Gene TBCK (Sea Urchin)

TBCK

Species: Sea Urchin
Alias: SPU_017455, Spk193, TBCK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: TBCK

Sequence

Name Sequence Type Origin Length Description Download
TBCK.AA Protein None 1166 None Fasta, JSON
TBCK.kin_dom Protein Kinase Domain None 239 None Fasta, JSON

Protein domain

Protein domains of TBCK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TBCK.AA TBCK 25-290 41 1.3e-172 579.79 In-house 1-346 (346) Show / Hide 
Range on Protein: 25-290
Range on HMM: 1-346/346
Sequence Identity: 41% (142 aa)

RYANDQCGADGLPLTPSSIKIVGRFQELRVLHHPRLCQYLDAVRGK--HERLIIVAEHYSNNLGL----EAKKGTFKDPGQILPIIHQTLEGLSFMHKYG
    | |.  |||.|| .... |||| |..|.||.||||||..|||  |||.|.|.|||..||..    .||..|.||..|||.|..|.|.|||.|||..
QEKHDRCCINGLPVTPNAKQMLGRFQYLKSLQHPNLCQYLDFSRGKIHHERMIVVMEHYKMNLEDQIEIYAKRHTPKDCSQILCIYYQILCGLSYMHKHH

LVHRGLSPSNILLNPEG----HVKLAKFGLYHITNCGSDVPFPIGHPRYMAPEVLTPGPMLPTNGDTPTTPLPPKTTNLSSGPKGDVWSLGMVILELCLG
.|||.|.|.||.|...|    |||||..||||.||.|.|||||||.|||||||....|.|..|....||.|||||||||||.||.||||||...||.|||
IVHRFLHPHNIYLDDNGNQKLHVKLANYGLYHMTNHGKDVPFPIGYPRYMAPERILQGEMKTTDHMPPTNPLPPKTTNLSSNPKSDVWSLGCIMLEICLG

QTLWPVATLPQILAKVMLLGKH---------------------------------------------------------GAQKHPLDTILDEHAGQQK--
..||...||...|.|.|..|.|                                                         ....|.......||...|.  
ICLWQELTLSEVLNKIMHYGTHSTTQSFNSISKSFEQCELKKTIINEKQHEEYEEYDDDEDISEEEKEKRIKDIKLNDQDCMNHFMEDLAREHQCHQRSN

-----------LDAYPASLQSFLRKCLSASPLERPSTTELLESDML
           .......|....||||...|..|||.|||.|..|.
SGSSNSNIGIPYHQMCEWLIQIIRKCLQMCPMKRPSPTELMEHPMF
Kinase TBCK.AA Pkinase 52-290 22 7e-28 99.66 Pfam 54-293 (293) Show / Hide 
Range on Protein: 52-290
Range on HMM: 54-293/293
Sequence Identity: 22% (59 aa)

LRVLHHPRLCQYLDAVRGKHERLIIVAEHYSNNL---GLE-----AKKGTF-KDPGQILPIIHQTLEGLSFMHKYGLVHRGLSPSNILLNPEGHV----K
.. |.||  ....|...  . .. .| |.  . |    |       ..|.|  .. ..  .. |.|.|| ..|. | .|| | |.|||.. .||.    |
MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK

LAKFGLYHI--TNCGSDVPFPIGHPRYMAPEVLTPGPMLPTNGDTPTTPLPPKTTNLSSGPKGDVWSLGMVILELCLGQTLWPVA------TLPQILAKV
.. |||     .  .|    . | |.||||||.                     ..   ||| |.||.| .. |...|....| .      .  |.....
ICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRI

ML--LGKHGAQKHPLD----TILDEHAGQQKLDAYPASLQSFLRKCLSASPLERPSTTELLESDML
|   |  .  ....      .. . |   ..... . ....|...||   | .||. ...|... .
MGPPLHFDWPWWCSISYFFFRH-W-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TBCK.AA STE 103-290 21 4.8e-20 67.56 In-house 156-359 (359) Show / Hide 
Range on Protein: 103-290
Range on HMM: 156-359/359
Sequence Identity: 21% (48 aa)

IIHQTLEG-LSFMHKYGLVHRGLSPSNILLNPEGHVKLAKFGLYH-ITN---------------CGSDVP-FPIGHPRYMAPEVLTPGPMLPTNGDTPTT
|..|.|.| |.. |. . .|| . |.||||     |||. ||.   .|.                ..      .| | .|||||....    .       
ICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-------

PLPPKTTNLSSGPKGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGA----------QKHPLDTILDEHAGQQK---------LDAYPASLQS
       .   . | |.|||| .|.|.. |.  |   . .. .   .  .. ..          .  || . |..  .  .          . .  ... 
-------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM--ISYGGSGTTYPHKWSPEFKD

FLRKCLSASPLERPSTTELLE--SDML
|..|||   | .||....||.     .
FINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TBCK.AA TKL 103-288 17 3.9e-19 65.57 In-house 137-364 (364) Show / Hide 
Range on Protein: 103-288
Range on HMM: 137-364/364
Sequence Identity: 17% (41 aa)

IIHQTLEGLSFMHKYG--------LVHRGLSPSNILLNPEGH--------------VKLAKFGLYHITNCGSD--------------------VPFPIGH
.....  |....|  .        ..|| | ..|||..  ..              .|.. |||    .  ..                       ..|.
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

PRYMAPEVLTPGPMLPT---NGDTPTTPLPPKTTNLSSGPKGDVWSLGMVILELCLGQTLWP-VATLPQILA----KVMLLGKHGAQKHPLDTILDE--H
||.||||||   . ..    .        . .  ...  .| ||.| |.|. |.. ... .      |.|..      . .  .  .. |...|  .   
PRWMAPEVLRGQMNYTEKVGI-------DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK

AGQQKLDAYPASLQSFLRKCLSASPLERPSTTELLESD
 . .. .  | |. . . .| .. | .||| .|.|.  
-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc TBCK.AA S_TKc 3-290 19 1.3e-16 62.47 SMART 14-231 (231) Show / Hide 
Range on Protein: 3-290
Range on HMM: 14-231/231
Sequence Identity: 19% (59 aa)

SVTLAMQPFGDAEIGVSTFYASRYANDQCGADGLPLTPSSIKIVGRFQELRVLH--HPRLCQYLDAVRGKHERLIIVAEHYSN---NLGLEAKKGTF---
.| ..              .|    .                     .|...|.  || .....|. .   ..| .| |. ..   .|    ||      
KVYKCRHKK------TGRIVAIKIIK-----------------EHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---KDPGQILPIIHQTLEGLSFMHKYGLVHRGLSPSNILLNPEGHVKLAKFGLYHITNCGSDVPFPIGHPRYMAPEVLTPGPMLPTNGDTPTTPLPPKTT
    .. ..  ...|....| ..|. | .|| | |.||||.   |.|.. |||  .          .| | |||||||                      
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----------------------

NLSSGP-KGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQKHPLDTILDEHAGQQKLDAYPASLQSFLRKCLSASPLERPSTTELLE----
  . |. | |.||.| .. |.. |....|  .. ... |..                            . .. .|.||||   | .||.  |.|.    
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---SDML
      .
IKCHPWF
Kinase TBCK.AA Ciliate-E2 99-290 16 3.8e-16 51.91 In-house 146-365 (365) Show / Hide 
Range on Protein: 99-290
Range on HMM: 146-365/365
Sequence Identity: 16% (43 aa)

QILPIIHQTLE---------------GLSFMHKYG-LVHRGLSPSNILLNPEGHVKLAKFGL-----------------YHITNCGSDVPFPIG------
.|. |. | |.               .| ..|. .  .|| . |.|||.     .|.. |||                 . ... ..|    .|      
EIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQII

----------HPRYMAPEVLT------PGPMLPTNGDTPTTPLPPKTTNLS--SGPKGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQKH
           | |||||.|                            ...   . | |.||||... |.. |.. .    . ||. .   . .   ||.
QQNMFNTICGTPGYMAPEILNGKKYDNQ--------------------QKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKD

PLDTILDEHAGQQK-LDAYPASLQSFLRK----CLSASPLERPS-TTELLESDML
 .. .  .  .  |  .  . . . ...|    .|   | .|..   ..|.   .
-TQ-CI-Q-CKW-KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TBCK.AA STE7-Unclassified 198-290 19 1.5e-10 33.49 In-house 205-301 (301) Show / Hide 
Range on Protein: 198-290
Range on HMM: 205-301/301
Sequence Identity: 19% (21 aa)

KGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQKHP----------LDTILDEHAGQQKLDA----YPASLQSFLRKCLSASPLERPSTTE
|.|.|||| .|.|. .|  . ..            .   .... .          |. |... . . . |     .......|  ||.  .| |||. ..
KSDIWSLGLTIWECATGKYPYEYN-----------FQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQ

LLE-SDML
||.  ...
LLNEHPWI
Kinase TBCK.AA GCN2 108-144 54 1.9e-10 32.36 In-house 318-354 (511) Show / Hide 
Range on Protein: 108-144
Range on HMM: 318-354/511
Sequence Identity: 54% (20 aa)

LEGLSFMHKYGLVHRGLSPSNILLNPEGHVKLAKFGL
||||...|. | .|| |.||||.|  .|.|| . |||
LEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGL
Kinase TBCK.AA PEK 96-144 44 4.7e-10 30.44 In-house 425-478 (655) Show / Hide 
Range on Protein: 96-144
Range on HMM: 425-478/655
Sequence Identity: 44% (24 aa)

DPGQILPIIHQTLEGLSFMHKYGLVHRGLSPSNILLNPEGH-----VKLAKFGL
|  |.. |..| |||| ..|  |..|| | ||||.|  .|.     || . |||
DKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGL
Kinase TBCK.AA PAKA 98-143 41 1.5e-09 29.88 In-house 103-148 (260) Show / Hide 
Range on Protein: 98-143
Range on HMM: 103-148/260
Sequence Identity: 41% (19 aa)

GQILPIIHQTLEGLSFMHKYGLVHRGLSPSNILLNPEGHVKLAKFG
|||  .. ..| ||.|.|. . .|| .   ||||. .| ||.. ||
GQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFG
Kinase TBCK.AA STE-Unique 198-290 24 1.7e-08 25.66 In-house 533-616 (616) Show / Hide 
Range on Protein: 198-290
Range on HMM: 533-616/616
Sequence Identity: 24% (23 aa)

KGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQKHPLDTILDEHAGQQKLDAYPASLQSFLRKCLSASPLERPSTTELLESDML
| |.||||......| |  .|   .  | ..   ....    . |..  ... . . ...     .| |..|||.  |  |||. .||..  |
KVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIH----CQPPQCPIENIPPKCQPE-----QQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase TBCK.AA PEK 263-290 28 8.8e-08 22.37 In-house 628-655 (655) Show / Hide 
Range on Protein: 263-290
Range on HMM: 628-655/655
Sequence Identity: 28% (8 aa)

LQSFLRKCLSASPLERPSTTELLESDML
...|....|| .| .|||. ..|... .
QADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase TBCK.AA STE-Unique 99-144 32 1.1e-07 22.73 In-house 404-456 (616) Show / Hide 
Range on Protein: 99-144
Range on HMM: 404-456/616
Sequence Identity: 32% (17 aa)

QILPIIHQTLEGLSFMHKYG--LVHRGLSPSNILLNPEG-----HVKLAKFGL
... .. | |||| . |  .   .|| | |.||... .|     .||.. ||.
EVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGH
Kinase TBCK.AA MEK5 200-290 26 1.4e-07 23.74 In-house 173-254 (254) Show / Hide 
Range on Protein: 200-290
Range on HMM: 173-254/254
Sequence Identity: 26% (24 aa)

DVWSLGMVILELCLGQTLWPVATLPQ-ILAKVMLLGKHGAQKHPLDTILDEHAGQQKLDAYPASLQSFLRKCLSASPLERPSTTELLESDML
||||||. ..|. .|.  .|     |  |. . |          |  | |||.    .| . .    |. .|.   | .||   .|..   .
DVWSLGIFFMEMATGRFPYPQIQRDQGELMPIQL----------LQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase TBCK.AA TyrKc 43-290 16 1.7e-07 -101.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-290
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

IKIVGRFQE----------------------------------LRVL--HHPRLCQYLDAVRGKH------ERLIIVAEHYSN-NLG--LEAKKGTFKDP
|.      |                                  .. |  ||| . . . ... .       | | || |. .. .|   | .....   .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCM

GQILPIIHQTLEGLSFMHKYGLVHRGLSPSNILLNPEGHVKLAKFGL----YHI--------TNC-----GSDVPFPIGHPRYMAPEVLTPGPMLPTNGD
 . | . .|  .| .. |. ...|| |   |.|.. ...|| . |||    |.         .       |.. ..||   | ||||..           
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RWMAPECI-----------

TPTTPLPPKTTNLSSGPKGDVWSLGMVILELC-LGQTLWPV-----ATLPQILAKVMLLGKHGAQKHPLDTILDEHAGQQKLDAYPASLQSFLRKCLSAS
                .| |||| | .. |.. .||. .|       .  .....|.  .     ....  .             |. . .  ..|  . 
----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS--------FVCCPDEMYQIMKQCWHED

PLERPSTTELLESDML
| .||. .|.   . .
PEDRPTFSEI--HECF
Kinase TBCK.AA GCN2 264-290 40 1.9e-07 21.66 In-house 485-511 (511) Show / Hide 
Range on Protein: 264-290
Range on HMM: 485-511/511
Sequence Identity: 40% (11 aa)

QSFLRKCLSASPLERPSTTELLESDML
|...|.||.  | .|||. .||... |
QDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase TBCK.AA STE7-Unclassified 106-143 41 6.9e-07 20.41 In-house 127-165 (301) Show / Hide 
Range on Protein: 106-143
Range on HMM: 127-165/301
Sequence Identity: 41% (16 aa)

QTLEGLSFMHKYG-LVHRGLSPSNILLNPEGHVKLAKFG
| . ||.. |. . ..|| . |.|||.| .| ||.. ||
QVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFG
Kinase TBCK.AA MEK5 110-143 41 1.5e-05 16.17 In-house 105-138 (254) Show / Hide 
Range on Protein: 110-143
Range on HMM: 105-138/254
Sequence Identity: 41% (14 aa)

GLSFMHKYGLVHRGLSPSNILLNPEGHVKLAKFG
|| ..    ..||   |||.| | .|..||  ||
GLNYLWNLKIMHRDVKPSNMLVNTQGQIKLCDFG
Kinase TBCK.AA PAKA 262-290 37 5.4e-05 13.63 In-house 232-260 (260) Show / Hide 
Range on Protein: 262-290
Range on HMM: 232-260/260
Sequence Identity: 37% (11 aa)

SLQSFLRKCLSASPLERPSTTELLESDML
... || |||   . .|.|..|||.   |
EFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase TBCK.AA GCN2 198-215 31 0.002774 6.86 In-house 432-450 (511) Show / Hide 
Range on Protein: 198-215
Range on HMM: 432-450/511
Sequence Identity: 31% (6 aa)

KGDVWSL-GMVILELCLGQ
|.|..|| | ...|.. ..
KVDMYSLGGIIFFEMWYPP
Kinase TBCK.AA PEK 158-215 20 0.00599 5.24 In-house 550-591 (655) Show / Hide 
Range on Protein: 158-215
Range on HMM: 550-591/655
Sequence Identity: 20% (12 aa)

IGHPRYMAPEVLTPGPMLPTNGDTPTTPLPPKTTNLSSGPKGDVWSLGMVILELCLGQ
.| ..||.||.|  .                . ..   . |.|..||| ...|.. ..
VGTCLYMSPEQLSGQ----------------HYQKSHYNHKVDMYSLGIIFFEMWYPF
Kinase TBCK.AA PAKA 196-215 40 0.036294 3.59 In-house 181-200 (260) Show / Hide 
Range on Protein: 196-215
Range on HMM: 181-200/260
Sequence Identity: 40% (8 aa)

GPKGDVWSLGMVILELCLGQ
..| |.||||  ..|.  |.
DEKVDIWSLGIMAIEMIEGE
Kinase TBCK.AA TBCK 355-514 36 5.3e-96 325.25 In-house 113-346 (346) Show / Hide 
Range on Protein: 355-514
Range on HMM: 113-346/346
Sequence Identity: 36% (86 aa)

LYDDG----HVKLAKFGLYHITNCGSDVPFPIGHPRYMAPEVLTPGPMLPTNGDTPTMPLPPKTTNLSSGPKGDVWSLGMVILELCLGQTLWPVATLPQI
| |.|    |||||..||||.||.|.|||||||.|||||||....|.|..|....|| |||||||||||.||.||||||...||.|||..||...||...
LDDNGNQKLHVKLANYGLYHMTNHGKDVPFPIGYPRYMAPERILQGEMKTTDHMPPTNPLPPKTTNLSSNPKSDVWSLGCIMLEICLGICLWQELTLSEV

LAKVMLLGKH---------------------------------------------------------GAQNHPLDTILDEHAGRQK-------------L
|.|.|..|.|                                                         ...||.......||.. |.             .
LNKIMHYGTHSTTQSFNSISKSFEQCELKKTIINEKQHEEYEEYDDDEDISEEEKEKRIKDIKLNDQDCMNHFMEDLAREHQCHQRSNSGSSNSNIGIPY

DAYPASLQSFLRKCLSASPLERPSTTELLEGDML
......|....||||...|..|||.|||.| .|.
HQMCEWLIQIIRKCLQMCPMKRPSPTELMEHPMF
Kinase TBCK.AA Pkinase 385-514 19 4.1e-14 50.97 Pfam 175-293 (293) Show / Hide 
Range on Protein: 385-514
Range on HMM: 175-293/293
Sequence Identity: 19% (28 aa)

PRYMAPEVLTPGPMLPTNGDTPTMPLPPKTTNLSSGPKGDVWSLGMVILELCLGQTLWPVA------TLPQILAKVMLLGKHGAQNHPLD------TILD
|.||||||.                     ..   ||| |.||.| .. |...|....| .      .  |.....|    |     . .      .. .
PWYMAPEVIR--------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W

EHAGRQKLDAYPASLQSFLRKCLSASPLERPSTTELLEGDML
 |  ...... . ....|...||   | .||. ...|. . .
-HF-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TBCK.AA STE 382-514 18 4e-11 35.66 In-house 224-359 (359) Show / Hide 
Range on Protein: 382-514
Range on HMM: 224-359/359
Sequence Identity: 18% (28 aa)

IGHPRYMAPEVLTPGPMLPTNGDTPTMPLPPKTTNLSSGPKGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGA---------QNHP--LDTI
.| | .|||||....    .              .   . | |.|||| .|.|.. |.  |   . .. .   .  .. ..         ...|   |..
VGTP-WMAPEVIQQNGQG-R--------------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHL

LDEHAGRQKL--------DAYPASLQSFLRKCLSASPLERPSTTELLE--GDML
 ..   ..          . .  ... |..|||   | .||....||.     .
SQNEM-IS-YGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TBCK.AA STE7-Unclassified 422-514 20 7.8e-11 34.5 In-house 205-301 (301) Show / Hide 
Range on Protein: 422-514
Range on HMM: 205-301/301
Sequence Identity: 20% (22 aa)

KGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQNHP----------LDTILDEHAGRQKLDA----YPASLQSFLRKCLSASPLERPSTTE
|.|.|||| .|.|. .|  . ..            .   .... .          |. |... . | . |     .......|  ||.  .| |||. ..
KSDIWSLGLTIWECATGKYPYEYN-----------FQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQ

LLE-GDML
||.  ...
LLNEHPWI
Kinase TBCK.AA TKL 355-510 16 5.8e-10 32.06 In-house 173-362 (364) Show / Hide 
Range on Protein: 355-510
Range on HMM: 173-362/364
Sequence Identity: 16% (33 aa)

LYDDGH--------------VKLAKFGLYHITNCGSD--------------------VPFPIGHPRYMAPEVLTPGPMLPT---NGDTPTMPLPPKTTNL
. ....              .|.. |||    .  ..                       ..|.||.||||||   . ..    .        . .  ..
VDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI-------DE-FCKGF

SSGPKGDVWSLGMVILELCLGQTLWP-VATLPQILA----KVMLLGKHGAQNHPLDTILDE--HAGRQKLDAYPASLQSFLRKCLSASPLERPSTTELLE
.  .| ||.| |.|. |.. ... .      |.|..      . .  .  .  |...|  .    . .. .  | |. . . .| .. | .||| .|.|.
EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK
Kinase TBCK.AA MEK5 424-514 27 5.3e-08 25.27 In-house 173-254 (254) Show / Hide 
Range on Protein: 424-514
Range on HMM: 173-254/254
Sequence Identity: 27% (25 aa)

DVWSLGMVILELCLGQTLWPVATLPQ-ILAKVMLLGKHGAQNHPLDTILDEHAGRQKLDAYPASLQSFLRKCLSASPLERPSTTELLEGDML
||||||. ..|. .|.  .|     |  |. . |          |  | |||. |  .| . .    |. .|.   | .||   .|..   .
DVWSLGIFFMEMATGRFPYPQIQRDQGELMPIQL----------LQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase TBCK.AA STE-Unique 422-514 25 1.2e-07 22.66 In-house 533-616 (616) Show / Hide 
Range on Protein: 422-514
Range on HMM: 533-616/616
Sequence Identity: 25% (24 aa)

KGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQNHPLDTILDEHAGRQKLDAYPASLQSFLRKCLSASPLERPSTTELLEGDML
| |.||||......| |  .|   .  | ..   ....  . . |.. | .          .   .| |..|||.  |  |||. .||.   |
KVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPK---------CQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase TBCK.AA PEK 487-514 28 3.3e-07 20.34 In-house 628-655 (655) Show / Hide 
Range on Protein: 487-514
Range on HMM: 628-655/655
Sequence Identity: 28% (8 aa)

LQSFLRKCLSASPLERPSTTELLEGDML
...|....|| .| .|||. ..|. . .
QADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase TBCK.AA GCN2 488-514 40 7.1e-07 19.65 In-house 485-511 (511) Show / Hide 
Range on Protein: 488-514
Range on HMM: 485-511/511
Sequence Identity: 40% (11 aa)

QSFLRKCLSASPLERPSTTELLEGDML
|...|.||.  | .|||. .||... |
QDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase TBCK.AA PAKA 486-514 37 7.7e-05 13.09 In-house 232-260 (260) Show / Hide 
Range on Protein: 486-514
Range on HMM: 232-260/260
Sequence Identity: 37% (11 aa)

SLQSFLRKCLSASPLERPSTTELLEGDML
... || |||   . .|.|..|||.   |
EFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase TBCK.AA Ciliate-E2 422-514 17 0.000685 9.22 In-house 276-365 (365) Show / Hide 
Range on Protein: 422-514
Range on HMM: 276-365/365
Sequence Identity: 17% (17 aa)

KGDVWSLGMVILELCLGQTLWPVATLPQILAKVMLLGKHGAQNHPLDTILDEHAGRQK-LDAYPASLQSFLRK----CLSASPLERPS-TTELLEGDML
| |.||||... |.. |.. .    . ||. .   . .   |.. .. .  .  .  |  .  . . . ...|    .|   | .|..   ..|.   .
KCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKW-KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TBCK.AA GCN2 422-439 31 0.002774 6.86 In-house 432-450 (511) Show / Hide 
Range on Protein: 422-439
Range on HMM: 432-450/511
Sequence Identity: 31% (6 aa)

KGDVWSL-GMVILELCLGQ
|.|..|| | ...|.. ..
KVDMYSLGGIIFFEMWYPP
Kinase TBCK.AA PEK 382-439 20 0.010336 4.4 In-house 550-591 (655) Show / Hide 
Range on Protein: 382-439
Range on HMM: 550-591/655
Sequence Identity: 20% (12 aa)

IGHPRYMAPEVLTPGPMLPTNGDTPTMPLPPKTTNLSSGPKGDVWSLGMVILELCLGQ
.| ..||.||.|  .                . ..   . |.|..||| ...|.. ..
VGTCLYMSPEQLSGQ----------------HYQKSHYNHKVDMYSLGIIFFEMWYPF
Kinase TBCK.AA PAKA 420-439 40 0.036294 3.59 In-house 181-200 (260) Show / Hide 
Range on Protein: 420-439
Range on HMM: 181-200/260
Sequence Identity: 40% (8 aa)

GPKGDVWSLGMVILELCLGQ
..| |.||||  ..|.  |.
DEKVDIWSLGIMAIEMIEGE
TBC TBCK.AA TBC 794-963 25 2.8e-43 154.91 Pfam 49-240 (240) Show / Hide 
Range on Protein: 794-963
Range on HMM: 49-240/240
Sequence Identity: 25% (50 aa)

DRQIEVDIPRCHQ---YNELLSSVVAHN-KFKRILKAWVVSHPELTYWQGLDSLCAPFLYLNFSNEAL-----AYACLKAFI--PKYLYKFFMKD-NSLV
..||| |..|...   ... ...   .. . ..||||. . .|.. |.||.  ..|||||. . .|       |. |. ...   ..|  ....| .  .
YHQIEKDVHRTFPNHHHFFFFQNGQGQQVQLRNILKAYSNYNPDVGYCQGMNFIAAPFLYMYMMDEEDFQAEDAFWCFCQLMNENYHLRDYYTHDMPG-H

IQEYLA--VFSHMIAFHDPELSNHLQS--IGFIPELFAIPWFLTMFSHVFPLHKIFHLWDTLLL---GT--SSFPLCIGVA-IL-QQLRVGLL
.| ..   || . .  |||.| .|.|.  ..  | .||..||...|.|.||.  ....|| ...   |   . | . ...| ||  ..|  .|
LQRDFYFQVFEELLKKHDPKLYKHFQKDCLNIDPSMFATQWFMCLFTHCFPFETVLRIWDCFFFYCEGWNAKFFLFRFCLACILVKYHRQEIL
TBC TBCK.AA TBC 756-966 17 2.3e-37 131.36 SMART 1-310 (310) Show / Hide 
Range on Protein: 756-966
Range on HMM: 1-310/310
Sequence Identity: 17% (55 aa)

IGKGRPKISWKDV------VKKEGSKG--------------------DIQANYDAIDKETPTAM--------------------------------DRQI
...|.|    ..|       ... ..                     . . .|| . ..... .                                . ||
WWQGIPHHYRGWVWWLLLNCQPMNTSNWERMQYMWDGENCYFPVNWDRCKDYYDRMLNQHCPCDHHHDNWQDIMMNNNDHECCWMSYWHFFQDCWHWHQI

EVDIPRCHQYNELLSSV---------------VAHNKFKRILKAWVVSHPE--LTYWQGLDSLCAPFLYLNF-SNEALAYACLKAFIPKYLYKFFM----
|.|..|... ...  .                . . .  |.|.|. . .||  . |.||.  ..||.|. .  ..|. |..|.....  |. .|.     
EKDLRRTFPNHPFFQFRMRYNQHCIMLHDQNGPHQESLRRVLYAYSWHNPEHIVGYCQGMNFIAAPLLLHMPCYDEEDAFWCFCKLMERYCPWFYFCDDQ

---KDNSLVIQEYLAVFSHMIAFHDPELSNHLQSI------------GFIPELFAIPWFLTMFSHVFPLHKIFHLWDTLLLG----TSSFPLCIGVAILQ
   . .   ... . .|.|..  |||.|..|||.             .. |...|..||||.|.. |||. ....|| ...      . |..||..|.|.
NCYTPDMMGMHWQMYQFDHLLQEHDPDLYKHLQEQDHHSMKWHFDHLEIDPSMYAFRWFLTCFAREFPLEDVCRIWDCYFFEYGRHGHPFLFCIALAMLK

QLRVGLLMAG
..|  ||   
MHRQKLLQHD
Rhodanese TBCK.AA Rhodanese 1074-1141 18 4.4e-07 24.11 Pfam 1-63 (102) Show / Hide 
Range on Protein: 1074-1141
Range on HMM: 1-63/102
Sequence Identity: 18% (13 aa)

SHSPTKKNKNSKPIILIVDIRSSDDFSRGHIPSS-VNTPFNSAFSPEGDLIP--CPAVTQLYNHRGRV-VTV
.    |..   .| ..|.|.|. .....|||| . || |.          .   .. . .  ..  .. |..
TPEWLKEMM-NDPDYVIIDVRPPEEYEKGHIPGAHVNIPW--------LEEEHDLEELGIKLDKDKPIIVVY