Gene Slob (Sea Urchin)
Slob
Sequence
Protein domains of Slob.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PX | Slob.AA | PX | 17-122 | 30 | 1.1e-21 | 76.87 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 17-122 Range on HMM: 1-120/120 Sequence Identity: 30% (37 aa) TITLTCSIEAAQ-----NLESHTDYVIRVQRGPN--PENSWQINRRYSDFVTLHDGLKV--SGMEL-GLPPKKVFGN---MEREFIAERQQALQGYLNRI . .| ... . . ..|. ||..... | .. .|.. ||||||. ||. || .. . ||||..||. ...||| .|.|.|. ||.|. DHFLQVHVVDPETHKHYGDKMHYYYVYEIHMNTNPFQKKEWHVWRRYSDFHWLHKQLKRHFPMCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQYLQRV LSHQLLSS-CFLVKRFLDPT ..| .|.. | ....|| | CQHPELCNHCEVFHDFLHPD |
|||||||||
| PX | Slob.AA | PX | 17-122 | 21 | 3.4e-15 | 57.72 | SMART | 1-142 (142) | Show / Hide |
Range on Protein: 17-122 Range on HMM: 1-142/142 Sequence Identity: 21% (30 aa) TITLTCSIEAAQ------NLESHTDYVIRVQRGPNP-ENSWQINRRYSDFVTLHDGLK--VS----GMELGLPPKKV-------------------FGNM . .. ... . . .|. ||...... |. . |.. ||||||. || || .. . .| |. |.|. DHIFIITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEKRMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFNNF EREFIAERQQALQGYLNRILSHQLLSS----CFLVKRFLDPT ..|| .|.. |. ||.|...| .... | .|..|... DEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS |
|||||||||
| Kinase | Slob.AA | Slob | 152-393 | 41 | 2.4e-108 | 366.26 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 152-393 Range on HMM: 1-268/268 Sequence Identity: 41% (111 aa) LRDIGWRIRKTYFMVRPKSQPKVKQVLAWSYYGPD----KDLDYKDLVPIMKLLPTIQHPFIYPVT----YVSASDSGGLAIRTFHGTGTLKDFICKAKP | .||||.|| ..|.. . ||. |. | |||| |.|. |. .||.|. .||.||||. .... .. . ||.|. |.|||||.|||| LDHIGWRHRKNWCMMKNDMQPGEECVQSWIDYGPDCCPWKMLNEKECQCFMKILMSCHHPYIYPVINLVFFINHKHNYCCVIRFFNKRGSLKDFIYKAKP KAHYLKKYCL----------------PKSYTAFNIMNIKSYGRMILEALKFLHEKGLPYGHLHAGNVILEG--NACRLLDIENTLLGLPFFYRGYLSHFR | ...||| .|. .. . .. |.| |||||.|||.|| ||||||.|||.. . ..|||.|||| |||.| ||. | . .| KMPWARKYCNKQPKSSSSSSSSSSSSHKKQNGLPMKQVQKYCRQILEALIFLHSKGFPYGHLHSGNVMIDDSNDCCRLSDIENCLLGMPPFYNDYIMWHR KINTTEAVDVYSFGHVLYEMTFGSPLNVASKDDFPHTIPPPIKSVLESILTTEACKTKLPTVDDLLAD ||...|.||||.|||.||||..|.|. | . || ... ..|.|| |.|| ..||. || KIHEIENVDVYCFGHCLYEMCCGYPMQNHSVRNFPPCPFIALFCDKEHILSCEICKHCMPTMRQLLQM |
|||||||||
| S_TKc | Slob.AA | S_TKc | 149-396 | 18 | 4.5e-05 | -102.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 149-396
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)
VEPLRDIG-------WRIRKTY--FMVRPKSQPKVKQVLAWSYYGPDKDLDYKDLVPIMKLLPTIQHPFIYPVTYVSASDSGGLAIRTFHGTG---TLKD
| || || .. |.. | | . ... ...| .||.| .| . . | . . . | .|.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFD
FICKAKPKAHYLKKYCLPKSYTAFNIMNIKSYGRMILEALKFLHEKGLPYGHLHAGNVILE--------GNACRLLDIENTLLGLPFF-----YRGYLSH
.|.| ... . . |. ...| . |..||...|..| . | |. | | |..| .|. | |..
YIKKRGRH----------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL----TTFCGTPWYMAPEVL------
FRKINTTE-AVDVYSFGHVLYEMTFGSP----LNVASKDDFPHTIPPPIKSVLESILTTEACKTKLPTVDDLLA-------DPLF
. ..|..|.| .|||| | | ... | .|. |. .. .|. . .| ||. ..|. .| |
----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----SPEAKDFIRKCLQKDP--EKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | Slob.AA | Dicty4 | 330-345 | 62 | 6.3e-05 | 12.57 | In-house | 195-210 (277) | Show / Hide |
Range on Protein: 330-345 Range on HMM: 195-210/277 Sequence Identity: 62% (10 aa) TEAVDVYSFGHVLYEM .|..|||||| ||.|. NEKADVYSFGIVLWEI |
|||||||||
| Kinase | Slob.AA | Ciliate-D1 | 334-352 | 57 | 9.4e-05 | 16.62 | In-house | 1-19 (19) | Show / Hide |
Range on Protein: 334-352 Range on HMM: 1-19/19 Sequence Identity: 57% (11 aa) DVYSFGHVLYEMTFGSPLN |..||| .|||| ||.| DIWSFGCILYEMLFGQPPF |
|||||||||
| Kinase | Slob.AA | TKL-Unique | 330-345 | 62 | 0.000157 | 12.1 | In-house | 206-221 (290) | Show / Hide |
Range on Protein: 330-345 Range on HMM: 206-221/290 Sequence Identity: 62% (10 aa) TEAVDVYSFGHVLYEM .| .|||||| ||.|. SEKSDVYSFGIVLWEI |
|||||||||
| Kinase | Slob.AA | Dicty5 | 330-345 | 62 | 0.000819 | 9.0 | In-house | 181-196 (260) | Show / Hide |
Range on Protein: 330-345 Range on HMM: 181-196/260 Sequence Identity: 62% (10 aa) TEAVDVYSFGHVLYEM .. .|||||| ||.|| HQKCDVYSFGIVLWEM |
|||||||||
| Kinase | Slob.AA | Shk | 331-345 | 60 | 0.000892 | 9.83 | In-house | 185-199 (269) | Show / Hide |
Range on Protein: 331-345 Range on HMM: 185-199/269 Sequence Identity: 60% (9 aa) EAVDVYSFGHVLYEM | .|||||| .|.|. EKADVYSFGIILWEI |
|||||||||
| Kinase | Slob.AA | KSR | 330-345 | 50 | 0.000935 | 8.68 | In-house | 194-209 (272) | Show / Hide |
Range on Protein: 330-345 Range on HMM: 194-209/272 Sequence Identity: 50% (8 aa) TEAVDVYSFGHVLYEM ... |||.|| ..||| SHHSDVYAFGTIWYEM |
|||||||||
| Kinase | Slob.AA | ULK | 333-350 | 38 | 0.000957 | 9.24 | In-house | 233-250 (324) | Show / Hide |
Range on Protein: 333-350 Range on HMM: 233-250/324 Sequence Identity: 38% (7 aa) VDVYSFGHVLYEMTFGSP .|..|.| ..||| .|.. CDIWSLGCIFYEMLYGKY |
|||||||||