVMDD-----
.| ||.  .|..|   | .          |. ...| ....|.|....  ||| |.|| |||. .|          .  | .|..|||..|. |.     
NGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQ

EHFNSQEGGMDLTSQGA---GTYWYLPPECFVVGKE--PPKIS-SKVDVWSTGIIFYQCLYGKKPFGHN-LSQA----SILEQ----NTILRATQVQFS-
  . .. .      .     ||  |  |.  .. ..    . . .|.|.|| |.|||..|||| ||  .  .|     . ...     .. . ...||  
QMCQTCVN------E-KRIKGTPLYMAPQ--ILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPK

--PKPTVSQEAKDFIRRCLMYRKEDRADVLALAKDPYL
  . | .|.| ||.|||.| |  .|| .   . . | .
PPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TLK.AA Pkinase 189-469 26 1.7e-57 202.1 Pfam 1-293 (293) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-293/293
Sequence Identity: 26% (85 aa)

YLLLRLLGKGGFSEVYKGYDLKDHRDVACKIHQLSKEWKEDKKANYIKHALR--EYEIHKSLDHARVVKLYDVFEIDANSFCTVLEFCPGN----DLDFH
| ..| .|.|.|..|||... .. . ||.||      .|...| .  ....|  | .|.|.|.|  .|.|||.||   .. . |.|.|.|     ||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI-----IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LK--QHKLM--VEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLC-HGSTCGAIKLTDFGLSKVMDDEHFNSQEGGMDLTSQGAGTYWYLPPECF
..  .|. .   |.|..... |....|.|. ..   ||| |||| |||.  .| ..  .|..||||.|..|       .     ..  .||.||..||  
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEVI

VVGKEPPKISSKVDVWSTGIIFYQCLYGKKPFGHNL----SQASILEQNTILRATQVQFSPKPTVS-------------------QEAKDFIRRCLMYRK
    . .....|||.|| |.|.|. | |. ||  .     . .. ..     . ... |.   . |                   .|.||||..|| .  
R---GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

EDRADVLALAKDPYL
..|     . ..|..
KKRPTAEQILQHPWF
Kinase TLK.AA Ciliate-E2 189-469 22 1e-56 193.25 In-house 1-365 (365) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

YLLLRLLGKGGFSEVYKGYDLKDHRDVA----------------CKIHQLSKEWKEDKKANYIKHALREY-EIH------------KSLDHARVVKLYDV
| .....|.|.|. |||. . |. ...|                .|| .  .. .. .. ..||  .... ||.            ..|.|  ..|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE-IDANSFCTVLEFCPGNDLDFHLKQHKL-----------MVEREARCIIMQVVS---------------ALKYLNERKPPIIHYDLKPGNILLCHGST
|. .| |..  |.|.| |.||  ..|..|.           ..|.|.. |. |...               ||.|| .... ||| |.|| |||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

CGAIKLTDFGLSKVMDDE---------HFNSQEGGMDLTSQG--------------AGTYWYLPPECFVVGK-----EPPKISSKVDVWSTGIIFYQCLY
   ||..||||||  ||.         . . ...... ...|              .||. |..|| .  .|     .    . |.|.|| |.|.|..|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GKKPFGHNLSQASILEQNTILRATQVQFSPK----------------PTVSQEAKDFIRR----CLMYRKEDRAD-VLALAKDPYL
|| ||              .    ...|...                  .|||.||.|..    .| .  | | .    . . |..
GKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TLK.AA ULK 189-469 28 1.9e-56 193.81 In-house 1-329 (329) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-329/329
Sequence Identity: 28% (97 aa)

YLLLRLLGKGGFSEVYKGYDLKDH----RDVACKIHQLSKEWKEDKKA--NYIKHALR-EYEIHKSLD--------HARVVKLYDVFEIDA-NSFCTVLE
| | . |||| |  ||||.. |..     .||||. ...|. .. . .  .|..  |. | .| | |.        |  .|||||.|| .  | .  ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCPGNDLDFHLKQHKLMVERE----------ARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHG----------STCGAIKLTDFGLSKVMDDE--
.|.| ||.  .|..| . | .          |. ...| ....|.|....  ||| |.|| |||.  |          .  | .|..|||..|..|..  
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNM

---HFNSQEGGMDLTSQGA---GTYWYLPPECFVVGKE--PPKIS-SKVDVWSTGIIFYQCLYGKKPFGHNLSQASILEQNTILRA-----------TQV
    . .. .      .     ||  |  |.  .. ..    . . .|.|.|| |.|||..|||| ||  .  .  .| ... |.            .. 
EQQMMMTCVN------E-KRLCGTPLYMAPQ--ILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPL

QFS---PKPTVSQEAKDFIRRCLMYRKEDRADVLALAKDPYL
||    ..|..|.| ||.|||.| |  .|| .   | . | .
QFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TLK.AA CAMK 194-469 20 1.1e-54 174.25 In-house 1-425 (425) Show / Hide 
Range on Protein: 194-469
Range on HMM: 1-425/425
Sequence Identity: 20% (90 aa)

LLGKGGFSEVYKGYDLKDH------------RDVACKI--------------------HQLSKEWKEDK-KANYIKHALREYEIHKS-------LDHARV
 ||.|.|..|..... ..             . ||.||                        . . ... ...  |  .||.||.|.       |||  .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYDVFE------------IDAN-------SFCTVL---EFCPGN----DLDFHLKQHKL---------------MVEREARCIIMQVVSALKYLNERK
.|||.|.|               .        .. |.   |.|.|     ||  ....|.                . ||||| .. |..||..|. ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHYDLKPGNILLC--HGSTC------------GAIKLTDFGLSKVMDDEHFNS----QEGGMDLTSQ-------------GAGTYWYLP-PECFVV-
  |.| |||| ||||.  .....            . ||..|||.....|. . |     ..||  . ..               ||  | . || .   
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

---------GKEPPKISSKVDVWSTGIIFYQCLYGKKPFGHNLSQASI-------LEQNTILRATQVQFS-PKPT-----------------------VS
           | | .. |.|.|| |.| | .| |. || .   .  .        ....  . .. ... | |                        ||
GHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS

QEAKDFIRRCLMYRKEDRADVLALAKDPYL
||.||.||..| .  |.|. .    ..| .
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TLK.AA Ciliate-E2-Unclassified 189-469 22 6.5e-49 167.8 In-house 1-352 (352) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-352/352
Sequence Identity: 22% (80 aa)

YLLLRLLGKGGFSEVYKGYDLKDHRDV-----ACKIHQLSKEWKEDKKANYIKHALREYEIH---------------KSLDHARVVKLYDVFEIDANSFC
| ... .|.|||..||| .. |.   .     ..||.. ..  .. |. ...  .... ..                ....|  .||....|. . | ..
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN-IY

TVLEFCPGNDLDFHLKQ------------HKLMV-----EREAR-----CIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHGSTCGAIKLTDFGLSK-
 |.|.|.|.|| ...|.            |...      |..|.      .. |....|.|| . .  |||.|.|| |||.  .   . ||..|||.|| 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

VMDDEHFNSQEG-------GMDLTSQGAGTYWYL----PPECFVV-GKEPPKISSKVDVWSTGIIFYQCLYGKKPFGHNLSQA--------------SIL
  ... .   ..         ..... .||. |.    .||..   . . .|   |.|.|| |.|.|..|.|. ||. | .                ..|
YQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

EQNTILRATQVQFSPK----PTVSQEAKDFIR----RCLMYRKEDRADVLALAKDPYL
.|| . . .|.. .|.     ..|.||||||.    ..| .. . | .   . . |..
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase TLK.AA CMGC 189-400 19 4.6e-39 125.37 In-house 1-326 (513) Show / Hide 
Range on Protein: 189-400
Range on HMM: 1-326/513
Sequence Identity: 19% (65 aa)

YLLLRLLGKGGFSEVYKGYD--------------LKDHRDVACKIHQLSKEWKEDK----KANYIKHALREYEIHKSL-----------------DHARV
|  .. .|.| ...|||..|               .. . || |.  . ..  . |    | .  . |||| .| | |                 .|  .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLYDVFEIDA----------------NSFCTVLEFCPGNDLDFHLKQH---------------------------KLMVEREARCIIMQVVSALK--YL
|||||.|  .                 |... | |... . ...  ...                           | ..    | .. |.  .||  |.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

NERKPPIIHYDLKPGNILLCHGSTC-----------------GAIKLTDFGLSKVMDDEHFN---------------SQEGGMDLTSQGAGTYWYLPPEC
  ..  ||| |||| |||..|  ..                 | .|. ||||..  .... .               . . .. .|.. . | || .|| 
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVV-TRWYRAPEI

FVVGKEP------PKISSKVDVWSTGIIFY
 .  |.        . ....|.|| | ||.
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFA
Kinase TLK.AA STE 189-469 20 6.6e-38 131.47 In-house 1-359 (359) Show / Hide 
Range on Protein: 189-469
Range on HMM: 1-359/359
Sequence Identity: 20% (77 aa)

YLLLRLLGKGGFSEVYKGYDLK---------------DHRDVACKIHQLSKEWKEDKK-----------ANYIKHALREYEIHKSLD--HARVVKLYDVF
. ... .|||.| .|||... |                .. .| |.  |... ..| .            . ..  |.| .|.| ..  |  .|| |. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EIDA------NSFCTVLEFCPGNDLDFHLKQHKLMV--------------EREARCIIMQVVSA-LKYLNERKPPIIHYDLKPGNILLCHGSTCGAIKLT
. .       .. . ..|...|  ||  .|. . .               | . ..|. |.. . |.|| . .  ||| |.||.||||        .||.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL--------VKLC

DFGLSKVMDDEHFNSQEGG---------MD-LTSQGAGTYWYLPPECFVVGKEP--PKISSKVDVWSTGIIFYQCLYGKKPF--GHNLSQASILEQNTIL
|||... ..|.. |. . .         |.  .   .||  .  ||    ....  .. . |.|.|| |.     . || |.  .|...      .|.. 
DFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

RA-----TQVQFSP---KP-------------------TVSQEAKDFIRRCLMYRKEDRADVLALAK--DPYL
 .      .|.. |   ..                    .|.| ||||..|| .  ..|...  | |   | .
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TLK.AA TKL 195-457 19 1.3e-33 117.97 In-house 1-354 (364) Show / Hide 
Range on Protein: 195-457
Range on HMM: 1-354/364
Sequence Identity: 19% (69 aa)

LGKGGFSEVYKGYDLKDHR---------DVACKIHQLSKEWKEDKKAN--------------------YIKHALREYEIHKSLDHARVVKLYD-VFEIDA
.|.|||.|||||. .. ..         ||| |.     . ...|. .                    . ..  .|  ....|.|  .|...  ..... 
IGSGGFGEVYKGK-WRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

NS-----------FCTVLEFCPGND-LDFHLKQHKLMVEREARCIIMQVVSALKYLNERK------PPIIHYDLKPGNILLCHGST-----------CGA
.            .| | |.||| . |....             ..... ... ||  ..      ||||| |||. |||.    |            . 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKLTDFGLSKVMDDE-HFNSQEGGMD----------LTSQGAGTYWYLPPECFVVGKEPP------------KISSKVDVWSTGIIFYQCLYGKKPFGHN
.|..|||||..|. . . | .. .|            |.   ||. ...||..    . .            . | |.||.| ||... .| ...|. ..
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

LS-------------QASILEQNTILRATQVQF----SPKPTVSQEAKDFIRRCLMYRKEDR
 .                .....  .. .. |     .| |.. .. |. . .|  .  |.|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase TLK.AA CAMKL 189-352 30 7.2e-32 98.87 In-house 1-189 (297) Show / Hide 
Range on Protein: 189-352
Range on HMM: 1-189/297
Sequence Identity: 30% (58 aa)

YLLLRLLGKGGFSEVYKGYD-LKDHRDVACKIHQLSKEW-KEDKKANYIK-------HALREYEIHKSLD---HARVVKLYDVFEIDAN-----SFCTVL
| ... ||||.|..|  . . .   . || ||   .| | .. .|.| ..       .  ||..|.|.|.   |  ..|||.|.| . .      .. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCPGND--LDFHLKQH----KLMVEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLC-HGSTCGAIKLTDFGLSKVMDD-----EHF
| |.| .  |  ....|    . | |.||| .  |.|||..|. ...  |.| |.|| ||||  .|.    ||..|||.|  ...     ...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQK
Kinase TLK.AA TyrKc 189-467 22 1.5e-12 -19.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 189-467
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YLLLRLLGKGGFSEVYKGYDLKDHRDVACKIHQLSKEWKEDKKANYIKHALREYEIHKSL--DHARVVKLYDVFEIDA------NSFCTVLEFCPGNDLD
  |.. || | | |||||      ..|| |  . ..          ..  .|| .| ..|  .|  .|.|| |   .          . |.|..|. ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

FHLKQHKL-MVEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHGSTCGAIKLTDFGLSKVMDDE---HFNSQEGGMDLTSQGA--GTYWYLPP
 .|. |.     ..   .  |. .   || ..  ..|| ||   |.|. ..     .| .|||||.  .|.     ...   .  ...|     .  ..|
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ECFVVGKEPPKISSKVDVWSTGIIFY-QCLYGKKPFGHN----LSQASILEQNTILRATQVQFSPKP-------TVSQEAKDFIRRCLMYRKEDRADVLA
||.  |    | ..| |||| |.  .  . ||..|        .| . ..|.   ...      |.        . ..|  . ...| ..  |||    .
ECINYG----KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY---VKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LAKDP
. .. 
IHECF
Kinase TLK.AA CAMKL 389-469 24 1.7e-10 29.53 In-house 216-297 (297) Show / Hide 
Range on Protein: 389-469
Range on HMM: 216-297/297
Sequence Identity: 24% (21 aa)

KVDVWSTGIIFYQCLYGKKPF-GHNL---SQASILEQNTILRATQVQFSPKPTVSQEAKDFIRRCLMYRKEDRADVLALAKDPYL
|||.|| |.| |  ..|. || . ..    .  | .   . . .  .. . . || ...|.||. |.   |.|. .  . ..| .
KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase TLK.AA CMGC 431-469 12 0.000222 9.28 In-house 443-513 (513) Show / Hide 
Range on Protein: 431-469
Range on HMM: 443-513/513
Sequence Identity: 12% (9 aa)

QFSPKPT--------------------------------VSQEAKDFIRRCLMYRKEDRADVLALAKDPYL
.| ..|.                                 ...| |.. ..| |  ..|  .    . ||.
LFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase TLK.AA Pkinase_Tyr 239-350 27 0.000242 15.33 Pfam 51-165 (270) Show / Hide 
Range on Protein: 239-350
Range on HMM: 51-165/270
Sequence Identity: 27% (33 aa)

LREYEIHKSL-DHARVVKLYDVFEIDANS--FCTVLEFCPGNDLDFHLKQH-----KLMVEREARCIIMQVVSALKYLNERKPPIIHYDLKPGNILLCHG
.|| .| |.| .|  .|.|| |   .  .   . |.|..|. ||. .|..|     .| ...   .. .|. ... || ...  .|| ||   |.|. . 
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE-

STCGAIKLTDFGLSKVM-DDE
 .   .| .||||.. . .|.
-NN-VVKICDFGLARDIYNDD
Kinase TLK.AA Pkinase_Tyr 189-207 47 0.540043 3.99 Pfam 1-19 (270) Show / Hide 
Range on Protein: 189-207
Range on HMM: 1-19/270
Sequence Identity: 47% (9 aa)

YLLLRLLGKGGFSEVYKGY
  ... ||.| | |||||.
ITFGKKLGEGAFGEVYKGT
Kinase TLK.AA Pkinase_Tyr 372-394 43 3.526237 1.23 Pfam 181-199 (270) Show / Hide 
Range on Protein: 372-394
Range on HMM: 181-199/270
Sequence Identity: 43% (10 aa)

LPPECFVVGKEPPKISSKVDVWS
..|||.  ||     ..| ||||
MAPECINYGK----FTTKSDVWS